[ Objective ] This study aimed to optimize the extraction process of astaxanthin from Haematococcus pluvialis with oil dissolution method. [ Method ] Small amounts of acetone or ethanol were separately added into soyb...[ Objective ] This study aimed to optimize the extraction process of astaxanthin from Haematococcus pluvialis with oil dissolution method. [ Method ] Small amounts of acetone or ethanol were separately added into soybean oil for astaxanthin extraction. The extraction efficiency of astaxanthin from H. pluvialis with different methods was compared. [ Result] The extraction efficiency of astaxanthin from H. pluvialis with acetone, acetone ＋ soybean oil, ethanol ＋ soybean oil, soybean oil was 20.46, 21.65, 20.85 mg/g and 13.05 mg/g, respectively. According to the results, acetone ＋ soybean oil led to the highest extraction rate, which was approximately twice that of soybean oil and higher than that of acetone. [ Conclusion ] This study laid the foundation for large-scale production of astaxanthin.展开更多
Objective: to analyze the influence of different dissolution evaluation methods on the level of pharmaceutical preparations, and to sort out the application strategies for improving the level of pharmaceutical prepara...Objective: to analyze the influence of different dissolution evaluation methods on the level of pharmaceutical preparations, and to sort out the application strategies for improving the level of pharmaceutical preparations. Methods: 100 paracetamol tablets were screened out and then divided into 2 groups according to the blind selection method, specifically referring to: the observation group and the control group, each group is 50 tablets, among which, the observation group selected 0.04%NaOH solution as the dissolution medium, and then the dissolution was evaluated;In the control group, phosphate buffer with PH 6.8 was selected as the dissolution medium, and then the dissolution was evaluated. The dissolution amount and dissolution percentage (80%) of the two groups were determined separately. Results: in terms of the changes of dissolution volume, percentage of dissolution and other indicators, the observation group far exceeded the control group. However, in terms of the average dissolution time, the observation group was significantly smaller than the control group, and the difference between the two groups was significant, with a statistical advantage (P < 0.05). Conclusion: since the evaluation methods of dissolution are different, there are obvious differences in the changes in the level of pharmaceutical preparations. If the level of pharmaceutical preparations is to be gradually improved, the best dissolution evaluation method must be selected before the corresponding test results can be obtained.展开更多
基金Supported by Project of Yantai Huarong Biological Technology Co.,Ltd
文摘[ Objective ] This study aimed to optimize the extraction process of astaxanthin from Haematococcus pluvialis with oil dissolution method. [ Method ] Small amounts of acetone or ethanol were separately added into soybean oil for astaxanthin extraction. The extraction efficiency of astaxanthin from H. pluvialis with different methods was compared. [ Result] The extraction efficiency of astaxanthin from H. pluvialis with acetone, acetone ＋ soybean oil, ethanol ＋ soybean oil, soybean oil was 20.46, 21.65, 20.85 mg/g and 13.05 mg/g, respectively. According to the results, acetone ＋ soybean oil led to the highest extraction rate, which was approximately twice that of soybean oil and higher than that of acetone. [ Conclusion ] This study laid the foundation for large-scale production of astaxanthin.
文摘Objective: to analyze the influence of different dissolution evaluation methods on the level of pharmaceutical preparations, and to sort out the application strategies for improving the level of pharmaceutical preparations. Methods: 100 paracetamol tablets were screened out and then divided into 2 groups according to the blind selection method, specifically referring to: the observation group and the control group, each group is 50 tablets, among which, the observation group selected 0.04%NaOH solution as the dissolution medium, and then the dissolution was evaluated;In the control group, phosphate buffer with PH 6.8 was selected as the dissolution medium, and then the dissolution was evaluated. The dissolution amount and dissolution percentage (80%) of the two groups were determined separately. Results: in terms of the changes of dissolution volume, percentage of dissolution and other indicators, the observation group far exceeded the control group. However, in terms of the average dissolution time, the observation group was significantly smaller than the control group, and the difference between the two groups was significant, with a statistical advantage (P < 0.05). Conclusion: since the evaluation methods of dissolution are different, there are obvious differences in the changes in the level of pharmaceutical preparations. If the level of pharmaceutical preparations is to be gradually improved, the best dissolution evaluation method must be selected before the corresponding test results can be obtained.
