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In-Plane Static Analysis of Curved Nanobeams Using Exact-Solution-Based Finite Element Formulation
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作者 Omer Ekim Genel Hilal Koc Ekrem Tufekci 《Computers, Materials & Continua》 2025年第2期2043-2059,共17页
Due to their superior properties, the interest in nanostructures is increasing today in engineering. This study presents a new two-noded curved finite element for analyzing the in-plane static behaviors of curved nano... Due to their superior properties, the interest in nanostructures is increasing today in engineering. This study presents a new two-noded curved finite element for analyzing the in-plane static behaviors of curved nanobeams. Opposite to traditional curved finite elements developed by using approximate interpolation functions, the proposed curved finite element is developed by using exact analytical solutions. Although this approach was first introduced for analyzing the mechanical behaviors of macro-scale curved beams by adopting the local theory of elasticity, the exact analytical expressions used in this study were obtained from the solutions of governing equations that were expressed via the differential form of the nonlocal theory of elasticity. Therefore, the effects of shear strain and axial extension included in the analytical formulation are also inherited by the curved finite element developed here. The rigidity matrix and the consistent force vector are developed for a circular finite element. To demonstrate the applicability of the method, static analyses of various curved nanobeams subjected to different boundary conditions and loading scenarios are performed, and the obtained results are compared with the exact analytical ones. The presented study provides an accurate and low computational cost method for researchers to investigate the in-plane static behavior of curved nanobeams. 展开更多
关键词 Nonlocal elasticity finite element exact solution static analysis nanobeam curved
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Exact solutions for the transcritical Riemann problem of two-parameter fluids
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作者 Haotong BAI Yixin YANG +2 位作者 Wenjia XIE Dejian LI Mingbo SUN 《Applied Mathematics and Mechanics(English Edition)》 2025年第12期2385-2406,共22页
Transcritical and supercritical fluids widely exist in aerospace propulsion systems,such as the coolant flow in the regenerative cooling channels of scramjet engines.To numerically simulate the coolant flow,we must ad... Transcritical and supercritical fluids widely exist in aerospace propulsion systems,such as the coolant flow in the regenerative cooling channels of scramjet engines.To numerically simulate the coolant flow,we must address the challenges in solving Riemann problems(RPs)for real fluids under complex flow conditions.In this study,an exact numerical solution for the one-dimensional RP of two-parameter fluids is developed.Due to the comprehensive resolution of fluid thermodynamics,the proposed solution framework is suitable for all forms of the two-parameter equation of state(EoS).The pressure splitting method is introduced to enable parallel calculation of RPs across multiple grid points.Theoretical analysis demonstrates the isentropic nature of weak waves in two-parameter fluids,ensuring that the same mathematical properties as ideal gas could be applied in Newton's iteration.A series of numerical cases validate the effectiveness of the proposed method.A comparative analysis is conducted on the exact Riemann solutions for the real fluid EoS,the ideal gas EoS,and the improved ideal gas EoS under supercritical and transcritical conditions.The results indicate that the improved one produces smaller errors in the calculation of momentum and energy fluxes. 展开更多
