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I-Fuzzy拓扑空间中的可数性 被引量:3
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作者 李清华 方进明 《模糊系统与数学》 CSCD 北大核心 2005年第3期71-75,共5页
引入I-fuzzy拓扑空间中的I-fuzzy第一可数性,I-fuzzy第二可数性,I-fuzzy稠密性,I-fuzzy可分性,I-fuzzyLindelo¨f性等概念。界定了它们的本质性质,并讨论了它们之间的关系,还给出了第一可数I-fuzzy拓扑空间中的映射连续性的序列刻画。
关键词 I-fuzzy 拓扑空间 I—fuzzy第一可数性 I—fuzzy第二可数性 I—fuzzy稠密性 I—fuzzy可分性 I—fuzzy Lindelof
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前列腺素F_(2α)受体激动剂fluprostenol对奶牛输卵管上皮细胞合成分泌细胞因子表达的影响
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作者 张莹 曹金山 张楠 《中国兽医学报》 CAS CSCD 北大核心 2017年第2期345-351,共7页
为验证前列腺素类化合物对输卵管分泌细胞因子有调控作用,以前列腺素F2α受体激动剂fluprostenol对奶牛输卵管上皮细胞合成分泌细胞因子TGF-α、TGF-β3、FGF-2、LIF和GM-CSF的调控机制为研究对象,采用实时荧光定量PCR技术检测吲哚美辛(... 为验证前列腺素类化合物对输卵管分泌细胞因子有调控作用,以前列腺素F2α受体激动剂fluprostenol对奶牛输卵管上皮细胞合成分泌细胞因子TGF-α、TGF-β3、FGF-2、LIF和GM-CSF的调控机制为研究对象,采用实时荧光定量PCR技术检测吲哚美辛(10-5 mol/L)作用不同时间(2,4,8,16,24,48h)对奶牛输卵管上皮细胞TGF-α、TGF-β3、FGF-2、LIF和GM-CSF mRNA表达的影响。结果显示,fluprostenol对奶牛输卵管上皮细胞中TGF-α和FGF-2mRNA有正调控的作用,均在4h时mRNA的表达量达到峰值;fluprostenol对奶牛输卵管上皮细胞中LIF和GMCSF mRNA有双重调控作用,均是先短暂显著促进(P<0.05)其mRNA的表达,之后表现为极显著抑制(P<0.01),并均在2h时达到表达量峰值;fluprostenol对奶牛输卵管上皮细胞中TGF-β3mRNA起到正调控作用,作用48h时与空白对照组相比极显著升高(P<0.01),达到峰值。 展开更多
关键词 前列腺素f2α受体激动剂 fluprostenol 奶牛输卵管上皮细胞 TGf—α TGf-β3 fGf2 LIf GM—CSf
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Neural Tucker Factorization
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作者 Peng Tang Xin Luo 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期475-477,共3页
Dear Editor,This letter presents a novel latent factorization model for high dimensional and incomplete (HDI) tensor, namely the neural Tucker factorization (Neu Tuc F), which is a generic neural network-based latent-... Dear Editor,This letter presents a novel latent factorization model for high dimensional and incomplete (HDI) tensor, namely the neural Tucker factorization (Neu Tuc F), which is a generic neural network-based latent-factorization-of-tensors model under the Tucker decomposition framework. 展开更多
关键词 neu tuc f neural tucker factorization latent factorization model high dimensional tensor tucker decomposition framework neural network incomplete tensor latent factorization
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Symmetry-Constrained Anomalous Transport in the Altermagnetic Material CuX_(2)(X=F,Cl)
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作者 Zhengxuan Wang Ruqian Wu +6 位作者 Chunlan Ma Shijing Gong Chuanxi Zhao Shuaikang Zhang Guangtao Wang Tianxing Wang Yipeng An 《Chinese Physics Letters》 2025年第8期175-184,共10页
Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport ef... Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport effects,including the anomalous Hall,Nernst,and thermal Hall effects,as well as magneto-optical Kerr and Faraday effects.These phenomena,previously thought unique to ferromagnets,are dictated by symmetry,as confirmed by density functional theory(DFT)calculations.However,an effective model-based approach to verify these symmetry constraints remains unavailable.In this Letter,we construct a k·ρ model for d-wave altermagnets CuX_(2)(X=F,Cl)using spin space group representations and apply it to calculate the anomalous Hall effect.The symmetry-imposed transport properties predicted by the model are in agreement with the DFT results,providing a foundation for further investigation into symmetry-restricted transport phenomena in altermagnetic materials. 展开更多
关键词 altermagnetic materials d wave altermagnetism symmetry constrained anomalous transport Cu f Cl anomalous hall effect density functional theory transport effectsincluding faraday effectsthese
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族F-遍历与F-混合 被引量:2
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作者 刘桂仙 杨润生 《南京师大学报(自然科学版)》 CAS CSCD 北大核心 2006年第3期14-19,共6页
本文给出族F-遍历,族F-强混合,族F-弱混合,族F-2混合,族F-一致混合和族F-Césaro一致混合的概念,研究了它们的性质、判定及相互关系,并且讨论了对于连续变换的不变测度的族F-遍历和族F-混合的刻划.
关键词 f-遍历 f-强混合 f-弱混合 f-2混合 f-一致混合 f-Césaro一致混合
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Fuzzy泛代数的理论框架 被引量:1
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作者 王家德 《纯粹数学与应用数学》 CSCD 1999年第3期1-7,共7页
通过一系列抽象概念的引入,建立了 Fuzzy 泛代数的理论框架,获得了若干有意义的结果.特别,本文可用来统一处理现行的有关各种具体的 Fuzzy 代数结构的孤立研究。
关键词 fΩ-代数 f-同余 f-缩商 f-理想 f-Birkhoff性质 f-根
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P-集合与(,F)-数据生成-辨识 被引量:83
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作者 汤积华 陈保会 史开泉 《山东大学学报(理学版)》 CAS CSCD 北大核心 2009年第11期83-88,92,共7页
P-集合(packet sets)是一个集合对,它由内P-集合(internal packet sets)与外P-集合(outer packet sets)共同构成,P-集合具有动态特性。利用P-集合,给出数据集合,-数据集合,F-数据集合与(,F)-数据集合概念;提出-F-数据集定理,F-数据... P-集合(packet sets)是一个集合对,它由内P-集合(internal packet sets)与外P-集合(outer packet sets)共同构成,P-集合具有动态特性。利用P-集合,给出数据集合,-数据集合,F-数据集合与(,F)-数据集合概念;提出-F-数据集定理,F-数据集定理,(,F)-数据带定理,数据集合恢复定理,(,F)-数据辨识定理,给出辨识准则。利用这些结果,给出(,F)-数据在信息系统中的应用。P-集合是研究动态信息系统的一个新理论与新方法。 展开更多
关键词 P-集合 (-↑f f)-数据集合 f-数据定理 -↑f-数据定理 (-↑f f)-数据带 辨识定理
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Performance of Different Machine Learning Algorithms for Credit Risk Classification
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作者 Martin M.Kasina John M.Kihoro Alex Kibet 《Journal of Data Analysis and Information Processing》 2025年第4期504-519,共16页
