AIM:To investigate the clinical features and prognosis of patients with orbital inflammatory myofibroblastic tumor(IMT).METHODS:This retrospective study collected clinical data from 22 patients diagnosed with orbital ...AIM:To investigate the clinical features and prognosis of patients with orbital inflammatory myofibroblastic tumor(IMT).METHODS:This retrospective study collected clinical data from 22 patients diagnosed with orbital IMT based on histopathological examination.The patients were followed up to assess their prognosis.Clinical data from patients,including age,gender,course of disease,past medical history,primary symptoms,ophthalmologic examination findings,general condition,as well as imaging,laboratory,histopathological,and immunohistochemical results from digital records were collected.Orbital magnetic resonance imaging(MRI)and(or)computed tomography(CT)scans were performed to assess bone destruction of the mass,invasion of surrounding tissues,and any inflammatory changes in periorbital areas.RESULTS:The mean age of patients with orbital IMT was 28.24±3.30y,with a male-to-female ratio of 1.2:1.Main clinical manifestations were proptosis,blurred vision,palpable mass,and pain.Bone destruction and surrounding tissue invasion occurred in 72.73%and 54.55%of cases,respectively.Inflammatory changes in the periorbital site were observed in 77.27%of the patients.Hematoxylin and eosin staining showed proliferation of fibroblasts and myofibroblasts,accompanied by infiltration of lymphocytes and plasma cells.Immunohistochemical staining revealed that smooth muscle actin(SMA)and vimentin were positive in 100%of cases,while anaplastic lymphoma kinase(ALK)showed positivity in 47.37%.The recurrence rate of orbital IMT was 27.27%,and sarcomatous degeneration could occur.There were no significant correlations between recurrence and factors such as age,gender,laterality,duration of the disease,periorbital tissue invasion,bone destruction,periorbital inflammation,tumor size,fever,leukocytosis,or treatment(P>0.05).However,lymphadenopathy and a Ki-67 index of 10%or higher may be risk factors for recurrence(P=0.046;P=0.023).CONCLUSION:Orbital IMT is a locally invasive disease that may recur or lead to sarcomatoid degeneration,primarily affecting young and middle-aged patients.The presence of lymphadenopathy and a Ki-67 index of 10%or higher may signify a poor prognosis.展开更多
BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic mal...BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.展开更多
Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish ...Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.展开更多
Hard disk drives(HDDs)serve as the primary storage devices in modern data centers.Once a failure occurs,it often leads to severe data loss,significantly degrading the reliability of storage systems.Numerous studies ha...Hard disk drives(HDDs)serve as the primary storage devices in modern data centers.Once a failure occurs,it often leads to severe data loss,significantly degrading the reliability of storage systems.Numerous studies have proposed machine learning-based HDD failure prediction models.However,the Self-Monitoring,Analysis,and Reporting Technology(SMART)attributes differ across HDD manufacturers.We define hard drives of the same brand and model as homogeneous HDD groups,and those from different brands or models as heterogeneous HDD groups.In practical engineering scenarios,a data center is often composed of a heterogeneous population of HDDs,spanning multiple vendors and models.Existing research predominantly focuses on homogeneous datasets,ignoring the model’s generalization capability across heterogeneous HDDs.As a result,HDD models with limited samples often suffer from poor training effectiveness and prediction performance.To address this issue,we investigate generalizable SMART predictors across heterogeneous HDD groups.By extracting time-series features within a fixed sliding time window,we propose a Heterogeneous Disk Failure Prediction Method based on Time Series Features(HDFPM)framework.This method is adaptable to HDD models with limited sample sizes,thereby enhancing its applicability and robustness across diverse drive populations.Experimental results show that the proposed model achieves an F1-score of 0.9518 when applied to two different Seagate HDD models,while maintaining the False Positive Rate(FPR)below 1%.After incorporating the Complexity-Ratio Dynamic Time Warping(CDTW)based feature enhancement method,the best prediction model achieves a True Positive Rate(TPR)of up to 0.93 between the two models.For next-day failure prediction across various Seagate models,the model achieves an F1-score of up to 0.8792.Moreover,the experimental results also show that within the same brand,the higher the proportion of shared SMART attributes across different models,the better the prediction performance.In addition,HDFPMdemonstrates the best stability andmost significant performance in heterogeneous environments.展开更多
In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,...In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.展开更多
Multi-Object Tracking(MOT)represents a fundamental but computationally demanding task in computer vision,with particular challenges arising in occluded and densely populated environments.While contemporary tracking sy...Multi-Object Tracking(MOT)represents a fundamental but computationally demanding task in computer vision,with particular challenges arising in occluded and densely populated environments.While contemporary tracking systems have demonstrated considerable progress,persistent limitations—notably frequent occlusion-induced identity switches and tracking inaccuracies—continue to impede reliable real-world deployment.This work introduces an advanced tracking framework that enhances association robustness through a two-stage matching paradigm combining spatial and appearance features.Proposed framework employs:(1)a Height Modulated and Scale Adaptive Spatial Intersection-over-Union(HMSIoU)metric for improved spatial correspondence estimation across variable object scales and partial occlusions;(2)a feature extraction module generating discriminative appearance descriptors for identity maintenance;and(3)a recovery association mechanism for refining matches between unassociated tracks and detections.Comprehensive evaluation on standard MOT17 and MOT20 benchmarks demonstrates significant improvements in tracking consistency,with state-of-the-art performance across key metrics including HOTA(64),MOTA(80.7),IDF1(79.8),and IDs(1379).These results substantiate the efficacy of our Cue-Tracker framework in complex real-world scenarios characterized by occlusions and crowd interactions.展开更多
Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learni...Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learning have significantly enhanced road scene classification,simultaneously achieving high accuracy,computational efficiency,and adaptability across diverse conditions continues to be difficult.To address these challenges,this study proposes HybridLSTM,a novel and efficient framework that integrates deep learning-based,object-based,and handcrafted feature extraction methods within a unified architecture.HybridLSTM is designed to classify four distinct road scene categories—crosswalk(CW),highway(HW),overpass/tunnel(OP/T),and parking(P)—by leveraging multiple publicly available datasets,including Places-365,BDD100K,LabelMe,and KITTI,thereby promoting domain generalization.The framework fuses object-level features extracted using YOLOv5 and VGG19,scene-level global representations obtained from a modified VGG19,and fine-grained texture features captured through eight handcrafted descriptors.This hybrid feature fusion enables the model to capture both semantic context and low-level visual cues,which are critical for robust scene understanding.To model spatial arrangements and latent sequential dependencies present even in static imagery,the combined features are processed through a Long Short-Term Memory(LSTM)network,allowing the extraction of discriminative patterns across heterogeneous feature spaces.Extensive experiments conducted on 2725 annotated road scene images,with an 80:20 training-to-testing split,validate the effectiveness of the proposed model.HybridLSTM achieves a classification accuracy of 96.3%,a precision of 95.8%,a recall of 96.1%,and an F1-score of 96.0%,outperforming several existing state-of-the-art methods.These results demonstrate the robustness,scalability,and generalization capability of HybridLSTM across varying environments and scene complexities.Moreover,the framework is optimized to balance classification performance with computational efficiency,making it highly suitable for real-time deployment in embedded autonomous driving systems.Future work will focus on extending the model to multi-class detection within a single frame and optimizing it further for edge-device deployments to reduce computational overhead in practical applications.展开更多
Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the...Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.展开更多
Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasi...Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasing volume of visual-language pre-training model parameters,direct transfer learning consumes a substantial amount of computational and storage resources.Moreover,recently proposed parameter-efficient transfer learning methods mainly focus on the reconstruction of channel features,ignoring the spatial features which are vital for modeling key entity relationships.To address these issues,we design an efficient transfer learning framework for RSCIR,which is based on spatial feature efficient reconstruction(SPER).A concise and efficient spatial adapter is introduced to enhance the extraction of spatial relationships.The spatial adapter is able to spatially reconstruct the features in the backbone with few parameters while incorporating the prior information from the channel dimension.We conduct quantitative and qualitative experiments on two different commonly used RSCIR datasets.Compared with traditional methods,our approach achieves an improvement of 3%-11% in sumR metric.Compared with methods finetuning all parameters,our proposed method only trains less than 1% of the parameters,while maintaining an overall performance of about 96%.展开更多
During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 202...During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.展开更多
BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features ...BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.展开更多
The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method f...The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method for infrared and visible image fusion is proposed.The encoder designed according to the optimization objective consists of a base encoder and a detail encoder,which is used to extract low-frequency and high-frequency information from the image.This extraction may lead to some information not being captured,so a compensation encoder is proposed to supplement the missing information.Multi-scale decomposition is also employed to extract image features more comprehensively.The decoder combines low-frequency,high-frequency and supplementary information to obtain multi-scale features.Subsequently,the attention strategy and fusion module are introduced to perform multi-scale fusion for image reconstruction.Experimental results on three datasets show that the fused images generated by this network effectively retain salient targets while being more consistent with human visual perception.展开更多
Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity am...Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity among cancer cells,which exhibit varying degrees of metabolic reprogramming and thus may result in differential contributions to drug resistance.A home-built single-cell quantitative mass spectrometry(MS)platform,which integrates micromanipulation and electro-osmotic sampling,was developed to quantitatively profile the tricarboxylic acid(TCA)cycle metabolites at the single-cell level.Using this platform,the metabolic profiles of drug-sensitive MCF-7 breast cancer cells and their drug-resistant derivative MCF-7/ADR cells were compared.This results revealed a selective upregulation of downstream TCA cycle metabolites includingα-ketoglutarate,succinate,fumarate,and malate in drug-resistant cancer cells,while early TCA metabolites remained largely unchanged.Furthermore,notable variations in the abundance of the metabolites were observed in individual cells.The comparative analysis also revealed that not all MCF-7/ADR cells exhibit the same degree of metabolic deviation from the parental line in the metabolites during resistance acquisition.The observed metabolic profiles indicate enhanced glutaminolysis,altered mitochondrial electron transport chain activity,and increased metabolic flexibility in drug-resistant cancer cells that support their survival under chemotherapeutic stress.The findings further suggest the potential for incorporating cellular metabolic heterogeneity into future drug resistance studies.展开更多