关键词 two-parameter fluid Riemann problem(RP) exact solution supercritical fluid pressure splitting transcritical fluid
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Exact solutions of differential equations:renormalization group based polynomial scheme
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作者 Pengfei Guo Yueheng Lan Jianyong Qiao 《Communications in Theoretical Physics》 2025年第10期39-58,共20页
A polynomial scheme is proposed here to compute exact solutions of nonlinear partial differential equations(NPDEs)based on a series expansions of solutions and a renormalization group(RG)related resummation.The most s... A polynomial scheme is proposed here to compute exact solutions of nonlinear partial differential equations(NPDEs)based on a series expansions of solutions and a renormalization group(RG)related resummation.The most salient feature of the current approach is that only linear algebraic equations need to be solved to implement the resummation for closed-form exact solution and parameter dependence,which does not require any sophisticated analysis like Cole-Hopf transformation or Painlevétest.New exact solutions of typical NPDEs are computed with this novel method,including one-and two-soliton(solitary wave)solutions,periodic solutions of exponential or elliptic function type.Moreover,exact reduced equations may also be conveniently computed for further analysis. 展开更多
关键词 polynomial method renormalization group exact solutions
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Continuous limit,exact rational solutions and combined rational-exponential solutions for a generalized Toda lattice equation with four potentials
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作者 Ming-juan Guo Xiao-Yong Wen 《Communications in Theoretical Physics》 2025年第11期28-37,共10页
The investigation centers on a generalized Toda lattice equation featuring four potentials.Initially,the continuous counterpart is first established using the continuous limit approach.Subsequently,leveraging its 3... The investigation centers on a generalized Toda lattice equation featuring four potentials.Initially,the continuous counterpart is first established using the continuous limit approach.Subsequently,leveraging its 3×3 matrix spectrum problem,the discrete generalized(m,3N-m)-fold Darboux transformation(DT)is formulated for this discrete system.Finally,the derived generalized DT is employed to generate precise rational solutions and hybrid rational-exponential solutions,which are thoroughly analyzed and graphically illustrated.These novel findings may offer insights into the lattice dynamical phenomena described by Toda lattice equation. 展开更多
关键词 generalized toda lattice equation continuous limit discrete(m 3N-m)-fold DT exact rational solution combined rational-exponential solution
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New exact traveling wave solutions of the coupled Boussinesq equations
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作者 Mingyue Wang Youhe Zhou Jizeng Wang 《Theoretical & Applied Mechanics Letters》 2025年第2期108-114,共7页
