Against the backdrop of digital education,the campus network has become an indispensable infrastructure in universities,yet the limitations of traditional operation models have become increasingly prominent.This paper...Against the backdrop of digital education,the campus network has become an indispensable infrastructure in universities,yet the limitations of traditional operation models have become increasingly prominent.This paper systematically presents the entire process of the free campus network reform initiated by Dalian Jiaotong University,focusing on its background,implementation paths,existing challenges,and optimization strategies.It explores the construction of an on-demand service system for campus networks,and practical experience can provide some reference and guidance for sister universities.展开更多
Errors due to split time stepping are discussed for an explicit free–surface ocean model. In commonly used split time stepping, the way of time integration for the barotropic momentum equation is not compatible with ...Errors due to split time stepping are discussed for an explicit free–surface ocean model. In commonly used split time stepping, the way of time integration for the barotropic momentum equation is not compatible with that of the baroclinic one. The baroclinic equation has three–time–level structure because of leapfrog scheme. The barotropic one, however, has two–time–level structure when represented in terms of the baroclinic time level, on which the baroclinic one is integrated. This incompatibility results in the splitting errors as shown in this paper. The proper split time stepping is therefore proposed in such a way that the compatibility is kept between the barotropic and baroclinic equations. Its splitting errors are shown extremely small, so that it is particularly relevant to long–term integration for climate studies. It is applied to a free–surface model for the North Pacific Ocean.展开更多
A controlled hydroponic experiment was undertaken to investigate Cd uptake in relation to the activity of Cd species in solution other than the free ion （Cd^2＋） by maintaining a constant Cd^2＋ activity under varia...A controlled hydroponic experiment was undertaken to investigate Cd uptake in relation to the activity of Cd species in solution other than the free ion （Cd^2＋） by maintaining a constant Cd^2＋ activity under variable SO4^2- and Cl^- concentrations exposed to maize （Zea mays vat. Cameron） plants. The objectives of these experiments were： （1） to distinguish and quantify the different uptake rates of free and inorganic-complexed Cd from nutrient solution, and （2） to model the uptake of Cd by maize with a Biotic Ligand Model （BLM） in a system which facilitates the close examination of root characteristics. Results of the current experiments suggest that, in addition to the free ion, CdSO4^0 complexes are important factors in determining Cd uptake in nutrient solution by maize plants. Higher nominal SO4^2- concentrations in solution generally resulted in a greater Cd accumulation by maize plants than predicted by the Cd^2＋ activity. A better integration of the complete dataset for the 3 harvest times （6, 9 and 11 days after treatment） was achieved by including consideration of both the duration of Cd exposure and especially the root surface area to express Cd uptake. Similarly, the fit of the BLM was also improved when taking into account exposure time and expressing uptake in terms of root morphological parameters.展开更多
A dynamic free energy hysteresis model in magnetostrictive actuators is presented.It is the free energy hysteresis model coupled to an ordinary different equation in an unusual way.According to its special structure,n...A dynamic free energy hysteresis model in magnetostrictive actuators is presented.It is the free energy hysteresis model coupled to an ordinary different equation in an unusual way.According to its special structure,numerical implementation method of the dynamic model is provided.The resistor parameter in the dynamic model changes according to different frequency ranges.This makes numerical implementation results reasonable in the discussed operating frequency range.The validity of the dynamic free energy model is illustrated by comparison with experimental data.展开更多
Background:This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas(over 4000 m to even 5000 m above sea level)and explore an aid model for early diagnosis and treatme...Background:This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas(over 4000 m to even 5000 m above sea level)and explore an aid model for early diagnosis and treatmentfor the Tibetan population.Methods:A total of 2242 students from different schools in Ngamring County,Xigaze City,Tibet from September 2019 to September 2020 were selected for screening.The students were examinedthrough the inquiry of their current medical history and family history,cardiac auscultation and a physicalexamination,in order to screen out the suspected cases of CHD,and then the suspected cases were confirmed bycardiac color ultrasound examinations.After that,positive patients were be transferred to Shandong Province forfree treatment.Results:The prevalence of CHD among children in Ngamring County was 3.70%(83 cases),which is the highest incidence rate ever reported.The most common type of CHD was patent ductus arteriosus(PDA),accounting for 55.42%of the total number of cases screened,followed by atrial septal defect(ASD)andventricular septal defect(VSD),accounting for 28.92%and 12.05%,respectively.The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude.The children with CHD weretransferred to Shandong Province for surgery,the operations were successful and their recoveries went well.Conclusions:The results show that high altitude is closely related to the prevalence of CHD,and the incidencein Ngamring County is much higher than that in previous reports.展开更多