To minimize the low classification accuracy and low utilization of spatial information in traditional hyperspectral image classification methods, we propose a new hyperspectral image classification method, which is ba...To minimize the low classification accuracy and low utilization of spatial information in traditional hyperspectral image classification methods, we propose a new hyperspectral image classification method, which is based on the Gabor spatial texture features and nonparametric weighted spectral features, and the sparse representation classification method（Gabor–NWSF and SRC）, abbreviated GNWSF–SRC. The proposed（GNWSF–SRC） method first combines the Gabor spatial features and nonparametric weighted spectral features to describe the hyperspectral image, and then applies the sparse representation method. Finally, the classification is obtained by analyzing the reconstruction error. We use the proposed method to process two typical hyperspectral data sets with different percentages of training samples. Theoretical analysis and simulation demonstrate that the proposed method improves the classification accuracy and Kappa coefficient compared with traditional classification methods and achieves better classification performance.展开更多
Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attack...Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.展开更多
Multiple Sclerosis(MS)poses significant health risks.Patients may face neurodegeneration,mobility issues,cognitive decline,and a reduced quality of life.Manual diagnosis by neurologists is prone to limitations,making ...Multiple Sclerosis(MS)poses significant health risks.Patients may face neurodegeneration,mobility issues,cognitive decline,and a reduced quality of life.Manual diagnosis by neurologists is prone to limitations,making AI-based classification crucial for early detection.Therefore,automated classification using Artificial Intelligence(AI)techniques has a crucial role in addressing the limitations of manual classification and preventing the development of MS to advanced stages.This study developed hybrid systems integrating XGBoost(eXtreme Gradient Boosting)with multi-CNN(Convolutional Neural Networks)features based on Ant Colony Optimization(ACO)and Maximum Entropy Score-based Selection(MESbS)algorithms for early classification of MRI(Magnetic Resonance Imaging)images in a multi-class and binary-class MS dataset.All hybrid systems started by enhancing MRI images using the fusion processes of a Gaussian filter and Contrast-Limited Adaptive Histogram Equalization(CLAHE).Then,the Gradient Vector Flow(GVF)algorithm was applied to select white matter(regions of interest)within the brain and segment them from the surrounding brain structures.These regions of interest were processed by CNN models(ResNet101,DenseNet201,and MobileNet)to extract deep feature maps,which were then combined into fused feature vectors of multi-CNN model combinations(ResNet101-DenseNet201,DenseNet201-MobileNet,ResNet101-MobileNet,and ResNet101-DenseNet201-MobileNet).The multi-CNN features underwent dimensionality reduction using ACO and MESbS algorithms to remove unimportant features and retain important features.The XGBoost classifier employed the resultant feature vectors for classification.All developed hybrid systems displayed promising outcomes.For multiclass classification,the XGBoost model using ResNet101-DenseNet201-MobileNet features selected by ACO attained 99.4%accuracy,99.45%precision,and 99.75%specificity,surpassing prior studies(93.76%accuracy).It reached 99.6%accuracy,99.65%precision,and 99.55%specificity in binary-class classification.These results demonstrate the effectiveness of multi-CNN fusion with feature selection in improving MS classification accuracy.展开更多
Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and a...Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.展开更多
This paper presents the morphologic,chemical and other typomorphic characteristics of native gold from four placer deposits(basins of the Lev.Nora,Skalistaya and Golysheva rivers,and Loginova brook),four placer occurr...This paper presents the morphologic,chemical and other typomorphic characteristics of native gold from four placer deposits(basins of the Lev.Nora,Skalistaya and Golysheva rivers,and Loginova brook),four placer occurrences(basins of the Lagernaya,Nizh.Litke and Prokhodimaya rivers,and Tikhiy brook),and the alluvial deposit of cape Mordovin on Bolshevik island of the Severnaya Zemlya archipelago(Russia).Optical microscopy,scanning electron microscopy and electron-probe microanalysis were used in this study.Placer gold from the Lagernaya,Golysheva,Nizh.Litke and Skalistaya rivers,Tikhiy brook and cape Mordovin is characterized by a very high fineness(>988‰)in the rims and a lower fineness(860‰–970‰)in the center.Gold particles from the placers of the Lev.Nora and Prokhodimaya rivers and Loginova brook are low fineness and widely vary in the center(from 647‰to 920‰)and are high fineness(950‰–980‰)in the rims.In some gold particles from the placers of the Lev.Nora and Skalistaya rivers,zones with Cu up to 1.2 wt.%and Hg up to 2.6 wt.%are observed.Titanite,monazite,cobaltite,ulmannite,brannerite,rutile,zircon,Y-xenotime,bismuthite,native bismuth and bismuthinite,garnet(almandine),Cu-or Ni-pyrrhotite were found in the native gold from the Skalistaya and Lev.Nora placers.Native gold from the Skalistaya river placer contains mineral micro-inclusions of cobaltite,Cu,Cd-bearing sphalerite and Fe,Cu-ullmannite.Native gold from the Lev.Nora river placer differs in the presence of brannerite and bismuth minerals.On the basis of the obtained results,available metallogenic characteristics of Bolshevik island and literature data,the following types of primary sources are predicted for these locations:(1)Lev.Nora river deposits of gold-copper rare metal and porphyry gold-copper formations;(2)Skalistaya river deposits of porphyry gold-copper and gold-quartz formation;(3)all the other locations:deposits of gold-quartz and gold-sulfide-quartz formations(hosted in terrigenous carbonaceous complexes).The presence of intermediate reservoirs near some of these locations is probable.展开更多