The Boussinesq equations,pivotal in the analysis of water wave dynamics,effectively model weakly nonlinear and long wave approximations.This study utilizes the complete discriminant system within a polynomial approach... The Boussinesq equations,pivotal in the analysis of water wave dynamics,effectively model weakly nonlinear and long wave approximations.This study utilizes the complete discriminant system within a polynomial approach to derive exact traveling wave solutions for the coupled Boussinesq equation.The solutions are articulated through soliton,trigonometric,rational,and Jacobi elliptic functions.Notably,the introduction of Jacobi elliptic function solutions for this model marks a pioneering advancement.Contour plots of the solutions obtained by assigning values to various parameters are generated and subsequently analyzed.The methodology proposed in this study offers a systematic means to tackle nonlinear partial differential equations in mathematical physics,thereby enhancing comprehension of the physical attributes and dynamics of water waves. 展开更多
关键词 Coupled Boussinesq equations exact traveling wave solutions Complete discriminant system Polynomial method
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Methods for Exact Solutions of Nonlinear Ordinary Differential Equations
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作者 Robert CONTE Micheline MUSETTE +1 位作者 Tuen Wai NG WU Chengfa 《数学进展》 北大核心 2025年第2期379-389,共11页
In order to find closed form solutions of nonintegrable nonlinear ordinary differential equations,numerous tricks have been proposed.The goal of this short review is to explain how a theorem of Eremenko on meromorphic... In order to find closed form solutions of nonintegrable nonlinear ordinary differential equations,numerous tricks have been proposed.The goal of this short review is to explain how a theorem of Eremenko on meromorphic solutions of some nonlinear ODEs together with some classical,19th-century results,can be turned into algorithms(thus avoiding ad hoc assumptions)which provide all(as opposed to some)solutions in a precise class.To illustrate these methods,we present some new such exact solutions,physically relevant. 展开更多
关键词 elliptic solution complex Ginzburg-Landau equation Closed-form solution Nevanlinna theory
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基于UPLC-Q-Exactive-Orbitrap-MS技术解析癃清胶囊的药效物质基础及大鼠体内代谢产物
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作者 张米婵 雷雨飞 +3 位作者 吴军 黄家宇 汤磊 李莉 《中国中药杂志》 北大核心 2026年第4期1141-1155,共15页
采用UPLC-Q-Exactive-Orbitrap-MS技术研究癃清胶囊的药效物质基础及其在大鼠体内的代谢产物并推断潜在的代谢途径。取癃清胶囊内容物分别制备供试品溶液及大鼠给药混悬液,SD大鼠灌胃给药后,采集不同时间点的血浆、尿液及粪便样本进样... 采用UPLC-Q-Exactive-Orbitrap-MS技术研究癃清胶囊的药效物质基础及其在大鼠体内的代谢产物并推断潜在的代谢途径。取癃清胶囊内容物分别制备供试品溶液及大鼠给药混悬液,SD大鼠灌胃给药后,采集不同时间点的血浆、尿液及粪便样本进样分析。利用Compound Discover 3.3、Xcalibur 4.1软件提取和分析质谱信息,根据化合物的精确质荷比、二级特征碎片、对照品信息及相关文献等从癃清胶囊中解析出128个化合物,包括生物碱类42个、萜类36个、有机酸类19个、黄酮类11个、苯乙酮类3个、柠檬苦素类2个,其他成分15个;从大鼠血浆、尿液、粪便中共解析出144个外源化合物,包括61个原型成分和83个代谢产物,主要代谢途径包括氧化、还原、水解、甲基化、硫酸化、葡萄糖醛酸化及多种反应类型的复合反应等。该研究首次阐明癃清胶囊的物质基础和大鼠体内代谢特征,为其药效物质基础及质量控制研究提供参考。 展开更多
关键词 癃清胶囊 UPLC-Q-exactive-Orbitrap-MS 化学成分 入血成分 代谢产物 代谢途径
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UHPLC-Q-Exactive-Orbitrap-MS联合网络药理学探讨黄英咳喘糖浆治疗支原体肺炎的潜在药效物质基础及作用机制
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作者 徐文涛 张秀英 +5 位作者 史俊祖 杨建树 凌京平 高瑜 杜筱晴 王雪峰 《中国医院药学杂志》 北大核心 2026年第4期403-409,共7页
