Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functio...Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.展开更多
The rnemmorphic functions of positive order(both finite positive order and infinite order) are discussed.First,the precise order and type function are given by using the characteristic function.Then some singular dire...The rnemmorphic functions of positive order(both finite positive order and infinite order) are discussed.First,the precise order and type function are given by using the characteristic function.Then some singular directions are defined and their existence is proved.展开更多
Aim To study the value distribution of meromorphic functions in angular domains, the deficiency, the deficient value, the Nevanlinna direction and other singular directions. Methods A fundamental inequality of Nevan...Aim To study the value distribution of meromorphic functions in angular domains, the deficiency, the deficient value, the Nevanlinna direction and other singular directions. Methods A fundamental inequality of Nevanlinna characteristic functions in the angular domain was used, which is similar with the Nevanlinna secondary fundamental theorem. Results The deficiency and deficient value of meromorphic functions about an angular domain and a direction were defined. The definition of Nevanlinna direction was improved. Conclusion For a family of meromorphic functions, it is proved that the number of deficient values is at most countable and the sum of deficiencies isnt greater than 2. The existence of the Nevanlinna direction is obtained. The existence of Borel and Julia directions and the relation between them are found.展开更多
目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语...目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语患者言语功能的效应。方法:检索CNKI、万方、维普、CBM、PubMed、Cochrane图书馆、Embase和Web of Science数据库,筛选有关非侵入性神经调控技术治疗脑卒中后非流畅性失语的随机对照试验,检索时限截至2025-06-01。对照组采用常规治疗或假刺激,试验组在对照组治疗的基础上加入非侵入性神经调控技术,结局指标为西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表。采用Stata 17.0软件对结局指标进行传统Meta分析和网状Meta分析,采用GRADE对结局指标进行证据等级评价。结果:共纳入33篇随机对照试验,涉及10种非侵入性神经调控方式。①传统Meta分析结果显示,低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、经颅直流电刺激左侧Broca区可改善患者西方失语成套测验评分(P<0.001),低频重复经颅磁刺激右侧Broca区、低频重复经颅磁刺激颞上回后部、低频重复经颅磁刺激右侧Broca区联合高频重复经颅磁刺激左侧Broca区可改善患者汉语失语成套测验评分(P<0.05),低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、连续性θ爆发刺激右侧Broca区联合间歇性θ爆发刺激左侧Broca区、高频重复经颅磁刺激刺激右侧Broca区、低频重复经颅磁刺激右侧Broca区联合高频刺激左侧Broca区可改善患者日常生活交流能力评定量表评分(P<0.05)。②网状Meta分析结果显示,低频重复经颅磁刺激右侧Broca区改善患者西方失语成套测验评分和汉语失语成套测验评分的疗效更佳[SMD=1.13,95%CI(0.59,1.67),P<0.05;SMD=4.73,95%CI(1.28,8.18),P<0.05],经颅直流电刺激双侧Broca区在改善患者日常生活交流能力评定量表评分的疗效更佳[SMD=1.81,95%CI(0.51,2.12),P<0.05]。③GRADE证据等级评价结果显示,西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表结局指标的证据等级均为低级。结论:不同非侵入性神经调控方式均能改善脑卒中后非流畅性失语患者的言语功能,低频重复经颅磁刺激右侧Broca区在改善多维度言语功能方面,尤其在自发言语连贯性、听觉理解准确性及命名流畅性等方面疗效显著;经颅直流电刺激双侧Broca区更侧重改善患者的日常生活交流能力,但研究结果受纳入研究的数量及质量影响,证据等级较低,仍需更多高质量的研究进一步验证。展开更多