A mathematical mechanism of the n-pentane pyrolysis process based on free radical reaction model was presented.The kinetic parameters of n-pentane pyrolysis are obtained by quantum chemistry and the reaction network i...A mathematical mechanism of the n-pentane pyrolysis process based on free radical reaction model was presented.The kinetic parameters of n-pentane pyrolysis are obtained by quantum chemistry and the reaction network is established. The solution of the stiff ordinary differential equations in the n-pentane pyrolysis model is completed by semi implicit Eular algorithm. Then the pyrolysis mechanism based on free radical reaction model is built,and the computational efficiency increases 10 times by algorithm optimization. The validity of this model and its solution method is confirmed by the experimental results of n-pentane pyrolysis.展开更多
Many interesting characteristics of sea ice drift depend on the atmospheric drag coefficient （Ca） and oceanic drag coefficient （Cw）. Parameterizations of drag coefficients rather than constant values provide us a ...Many interesting characteristics of sea ice drift depend on the atmospheric drag coefficient （Ca） and oceanic drag coefficient （Cw）. Parameterizations of drag coefficients rather than constant values provide us a way to look insight into the dependence of these characteristics on sea ice conditions. In the present study, the parameterized ice drag coefficients are included into a free-drift sea ice dynamic model, and the wind factor a and the deflection angle θ between sea ice drift and wind velocity as well as the ratio of Ca to Cw are studied to investigate their dependence on the impact factors such as local drag coefficients, floe and ridge geometry. The results reveal that in an idealized steady ocean, Ca/Cw increases obviously with the increasing ice concentration for small ice floes in the marginal ice zone, while it remains at a steady level （0.2-0.25） for large floes in the central ice zone. The wind factor a increases rapidly at first and approaches a steady level of 0.018 when A is greater than 20%. And the deflection angle ~ drops rapidly from an initial value of approximate 80° and decreases slowly as A is greater than 20% without a steady level like a. The values of these parameters agree well with the previously reported observations in Arctic. The ridging intensity is an important parameter to determine the dominant contribution of the ratio of skin friction drag coefficient （Cs＇/Cs） and the ratio of ridge form drag coefficient （Cr＇/Cr） to the value of Ca/Cw, a, and 8, because of the dominance of ridge form drag for large ridging intensity and skin friction for small ridging intensity among the total drag forces. Parameterization of sea ice drag coefficients has the potential to be embedded into ice dynamic models to better account for the variability of sea ice in the transient Arctic Ocean.展开更多
BACKGROUND: The fluidity of cell membrane can be affected by various factors. Many experiments have confirmed that the ischemia/reperfusion of organic tissue can increase the contents of free radicals, which lead to h...BACKGROUND: The fluidity of cell membrane can be affected by various factors. Many experiments have confirmed that the ischemia/reperfusion of organic tissue can increase the contents of free radicals, which lead to high rigidity and low fluidity of cell membrane, and the conditions can be changed by Chuanxiongqin. OBJECTIVE: To observe the effect and mechanism of Chuanxiongqin hydrochloride on the fluidity of brain cell membrane in rat models of ischemia/reperfusion. DESIGN: A completely randomized controlled animal trial. SETTINGS: Institute of Brain Sciences; Department of Physiology, Medical College, Datong University. MATERIALS: Twenty male grade Ⅰ Wistar rats of 170-220 g were randomly divided into model group (n =10) and control group (n =10). Chuanxiongqin hydrochloride (molecular mass was 172.2) was purchased from the National Institute for the Control of Pharmaceutical and Biological Products (batch number: 0817-9803); Spin labelers: 5-doxyl-stearlic acid methylester (5DS), 16-doxyl-stearlic acid methylester (16DS), xanthine, xanthine oxidase (XOD) and 5,5-dimeth-1-pyrroline- N-oxide (DMPO) from Sigma Company; Bruker ESP 300 electron paramagnetic resonance (EPR) spectrometer by Bruker Company (Germany). METHODS: The experiments were carried out in the State Key Laboratory of Natural and Biomimetic Drugs, Peking University from June 2001 to July 2002. In the model group, rats were made into models of cerebral ischemia by 30-minute ligation and 2-hour reperfusion of common carotid arteries; The rats in the control group were not made into models. The order parameter (S) and rotational correlation time (τc) were detected with the ESR spectrometer by means of spin labeling. The greater the S and τc, the smaller the fluidity. Meanwhile, the clearance rate of free radicals was detected with ESR spin trapping. The measurement data were compared using the t test. MAIN OUTCOME MEASURES: The S, τc and clearance rates of O2 · and OH· free radicals were compared between the model group and control group. RESULTS: The S and τc in the model group [0.738 4±0.003 5; (8.472±0.027)×10-10 s/circle] were obviously different from those in the control group [0.683 9±0.008 3; (7.945±0.082)×10-10 s/circle, t =5.731, 5.918, P < 0.05], which suggested that ischemia/reperfusion injury decreased the fluidity of brain cell membrane. After adding Chuanxiongqin hydrochloride, there were no obvious differences between the model group [0.688 5±0.030 5; (7.886±0.341)×10-10 s/circle] and control group (P > 0.05), indicating that Chuanxiongqin hydrochloride could recover the fluidity of brain cell membrane after ischemia/reperfusion injury close to the level in the normal control group. Chuanxiongqin hydrochloride could directly scavenge the O2 · and OH· free radicals, and the maximal clearance rates were 83.92% and 44.99% respectively. CONCLUSION: Chuanxiongqin hydrochloride increases the fluidity of membrane of ischemia-injured brain cell by scavenging both O2 ·and OH· free radicals.展开更多