目的:初步探讨黄英咳喘糖浆治疗支原体肺炎的潜在药效物质基础及作用机制。方法:基于超高效液相色谱-四极杆-静电场轨道阱高分辨质谱技术对黄英咳喘糖浆进行化学成分检测,并鉴定其入血成分,联合网络药理学探究潜在的药效成分及其作用机... 目的:初步探讨黄英咳喘糖浆治疗支原体肺炎的潜在药效物质基础及作用机制。方法:基于超高效液相色谱-四极杆-静电场轨道阱高分辨质谱技术对黄英咳喘糖浆进行化学成分检测,并鉴定其入血成分,联合网络药理学探究潜在的药效成分及其作用机制,并采用动物实验验证富集分析结果。结果:黄英咳喘糖浆中检测出88种药效成分及25种入血成分,入血成分与支原体肺炎交集靶点79个,涉及TNF、MAPK及PI3K-Akt等信号通路。动物实验结果进一步表明黄英咳喘糖浆可以抑制支原体肺炎引起的MAPK等信号通路的激活,上调TNF-α、IL-6相关炎性因子的表达。结论:黄英咳喘糖浆治疗支原体肺炎的潜在机制可能是通过调节TNF、MAPK及PI3K-Akt等信号通路,起到减轻支原体肺炎小鼠肺部炎症作用。 展开更多
关键词 黄英咳喘糖浆 支原体肺炎 超高效液相色谱-四极杆-静电场轨道阱高分辨质谱 入血成分 网络药理学
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基于UPLC-Q-Exactive Orbitrap-MS法同时测定扶正和肤止痒方透皮成分含量及透皮特性研究
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作者 钟海心 罗倩倩 +8 位作者 刘炎杰 唐斌 黄晓冰 谢建辉 陈永根 喻靖傑 邓浩 卢传坚 陈海明 《中药新药与临床药理》 北大核心 2026年第2期312-322,共11页
目的建立超高效液相色谱-四极杆静电场轨道阱质谱(UPLC-Q-Exactive Orbitrap-MS)法同时测定扶正和肤止痒方透皮成分的含量,并探讨其体外透皮扩散规律。方法采用Franz扩散池法进行体外释放与透皮试验,分别以BALB/c雄性小鼠空白皮肤和银... 目的建立超高效液相色谱-四极杆静电场轨道阱质谱(UPLC-Q-Exactive Orbitrap-MS)法同时测定扶正和肤止痒方透皮成分的含量,并探讨其体外透皮扩散规律。方法采用Franz扩散池法进行体外释放与透皮试验,分别以BALB/c雄性小鼠空白皮肤和银屑病样皮肤作为透过屏障,采用UPLC-Q-Exactive Orbitrap-MS技术测定扶正和肤止痒方及其接收液的成分含量;采用零级、一级、Higuchi动力学方程评价扶正和肤止痒方的透皮成分的释放与经皮渗透效果。结果共鉴定出扶正和肤止痒方中落新妇苷、茵芋碱、阿魏酸、花椒毒酚、白鲜碱、柠檬苦素、花椒毒素、吴茱萸苦素、蛇床子素、异茴芹内酯等10个透皮成分。建立的UPLC-Q-Exactive Orbitrap-MS多成分同时测定方法中,10个透皮成分在相应的浓度范围内呈现良好的线性关系(r>0.9960),且精密度、稳定性、准确度及基质效应均符合标准。以空白小鼠皮肤作为半透膜,落新妇苷、蛇床子素的透皮扩散规律遵循零级动力学方程;阿魏酸、花椒毒素、白鲜碱、吴茱萸苦素、柠檬苦素的透皮扩散规律遵循一级动力学方程;花椒毒酚、茵芋碱、异茴芹内酯的透皮扩散规律遵循Higuchi动力学方程。以模型小鼠银屑病样皮肤作为半透膜,花椒毒酚、花椒毒素、白鲜碱、异茴芹内酯、吴茱萸苦素的透皮扩散规律遵循一级动力学方程;落新妇苷、阿魏酸、茵芋碱、柠檬苦素、蛇床子素透皮扩散规律遵循Higuchi动力学方程。结论该研究建立的扶正和肤止痒方透皮成分定量检测方法准确、灵敏、稳定,明确了扶正和肤止痒方10个透皮成分的体外扩散规律,可为扶正和肤止痒方治疗银屑病的药效研究奠定基础。 展开更多
关键词 扶正和肤止痒方 透皮成分 经皮渗透 超高效液相色谱-四极杆静电场轨道阱质谱 同时测定
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基于UPLC-Q-Exactive Orbitrap-MS和网络药理学结合动物实验探讨干姜拌捣五味子治疗痰饮哮喘的作用机制
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作者 左玉婷 钟佩 +8 位作者 刘雨欣 汤雯雯 陶文瀚 王晓丽 赵权 刘产明 金莹 陈薇 黄玮 《中国中药杂志》 北大核心 2026年第4期1090-1098,共9页
基于成分分析、网络药理学和动物实验探究干姜拌捣五味子(Zingiberis Rhizoma mixed and triturated with Schisandrae Chinensis Fructus,ZMTS)对痰饮哮喘的影响。应用UPLC-Q-Exactive Orbitrap-MS对ZMTS进行成分分析,共鉴定出37个成分... 基于成分分析、网络药理学和动物实验探究干姜拌捣五味子(Zingiberis Rhizoma mixed and triturated with Schisandrae Chinensis Fructus,ZMTS)对痰饮哮喘的影响。应用UPLC-Q-Exactive Orbitrap-MS对ZMTS进行成分分析,共鉴定出37个成分,通过TCMSP和SwissADME筛选出活性成分33个,SwissTargetPrediction和Superpred查找活性成分对应的靶点,通过GeneCards查找痰饮哮喘疾病的靶点,二者交集靶点共有118个。采用STRING 11.0构建成分-疾病交集靶点的蛋白质-蛋白质相互作用(PPI)网络,并使用Cytoscape 3.10.0对PPI网络进行可视化。使用DAVID平台对交集靶点进行基因本体论(GO)和京都基因与基因组百科全书(KEGG)通路富集分析,磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)通路为治疗的重要通路。构建成分-靶点-通路网络,将分析得到的核心成分和核心靶点进行分子对接,结果显示,核心成分和核心靶点具有良好的结合作用。通过建立痰饮哮喘小鼠模型,以组织病理学染色、免疫组化(IHC)、酶联免疫吸附测定法(ELISA)和蛋白免疫印迹法(Western blot)对ZMTS的作用机制进行验证。动物实验结果显示,ZMTS高剂量可显著改善痰饮哮喘小鼠的气道炎症反应,降低白细胞介素-17(IL-17)和白细胞介素-23(IL-23)水平,显著抑制PI3K和Akt蛋白磷酸化水平。ZMTS通过多成分作用于IL-17、IL-23等靶点发挥改善痰饮哮喘的作用,其机制与PI3K/Akt信号通路的调控密切相关,充分体现了多成分、多靶点、多通路的综合作用。 展开更多
关键词 干姜拌捣五味子 痰饮哮喘 UPLC-Q-exactive Orbitrap-MS 网络药理学 孟河医派
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The Construction of Exact Solutions of the Two-Dimensional Gardner Equation via the∂¯-Dressing Method
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作者 Binlu FENG Linlin GUI Yufeng ZHANG 《Journal of Mathematical Research with Applications》 2025年第6期758-772,共15页
