Dear Editor,Angiogenesis,the process of forming new blood vessels,is closely linked to osteogenesis,the formation of new bone tissue,which is important for bone development and homeostasis(Kusumbe et al.,2014).Recent ...Dear Editor,Angiogenesis,the process of forming new blood vessels,is closely linked to osteogenesis,the formation of new bone tissue,which is important for bone development and homeostasis(Kusumbe et al.,2014).Recent studies have established that Endothelial-to-Osteoblast Conversion(EC-to-OSB),mediated by Endothelial-to-Mesenchymal Transition and subsequent osteogenesis,plays a crucial role ectopic ossification during cancer bone metastasis(Lin et al.,2017;Medici et al.,2010).Moreover,research suggests that endothelial cells are one of the sources of bone marrow mesenchymal stem cells(BMSCs)which contribute to the reconstruction of the bone marrow niche during bone marrow transplantation(Kenswil et al.,2021).However,this view remains controversial,as other studies(Cao et al.,2023).Since it remains unclear whether and how EC-to-OSB regulates bone formation and homeostasis under physiological or aged conditions.Therefore,further research on the pathogenesis of osteoporosis(OP)is urgent.展开更多
基金supported,in part,by the National Key Research and Development Program of China Grants(2019YFA0906001)the National Natural Science Foundation of China Grants(82372476 and 82350710800)Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018)。
文摘Dear Editor,Angiogenesis,the process of forming new blood vessels,is closely linked to osteogenesis,the formation of new bone tissue,which is important for bone development and homeostasis(Kusumbe et al.,2014).Recent studies have established that Endothelial-to-Osteoblast Conversion(EC-to-OSB),mediated by Endothelial-to-Mesenchymal Transition and subsequent osteogenesis,plays a crucial role ectopic ossification during cancer bone metastasis(Lin et al.,2017;Medici et al.,2010).Moreover,research suggests that endothelial cells are one of the sources of bone marrow mesenchymal stem cells(BMSCs)which contribute to the reconstruction of the bone marrow niche during bone marrow transplantation(Kenswil et al.,2021).However,this view remains controversial,as other studies(Cao et al.,2023).Since it remains unclear whether and how EC-to-OSB regulates bone formation and homeostasis under physiological or aged conditions.Therefore,further research on the pathogenesis of osteoporosis(OP)is urgent.