We study the detailed malicious code propagating process in scale-free networks with link weights that denotes traffic between two nodes. It is found that the propagating velocity reaches a peak rapidly then decays in...We study the detailed malicious code propagating process in scale-free networks with link weights that denotes traffic between two nodes. It is found that the propagating velocity reaches a peak rapidly then decays in a power-law form, which is different from the well-known result in unweighted network case. Simulation results show that the nodes with larger strength are preferential to be infected, but the hierarchical dynamics are not clearly found. The simulation results also show that larger dispersion of weight of networks leads to slower propagating, which indicates that malicious code propagates more quickly in unweighted scale-free networks than in weighted scale-free networks under the same condition. These results show that not only the topology of networks but also the link weights affect the malicious propagating process.展开更多
In this paper, we apply the recursive genetic programming (RGP) approach to the cognition of a system, and then proceed to the detecting procedure for structural changes in the system whose components are of long memo...In this paper, we apply the recursive genetic programming (RGP) approach to the cognition of a system, and then proceed to the detecting procedure for structural changes in the system whose components are of long memory. This approach is adaptive and model-free, which can simulate the individual activities of the system's participants, therefore, it has strong ability to recognize the operating mechanism of the system. Based on the previous cognition about the system, a testing statistic is developed for the detection of structural changes in the system. Furthermore, an example is presented to illustrate the validity and practical value of the proposed.展开更多
This paper introduces a model-free reinforcement learning technique that is used to solve a class of dynamic games known as dynamic graphical games. The graphical game results from to make all the agents synchronize t...This paper introduces a model-free reinforcement learning technique that is used to solve a class of dynamic games known as dynamic graphical games. The graphical game results from to make all the agents synchronize to the state of a command multi-agent dynamical systems, where pinning control is used generator or a leader agent. Novel coupled Bellman equations and Hamiltonian functions are developed for the dynamic graphical games. The Hamiltonian mechanics are used to derive the necessary conditions for optimality. The solution for the dynamic graphical game is given in terms of the solution to a set of coupled Hamilton-Jacobi-Bellman equations developed herein. Nash equilibrium solution for the graphical game is given in terms of the solution to the underlying coupled Hamilton-Jacobi-Bellman equations. An online model-free policy iteration algorithm is developed to learn the Nash solution for the dynamic graphical game. This algorithm does not require any knowledge of the agents＇ dynamics. A proof of convergence for this multi-agent learning algorithm is given under mild assumption about the inter-connectivity properties of the graph. A gradient descent technique with critic network structures is used to implement the policy iteration algorithm to solve the graphical game online in real-time.展开更多
A model-flee compound controller design method is proposed to achieve the wide frequency bandwidth requirement of flight simulators. The method based on quantitative feedback theory, acquires system uncertainty under ...A model-flee compound controller design method is proposed to achieve the wide frequency bandwidth requirement of flight simulators. The method based on quantitative feedback theory, acquires system uncertainty under different working conditions through closed-loop identification with power spectrum estimation. Then in controller designing, it makes a trade, off between the strict requirements for magnitude-frequency characteristics and those for phase-frequency characteristics of flight simulators, by converting the indices of magnitude-frequency characteristics of flight simulators into quantitative feedback theory-based tracking specification bounds and using feedforward controller to attain the required phase-flequency characteristics. Simulation and experimental results indicate that, when used to design inner flame controller of flight simulator, the proposed method can fulfill the requirements for wide frequency bandwidth indices. Compared with other controller design methods, it has the property of model-free and transparency.展开更多