The(2+1)-dimensional integrable generalization of the Gardner(2DG)equation is solved via the inverse scattering transform method in this paper.A kind of general solution of the equation is obtained by introducing long... The(2+1)-dimensional integrable generalization of the Gardner(2DG)equation is solved via the inverse scattering transform method in this paper.A kind of general solution of the equation is obtained by introducing long derivatives V_(x),V_(y),V_(t).Two different constraints on the kernel function K are introduced under the reality of the solution u of the 2DG equation.Then,two classes of exact solutions with constant asymptotic values at infinity u|x^(2)+y^(2)→∞→0 are constructed by means of the∂¯-dressing method for the casesσ=1 andσ=i.The rational and multiple pole solutions of the 2DG equation are obtained with the kernel functions of zero-order and higher-order Dirac delta functions,respectively. 展开更多
关键词 2DG equation kernel function ∂¯-dressing method rational solution multiple pole solution
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肾衰宁片化学成分的UPLC-Q-Exactive Orbitrap MS鉴定
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作者 潘琼群 王建海 +3 位作者 敦晓旭 张雨萌 赵旻 赵春杰 《中国处方药》 2026年第4期83-91,共9页
目的采用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(UPLC-Q-Exactive Orbitrap MS)技术系统鉴定肾衰宁片的化学成分。方法采用XDB C_(18)色谱柱(150 mm×2.1 mm,1.8μm),以0.1%甲酸-水溶液与乙腈为流动相进行梯度洗脱,在正、... 目的采用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(UPLC-Q-Exactive Orbitrap MS)技术系统鉴定肾衰宁片的化学成分。方法采用XDB C_(18)色谱柱(150 mm×2.1 mm,1.8μm),以0.1%甲酸-水溶液与乙腈为流动相进行梯度洗脱,在正、负离子两种模式下采集数据。结果共从肾衰宁片中鉴定出137种化合物,包括萜类33种、黄酮类31种、蒽醌类18种、生物碱类16种、有机酸类15种、鞣质类4种、环肽类4种及其他类16种。结论UPLC-Q-Exactive Orbitrap MS技术分离效率高、分析速度快,操作简便,可为肾衰宁片的药效物质基础研究与质量控制提供可靠依据。 展开更多
关键词 肾衰宁片 UPLC-Q-exactive Orbitrap MS 成分鉴定 化学成分
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基于UHPLC-Q-Exactive HF-X结合多元统计分析探究鲜、干冬凌草化学成分差异
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作者 张金英 田硕 +3 位作者 郭琳 茆志国 胡毅龙 苗明三 《中华中医药学刊》 北大核心 2026年第2期148-155,I0027-I0029,共11页
目的探究鲜冬凌草与其干品(自然晒干、真空冷冻干燥)的化学成分差异。方法利用超高效液相-四极杆-静电轨道阱高分辨质谱(Ultra-high performance liquid chromatography-quadrupole-exactive mass spectrometry,UHPLC-Q-Exactive HF-X/... 目的探究鲜冬凌草与其干品(自然晒干、真空冷冻干燥)的化学成分差异。方法利用超高效液相-四极杆-静电轨道阱高分辨质谱(Ultra-high performance liquid chromatography-quadrupole-exactive mass spectrometry,UHPLC-Q-Exactive HF-X/MS)联用技术在正、负离子模式下采集冬凌草化学成分质谱数据,并基于在线数据库、本地自建标准品数据库及文献报道对其成分进行鉴定分析;通过SIMCA软件对采集的数据进行主成分分析(Principal component analysis,PCA)和正交偏最小二乘法判别分析(Orthogonal partial least squares-discriminant analysis,OPLS-DA),根据获得的变量投影重要性(Variable importance in projection,VIP)和t检验筛选鲜干冬凌草间的差异化学成分;最后,根据差异成分离子峰面积进行相对定量分析。结果共鉴定出61个化学成分,包括二萜类31个、酚酸类12个、黄酮类9个、二萜类4个、三萜类4个、其他类5个;PCA图直观地显示冬凌草鲜品化学轮廓与其干品有明显的差异;通过OPLS-DA筛选出VIP>1和P<0.05的差异化学成分32个,其中差异成分冬凌草甲素、冬凌草乙素等二萜类活性成分在鲜品中相对含量显著高于其干品。结论UHPLC-Q-Exactive HF-X/MS结合多元统计分析可用于明确鲜干冬凌草的化学成分差异,进而为鲜干冬凌草资源的合理开发应用提供重要的数据参考。 展开更多
关键词 冬凌草 鲜药 干品 UHPLC-Q-exactive HF-X/MS 多元统计分析 差异成分
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Stability,bifurcation,chaotic pattern,phase portrait and exact solutions of a class of semi-linear Schrödinger equations with Kudryashov's power law self-phase modulation and multiplicative white noise based on Stratonvich's calculus
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作者 Cheng-Qiang Wang Xiang-Qing Zhao +1 位作者 Yu-Lin Zhang Zhi-Wei Lv 《Chinese Physics B》 2025年第12期276-291,共16页