目的:研究表明,重复经颅磁刺激和经颅直流电刺激对改善脑瘫患儿粗大运动功能具有积极作用。采用网状Meta分析方法评价重复经颅磁刺激和经颅直流电刺激对脑瘫患儿下肢运动功能及步态改善的临床疗效。方法:检索中国知网、万方、维普、Sino...目的:研究表明,重复经颅磁刺激和经颅直流电刺激对改善脑瘫患儿粗大运动功能具有积极作用。采用网状Meta分析方法评价重复经颅磁刺激和经颅直流电刺激对脑瘫患儿下肢运动功能及步态改善的临床疗效。方法:检索中国知网、万方、维普、SinoMed、PubMed、Web of Science、Medline数据库,搜索关于重复经颅磁刺激与经颅直流电刺激改善脑瘫患儿下肢运动功能及步态的随机对照试验,检索时限均为数据库建库至2024-10-05。筛选文献、提取资料并评价纳入研究的偏倚风险,采用Stata 15.0软件进行网状Meta分析,使用GRADE证据分级系统进行质量评价。结果:最终纳入19篇研究,涉及常规治疗、高频重复经颅磁刺激、低频重复经颅磁刺激、阳极经颅直流电刺激4种治疗方案。网状Meta分析结果显示,与常规治疗相比,低频重复经颅磁刺激改善脑瘫患儿粗大运动功能方面的疗效最佳[MD=9.48,95%CI(6.61,12.34),P<0.05],在缓解痉挛方面,高频重复经颅磁刺激的疗效最佳[MD=-0.63,95%CI(-1.72,0.45),P<0.05],经颅直流电刺激改善脑瘫患儿踝关节活动度和步速方面的疗效最佳[MD=2.27,95%CI(1.37,3.17),P<0.05;MD=0.11,95%CI(0.05,0.17),P<0.05]。结论:现有临床证据表明,对于脑瘫患儿,在改善下肢粗大运动功能方面,低频重复经颅磁刺激展现出最佳疗效;对于降低肌痉挛程度,高频重复经颅磁刺激的效果更为显著;在步态改善方面,经颅直流电刺激则表现出明显优势。展开更多
目的观察经颅直流电刺激(transcranial direct current stimulation,tDCS)对慢性耳鸣治疗效果及其神经心理学变化。方法对100名慢性耳鸣诊断明确的患者采用数字表法,进行单盲(受试者盲)随机对照tDCS治疗,治疗组为真刺激,对照组为伪刺激...目的观察经颅直流电刺激(transcranial direct current stimulation,tDCS)对慢性耳鸣治疗效果及其神经心理学变化。方法对100名慢性耳鸣诊断明确的患者采用数字表法,进行单盲(受试者盲)随机对照tDCS治疗,治疗组为真刺激,对照组为伪刺激,阳极电极片置于受试者左侧颞顶处,阴极作为参考电极,置于右侧肩部,电流强度1.5 mA,刺激时间20 min,每天1次,两周内治疗10次,治疗前和治疗后3个月进行耳鸣严重程度和神经心理学评估。结果实验组治疗后耳鸣致残量表(THI)和老年听力障碍筛查量表(HHIE-S)得分变化不明显(P>0.05),但耳鸣响度和耳鸣痛苦度分值有所减低,且治疗前后差异有统计学意义(P<0.05)。在神经心理学方面,实验组和对照组的总体认知功能量表蒙特利尔认知评估量表-基础版得分(MoCA-B)、听觉词语学习测验(AVLT)短时回忆分治疗前后变化不明显(P>0.05),实验组Stroop色词干扰测验(SCWT)耗时数和正确数治疗后有改善,差异有统计学意义(P<0.05),而对照组没有。AVLT线索回忆及再认得分和连线测验(TMT)耗时数实验组和对照组治疗后的复测分值均有所改善,差异有统计学意义(P<0.05);对照组治疗前后AVLT即刻回忆总分和延时回忆得分差异有统计学意义(P<0.05),而实验组没有。在情绪方面,实验组和对照组汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)复测分值均有下降,差异有统计学意义(P<0.05)。结论tDCS阳极刺激左侧颞顶皮质治疗慢性耳鸣有一定效果,可改善患者主观耳鸣响度和痛苦度,对其睡眠、听觉词语学习测验线索回忆和再认、执行功能(TMT和Stroop)、焦虑抑郁情绪等神经心理学表现亦有所改善。展开更多
基金the National Natural Science Foundation of China(Grant No.12171294)。
文摘Interval-valued pre-aggregation functions are a hot topic in the research of aggregation functions and have received considerable attention in recent years.As a special class of interval-valued pre-aggregation functions,(light)interval-valued pre-t-norms were initially proposed by Wang and Hu,but their properties were not further discussed by the authors.The main purpose of this paper is to study in depth the properties and generation of(light)intervalvalued pre-t-norms.Firstly,several properties of(light)interval-valued pre-t-norms and their relationship with(light)pre-t-norms are presented.Then,two different generation methods for(light)interval-valued pre-t-norms are introduced.Finally,it demonstrates a specific application of(light)interval-valued pre-t-norms in constructing interval-valued directional monotonic fuzzy implications,namely,using the(light)interval-valued pre-t-norm IT,interval-valued fuzzy negations IN,and(light)interval-valued pre-t-conorm IS to construct interval-valued QL-directional monotonic operations.