Objective To explore the feasibility of constructing a lung cancer early-warning risk model based on facial image features,providing novel insights into the early screening of lung cancer.Methods This study included p...Objective To explore the feasibility of constructing a lung cancer early-warning risk model based on facial image features,providing novel insights into the early screening of lung cancer.Methods This study included patients with pulmonary nodules diagnosed at the Physical Examination Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 1,2019 to December 31,2024,as well as patients with lung cancer diagnosed in the Oncology Departments of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and Longhua Hospital during the same period.The facial image information of patients with pulmonary nodules and lung cancer was collected using the TFDA-1 tongue and facial diagnosis instrument,and the facial diagnosis features were extracted from it by deep learning technology.Statistical analysis was conducted on the objective facial diagnosis characteristics of the two groups of participants to explore the differences in their facial image characteristics,and the least absolute shrinkage and selection operator(LASSO)regression was used to screen the characteristic variables.Based on the screened feature variables,four machine learning methods:random forest,logistic regression,support vector machine(SVM),and gradient boosting decision tree(GBDT)were used to establish lung cancer classification models independently.Meanwhile,the model performance was evaluated by indicators such as sensitivity,specificity,F1 score,precision,accuracy,the area under the receiver operating characteristic(ROC)curve(AUC),and the area under the precision-recall curve(AP).Results A total of 1275 patients with pulmonary nodules and 1623 patients with lung cancer were included in this study.After propensity score matching(PSM)to adjust for gender and age,535 patients were finally included in the pulmonary nodule group and the lung cancer group,respectively.There were significant differences in multiple color space metrics(such as R,G,B,V,L,a,b,Cr,H,Y,and Cb)and texture metrics[such as gray-levcl co-occurrence matrix(GLCM)-contrast(CON)and GLCM-inverse different moment(IDM)]between the two groups of individuals with pulmonary nodules and lung cancer(P<0.05).To construct a classification model,LASSO regression was used to select 63 key features from the initial 136 facial features.Based on this feature set,the SVM model demonstrated the best performance after 10-fold stratified cross-validation.The model achieved an average AUC of 0.8729 and average accuracy of 0.7990 on the internal test set.Further validation on an independent test set confirmed the model’s robust performance(AUC=0.8233,accuracy=0.7290),indicating its good generalization ability.Feature importance analysis demonstrated that color space indicators and the whole/lip Cr components(including color-B-0,wholecolor-Cr,and lipcolor-Cr)were the core factors in the model’s classification decisions,while texture indicators[GLCM-angular second moment(ASM)_2,GLCM-IDM_1,GLCM-CON_1,GLCM-entropy(ENT)_2]played an important auxiliary role.Conclusion The facial image features of patients with lung cancer and pulmonary nodules show significant differences in color and texture characteristics in multiple areas.The various models constructed based on facial image features all demonstrate good performance,indicating that facial image features can serve as potential biomarkers for lung cancer risk prediction,providing a non-invasive and feasible new approach for early lung cancer screening.展开更多
The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting...The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.展开更多
基金Supported by the National Key R&D Program of China(No.2023YFC2410203)Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.ZLRK202503).
文摘AIM:To investigate the clinical features and prognosis of patients with orbital inflammatory myofibroblastic tumor(IMT).METHODS:This retrospective study collected clinical data from 22 patients diagnosed with orbital IMT based on histopathological examination.The patients were followed up to assess their prognosis.Clinical data from patients,including age,gender,course of disease,past medical history,primary symptoms,ophthalmologic examination findings,general condition,as well as imaging,laboratory,histopathological,and immunohistochemical results from digital records were collected.Orbital magnetic resonance imaging(MRI)and(or)computed tomography(CT)scans were performed to assess bone destruction of the mass,invasion of surrounding tissues,and any inflammatory changes in periorbital areas.RESULTS:The mean age of patients with orbital IMT was 28.24±3.30y,with a male-to-female ratio of 1.2:1.Main clinical manifestations were proptosis,blurred vision,palpable mass,and pain.Bone destruction and surrounding tissue invasion occurred in 72.73%and 54.55%of cases,respectively.Inflammatory changes in the periorbital site were observed in 77.27%of the patients.Hematoxylin and eosin staining showed proliferation of fibroblasts and myofibroblasts,accompanied by infiltration of lymphocytes and plasma cells.Immunohistochemical staining revealed that smooth muscle actin(SMA)and vimentin were positive in 100%of cases,while anaplastic lymphoma kinase(ALK)showed positivity in 47.37%.The recurrence rate of orbital IMT was 27.27%,and sarcomatous degeneration could occur.There were no significant correlations between recurrence and factors such as age,gender,laterality,duration of the disease,periorbital tissue invasion,bone destruction,periorbital inflammation,tumor size,fever,leukocytosis,or treatment(P>0.05).However,lymphadenopathy and a Ki-67 index of 10%or higher may be risk factors for recurrence(P=0.046;P=0.023).CONCLUSION:Orbital IMT is a locally invasive disease that may recur or lead to sarcomatoid degeneration,primarily affecting young and middle-aged patients.The presence of lymphadenopathy and a Ki-67 index of 10%or higher may signify a poor prognosis.
文摘BACKGROUND SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma is a highly aggressive tumor,and spontaneous splenic rupture(SSR)as its presenting manifestation is rarely reported among pancreatic malignancies.CASE SUMMARY We herein report a rare case of a 59-year-old female who presented with acute left upper quadrant abdominal pain without any history of trauma.Abdominal imaging demonstrated a heterogeneous splenic lesion with hemoperitoneum,raising clinical suspicion of SSR.Emergency laparotomy revealed a pancreatic tumor invading the spleen and left kidney,with associated splenic rupture and dense adhesions,necessitating en bloc resection of the distal pancreas,spleen,and left kidney.Histopathology revealed a biphasic malignancy composed of moderately differentiated pancreatic ductal adenocarcinoma and an undifferentiated carcinoma with rhabdoid morphology and loss of SMARCB1 expression.Immunohistochemical analysis confirmed complete loss of SMARCB1/INI1 in the undifferentiated component,along with a high Ki-67 index(approximately 80%)and CD10 positivity.The ductal adenocarcinoma component retained SMARCB1/INI1 expression and was positive for CK7 and CK-pan.Transitional zones between the two tumor components suggested progressive dedifferentiation and underlying genomic instability.The patient received adjuvant chemotherapy with gemcitabine and nab-paclitaxel and maintained a satisfactory quality of life at the 6-month follow-up.CONCLUSION This study reports a rare case of SMARCB1/INI1-deficient undifferentiated rhabdoid carcinoma of the pancreas combined with ductal adenocarcinoma,presenting as SSR-an exceptionally uncommon initial manifestation of pancreatic malignancy.