We devote ourselves to finding exact solutions(including perturbed soliton solutions)to a class of semi-linear Schrödinger equations incorporating Kudryashov's self-phase modulation subject to stochastic pert... We devote ourselves to finding exact solutions(including perturbed soliton solutions)to a class of semi-linear Schrödinger equations incorporating Kudryashov's self-phase modulation subject to stochastic perturbations described by multiplicative white noise based on Stratonvich's calculus.By borrowing ideas of the sub-equation method and utilizing a series of changes of variables,we transform the problem of identifying exact solutions into the task of analyzing the dynamical behaviors of an auxiliary planar Hamiltonian dynamical system.We determine the equilibrium points of the introduced auxiliary Hamiltonian system and analyze their Lyapunov stability.Additionally,we conduct a brief bifurcation analysis and a preliminary chaos analysis of the auxiliary Hamiltonian system,assessing their impact on the Lyapunov stability.Based on the insights gained from investigating the dynamics of the introduced auxiliary Hamiltonian system,we discover‘all'of the exact solutions to the stochastic semi-linear Schrödinger equations under consideration.We obtain explicit formulas for exact solutions by examining the phase portrait of the introduced auxiliary Hamiltonian system.The obtained exact solutions include singular and periodic solutions,as well as perturbed bright and dark solitons.For each type of obtained exact solution,we pick one representative to plot its graph,so as to visually display our theoretical results.Compared with other methods for finding exact solutions to deterministic or stochastic partial differential equations,the dynamical system approach has the merit of yielding all possible exact solutions.The stochastic semi-linear Schrödinger equation under consideration can be used to portray the propagation of pulses in an optical fiber,so our study therefore lays the foundation for discovering new solitons optimized for optical communication and contributes to the improvement of optical technologies. 展开更多
关键词 stochastic semi-linear Schrödinger equations self-phase modulation soliton solutions Stratonvich's calculus
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基于UHPLC-Q-Exactive-MS与网络药理学探讨芩柏软膏外用治疗银屑病的作用机制
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作者 张林华 贾利影 +5 位作者 关佳莉 徐媛媛 拱健婷 丛悦 李萍 韩旭阳 《中国现代中药》 2026年第2期283-292,共10页
目的:采用超高效液相色谱-四极杆-轨道离子阱高分辨质谱法(UHPLC-Q-Exactive-MS)鉴定芩柏软膏的主要化学成分,结合网络药理学和分子对接技术,探讨其治疗银屑病的作用机制。方法:通过质谱数据采集,结合对照品比对、相关文献查阅及数据库... 目的:采用超高效液相色谱-四极杆-轨道离子阱高分辨质谱法(UHPLC-Q-Exactive-MS)鉴定芩柏软膏的主要化学成分,结合网络药理学和分子对接技术,探讨其治疗银屑病的作用机制。方法:通过质谱数据采集,结合对照品比对、相关文献查阅及数据库检索,鉴定并表征芩柏软膏的化学成分;从SwissTargetPrediction数据库获取药物潜在靶点,利用GeneCards、OMIM、TTD、DrugBank数据库筛选银屑病的相关疾病靶点,取两者交集得到共同靶点;借助String数据库和Cytoscape 3.9.1软件构建蛋白质-蛋白质相互作用网络并筛选核心靶点;利用Metascape平台对交集靶点进行基因本体(GO)功能和京都基因与基因组百科全书(KEGG)通路分析,最后通过AutoDock与Pymol软件对预测的靶点及其对应的成分进行分子对接验证。结果:从芩柏软膏中鉴定出50个化合物。筛选得到治疗银屑病的共同靶点180个,其作用机制可能涉及磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)、丝裂原活化蛋白激酶(MAPK)、缺氧诱导因子-1(HIF-1)信号通路等,肿瘤蛋白p53(TP53)、缺氧诱导因子-1α(HIF1A)、Jun原癌基因(JUN)、信号转导和转录激活因子(STAT3)、B淋巴细胞瘤-2(BCL2)、MAPK1等关键靶点。结论:本研究较全面地分析了芩柏软膏的化学成分,初步推测其可能通过多组分、多靶点、多通路发挥治疗银屑病的作用,为其临床应用及后续实验提供参考。 展开更多
关键词 超高效液相色谱-四极杆-轨道离子阱高分辨质谱法 网络药理学 分子对接 芩柏软膏 银屑病 分子机制 信号通路
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Facile synthesis of Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)solid solutions for improving photocatalytic CO_(2)reduction
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作者 WANG Jingzhou YAO Chenzhong +2 位作者 ZHANG Xisheng MA Ziwei LI Linfeng 《燃料化学学报(中英文)》 北大核心 2026年第1期15-25,共11页