In this work, a Revisited form of the so-called Model-Free Control（R-MFC） is derived.Herein, the MFC principle is employed to deal with the unknown part of a plant only（i.e., unmodeled dynamics, disturbances, etc....In this work, a Revisited form of the so-called Model-Free Control（R-MFC） is derived.Herein, the MFC principle is employed to deal with the unknown part of a plant only（i.e., unmodeled dynamics, disturbances, etc.） and occurs beside an Interconnection and Damping AssignmentPassivity Based Control（IDA-PBC） strategy. Using the proposed formulation, it is shown that we can significantly improve the performance of the control through the reshaping properties of the IDA-PBC technique. Moreover, the control robustness level is increased via a compensation of the time-varying disturbances and the unmodeled system dynamics. This on-line compensation capability is provided by the MFC principle. The problem is studied in the case of Multi-Input Multi-Output（MIMO） mechanical systems with an explicit application to a small Vertical Take-Off and Landing（VTOL） Unmanned Aerial Vehicle（UAV） where a stability analysis is also provided. Numerical simulations have shown satisfactory results, in comparison with some other control strategies, where an in-depth discussion with respect to the control performance is highlighted by considering several scenarios and using several metrics.展开更多
In this paper,a new model free adaptive control method based on self-adjusting PID algorithm(MFACSA-PID)is proposed to solve the problem that the pH process with strong nonlinearity is difficult to control near the ne...In this paper,a new model free adaptive control method based on self-adjusting PID algorithm(MFACSA-PID)is proposed to solve the problem that the pH process with strong nonlinearity is difficult to control near the neutralization point.The MFAC-SA-PID method also solves the problem that the parameters of the model free adaptive control(MFAC)method are not easy to be adjusted and the effect is not obvious by introducing a fuzzy self-adjusting algorithm to adjust the controller parameters.Then the convergence and stability of the MFAC-SA-PID method are proved in this paper.In the simulation study,the control performance of the MFAC-SA-PID method proposed in this paper is compared with the traditional MFAC method and the improved model free adaptive control(IMFAC)method,respectively.The results show that the proposed MFAC-SA-PID method has better control effect on the pH neutralization process.The MFAC-SA-PID control performance also outperforms the traditional MFAC method and IMFAC method when step input disturbances are added,which indicates that the MFAC-SA-PID method has better robustness and stability.展开更多
Volatility forecasting is important in financial econometrics and is mainly based on the application of various GARCH-type models.However,it is difficult to choose a specific GARCH model that works uniformly well acro...Volatility forecasting is important in financial econometrics and is mainly based on the application of various GARCH-type models.However,it is difficult to choose a specific GARCH model that works uniformly well across datasets,and the traditional methods are unstable when dealing with highly volatile or short-sized datasets.The newly pro-posed normalizing and variance stabilizing(NoVaS)method is a more robust and accu-rate prediction technique that can help with such datasets.This model-free method was originally developed by taking advantage of an inverse transformation based on the frame of the ARCH model.In this study,we conduct extensive empirical and simu-lation analyses to investigate whether it provides higher-quality long-term volatility forecasting than standard GARCH models.Specifically,we found this advantage to be more prominent with short and volatile data.Next,we propose a variant of the NoVaS method that possesses a more complete form and generally outperforms the current state-of-the-art NoVaS method.The uniformly superior performance of NoVaS-type methods encourages their wide application in volatility forecasting.Our analyses also highlight the flexibility of the NoVaS idea that allows the exploration of other model structures to improve existing models or solve specific prediction problems.展开更多
Identifying the unknown geometric and material information of a multi-shield object by analyzing the radiation signature measurements is always an important problem in national and global security. In order to identif...Identifying the unknown geometric and material information of a multi-shield object by analyzing the radiation signature measurements is always an important problem in national and global security. In order to identify the unknown shielding layer thicknesses of a source/shield system with gamma-ray spectra, we have developed a derivative-free inverse radiation transport model based on a differential evolution algorithm with global and local neighbourhoods(IRT-DEGL). In the present paper, the IRT-DEGL model is further extended for estimating the unknown thicknesses with random initial guesses and material mass densities of multi-shielding layers as well as their combinations. Using the detected gamma-ray spectra,the illustration of inverse studies is implemented and the main influence factors for inverse results are also analyzed.展开更多
文摘Against the backdrop of digital education,the campus network has become an indispensable infrastructure in universities,yet the limitations of traditional operation models have become increasingly prominent.This paper systematically presents the entire process of the free campus network reform initiated by Dalian Jiaotong University,focusing on its background,implementation paths,existing challenges,and optimization strategies.It explores the construction of an on-demand service system for campus networks,and practical experience can provide some reference and guidance for sister universities.