Microfinance institutions in Kenya play a unique role in promoting financial inclusion,loans,and savings provision,especially to low-income individuals and small-scale entrepreneurs.However,despite their benefits,most... Microfinance institutions in Kenya play a unique role in promoting financial inclusion,loans,and savings provision,especially to low-income individuals and small-scale entrepreneurs.However,despite their benefits,most of their products and programs in Machakos County have been reducing due to re-payment challenges,threatening their financial ability to extend further credit.This could be attributed to ineffective credit scoring models which are not able to establish the nuanced non-linear repayment behavior and patterns of the loan applicants.The research objective was to enhance credit risk scoring for microfinance institutions in Machakos County using supervised machine learning algorithms.The study adopted a mixed research design under supervised machine learning approach.It randomly sampled 6771 loan application ac-count records and repayment history.Rstudio and Python programming lan-guages were deployed for data pre-processing and analysis.Logistic regression algorithm,XG Boosting and the random forest ensemble method were used.Metric evaluations used included the performance accuracy,Area under the Curve and F1-Score.Based on the study findings:XG Boosting was the best performer with 83.3%accuracy and 0.202 Brier score.Development of legal framework to govern ethical and open use of machine learning assessment was recommended.A similar research but using different machine learning al-gorithms,locations,and institutions,to ascertain the validity,reliability and the generalizability of the study findings was recommended for further re-search. 展开更多
关键词 Supervised Machine Learning Loan Payment Default Random forest XG Boost Logistic Regression Confusion Matrix f1-Score
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Early Spatiotemporal Dynamic of Green Fluorescent Protein-Tagged Fusarium oxysporum f.sp.batatas in Susceptible and Resistant Sweet Potato
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作者 Hong Zhang Ying Zhu +8 位作者 Xingyu Li Zhonghua Liu Guoliang Li Zhaomiao Lin Yongxiang Qiu Yongqing Xu Shimin Lyu Jiyang Wang Sixin Qiu 《Phyton-International Journal of Experimental Botany》 2025年第8期2479-2498,共20页
Vascular wilt caused by Fusarium oxysporum f.sp.batatas(Fob)is a devastating disease threatening global sweet potato production.To elucidate Fob’s pathogenicitymechanisms and informeffective control strategies,we gen... Vascular wilt caused by Fusarium oxysporum f.sp.batatas(Fob)is a devastating disease threatening global sweet potato production.To elucidate Fob’s pathogenicitymechanisms and informeffective control strategies,we generated a green fluorescent protein(GFP)-tagged Fob strain to track infection dynamics in sweet potato susceptible cultivar Xinzhonghua and resistant cultivar Xiangshu75-55,respectively.Through cytological observation,we found in the susceptible Xinzhonghua,Fob predominantly colonized stem villi,injured root growth points,and directly invaded vascular bundles through stemwounds.Spore germination peaked at 2-3 h