In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar perce... In this study,a straightforward one-step hydrothermal method was successfully utilized to synthesize the solid solution Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)-Na_(2)Ni_(2)Ti_(6)O_(16)(NNMTO-x),where x denotes the molar percentage of Na_(2)Ni_(2)Ti_(6)O_(16)(NNTO)within Na_(0.9)Mg_(0.45)Ti_(3.55)O_(8)(NMTO),with x values of 10,20,30,40,and 50.Both XPS(X-ray Photoelectron Spectroscopy)and EDX(Energy Dispersive X-ray Spectroscopy)analyses unequivocally validated the formation of the NNMTO-x solid solutions.It was observed that when x is below 40,the NNMTO-x solid solution retains the structural characteristics of the original NMTO.However,beyond this threshold,significant alterations in crystal morphology were noted,accompanied by a noticeable decline in photocatalytic activity.Notably,the absorption edge of NNMTO-x(x<40)exhibited a shift towards the visible-light spectrum,thereby substantially broadening the absorption range.The findings highlight that NNMTO-30 possesses the most pronounced photocatalytic activity for the reduction of CO_(2).Specifically,after a 6 h irradiation period,the production rates of CO and CH_(4)were recorded at 42.38 and 1.47μmol/g,respectively.This investigation provides pivotal insights that are instrumental in the advancement of highly efficient and stable photocatalysts tailored for CO_(2)reduction processes. 展开更多
关键词 photocatalytic conversion hydrothermal method optical response range solid solution charge separation
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The time-fractional(2+1)-dimensional Heisenberg ferromagnetic spin chain equation:its Lie symmetries,exact solutions and conservation laws
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作者 Jicheng Yu Yuqiang Feng 《Communications in Theoretical Physics》 2025年第5期21-30,共10页
In this paper,the Lie symmetry analysis method is applied to the(2+1)-dimensional time-fractional Heisenberg ferromagnetic spin chain equation.We obtain all the Lie symmetries admitted by the governing equation and re... In this paper,the Lie symmetry analysis method is applied to the(2+1)-dimensional time-fractional Heisenberg ferromagnetic spin chain equation.We obtain all the Lie symmetries admitted by the governing equation and reduce the corresponding(2+1)-dimensional fractional partial differential equations with the Riemann–Liouville fractional derivative to(1+1)-dimensional counterparts with the Erdélyi–Kober fractional derivative.Then,we obtain the power series solutions of the reduced equations,prove their convergence and analyze their dynamic behavior graphically.In addition,the conservation laws for all the obtained Lie symmetries are constructed using the new conservation theorem and the generalization of Noether operators. 展开更多
关键词 Lie symmetries fractional partial differential equation Heisenberg ferromagnetic spin chain equation power series solutions conservation laws
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基于UPLC-Q-Exactive Orbitrap MS分析泻白散在正常和慢性支气管炎小鼠体内的入血成分及其代谢差异
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作者 彭鹏 李佳欣 +4 位作者 杨新月 刘方乐 祝晨蔯 林朝展 姚宇峰 《中国实验方剂学杂志》 北大核心 2026年第1期219-227,共9页