基金General Program of National Natural Science Foundation of China(82474390)Construction Project of Pudong New Area Famous TCM Studios(National Pilot Zone for TCM Development,Shanghai)(PDZY-2025-0716)Shanghai Municipal Science and Technology Program Project Shanghai Key Laboratory of Health Identification and Assessment(21DZ2271000).
文摘Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.
基金supported by the Tianjin Manufacturing High Quality Development Special Foundation(No.20232185)the Roycom Foundation(No.70306901).
文摘Hard disk drives(HDDs)serve as the primary storage devices in modern data centers.Once a failure occurs,it often leads to severe data loss,significantly degrading the reliability of storage systems.Numerous studies have proposed machine learning-based HDD failure prediction models.However,the Self-Monitoring,Analysis,and Reporting Technology(SMART)attributes differ across HDD manufacturers.We define hard drives of the same brand and model as homogeneous HDD groups,and those from different brands or models as heterogeneous HDD groups.In practical engineering scenarios,a data center is often composed of a heterogeneous population of HDDs,spanning multiple vendors and models.Existing research predominantly focuses on homogeneous datasets,ignoring the model’s generalization capability across heterogeneous HDDs.As a result,HDD models with limited samples often suffer from poor training effectiveness and prediction performance.To address this issue,we investigate generalizable SMART predictors across heterogeneous HDD groups.By extracting time-series features within a fixed sliding time window,we propose a Heterogeneous Disk Failure Prediction Method based on Time Series Features(HDFPM)framework.This method is adaptable to HDD models with limited sample sizes,thereby enhancing its applicability and robustness across diverse drive populations.Experimental results show that the proposed model achieves an F1-score of 0.9518 when applied to two different Seagate HDD models,while maintaining the False Positive Rate(FPR)below 1%.After incorporating the Complexity-Ratio Dynamic Time Warping(CDTW)based feature enhancement method,the best prediction model achieves a True Positive Rate(TPR)of up to 0.93 between the two models.For next-day failure prediction across various Seagate models,the model achieves an F1-score of up to 0.8792.Moreover,the experimental results also show that within the same brand,the higher the proportion of shared SMART attributes across different models,the better the prediction performance.In addition,HDFPMdemonstrates the best stability andmost significant performance in heterogeneous environments.
文摘In the field of intelligent air combat,real-time and accurate recognition of within-visual-range(WVR)maneuver actions serves as the foundational cornerstone for constructing autonomous decision-making systems.However,existing methods face two major challenges:traditional feature engineering suffers from insufficient effective dimensionality in the feature space due to kinematic coupling,making it difficult to distinguish essential differences between maneuvers,while end-to-end deep learning models lack controllability in implicit feature learning and fail to model high-order long-range temporal dependencies.This paper proposes a trajectory feature pre-extraction method based on a Long-range Masked Autoencoder(LMAE),incorporating three key innovations:(1)Random Fragment High-ratio Masking(RFH-Mask),which enforces the model to learn long-range temporal correlations by masking 80%of trajectory data while retaining continuous fragments;(2)Kalman Filter-Guided Objective Function(KFG-OF),integrating trajectory continuity constraints to align the feature space with kinematic principles;and(3)Two-stage Decoupled Architecture,enabling efficient and controllable feature learning through unsupervised pre-training and frozen-feature transfer.Experimental results demonstrate that LMAE significantly improves the average recognition accuracy for 20-class maneuvers compared to traditional end-to-end models,while significantly accelerating convergence speed.The contributions of this work lie in:introducing high-masking-rate autoencoders into low-informationdensity trajectory analysis,proposing a feature engineering framework with enhanced controllability and efficiency,and providing a novel technical pathway for intelligent air combat decision-making systems.
文摘Multi-Object Tracking(MOT)represents a fundamental but computationally demanding task in computer vision,with particular challenges arising in occluded and densely populated environments.While contemporary tracking systems have demonstrated considerable progress,persistent limitations—notably frequent occlusion-induced identity switches and tracking inaccuracies—continue to impede reliable real-world deployment.This work introduces an advanced tracking framework that enhances association robustness through a two-stage matching paradigm combining spatial and appearance features.Proposed framework employs:(1)a Height Modulated and Scale Adaptive Spatial Intersection-over-Union(HMSIoU)metric for improved spatial correspondence estimation across variable object scales and partial occlusions;(2)a feature extraction module generating discriminative appearance descriptors for identity maintenance;and(3)a recovery association mechanism for refining matches between unassociated tracks and detections.Comprehensive evaluation on standard MOT17 and MOT20 benchmarks demonstrates significant improvements in tracking consistency,with state-of-the-art performance across key metrics including HOTA(64),MOTA(80.7),IDF1(79.8),and IDs(1379).These results substantiate the efficacy of our Cue-Tracker framework in complex real-world scenarios characterized by occlusions and crowd interactions.