post-inoculation(hpi),followed by cyclical mycelial expansion and sporulation within vascular tissues with sustaining infection.In contrast,the resistant Xiangshu75-55 exhibited strong suppression of Fob:spores rarely germinated in vascular bundles or on trichomes by 3 hpi,and mature hyphae were absent in stems at 24 hpi.Quantitative reverse transcription PCR(qRT-PCR)confirmed significantly higher Fob biomass in Xinzhonghua than in Xiangshu75-55 by 16 hpi.Additionally,transcriptional profiling revealed distinct pathogen-host interactions during the compatible and incompatible reactions.In Xinzhonghua,Fob virulence genes FobPGX1,FobICL1,FobCTF2,FobFUB5 and FobFUB6 were upregulated within 16 hpi.Conversely,host defense genes IbMAPKK9,IbWRKY61,IbWRKY75,IbSWEET10,IbBBX24 and IbPIF4 were activated in Xiangshu75-55 during the same period.This study provides spatiotemporal cytological and molecular insights into Fob pathogenicity and host resistance,offering a foundation for early disease detection and improved Fusarium wilt management in sweet potato. 展开更多
关键词 fusarium wilt of sweet potato fusarium oxysporum f.sp.batatas infection green fluorescent protein compatibility TRICHOME
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YOLO-based lightweight traffic sign detection algorithm and mobile deployment
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作者 WU Yaqin ZHANG Tao +2 位作者 NIU Jianjun CHANG Yan LIU Ganjun 《Optoelectronics Letters》 2025年第4期249-256,共8页
This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolu... This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolution and bi-directional feature pyramid network(BiFPN)_Concat to improve the adaptability of the network.Secondly,the simple attention module(SimAm)is embedded to prioritize key features and reduce the complexity of the model after the C2f layer at the end of the backbone network.Next,the focal efficient intersection over union(EloU)is introduced to adjust the weights of challenging samples.Finally,we accomplish the design and deployment for the mobile app.The results demonstrate improvements,with the F1 score of 0.8987,mean average precision(mAP)@0.5 of 98.8%,mAP@0.5:0.95 of 75.6%,and the detection speed of 50 frames per second(FPS). 展开更多
关键词 c f layer simple attention module simam reduce complexity traffic sign detection prioritize key features backbone networkemploying classification backbone networknextthe
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F-干扰规律生成与它的特征识别 被引量:6
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作者 邱锦明 夏佳荣 史开泉 《山东大学学报(理学版)》 CAS CSCD 北大核心 2007年第8期36-41,共6页
利用单向S-粗集概念给出了知识的f-干扰生成与f-干扰规律生成,单向S-粗集的F-干扰生成与F-干扰规律生成的概念.提出了F-干扰损失与F-干扰度关系定理,F-干扰损失规律与F-干扰度规律关系定理,F-干扰分辨定理,干扰规律分辨定理,给出了F-干... 利用单向S-粗集概念给出了知识的f-干扰生成与f-干扰规律生成,单向S-粗集的F-干扰生成与F-干扰规律生成的概念.提出了F-干扰损失与F-干扰度关系定理,F-干扰损失规律与F-干扰度规律关系定理,F-干扰分辨定理,干扰规律分辨定理,给出了F-干扰规律识别准则与应用. 展开更多