基金Hundred Talent Program of Chinese Academy of Sciences under Grant No. 0300YQ000101. Partly supported by the National Natural Sci
文摘Errors due to split time stepping are discussed for an explicit free–surface ocean model. In commonly used split time stepping, the way of time integration for the barotropic momentum equation is not compatible with that of the baroclinic one. The baroclinic equation has three–time–level structure because of leapfrog scheme. The barotropic one, however, has two–time–level structure when represented in terms of the baroclinic time level, on which the baroclinic one is integrated. This incompatibility results in the splitting errors as shown in this paper. The proper split time stepping is therefore proposed in such a way that the compatibility is kept between the barotropic and baroclinic equations. Its splitting errors are shown extremely small, so that it is particularly relevant to long–term integration for climate studies. It is applied to a free–surface model for the North Pacific Ocean.
基金supported by the Severn Trent Water Ltd. as co-funders of the Biorem 11 (PASS) Project under the Bioremediation Link Programme (UK BBSRC)the financia support from CONACYT,Mexico (No. 137972)
文摘A controlled hydroponic experiment was undertaken to investigate Cd uptake in relation to the activity of Cd species in solution other than the free ion （Cd^2＋） by maintaining a constant Cd^2＋ activity under variable SO4^2- and Cl^- concentrations exposed to maize （Zea mays vat. Cameron） plants. The objectives of these experiments were： （1） to distinguish and quantify the different uptake rates of free and inorganic-complexed Cd from nutrient solution, and （2） to model the uptake of Cd by maize with a Biotic Ligand Model （BLM） in a system which facilitates the close examination of root characteristics. Results of the current experiments suggest that, in addition to the free ion, CdSO4^0 complexes are important factors in determining Cd uptake in nutrient solution by maize plants. Higher nominal SO4^2- concentrations in solution generally resulted in a greater Cd accumulation by maize plants than predicted by the Cd^2＋ activity. A better integration of the complete dataset for the 3 harvest times （6, 9 and 11 days after treatment） was achieved by including consideration of both the duration of Cd exposure and especially the root surface area to express Cd uptake. Similarly, the fit of the BLM was also improved when taking into account exposure time and expressing uptake in terms of root morphological parameters.
文摘A dynamic free energy hysteresis model in magnetostrictive actuators is presented.It is the free energy hysteresis model coupled to an ordinary different equation in an unusual way.According to its special structure,numerical implementation method of the dynamic model is provided.The resistor parameter in the dynamic model changes according to different frequency ranges.This makes numerical implementation results reasonable in the discussed operating frequency range.The validity of the dynamic free energy model is illustrated by comparison with experimental data.
文摘Background:This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas(over 4000 m to even 5000 m above sea level)and explore an aid model for early diagnosis and treatmentfor the Tibetan population.Methods:A total of 2242 students from different schools in Ngamring County,Xigaze City,Tibet from September 2019 to September 2020 were selected for screening.The students were examinedthrough the inquiry of their current medical history and family history,cardiac auscultation and a physicalexamination,in order to screen out the suspected cases of CHD,and then the suspected cases were confirmed bycardiac color ultrasound examinations.After that,positive patients were be transferred to Shandong Province forfree treatment.Results:The prevalence of CHD among children in Ngamring County was 3.70%(83 cases),which is the highest incidence rate ever reported.The most common type of CHD was patent ductus arteriosus(PDA),accounting for 55.42%of the total number of cases screened,followed by atrial septal defect(ASD)andventricular septal defect(VSD),accounting for 28.92%and 12.05%,respectively.The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude.The children with CHD weretransferred to Shandong Province for surgery,the operations were successful and their recoveries went well.Conclusions:The results show that high altitude is closely related to the prevalence of CHD,and the incidencein Ngamring County is much higher than that in previous reports.