文摘Recognizing road scene context from a single image remains a critical challenge for intelligent autonomous driving systems,particularly in dynamic and unstructured environments.While recent advancements in deep learning have significantly enhanced road scene classification,simultaneously achieving high accuracy,computational efficiency,and adaptability across diverse conditions continues to be difficult.To address these challenges,this study proposes HybridLSTM,a novel and efficient framework that integrates deep learning-based,object-based,and handcrafted feature extraction methods within a unified architecture.HybridLSTM is designed to classify four distinct road scene categories—crosswalk(CW),highway(HW),overpass/tunnel(OP/T),and parking(P)—by leveraging multiple publicly available datasets,including Places-365,BDD100K,LabelMe,and KITTI,thereby promoting domain generalization.The framework fuses object-level features extracted using YOLOv5 and VGG19,scene-level global representations obtained from a modified VGG19,and fine-grained texture features captured through eight handcrafted descriptors.This hybrid feature fusion enables the model to capture both semantic context and low-level visual cues,which are critical for robust scene understanding.To model spatial arrangements and latent sequential dependencies present even in static imagery,the combined features are processed through a Long Short-Term Memory(LSTM)network,allowing the extraction of discriminative patterns across heterogeneous feature spaces.Extensive experiments conducted on 2725 annotated road scene images,with an 80:20 training-to-testing split,validate the effectiveness of the proposed model.HybridLSTM achieves a classification accuracy of 96.3%,a precision of 95.8%,a recall of 96.1%,and an F1-score of 96.0%,outperforming several existing state-of-the-art methods.These results demonstrate the robustness,scalability,and generalization capability of HybridLSTM across varying environments and scene complexities.Moreover,the framework is optimized to balance classification performance with computational efficiency,making it highly suitable for real-time deployment in embedded autonomous driving systems.Future work will focus on extending the model to multi-class detection within a single frame and optimizing it further for edge-device deployments to reduce computational overhead in practical applications.
文摘Malaria is considered one of the major causes of travel-related morbidity and mortality,especially among non-immune travelers from non-endemic countries to the endemic regions.According to a multicenter study from the GeoSentinel surveillance network,malaria was the most frequent cause of fever in 21%of returning travelers,followed by dengue,typhoid fever,chikungunya and rickettsiosis[1].Individuals traveling from regions without malaria transmission to areas where it is endemic face a heightened risk of contracting the disease due to their lack of immunity.Despite the official malaria-free status of the Russian Federation since 2010,annual cases of severe Plasmodium(P.)falciparum malaria continue to be reported[2].This underscores the necessity for heightened clinical vigilance and improved preventive strategies especially in non-endemic settings.
基金supported by the National Key R&D Program of China(No.2022ZD0118402)。
文摘Remote sensing cross-modal image-text retrieval(RSCIR)can flexibly and subjectively retrieve remote sensing images utilizing query text,which has received more researchers’attention recently.However,with the increasing volume of visual-language pre-training model parameters,direct transfer learning consumes a substantial amount of computational and storage resources.Moreover,recently proposed parameter-efficient transfer learning methods mainly focus on the reconstruction of channel features,ignoring the spatial features which are vital for modeling key entity relationships.To address these issues,we design an efficient transfer learning framework for RSCIR,which is based on spatial feature efficient reconstruction(SPER).A concise and efficient spatial adapter is introduced to enhance the extraction of spatial relationships.The spatial adapter is able to spatially reconstruct the features in the backbone with few parameters while incorporating the prior information from the channel dimension.We conduct quantitative and qualitative experiments on two different commonly used RSCIR datasets.Compared with traditional methods,our approach achieves an improvement of 3%-11% in sumR metric.Compared with methods finetuning all parameters,our proposed method only trains less than 1% of the parameters,while maintaining an overall performance of about 96%.
文摘During Donald Trump’s first term,the“Trump Shock”brought world politics into an era of uncertainties and pulled the transatlantic alliance down to its lowest point in history.The Trump 2.0 tsunami brewed by the 2024 presidential election of the United States has plunged the U.S.-Europe relations into more gloomy waters,ushering in a more complex and turbulent period of adjustment.
文摘BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.
基金Supported by the Henan Province Key Research and Development Project(231111211300)the Central Government of Henan Province Guides Local Science and Technology Development Funds(Z20231811005)+2 种基金Henan Province Key Research and Development Project(231111110100)Henan Provincial Outstanding Foreign Scientist Studio(GZS2024006)Henan Provincial Joint Fund for Scientific and Technological Research and Development Plan(Application and Overcoming Technical Barriers)(242103810028)。
文摘The fusion of infrared and visible images should emphasize the salient targets in the infrared image while preserving the textural details of the visible images.To meet these requirements,an autoencoder-based method for infrared and visible image fusion is proposed.The encoder designed according to the optimization objective consists of a base encoder and a detail encoder,which is used to extract low-frequency and high-frequency information from the image.This extraction may lead to some information not being captured,so a compensation encoder is proposed to supplement the missing information.Multi-scale decomposition is also employed to extract image features more comprehensively.The decoder combines low-frequency,high-frequency and supplementary information to obtain multi-scale features.Subsequently,the attention strategy and fusion module are introduced to perform multi-scale fusion for image reconstruction.Experimental results on three datasets show that the fused images generated by this network effectively retain salient targets while being more consistent with human visual perception.