关键词 单向S-粗集 f-干扰 f-干扰规律 f-干扰分辨 f-干扰规律分辨 f-干扰规律识别
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A rapid tool for quantification of latent infection of wheat leaves by powdery mildew
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作者 Aolin Wang Ru Jiang +9 位作者 Meihui Zhang Hudie Shao Fei Xu Kouhan Liu Haifeng Gao Jieru Fan Wei Liu Xiaoping Hu Yilin Zhou Xiangming Xu 《Journal of Integrative Agriculture》 2025年第12期4690-4702,共13页
Wheat powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt)is an important disease worldwide.Detection of latent infection of leaves by the pathogen in late autumn is valuable for estimating the inoculum potent... Wheat powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt)is an important disease worldwide.Detection of latent infection of leaves by the pathogen in late autumn is valuable for estimating the inoculum potential to assess disease risks in the spring.We developed a new tool for rapid detection and quantification of latent infection of seedlings by the pathogen.The method was based on recombinase polymerase amplification(RPA)coupled with an end-point detection via lateral flow device(LFD).The limit of detection is 100 agμL^(-1)of Bgt DNA,without noticeable interference from either other common wheat pathogens or wheat material(Triticum aestivum).It was evaluated on wheat seedlings for this accuracy and sensitivity in detecting latent infection of Bgt.We further extended this RPALFD assay to estimate the level of latent infection by Bgt based on imaging analysis.There was a strong correlation between the image-based and real-time PCR assay estimates of Bgt DNA.The present results suggested that this new tool can provide rapid and accurate quantification of Bgt in latently infected leaves and can be further development as an on-site monitoring tool. 展开更多
关键词 Blumeria graminis f.sp.tritici(Bgt) recombinase polymerase amplification(RPA) lateral flow device(LfD) image-based quantification disease monitoring
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放射性核素药物^(18)F-FAPI与^(18)F-FDG在肝恶性肿瘤PET/CT显像中的应用比较
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作者 吴娜静 李庆波 +4 位作者 陈礼平 王全鹏 葛雨秋 郁春景 贺慧慧 《中国现代应用药学》 北大核心 2025年第18期3126-3133,共8页
目的 比较评价^(18)F-FAPI PET/CT与^(18)F-FDG PET/CT在肝脏恶性肿瘤中的诊断效能,对比分析2种显像剂的最大标准摄取值(SUV_(max)),探讨其在肝脏恶性肿瘤中的诊断价值。方法 研究分析2023年2月至2023年7月于江南大学附属医院行^(18)F-F... 目的 比较评价^(18)F-FAPI PET/CT与^(18)F-FDG PET/CT在肝脏恶性肿瘤中的诊断效能,对比分析2种显像剂的最大标准摄取值(SUV_(max)),探讨其在肝脏恶性肿瘤中的诊断价值。方法 研究分析2023年2月至2023年7月于江南大学附属医院行^(18)F-FAPI-04 PET/CT与^(18)F-FDG PET/CT检查的20例患者(其中男性16例、女性4例,中位年龄65岁)的临床及影像资料。20例患者分别行^(18)F-FAPI-04 PET/CT与^(18)F-FDG PET/CT,显像间隔时间≤7 d。入组病例以组织病理学作为最终诊断的金标准;对于组织学诊断不适用的病例,以影像学随访判断是否存在肝脏恶性肿瘤。