AIM:To study the methods of preparing the magnetic nano-microspheres of Fe2O3 and As2O3/Fe2O3 complexes and their therapeutic effects with magnetic fluid hyperthermia(MFH). METHODS:Nanospheres were prepared by chemica...AIM:To study the methods of preparing the magnetic nano-microspheres of Fe2O3 and As2O3/Fe2O3 complexes and their therapeutic effects with magnetic fluid hyperthermia(MFH). METHODS:Nanospheres were prepared by chemical co-precipitation and their shape and diameter were observed.Hemolysis,micronucleus,cell viability,and LD50 along with other in vivo tests were performed to evaluate the Fe2O3 microsphere biocompatibility.The inhibition ratio of tumors after Fe2O3 and As2O3/Fe2O3 injections combined with induced hyperthermia in xenograft human hepatocarcinoma was calculated. RESULTS:Fe2O3 and As2O3/Fe2O3 particles were round with an average diameter of 20 nm and 100 nm as observed under transmission electron microscope.Upon exposure to an alternating magnetic field(AMF),the temperature of the suspension of magnetic particles increased to 41-51℃,depending on different particle concentrations,and remained stable thereafter.Nanosized Fe2O3 microspheres are a new kind of biomaterial without cytotoxic effects.The LD50 of both Fe2O3 and As2O3/Fe2O3 in mice was higher than 5 g/kg.One to four weeks after Fe2O3 and As2O3/Fe2O3 complex injections into healthy pig livers,no significant differences were found in serum AST,ALT,BUN and Cr levels among thepigs of all groups(P>0.05),and no obvious pathological alterations were observed.After exposure to alternating magnetic fields,the inhibition ratio of the tumors was significantly different from controls in the Fe2O3 and As2O3/Fe2O3 groups(68.74% and 82.79%,respectively; P<0.01).Tumors of mice in treatment groups showed obvious necrosis,while normal tissues adjoining the tumor and internal organs did not. CONCLUSION:Fe2O3 and As2O3/Fe2O3 complexes exerted radiofrequency-induced hyperthermia and drug toxicity on tumors without any liver or kidney damage. Therefore,nanospheres are ideal carriers for tumortargeted therapy.展开更多
CoFe2O4 nanoparticles(NPs)and surface modified with gold(Au)have been synthesized by a thermal decomposition method.The obtained NPs and formation of CoFe2O4@Au core–shell(CS)were confirmed by characterizing their st...CoFe2O4 nanoparticles(NPs)and surface modified with gold(Au)have been synthesized by a thermal decomposition method.The obtained NPs and formation of CoFe2O4@Au core–shell(CS)were confirmed by characterizing their structural and optical properties using X-ray powder diffraction(XRD)patterns,Fourier transform infrared spectroscopy,Raman spectroscopy,UV–Visible and photoluminescence studies.Morphological and compositional studies were carried out using high-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy,while the magnetic properties were determined using alternating gradient magnetometer and Mossbauer to define the magneto-structural effects of shell formation on the core NPs.Induction heating properties of CoFe2O4 and CoFe2O4@Au CS magnetic nanoparticles(MNPs)have been investigated and correlated with magneto-structural properties.Specific absorption rate and intrinsic loss power were calculated for these MNPs within the human tolerable range of frequency and amplitude,suggesting their potential in magnetic fluid hyperthermia therapy for possible cancer treatment.展开更多
The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. ...The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. The study pertains to a situation where magnetization of the fluid varies with temperature. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid. The walls of the channel are assumed to be stretchable, where the surface velocity is proportional to the longitudinal distance from the origin of coordinates. The problem is first reduced to solving a system of coupled nonlinear differential equations involving seven parameters. Considering blood as a biomagnetic fluid and using the present analysis, an attempt is made to compute some parameters of the blood flow by developing a suitable numerical method and by devising an appropriate finite difference scheme. The computational results are presented in graphical form, and thereby some theoretical predictions are made with respect to the hemodynamical flow of the blood in a hyperthermal state under the action of a magnetic field. The results clearly indicate that the presence of a magnetic dipole bears the potential so as to affect the characteristics of the blood flow in arteries to a significant extent during the therapeutic procedure of electromagnetic hyperthermia. The study will attract the attention of clinicians, to whom the results would be useful in the treatment of cancer patients by the method of electromagnetic hyperthermia.展开更多
Fe3O4 ferrofluids containing monodisperse Fe3O4 nanoparticles with different diameters of 8, 12, 16 and 18nm are prepared by using high-temperature solution phase reaction. The particles have single crystal structures...Fe3O4 ferrofluids containing monodisperse Fe3O4 nanoparticles with different diameters of 8, 12, 16 and 18nm are prepared by using high-temperature solution phase reaction. The particles have single crystal structures with narrow size distributions. At room temperature, the 8-nm ferrofluid shows superparamagnetic behaviour, whereas the others display hysteresis properties and the coercivity increases with the increasing particle size. The spin glass-like behaviour and cusps near 190K are observed on all ferrofluids according to the temperature variation of field-cooled （FC） and zero-field-cooled （ZFC） magnetization measurements. The cusps are found to be associated with the freezing point of the solvent. As a comparison, the ferrofluids are dried and the FC and ZFC magnetization curves of powdery samples are also investigated. It is found that the blocking temperatures for the powdery samples are higher than those for their corresponding ferrofluids. Moreover, the size dependent heating effect of the ferrofluids is also investigated in ac magnetic field with a frequency of 55 kHz and amplitude of 200 Oe.展开更多