基金supported by National Natural Science Foundation of China(22374080,22174068,21722504)Primary Research&Development Plan of Jiangsu Province(BK20221303,BE2022796)+1 种基金Open Foundation of State Key Laboratory of Reproductive Medicine(SKLRM-2022BP1,JX116GSP20240507)Science and Technology Development Fund of NJMU(NJMUQY2022003)。
文摘Drug resistance remains a major challenge in breast cancer chemotherapy,yet the metabolic alterations underlying this phenomenon are not fully understood.There is much evidence indicating the cellular heterogeneity among cancer cells,which exhibit varying degrees of metabolic reprogramming and thus may result in differential contributions to drug resistance.A home-built single-cell quantitative mass spectrometry(MS)platform,which integrates micromanipulation and electro-osmotic sampling,was developed to quantitatively profile the tricarboxylic acid(TCA)cycle metabolites at the single-cell level.Using this platform,the metabolic profiles of drug-sensitive MCF-7 breast cancer cells and their drug-resistant derivative MCF-7/ADR cells were compared.This results revealed a selective upregulation of downstream TCA cycle metabolites includingα-ketoglutarate,succinate,fumarate,and malate in drug-resistant cancer cells,while early TCA metabolites remained largely unchanged.Furthermore,notable variations in the abundance of the metabolites were observed in individual cells.The comparative analysis also revealed that not all MCF-7/ADR cells exhibit the same degree of metabolic deviation from the parental line in the metabolites during resistance acquisition.The observed metabolic profiles indicate enhanced glutaminolysis,altered mitochondrial electron transport chain activity,and increased metabolic flexibility in drug-resistant cancer cells that support their survival under chemotherapeutic stress.The findings further suggest the potential for incorporating cellular metabolic heterogeneity into future drug resistance studies.
基金supported by the National Natural Science Foundation of China(No.61275010)the Ph.D.Programs Foundation of Ministry of Education of China(No.20132304110007)+1 种基金the Heilongjiang Natural Science Foundation(No.F201409)the Fundamental Research Funds for the Central Universities(No.HEUCFD1410)
文摘To minimize the low classification accuracy and low utilization of spatial information in traditional hyperspectral image classification methods, we propose a new hyperspectral image classification method, which is based on the Gabor spatial texture features and nonparametric weighted spectral features, and the sparse representation classification method（Gabor–NWSF and SRC）, abbreviated GNWSF–SRC. The proposed（GNWSF–SRC） method first combines the Gabor spatial features and nonparametric weighted spectral features to describe the hyperspectral image, and then applies the sparse representation method. Finally, the classification is obtained by analyzing the reconstruction error. We use the proposed method to process two typical hyperspectral data sets with different percentages of training samples. Theoretical analysis and simulation demonstrate that the proposed method improves the classification accuracy and Kappa coefficient compared with traditional classification methods and achieves better classification performance.
基金partially supported by the National Natural Science Foundation (62272248)the Open Project Fund of State Key Laboratory of Computer Architecture,Institute of Computing Technology,Chinese Academy of Sciences (CARCHA202108,CARCH201905)+1 种基金the Natural Science Foundation of Tianjin (20JCZDJC00610)Sponsored by Zhejiang Lab (2021KF0AB04)。
文摘Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.
文摘Multiple Sclerosis(MS)poses significant health risks.Patients may face neurodegeneration,mobility issues,cognitive decline,and a reduced quality of life.Manual diagnosis by neurologists is prone to limitations,making AI-based classification crucial for early detection.Therefore,automated classification using Artificial Intelligence(AI)techniques has a crucial role in addressing the limitations of manual classification and preventing the development of MS to advanced stages.This study developed hybrid systems integrating XGBoost(eXtreme Gradient Boosting)with multi-CNN(Convolutional Neural Networks)features based on Ant Colony Optimization(ACO)and Maximum Entropy Score-based Selection(MESbS)algorithms for early classification of MRI(Magnetic Resonance Imaging)images in a multi-class and binary-class MS dataset.All hybrid systems started by enhancing MRI images using the fusion processes of a Gaussian filter and Contrast-Limited Adaptive Histogram Equalization(CLAHE).Then,the Gradient Vector Flow(GVF)algorithm was applied to select white matter(regions of interest)within the brain and segment them from the surrounding brain structures.These regions of interest were processed by CNN models(ResNet101,DenseNet201,and MobileNet)to extract deep feature maps,which were then combined into fused feature vectors of multi-CNN model combinations(ResNet101-DenseNet201,DenseNet201-MobileNet,ResNet101-MobileNet,and ResNet101-DenseNet201-MobileNet).The multi-CNN features underwent dimensionality reduction using ACO and MESbS algorithms to remove unimportant features and retain important features.The XGBoost classifier employed the resultant feature vectors for classification.All developed hybrid systems displayed promising outcomes.For multiclass classification,the XGBoost model using ResNet101-DenseNet201-MobileNet features selected by ACO attained 99.4%accuracy,99.45%precision,and 99.75%specificity,surpassing prior studies(93.76%accuracy).It reached 99.6%accuracy,99.65%precision,and 99.55%specificity in binary-class classification.These results demonstrate the effectiveness of multi-CNN fusion with feature selection in improving MS classification accuracy.
基金supported by the Natural Science Foundation of Sichuan Province,China(2024NSFSC1272)the Innovation Team Development Funds for Sichuan Mutton Goat&Sheep,China(SCCXTD-2024-14)Scientific and Technological Innovation Team for Qinghai-Tibetan Plateau Research in Southwest Minzu University,China(2024CXTD08)。
文摘Bocapavovirus,a member of the genus Bocaparvovirus within the subfamily Parvovirinae and the family Parvoviridae,is a small,non-enveloped,single-stranded DNA virus.This pathogen poses health risks to both humans and animals.The Bocaparvovirus genome.
基金The work was carried out within the framework the State assignment of the Federal Agency for Subsoil Use of 27.12.2023№049-00003-24-00a State Assignment of the Sobolev Institute of Geology and Mineralogy,Russian Academy of Sciences(project no.122041400237-8).