目的:利用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱法(UPLC-Q-Exactive Orbitrap MS),系统分析泻白散在正常状态和慢性支气管炎(CB)模型小鼠中的入血成分及其代谢轮廓,并比较两者之间的差异。方法30只雌性BABL/c小鼠随机分为正常... 目的:利用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱法(UPLC-Q-Exactive Orbitrap MS),系统分析泻白散在正常状态和慢性支气管炎(CB)模型小鼠中的入血成分及其代谢轮廓,并比较两者之间的差异。方法30只雌性BABL/c小鼠随机分为正常组、正常给药组、CB组、CB给药组和地塞米松组,每组6只。采用卵清蛋白(OVA)诱导建立CB小鼠模型。正常给药组和CB给药组小鼠于第21天开始灌胃泻白散(生药量13.2 g·kg^(-1)),地塞米松组小鼠同时灌胃地塞米松(0.5 mg·kg^(-1))直至第35天实验结束,随后采集血清样本经药效评价指标确定泻白散干预CB的药效作用。采用UPLC-Q-Exactive Orbitrap MS对泻白散的化学成分、入血成分及其代谢产物进行鉴定和分析,并结合化学计量法揭示泻白散在正常及CB状态下的代谢轮廓差异。同时,利用实时荧光定量聚合酶链式反应(Real-time PCR)检测肝脏关键代谢酶细胞色素P4502E1(CYP2E1)、细胞色素P4503A1(CYP3A1)、尿苷二磷酸葡萄糖醛酸基转移酶1A1(UGT1A1)和尿苷二磷酸葡萄糖醛酸基转移酶1A6(UGT1A6)酶的表达水平。结果在正常小鼠血清中,初步鉴定出泻白散的原型成分28个,代谢产物158个(包括Ⅰ相代谢产物48个和Ⅱ相代谢产物110个);在CB模型小鼠血清中,鉴定出原型成分32个,代谢产物178个(包括Ⅰ相代谢产物50个和Ⅱ相代谢产物128个)。其中,27个原型成分在2种状态下均被检出,主要包括12个黄酮类、2个生物碱类、3个三萜类、4个有机酸类、3个酰胺类、1个二苯乙烯类化合物和2个其他类化合物。化学计量分析表明,泻白散在正常和CB小鼠中的入血成分及其代谢产物的种类无明显差异,但其在CB小鼠体内的暴露量明显增加。与正常小鼠比较,CB小鼠体内泻白散的氧化、还原、甲基化等Ⅰ相代谢产物及葡萄糖醛酸化等Ⅱ相代谢产物的含量变化尤为显著。Real-time PCR结果显示,与正常组比较,CB小鼠肝脏中CYP2E1(P<0.05)、CYP3A1(P>0.05)、UGT1A1(P<0.01)和UGT1A6(P<0.01)的mRNA表达水平升高,这可能是导致代谢产物含量变化的主要原因。结论泻白散在正常和CB小鼠中的入血成分及其代谢轮廓存在明显差异,尤其Ⅰ相代谢中的氧化、还原、甲基化及Ⅱ相代谢中的葡萄糖醛酸化,且与肝脏中Ⅰ相和Ⅱ相代谢酶CYP2E1、CYP3A1、UGT1A1和UGT1A6表达水平升高密切相关。 展开更多
关键词 泻白散 入血成分 代谢轮廓 超高效液相色谱-四极杆-静电场轨道阱高分辨质谱法(UPLC-Q-exactive Orbitrap MS) 化学计量学 慢性支气管炎
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Strategic and Regional Investigation of the Exact Controllability of the Vibrating Plate Equation on a Regular Domain
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作者 Mouhamadou NGOM Cheikh SECK 《Journal of Mathematical Research with Applications》 2026年第1期134-142,共9页
In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regiona... In this paper,we define for the trace operator,the solution of certain models of vibrating plates standards with initial data in a strategic region spaces of weak regularities.Indeed,we know that the notion of regional controllability is more adapted to systems described by dynamic systems.Regional controllability results in a strategic area were established for vibrating plates by the Hilbertian Uniqueness Method. 展开更多
关键词 exact controllability vibrating plates strategic regional control Hilbert uniqueness method
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All Non-Commuting Solutions of the Yang-Baxter-like Matrix Equation Which Coefficient Matrix is Similar to diag(λ,J_(2)(λ))
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作者 WANG Yun-jie 《Chinese Quarterly Journal of Mathematics》 2026年第1期92-110,共19页
Let A be a 3×3 singular or diagonalizable matrix,all solutions to the Yang-Baxter-like matrix equation have been determined.However,finding all solutions for full rank,non-diagonalizable matrices remains challeng... Let A be a 3×3 singular or diagonalizable matrix,all solutions to the Yang-Baxter-like matrix equation have been determined.However,finding all solutions for full rank,non-diagonalizable matrices remains challenging.By utilizing classification techniques,we establish all solutions of the Yang-Baxter-like matrix equation in this paper when the coefficient matrix A is similar to non-diagonalizable matrix diag(λ,J_(2)(λ))withλ̸=0.More specifically,we divide the non-diagonal elements of the solution into 10 different cases.By discussing each situation,we establish all solutions of the Yang-Baxter-like matrix equation.The results of this work enrich the existing ones. 展开更多
关键词 Yang–Baxter–like matrix equation Yang–Baxter equation Commuting solutions Non–commuting solutions
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