比较2种显像剂的PET/CT影像学表现,采用Wilcoxon signed-rank test比较^(18)F-FAPI PET/CT与^(18)F-FDG PET/CT显像SUV_(max)、肿瘤代谢体积(metabolic tumor volume, MTV)、病灶糖酵解总量(total lesion glycolysis, TLG)、病灶FAP摄取总量(total lesion FAP uptake,TLF)之间的差异性;通过Kappa检验评价2位观察者识别病灶区域的一致性;通过SUV_(max)[M(P25,75)]的Wilcoxon配对秩和检验评价1、2 h显像的图像对比度及相关性。结果^(18)F-FAPI PET/CT与^(18)F-FDG PET/CT在18例阳性病变(原发性9例、转移性9例)中的SUV_(max)分别为11.74(7.65, 15.51)、 8.05(4.91, 10.33),差异具有统计学意义(z=-2.461、P=0.014);在9例肝脏原发性病变中的SUV_(max)分别为13.06(7.30,18.22)、5.94(3.01,8.82),差异具有统计学意义(z=-2.429、P=0.015);在9例肝脏转移性病变中的SUV_(max)分别为10.42(7.70,14.17)、10.16(6.53,13.86),差异无统计学意义(z=-0.533、P=0.594)。18例阳性病变(原发性9例、转移性9例)的肿瘤代谢体积参数MTV4.0分别为29.29(3.41,34.72)、18.02(0.85,31.05),差异有统计学意义(z=-2.243、P=0.025);TLF4.0分别为208.73(19.49,262.61)、111.48(3.73,213.38),差异有统计学意义(z=-2.373、 P=0.018);9例肝脏原发性病变TLF2.5分别为337.06(78.41, 462.48)、191.25(10.41,352.41),差异有统计学意义(z=-2.073、P=0.048);肝脏原发性病变TLF3.0分别为307.95(55.89,393.50)、160.46(0.05,279.24),差异有统计学意义(z=-2.429、P=0.015);9例肝脏转移性病变在不同固定阈值及百分比阈值MTV与TLF之间的比较,差异均无统计学意义。2位观察者对肝脏病灶视觉分析一致性为100%,Kappa=1.000,z=4.88、P<0.001。2位观察者对肝脏病灶数量一致性为88.89%,Kappa=0.825 2,z=5.36、P<0.001;FDG显像分析一致性为88.89%,Kappa=0.826 9,z=6.24、P<0.001。1、2 h显像的图像对比度无明显统计学差异(P=0.128 9);1 h SUV_(max)和2 h SUV_(max)之间Pearson相关系数为0.792 8,P<0.05,表明两者具有显著相关性。结论^(18)F-FAPI在肝脏原发性病变中显示出较高的靶本底比值,可以弥补^(18)F-FDG PET/CT在检测原发性肝癌方面的不足。因此,FAPI在肝脏肿瘤中的高选择性摄取可能为肿瘤的无创性诊断、分期以及肿瘤治疗疗效监测开辟新的应用领域。 展开更多
关键词 ^(18)f-fAPI ^(18)f-fDG 肝脏恶性肿瘤 PET/CT 成纤维细胞激活蛋白
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HFSS软件在天线设计教学中的应用
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作者 牛芳琳 吕星 于玲 《实验室科学》 2025年第4期133-137,共5页
为了加深通信专业学生对“天线技术”理论及设计的理解,提出了一种基于HFSS软件的实验教学方法。此方法结合教学理论知识来设计实验内容,利用HFSS软件建立天线模型并运行仿真,使学生能够直观地观察到天线设计的结构及运行结果。该教学... 为了加深通信专业学生对“天线技术”理论及设计的理解,提出了一种基于HFSS软件的实验教学方法。此方法结合教学理论知识来设计实验内容,利用HFSS软件建立天线模型并运行仿真,使学生能够直观地观察到天线设计的结构及运行结果。该教学方法的操作过程简便,且能够使学生清晰地理解天线的各项参数及其对性能的影响。通过这种实践操作,学生不仅能够掌握分析天线性能的技能,还能在一定程度上培养出设计天线的基本能力,符合国家对新工科学生培养的期望和要求。 展开更多
关键词 HfSS软件 f天线 增益方向图 电压驻波比
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基于Relief-F特征优选的滑坡影响因子提取及易发性建模分析
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作者 方露 邢尹 《测绘通报》 北大核心 2025年第6期90-96,共7页
为解决现有滑坡易发性评价模型精度不足和单一决策模型局限性的问题,本文提出了一种集成智能组合算法优化RF的PSO-GA-RF集成模型。采用著名的过滤式特征选择方法——Relief-F算法,对滑坡致灾因子进行权重排序,剔除冗余特征,优化分类结果... 为解决现有滑坡易发性评价模型精度不足和单一决策模型局限性的问题,本文提出了一种集成智能组合算法优化RF的PSO-GA-RF集成模型。采用著名的过滤式特征选择方法——Relief-F算法,对滑坡致灾因子进行权重排序,剔除冗余特征,优化分类结果,从而减少了依赖主观判断提取影响因子的问题,降低了人为误差。PSO-GA-RF集成模型融合了多种算法的优势,对RF模型的参数进行优化,简化了参数选择的烦琐过程,减小了误差。试验结果表明,PSO-GA-RF集成模型在预测性能和效率上均优于RF和GA-RF模型。 展开更多
关键词 滑坡 易发性 影响因子 Relief-f PSO-GA-Rf
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加味升降散对急性胃黏膜损伤大鼠6-keto-PGF_(1α),TXB_2,TNF-α和EGF含量的影响 被引量:9
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作者 牛栋 侯菲 李士懋 《武警医学》 CAS 2005年第6期417-419,共3页