文摘The rnemmorphic functions of positive order(both finite positive order and infinite order) are discussed.First,the precise order and type function are given by using the characteristic function.Then some singular directions are defined and their existence is proved.
文摘Aim To study the value distribution of meromorphic functions in angular domains, the deficiency, the deficient value, the Nevanlinna direction and other singular directions. Methods A fundamental inequality of Nevanlinna characteristic functions in the angular domain was used, which is similar with the Nevanlinna secondary fundamental theorem. Results The deficiency and deficient value of meromorphic functions about an angular domain and a direction were defined. The definition of Nevanlinna direction was improved. Conclusion For a family of meromorphic functions, it is proved that the number of deficient values is at most countable and the sum of deficiencies isnt greater than 2. The existence of the Nevanlinna direction is obtained. The existence of Borel and Julia directions and the relation between them are found.
文摘近年来,抑郁症(major depressive disorder,MDD)与注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)共病的现象愈发受到关注。在成人患者中,MDD共病ADHD通常意味着治疗费用高昂、药物反应欠佳以及疾病预后不良,且现有药物治疗存在一定局限性。考虑到执行功能障碍作为MDD和ADHD的关键共同特征,从执行功能层面出发,探讨共病在脑影像学方面的潜在机制,并寻求更为有效的治疗方法,显得尤为重要。近年来的研究表明,经颅直流电刺激(transcranial direct current stimulation,tDCS)作为一种能够调节特定脑区活动的非侵入性物理治疗方法,可有效改善MDD及成人ADHD的相关症状。该文回顾成人MDD共病ADHD所面临的治疗困境,从与执行功能相关的脑结构、脑功能网络等多个维度,综述成人MDD共病ADHD的可能机制,同时探讨了tDCS在治疗成人MDD共病ADHD的应用前景。
文摘目的:大量研究表明,非侵入性神经调控技术能够有效改善脑卒中后非流畅性失语的症状,然而,针对该类技术的最优刺激方案仍有待深入验证与探究。此次研究借助网状Meta分析方法,系统评价不同非侵入性神经调控技术改善脑卒中后非流畅性失语患者言语功能的效应。方法:检索CNKI、万方、维普、CBM、PubMed、Cochrane图书馆、Embase和Web of Science数据库,筛选有关非侵入性神经调控技术治疗脑卒中后非流畅性失语的随机对照试验,检索时限截至2025-06-01。对照组采用常规治疗或假刺激,试验组在对照组治疗的基础上加入非侵入性神经调控技术,结局指标为西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表。采用Stata 17.0软件对结局指标进行传统Meta分析和网状Meta分析,采用GRADE对结局指标进行证据等级评价。结果:共纳入33篇随机对照试验,涉及10种非侵入性神经调控方式。