文摘A mathematical mechanism of the n-pentane pyrolysis process based on free radical reaction model was presented.The kinetic parameters of n-pentane pyrolysis are obtained by quantum chemistry and the reaction network is established. The solution of the stiff ordinary differential equations in the n-pentane pyrolysis model is completed by semi implicit Eular algorithm. Then the pyrolysis mechanism based on free radical reaction model is built,and the computational efficiency increases 10 times by algorithm optimization. The validity of this model and its solution method is confirmed by the experimental results of n-pentane pyrolysis.
基金The National Natural Science Foundation of China under contracts Nos 41276191 and 41306207the Public Science and Technology Research Funds Projects of Ocean under contract No.201205007-05the Global Change Research Program of China under contract No.2015CB953901
文摘Many interesting characteristics of sea ice drift depend on the atmospheric drag coefficient （Ca） and oceanic drag coefficient （Cw）. Parameterizations of drag coefficients rather than constant values provide us a way to look insight into the dependence of these characteristics on sea ice conditions. In the present study, the parameterized ice drag coefficients are included into a free-drift sea ice dynamic model, and the wind factor a and the deflection angle θ between sea ice drift and wind velocity as well as the ratio of Ca to Cw are studied to investigate their dependence on the impact factors such as local drag coefficients, floe and ridge geometry. The results reveal that in an idealized steady ocean, Ca/Cw increases obviously with the increasing ice concentration for small ice floes in the marginal ice zone, while it remains at a steady level （0.2-0.25） for large floes in the central ice zone. The wind factor a increases rapidly at first and approaches a steady level of 0.018 when A is greater than 20%. And the deflection angle ~ drops rapidly from an initial value of approximate 80° and decreases slowly as A is greater than 20% without a steady level like a. The values of these parameters agree well with the previously reported observations in Arctic. The ridging intensity is an important parameter to determine the dominant contribution of the ratio of skin friction drag coefficient （Cs＇/Cs） and the ratio of ridge form drag coefficient （Cr＇/Cr） to the value of Ca/Cw, a, and 8, because of the dominance of ridge form drag for large ridging intensity and skin friction for small ridging intensity among the total drag forces. Parameterization of sea ice drag coefficients has the potential to be embedded into ice dynamic models to better account for the variability of sea ice in the transient Arctic Ocean.
文摘BACKGROUND: The fluidity of cell membrane can be affected by various factors. Many experiments have confirmed that the ischemia/reperfusion of organic tissue can increase the contents of free radicals, which lead to high rigidity and low fluidity of cell membrane, and the conditions can be changed by Chuanxiongqin. OBJECTIVE: To observe the effect and mechanism of Chuanxiongqin hydrochloride on the fluidity of brain cell membrane in rat models of ischemia/reperfusion. DESIGN: A completely randomized controlled animal trial. SETTINGS: Institute of Brain Sciences; Department of Physiology, Medical College, Datong University. MATERIALS: Twenty male grade Ⅰ Wistar rats of 170-220 g were randomly divided into model group (n =10) and control group (n =10). Chuanxiongqin hydrochloride (molecular mass was 172.2) was purchased from the National Institute for the Control of Pharmaceutical and Biological Products (batch number: 0817-9803); Spin labelers: 5-doxyl-stearlic acid methylester (5DS), 16-doxyl-stearlic acid methylester (16DS), xanthine, xanthine oxidase (XOD) and 5,5-dimeth-1-pyrroline- N-oxide (DMPO) from Sigma Company; Bruker ESP 300 electron paramagnetic resonance (EPR) spectrometer by Bruker Company (Germany). METHODS: The experiments were carried out in the State Key Laboratory of Natural and Biomimetic Drugs, Peking University from June 2001 to July 2002. In the model group, rats were made into models of cerebral ischemia by 30-minute ligation and 2-hour reperfusion of common carotid arteries; The rats in the control group were not made into models. The order parameter (S) and rotational correlation time (τc) were detected with the ESR spectrometer by means of spin labeling. The greater the S and τc, the smaller the fluidity. Meanwhile, the clearance rate of free radicals was detected with ESR spin trapping. The measurement data were compared using the t test. MAIN OUTCOME MEASURES: The S, τc and clearance rates of O2 · and OH· free radicals were compared between the model group and control group. RESULTS: The S and τc in the model group [0.738 4±0.003 5; (8.472±0.027)×10-10 s/circle] were obviously different from those in the control group [0.683 9±0.008 3; (7.945±0.082)×10-10 s/circle, t =5.731, 5.918, P < 0.05], which suggested that ischemia/reperfusion injury decreased the fluidity of brain cell membrane. After adding Chuanxiongqin hydrochloride, there were no obvious differences between the model group [0.688 5±0.030 5; (7.886±0.341)×10-10 s/circle] and control group (P > 0.05), indicating that Chuanxiongqin hydrochloride could recover the fluidity of brain cell membrane after ischemia/reperfusion injury close to the level in the normal control group. Chuanxiongqin hydrochloride could directly scavenge the O2 · and OH· free radicals, and the maximal clearance rates were 83.92% and 44.99% respectively. CONCLUSION: Chuanxiongqin hydrochloride increases the fluidity of membrane of ischemia-injured brain cell by scavenging both O2 ·and OH· free radicals.