基金Supported by The National Natural Science Foundation of China,30770584the State 863 Plan,2002AA302207,2007AA03Z356
文摘AIM:To study the methods of preparing the magnetic nano-microspheres of Fe2O3 and As2O3/Fe2O3 complexes and their therapeutic effects with magnetic fluid hyperthermia(MFH). METHODS:Nanospheres were prepared by chemical co-precipitation and their shape and diameter were observed.Hemolysis,micronucleus,cell viability,and LD50 along with other in vivo tests were performed to evaluate the Fe2O3 microsphere biocompatibility.The inhibition ratio of tumors after Fe2O3 and As2O3/Fe2O3 injections combined with induced hyperthermia in xenograft human hepatocarcinoma was calculated. RESULTS:Fe2O3 and As2O3/Fe2O3 particles were round with an average diameter of 20 nm and 100 nm as observed under transmission electron microscope.Upon exposure to an alternating magnetic field(AMF),the temperature of the suspension of magnetic particles increased to 41-51℃,depending on different particle concentrations,and remained stable thereafter.Nanosized Fe2O3 microspheres are a new kind of biomaterial without cytotoxic effects.The LD50 of both Fe2O3 and As2O3/Fe2O3 in mice was higher than 5 g/kg.One to four weeks after Fe2O3 and As2O3/Fe2O3 complex injections into healthy pig livers,no significant differences were found in serum AST,ALT,BUN and Cr levels among thepigs of all groups(P>0.05),and no obvious pathological alterations were observed.After exposure to alternating magnetic fields,the inhibition ratio of the tumors was significantly different from controls in the Fe2O3 and As2O3/Fe2O3 groups(68.74% and 82.79%,respectively; P<0.01).Tumors of mice in treatment groups showed obvious necrosis,while normal tissues adjoining the tumor and internal organs did not. CONCLUSION:Fe2O3 and As2O3/Fe2O3 complexes exerted radiofrequency-induced hyperthermia and drug toxicity on tumors without any liver or kidney damage. Therefore,nanospheres are ideal carriers for tumortargeted therapy.
基金Author (Sandip Sabale) is thankful to University Grants Commission, New Delhi, India, for Raman Fellowship to work in USA (F. No. 5-105/2016 (IC), February 10, 2016
文摘CoFe2O4 nanoparticles(NPs)and surface modified with gold(Au)have been synthesized by a thermal decomposition method.The obtained NPs and formation of CoFe2O4@Au core–shell(CS)were confirmed by characterizing their structural and optical properties using X-ray powder diffraction(XRD)patterns,Fourier transform infrared spectroscopy,Raman spectroscopy,UV–Visible and photoluminescence studies.Morphological and compositional studies were carried out using high-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy,while the magnetic properties were determined using alternating gradient magnetometer and Mossbauer to define the magneto-structural effects of shell formation on the core NPs.Induction heating properties of CoFe2O4 and CoFe2O4@Au CS magnetic nanoparticles(MNPs)have been investigated and correlated with magneto-structural properties.Specific absorption rate and intrinsic loss power were calculated for these MNPs within the human tolerable range of frequency and amplitude,suggesting their potential in magnetic fluid hyperthermia therapy for possible cancer treatment.
文摘The paper deals with the theoretical investigation of a fundamental problem of biomaguetic fluid flow through a porous medium subject to a magnetic field by using the principles of biomagnetic fluid dynamics （BFD）. The study pertains to a situation where magnetization of the fluid varies with temperature. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid. The walls of the channel are assumed to be stretchable, where the surface velocity is proportional to the longitudinal distance from the origin of coordinates. The problem is first reduced to solving a system of coupled nonlinear differential equations involving seven parameters. Considering blood as a biomagnetic fluid and using the present analysis, an attempt is made to compute some parameters of the blood flow by developing a suitable numerical method and by devising an appropriate finite difference scheme. The computational results are presented in graphical form, and thereby some theoretical predictions are made with respect to the hemodynamical flow of the blood in a hyperthermal state under the action of a magnetic field. The results clearly indicate that the presence of a magnetic dipole bears the potential so as to affect the characteristics of the blood flow in arteries to a significant extent during the therapeutic procedure of electromagnetic hyperthermia. The study will attract the attention of clinicians, to whom the results would be useful in the treatment of cancer patients by the method of electromagnetic hyperthermia.
文摘Fe3O4 ferrofluids containing monodisperse Fe3O4 nanoparticles with different diameters of 8, 12, 16 and 18nm are prepared by using high-temperature solution phase reaction. The particles have single crystal structures with narrow size distributions. At room temperature, the 8-nm ferrofluid shows superparamagnetic behaviour, whereas the others display hysteresis properties and the coercivity increases with the increasing particle size. The spin glass-like behaviour and cusps near 190K are observed on all ferrofluids according to the temperature variation of field-cooled （FC） and zero-field-cooled （ZFC） magnetization measurements. The cusps are found to be associated with the freezing point of the solvent. As a comparison, the ferrofluids are dried and the FC and ZFC magnetization curves of powdery samples are also investigated. It is found that the blocking temperatures for the powdery samples are higher than those for their corresponding ferrofluids. Moreover, the size dependent heating effect of the ferrofluids is also investigated in ac magnetic field with a frequency of 55 kHz and amplitude of 200 Oe.