目的研究中药加味升降散对胃黏膜攻击因子、保护因子的调节作用。方法随机对照吲哚美辛所致胃黏膜急性损伤大鼠,对比加味升降散、丽珠得乐以及模型和空白组在血栓素B2(TXB2)、血小板活化因子(PAF)、6-酮-前列腺素F1α(6ketoPGF1α)、表... 目的研究中药加味升降散对胃黏膜攻击因子、保护因子的调节作用。方法随机对照吲哚美辛所致胃黏膜急性损伤大鼠,对比加味升降散、丽珠得乐以及模型和空白组在血栓素B2(TXB2)、血小板活化因子(PAF)、6-酮-前列腺素F1α(6ketoPGF1α)、表皮生长因子(EGF)的含量的差别。结果加味升降散能够降低实验性胃黏膜急性损伤大鼠血浆的TXB2,PAF含量,升高6ketoPGF1α,EGF的含量。结论加味升降散可通过削弱攻击因子和增强保护因子两个环节发挥细胞保护作用,从而保护胃黏膜免遭损伤。 展开更多
关键词 6-KETO-PGf 加味升降散 急性胃黏膜损伤 TNf 含量 血小板活化因子(PAf) 血栓素B2(TXB2) 6-酮-前列腺素f 表皮生长因子(EGf) 细胞保护作用 攻击因子 保护因子 急性损伤 调节作用 吲哚美辛 随机对照 丽珠得乐 大鼠血浆
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利多卡因通过FOXO1/miR-203b/Cacna1f信号轴在带状疱疹后遗神经痛中的作用机制
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作者 郑颖 周武碧 +1 位作者 王祥 戴京京 《西北药学杂志》 2025年第1期38-45,共8页
目的研究带状疱疹病毒(varicella-zoster virus,VZV)感染神经后,利多卡因通过FOXO1/miR-203b/Cacna1f信号轴在后遗神经痛中的作用机制。方法构建VZV感染的大鼠带状疱疹后遗神经痛(post herpetic neuralgia,PHN)动物模型,造模成功后,检... 目的研究带状疱疹病毒(varicella-zoster virus,VZV)感染神经后,利多卡因通过FOXO1/miR-203b/Cacna1f信号轴在后遗神经痛中的作用机制。方法构建VZV感染的大鼠带状疱疹后遗神经痛(post herpetic neuralgia,PHN)动物模型,造模成功后,检测SD大鼠背跟神经节在感染VZV后的差异基因表达水平,结合生物信息学分析与疼痛相关的基因FOXO1(保护性)、Cacna1f(钙离子通道蛋白)和miRNA(Targetscan数据库分析并进行Realtime PCR验证),并利用双荧光素酶报告基因验证上、下游调控靶点。同时检测利多卡因组FOXO1、Cacna1f和miRNA的表达情况。结果SD大鼠PHN造模成功,且共鉴定出差异表达基因89个。生物信息分析结果显示,VZV感染后,FOXO1的表达下调,Cacna1f的表达上调;而利多卡因治疗组与VZV感染组比较,FOXO1的表达上调,Cacna1f的表达下调。Targetscan数据库分析结果显示,Cacna1f基因具有6个miRNA的结合位点,且仅有miR-203b的表达水平显著下降。通过双荧光素酶报告基因发现,在PHN中FOXO1对miR-203b具有转录调控作用,同时miR-203b可靶向于Cacna1f分子。结论FOXO1/miR-203b/Cacna1f信号轴在PHN中起重要的疼痛信号传递作用,利多卡因可通过作用于该轴减弱疼痛信号的转导,FOXO1/miR-203b/Cacna1f信号轴可以作为治疗PHN的靶点通路。 展开更多
关键词 带状疱疹后遗神经痛(PHN) 利多卡因 生物信息学 缩足阈值 差异表达基因 fOXO1 Cacna1f miR-203b
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肝细胞癌组织中FOXF1、FCRL5表达及与患者临床病理特征和预后的关系
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作者 周林 向世春 +1 位作者 鲜成萼 张铁泉 《肝胆外科杂志》 2025年第2期149-154,共6页
目的分析肝细胞癌(HCC)组织中叉头盒F1(FOXF1)、Fc受体样5(FCRL5)表达及与患者临床病理特征和预后的关系。方法选择2019年1月至2021年12月本院收治的HCC患者80例,根据患者的预后情况将患者分为生存组和死亡组。采用免疫组化法检测癌组... 目的分析肝细胞癌(HCC)组织中叉头盒F1(FOXF1)、Fc受体样5(FCRL5)表达及与患者临床病理特征和预后的关系。方法选择2019年1月至2021年12月本院收治的HCC患者80例,根据患者的预后情况将患者分为生存组和死亡组。采用免疫组化法检测癌组织与癌旁组织中FOXF1、FCRL5表达;Spearman分析HCC癌组织中FOXF1、FCRL5的相关性;HCC癌组织FOXF1、FCRL5表达与预后的关系采用Kaplan-Meier生存曲线完成;预后不良的影影响因素采用COX回归完成。结果癌组织的FOXF1、FCRL5阳性表达率较高(P<0.05);Spearman分析显示,HCC患者癌组织中FOXF1、FCRL5呈正相关;癌组织FOXF1、FCRL5阳性表达患者肿瘤数目、分化程度、TNM分期、肿瘤最大直径与阴性表达患者比较差异显著(P<0.05);死亡组FOXF1、FCRL5阳性表达率均高于生存组(P<0.05);Kaplan-Meier生存曲线显示,FOXF1、FCRL5阳性表达患者3年生存率均低于阴性表达患者(P<0.05);多因素COX回归分析显示,TNM分期、FOXF1、FCRL5表达是HCC患者预后不良的影响因素(P<0.05)。结论在HCC癌组织中FOXF1、FCRL5呈现高表达,且两个指标均与临床病理特征和预后密切相关。 展开更多
关键词 肝细胞癌 叉头盒f1 fc受体样5 临床病理特征 预后
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Isolation and identification of Fusarium oxysporum f. sp. cubense in Fujian Province, China 被引量:2
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作者 WU Kai-li CHEN Wei-zhong +5 位作者 YANG Shuai WEN Ya ZHENG Yu-ru Wilfred Mabeche Anjago YUN Ying-zi WANG Zong-hua 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第8期1905-1913,共9页