①传统Meta分析结果显示,低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、经颅直流电刺激左侧Broca区可改善患者西方失语成套测验评分(P<0.001),低频重复经颅磁刺激右侧Broca区、低频重复经颅磁刺激颞上回后部、低频重复经颅磁刺激右侧Broca区联合高频重复经颅磁刺激左侧Broca区可改善患者汉语失语成套测验评分(P<0.05),低频重复经颅磁刺激右侧Broca区、经颅直流电刺激双侧Broca区、连续性θ爆发刺激右侧Broca区联合间歇性θ爆发刺激左侧Broca区、高频重复经颅磁刺激刺激右侧Broca区、低频重复经颅磁刺激右侧Broca区联合高频刺激左侧Broca区可改善患者日常生活交流能力评定量表评分(P<0.05)。②网状Meta分析结果显示,低频重复经颅磁刺激右侧Broca区改善患者西方失语成套测验评分和汉语失语成套测验评分的疗效更佳[SMD=1.13,95%CI(0.59,1.67),P<0.05;SMD=4.73,95%CI(1.28,8.18),P<0.05],经颅直流电刺激双侧Broca区在改善患者日常生活交流能力评定量表评分的疗效更佳[SMD=1.81,95%CI(0.51,2.12),P<0.05]。③GRADE证据等级评价结果显示,西方失语成套测验、汉语失语成套测验、日常生活交流能力评定量表结局指标的证据等级均为低级。结论:不同非侵入性神经调控方式均能改善脑卒中后非流畅性失语患者的言语功能,低频重复经颅磁刺激右侧Broca区在改善多维度言语功能方面,尤其在自发言语连贯性、听觉理解准确性及命名流畅性等方面疗效显著;经颅直流电刺激双侧Broca区更侧重改善患者的日常生活交流能力,但研究结果受纳入研究的数量及质量影响,证据等级较低,仍需更多高质量的研究进一步验证。
文摘目的:研究表明,重复经颅磁刺激和经颅直流电刺激对改善脑瘫患儿粗大运动功能具有积极作用。采用网状Meta分析方法评价重复经颅磁刺激和经颅直流电刺激对脑瘫患儿下肢运动功能及步态改善的临床疗效。方法:检索中国知网、万方、维普、SinoMed、PubMed、Web of Science、Medline数据库,搜索关于重复经颅磁刺激与经颅直流电刺激改善脑瘫患儿下肢运动功能及步态的随机对照试验,检索时限均为数据库建库至2024-10-05。筛选文献、提取资料并评价纳入研究的偏倚风险,采用Stata 15.0软件进行网状Meta分析,使用GRADE证据分级系统进行质量评价。结果:最终纳入19篇研究,涉及常规治疗、高频重复经颅磁刺激、低频重复经颅磁刺激、阳极经颅直流电刺激4种治疗方案。网状Meta分析结果显示,与常规治疗相比,低频重复经颅磁刺激改善脑瘫患儿粗大运动功能方面的疗效最佳[MD=9.48,95%CI(6.61,12.34),P<0.05],在缓解痉挛方面,高频重复经颅磁刺激的疗效最佳[MD=-0.63,95%CI(-1.72,0.45),P<0.05],经颅直流电刺激改善脑瘫患儿踝关节活动度和步速方面的疗效最佳[MD=2.27,95%CI(1.37,3.17),P<0.05;MD=0.11,95%CI(0.05,0.17),P<0.05]。结论:现有临床证据表明,对于脑瘫患儿,在改善下肢粗大运动功能方面,低频重复经颅磁刺激展现出最佳疗效;对于降低肌痉挛程度,高频重复经颅磁刺激的效果更为显著;在步态改善方面,经颅直流电刺激则表现出明显优势。
文摘目的观察经颅直流电刺激(transcranial direct current stimulation,tDCS)对慢性耳鸣治疗效果及其神经心理学变化。方法对100名慢性耳鸣诊断明确的患者采用数字表法,进行单盲(受试者盲)随机对照tDCS治疗,治疗组为真刺激,对照组为伪刺激,阳极电极片置于受试者左侧颞顶处,阴极作为参考电极,置于右侧肩部,电流强度1.5 mA,刺激时间20 min,每天1次,两周内治疗10次,治疗前和治疗后3个月进行耳鸣严重程度和神经心理学评估。结果实验组治疗后耳鸣致残量表(THI)和老年听力障碍筛查量表(HHIE-S)得分变化不明显(P>0.05),但耳鸣响度和耳鸣痛苦度分值有所减低,且治疗前后差异有统计学意义(P<0.05)。在神经心理学方面,实验组和对照组的总体认知功能量表蒙特利尔认知评估量表-基础版得分(MoCA-B)、听觉词语学习测验(AVLT)短时回忆分治疗前后变化不明显(P>0.05),实验组Stroop色词干扰测验(SCWT)耗时数和正确数治疗后有改善,差异有统计学意义(P<0.05),而对照组没有。AVLT线索回忆及再认得分和连线测验(TMT)耗时数实验组和对照组治疗后的复测分值均有所改善,差异有统计学意义(P<0.05);对照组治疗前后AVLT即刻回忆总分和延时回忆得分差异有统计学意义(P<0.05),而实验组没有。在情绪方面,实验组和对照组汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)复测分值均有下降,差异有统计学意义(P<0.05)。结论tDCS阳极刺激左侧颞顶皮质治疗慢性耳鸣有一定效果,可改善患者主观耳鸣响度和痛苦度,对其睡眠、听觉词语学习测验线索回忆和再认、执行功能(TMT和Stroop)、焦虑抑郁情绪等神经心理学表现亦有所改善。