文摘This paper presents the morphologic,chemical and other typomorphic characteristics of native gold from four placer deposits(basins of the Lev.Nora,Skalistaya and Golysheva rivers,and Loginova brook),four placer occurrences(basins of the Lagernaya,Nizh.Litke and Prokhodimaya rivers,and Tikhiy brook),and the alluvial deposit of cape Mordovin on Bolshevik island of the Severnaya Zemlya archipelago(Russia).Optical microscopy,scanning electron microscopy and electron-probe microanalysis were used in this study.Placer gold from the Lagernaya,Golysheva,Nizh.Litke and Skalistaya rivers,Tikhiy brook and cape Mordovin is characterized by a very high fineness(>988‰)in the rims and a lower fineness(860‰–970‰)in the center.Gold particles from the placers of the Lev.Nora and Prokhodimaya rivers and Loginova brook are low fineness and widely vary in the center(from 647‰to 920‰)and are high fineness(950‰–980‰)in the rims.In some gold particles from the placers of the Lev.Nora and Skalistaya rivers,zones with Cu up to 1.2 wt.%and Hg up to 2.6 wt.%are observed.Titanite,monazite,cobaltite,ulmannite,brannerite,rutile,zircon,Y-xenotime,bismuthite,native bismuth and bismuthinite,garnet(almandine),Cu-or Ni-pyrrhotite were found in the native gold from the Skalistaya and Lev.Nora placers.Native gold from the Skalistaya river placer contains mineral micro-inclusions of cobaltite,Cu,Cd-bearing sphalerite and Fe,Cu-ullmannite.Native gold from the Lev.Nora river placer differs in the presence of brannerite and bismuth minerals.On the basis of the obtained results,available metallogenic characteristics of Bolshevik island and literature data,the following types of primary sources are predicted for these locations:(1)Lev.Nora river deposits of gold-copper rare metal and porphyry gold-copper formations;(2)Skalistaya river deposits of porphyry gold-copper and gold-quartz formation;(3)all the other locations:deposits of gold-quartz and gold-sulfide-quartz formations(hosted in terrigenous carbonaceous complexes).The presence of intermediate reservoirs near some of these locations is probable.
基金National Natural Science Foundation of China(82305090)Shanghai Municipal Health Commission(20234Y0168)National Key Research and Development Program of China (2017YFC1703301)。
文摘Objective To explore the feasibility of constructing a lung cancer early-warning risk model based on facial image features,providing novel insights into the early screening of lung cancer.Methods This study included patients with pulmonary nodules diagnosed at the Physical Examination Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 1,2019 to December 31,2024,as well as patients with lung cancer diagnosed in the Oncology Departments of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and Longhua Hospital during the same period.The facial image information of patients with pulmonary nodules and lung cancer was collected using the TFDA-1 tongue and facial diagnosis instrument,and the facial diagnosis features were extracted from it by deep learning technology.Statistical analysis was conducted on the objective facial diagnosis characteristics of the two groups of participants to explore the differences in their facial image characteristics,and the least absolute shrinkage and selection operator(LASSO)regression was used to screen the characteristic variables.Based on the screened feature variables,four machine learning methods:random forest,logistic regression,support vector machine(SVM),and gradient boosting decision tree(GBDT)were used to establish lung cancer classification models independently.Meanwhile,the model performance was evaluated by indicators such as sensitivity,specificity,F1 score,precision,accuracy,the area under the receiver operating characteristic(ROC)curve(AUC),and the area under the precision-recall curve(AP).Results A total of 1275 patients with pulmonary nodules and 1623 patients with lung cancer were included in this study.After propensity score matching(PSM)to adjust for gender and age,535 patients were finally included in the pulmonary nodule group and the lung cancer group,respectively.There were significant differences in multiple color space metrics(such as R,G,B,V,L,a,b,Cr,H,Y,and Cb)and texture metrics[such as gray-levcl co-occurrence matrix(GLCM)-contrast(CON)and GLCM-inverse different moment(IDM)]between the two groups of individuals with pulmonary nodules and lung cancer(P<0.05).To construct a classification model,LASSO regression was used to select 63 key features from the initial 136 facial features.Based on this feature set,the SVM model demonstrated the best performance after 10-fold stratified cross-validation.The model achieved an average AUC of 0.8729 and average accuracy of 0.7990 on the internal test set.Further validation on an independent test set confirmed the model’s robust performance(AUC=0.8233,accuracy=0.7290),indicating its good generalization ability.Feature importance analysis demonstrated that color space indicators and the whole/lip Cr components(including color-B-0,wholecolor-Cr,and lipcolor-Cr)were the core factors in the model’s classification decisions,while texture indicators[GLCM-angular second moment(ASM)_2,GLCM-IDM_1,GLCM-CON_1,GLCM-entropy(ENT)_2]played an important auxiliary role.Conclusion The facial image features of patients with lung cancer and pulmonary nodules show significant differences in color and texture characteristics in multiple areas.The various models constructed based on facial image features all demonstrate good performance,indicating that facial image features can serve as potential biomarkers for lung cancer risk prediction,providing a non-invasive and feasible new approach for early lung cancer screening.
基金Supported by the National Health Commission’s Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment for The Year 2022,National Health Commission’s Master’s and Doctoral/Postdoctoral Fund Project,No.NHCDP2022001Gansu Provincial People’s Hospital Doctoral Supervisor Training Project,No.22GSSYA-3.
文摘The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.