基金Supported by the National Natural Science Foundation of China (90204012, 60573036) and the Natural Science Foundation of Hebei Province (F2006000177)
文摘We study the detailed malicious code propagating process in scale-free networks with link weights that denotes traffic between two nodes. It is found that the propagating velocity reaches a peak rapidly then decays in a power-law form, which is different from the well-known result in unweighted network case. Simulation results show that the nodes with larger strength are preferential to be infected, but the hierarchical dynamics are not clearly found. The simulation results also show that larger dispersion of weight of networks leads to slower propagating, which indicates that malicious code propagates more quickly in unweighted scale-free networks than in weighted scale-free networks under the same condition. These results show that not only the topology of networks but also the link weights affect the malicious propagating process.
文摘In this paper, we apply the recursive genetic programming (RGP) approach to the cognition of a system, and then proceed to the detecting procedure for structural changes in the system whose components are of long memory. This approach is adaptive and model-free, which can simulate the individual activities of the system's participants, therefore, it has strong ability to recognize the operating mechanism of the system. Based on the previous cognition about the system, a testing statistic is developed for the detection of structural changes in the system. Furthermore, an example is presented to illustrate the validity and practical value of the proposed.
基金supported by the Deanship of Scientific Research at King Fahd University of Petroleum & Minerals Project(No.JF141002)the National Science Foundation(No.ECCS-1405173)+3 种基金the Office of Naval Research(Nos.N000141310562,N000141410718)the U.S. Army Research Office(No.W911NF-11-D-0001)the National Natural Science Foundation of China(No.61120106011)the Project 111 from the Ministry of Education of China(No.B08015)
文摘This paper introduces a model-free reinforcement learning technique that is used to solve a class of dynamic games known as dynamic graphical games. The graphical game results from to make all the agents synchronize to the state of a command multi-agent dynamical systems, where pinning control is used generator or a leader agent. Novel coupled Bellman equations and Hamiltonian functions are developed for the dynamic graphical games. The Hamiltonian mechanics are used to derive the necessary conditions for optimality. The solution for the dynamic graphical game is given in terms of the solution to a set of coupled Hamilton-Jacobi-Bellman equations developed herein. Nash equilibrium solution for the graphical game is given in terms of the solution to the underlying coupled Hamilton-Jacobi-Bellman equations. An online model-free policy iteration algorithm is developed to learn the Nash solution for the dynamic graphical game. This algorithm does not require any knowledge of the agents＇ dynamics. A proof of convergence for this multi-agent learning algorithm is given under mild assumption about the inter-connectivity properties of the graph. A gradient descent technique with critic network structures is used to implement the policy iteration algorithm to solve the graphical game online in real-time.
文摘A model-flee compound controller design method is proposed to achieve the wide frequency bandwidth requirement of flight simulators. The method based on quantitative feedback theory, acquires system uncertainty under different working conditions through closed-loop identification with power spectrum estimation. Then in controller designing, it makes a trade, off between the strict requirements for magnitude-frequency characteristics and those for phase-frequency characteristics of flight simulators, by converting the indices of magnitude-frequency characteristics of flight simulators into quantitative feedback theory-based tracking specification bounds and using feedforward controller to attain the required phase-flequency characteristics. Simulation and experimental results indicate that, when used to design inner flame controller of flight simulator, the proposed method can fulfill the requirements for wide frequency bandwidth indices. Compared with other controller design methods, it has the property of model-free and transparency.