Fusarium wilt, caused by Fusarium oxyporum f. sp. cubense(Foc), is the most serious disease affecting banana production.To clarify the distribution of the Foc races in Fujian Province of China, 79 soil samples were co... Fusarium wilt, caused by Fusarium oxyporum f. sp. cubense(Foc), is the most serious disease affecting banana production.To clarify the distribution of the Foc races in Fujian Province of China, 79 soil samples were collected from four regions of Zhangzhou City, the primary banana production area in Fujian. We isolated and identified 12 Foc strains based on internal transcribed spacer(ITS) sequence analysis, PCR amplification by using Foc-specific primers and pathogenicity assays.Our analysis indicated that 11 isolates belong to Foc race 1, and 1 isolate belongs to the Foc tropical species race 4(TR4).Although TR4 has previously been reported to occur in primary banana-producing provinces, such as Hainan, Guangxi,and Guangdong of China, this is the first report of TR4 isolated from the soil in Fujian Province. Monitoring the presence of Foc, in particular, the TR4 strains in the soil, is the basic strategy to prevent and control Fusarium wilt. 展开更多
关键词 fUSARIUM OXYSPORUM f. sp. cubense(foc) identification of PHYSIOLOGICAL RACES PATHOGENICITY test fujian fUSARIUM WILT
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Performance Evaluation of Multiple Classifiers for Predicting Fake News
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作者 Arzina Tasnim Md. Saiduzzaman +2 位作者 Mohammad Arafat Rahman Jesmin Akhter Abu Sayed Md. Mostafizur Rahaman 《Journal of Computer and Communications》 2022年第9期1-21,共21页
The rise of fake news on social media has had a detrimental effect on society. Numerous performance evaluations on classifiers that can detect fake news have previously been undertaken by researchers in this area. To ... The rise of fake news on social media has had a detrimental effect on society. Numerous performance evaluations on classifiers that can detect fake news have previously been undertaken by researchers in this area. To assess their performance, we used 14 different classifiers in this study. Secondly, we looked at how soft voting and hard voting classifiers performed in a mixture of distinct individual classifiers. Finally, heuristics are used to create 9 models of stacking classifiers. The F1 score, prediction, recall, and accuracy have all been used to assess performance. Models 6 and 7 achieved the best accuracy of 96.13 while having a larger computational complexity. For benchmarking purposes, other individual classifiers are also tested. 展开更多
关键词 fake News Machine Learning Tf-IDf CLASSIfIER Estimator f1 Score RECALL Precision Voting Classifiers Stacking Classifier Soft Voting Hard Voting
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