文摘In this work, a Revisited form of the so-called Model-Free Control（R-MFC） is derived.Herein, the MFC principle is employed to deal with the unknown part of a plant only（i.e., unmodeled dynamics, disturbances, etc.） and occurs beside an Interconnection and Damping AssignmentPassivity Based Control（IDA-PBC） strategy. Using the proposed formulation, it is shown that we can significantly improve the performance of the control through the reshaping properties of the IDA-PBC technique. Moreover, the control robustness level is increased via a compensation of the time-varying disturbances and the unmodeled system dynamics. This on-line compensation capability is provided by the MFC principle. The problem is studied in the case of Multi-Input Multi-Output（MIMO） mechanical systems with an explicit application to a small Vertical Take-Off and Landing（VTOL） Unmanned Aerial Vehicle（UAV） where a stability analysis is also provided. Numerical simulations have shown satisfactory results, in comparison with some other control strategies, where an in-depth discussion with respect to the control performance is highlighted by considering several scenarios and using several metrics.
基金supported by the National Natural Science Foundation of China(61771034).
文摘In this paper,a new model free adaptive control method based on self-adjusting PID algorithm(MFACSA-PID)is proposed to solve the problem that the pH process with strong nonlinearity is difficult to control near the neutralization point.The MFAC-SA-PID method also solves the problem that the parameters of the model free adaptive control(MFAC)method are not easy to be adjusted and the effect is not obvious by introducing a fuzzy self-adjusting algorithm to adjust the controller parameters.Then the convergence and stability of the MFAC-SA-PID method are proved in this paper.In the simulation study,the control performance of the MFAC-SA-PID method proposed in this paper is compared with the traditional MFAC method and the improved model free adaptive control(IMFAC)method,respectively.The results show that the proposed MFAC-SA-PID method has better control effect on the pH neutralization process.The MFAC-SA-PID control performance also outperforms the traditional MFAC method and IMFAC method when step input disturbances are added,which indicates that the MFAC-SA-PID method has better robustness and stability.
文摘Volatility forecasting is important in financial econometrics and is mainly based on the application of various GARCH-type models.However,it is difficult to choose a specific GARCH model that works uniformly well across datasets,and the traditional methods are unstable when dealing with highly volatile or short-sized datasets.The newly pro-posed normalizing and variance stabilizing(NoVaS)method is a more robust and accu-rate prediction technique that can help with such datasets.This model-free method was originally developed by taking advantage of an inverse transformation based on the frame of the ARCH model.In this study,we conduct extensive empirical and simu-lation analyses to investigate whether it provides higher-quality long-term volatility forecasting than standard GARCH models.Specifically,we found this advantage to be more prominent with short and volatile data.Next,we propose a variant of the NoVaS method that possesses a more complete form and generally outperforms the current state-of-the-art NoVaS method.The uniformly superior performance of NoVaS-type methods encourages their wide application in volatility forecasting.Our analyses also highlight the flexibility of the NoVaS idea that allows the exploration of other model structures to improve existing models or solve specific prediction problems.
基金supported by the National Natural Science Foundation of China(Nos.11605163 and 21504085)the China Academy of Engineering Physics Foundation for Development of Science and Technology(No.201580103014 and No.2015B0301063)+1 种基金the Foundation for Special Talents in China Academy of Engineering Physics(No.TP201502-3)the Sichuan Science and Technology Development Foundation for Young Scientists(No.2017Q0050)
文摘Identifying the unknown geometric and material information of a multi-shield object by analyzing the radiation signature measurements is always an important problem in national and global security. In order to identify the unknown shielding layer thicknesses of a source/shield system with gamma-ray spectra, we have developed a derivative-free inverse radiation transport model based on a differential evolution algorithm with global and local neighbourhoods(IRT-DEGL). In the present paper, the IRT-DEGL model is further extended for estimating the unknown thicknesses with random initial guesses and material mass densities of multi-shielding layers as well as their combinations. Using the detected gamma-ray spectra,the illustration of inverse studies is implemented and the main influence factors for inverse results are also analyzed.
