Ambient mass spectrometry facilitates surface detection under ambient conditions and has quickly found its applications in various areas.However,the sensitivity of AMS methods is usually not as good as that of encapsu...Ambient mass spectrometry facilitates surface detection under ambient conditions and has quickly found its applications in various areas.However,the sensitivity of AMS methods is usually not as good as that of encapsulated ion sources due to less efficient ion transmission.In this work,a briefly machined external ion funnel(threepole electrostatic lens)was adopted and installed between direct analysis in real time and the mass spectrometer inlet to increase detection sensitivity.Software investigation with SIMION version 8.0 was employed to calculate electric fields and to simulate the trajectories of charged particles in the electric field.Both the geometrical parameters of the ion funnel and the electric parameters were studied to obtain the optimal ion focusing results,which demonstrated the ion funnel equipment would greatly improve the ion transmission efficiency.The equipment showed good prospect in direct analysis in real time-mass spectrometry analysis in the future.展开更多
Objective:To establish a rapid analysis method for the activity concentration of carbon-14(14C)in urine,in order to estimate the internal dose of 14C exposure,and to protect the health of occupational population.Metho...Objective:To establish a rapid analysis method for the activity concentration of carbon-14(14C)in urine,in order to estimate the internal dose of 14C exposure,and to protect the health of occupational population.Methods:Liquid scintillation counting(LSC)combined with the function of transformed spectral index of the external standard spectrum(tSIE)was used to measure the quenching level and counting rate,and the spiked urine samples with different shades of color were measured by LSC.After establishing the efficiency-quenching curve,the quenching correction and activity concentration analysis of the actual samples were carried out.Results:By LSC and the data fitting,the relationship between efficiency and quenching index could be represented using the equation y=0.0013x-0.0177(R^(2)=0.978).Three actual spiked samples were tested to verify this method,with recoveries of 97%,102%,and 89%,respectively.14C activity concentration of 4 actual urine samples were 0.12,0.11,0.10 and 0.08 Bq/mL,respectively,while the corresponding extended relative uncertainties were 0.0652,0.0929,0.0893 and 0.1043,respectively.Conclusion:The direct analysis method of 14C activity concentration in urine samples was established using LSC.The recovery of 14C activity concentration in urine samples showed that the proposed method had relatively high accuracy.By studying on the source of uncertainty,the uncertainty of the analysis results mainly came from the statistical error of LSC,and the uncertainty component of counting efficiency.展开更多
A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Saf...A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act(CPSIA),European Union legislations and Chinese national standards(GB)were analyzed.By a combined solid-phase micro-extraction(SPME)and direct analysis in real time mass spectrometry(DART-MS)approach,phthalates at sub-ng•mL^(−1)levels can be qualitatively and quantitatively analyzed in a short time.The use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or preparations.The limits of quantification(LOQs)were estimated to be at 0.3-5.0 ng•mL^(−1),lower than the Maximum Residue Limit(MRL)regulated by the European Union legislations(2007/19/EC)in foods,beverages,food packaging and toys(0.3-30 ng•mL^(−1)).This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety.展开更多
We aimed to establish for the rapid detection of morphine,O6‑monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin in human blood and urine by direct analysis in real‑time coupled w...We aimed to establish for the rapid detection of morphine,O6‑monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin in human blood and urine by direct analysis in real‑time coupled with tandem mass spectrometry(DART‑MS/MS).These samples were extracted by acetonitrile‑methanol(V/V=4:1),using DART 12 Dip‑it automatic sampling system.They were injected at 400℃,and analyzed by positive ion and multiple reaction monitoring mode.The detection limits of morphine,O6‑Monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin were 100,50,50,100,20,20,10,1,and 0.01 ng/mL,respectively.The practical cases contained methamphetamine,codeine,cocaine,and O6‑monoacetylmorphine were detected accurately and rapidly.The method has the advantages of high sensitivity and good accuracy.The sample processing is simple and can be analyzed in a short time.This method is suitable for the analysis of morphine,O6‑monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin in some practical cases.展开更多
A wave load computation approach in direct strength analysis of semi-submersible platform structures was presented in this paper. Considering the differences in shape of pontoon, column and beam, the combination of ac...A wave load computation approach in direct strength analysis of semi-submersible platform structures was presented in this paper. Considering the differences in shape of pontoon, column and beam, the combination of accumulative chord length cubic parameter spline theory and analytic method was adopted for generating the wet surface mesh of platform. The hydrodynamic coefficients of platform were calculated by the three-dimensional potential flow theory of the linear hydrodynamic problem for platform with low forward speed. The equation of platform motions was established and solved in frequency domain, and the responses of wave-induced loads on the platform can be obtained. With the interpolation method being utilized, the pressure loads on shell elements for finite element analysis (FEA) were converted from those on the hydrodynamic computation mesh, which pave the basis for FEA with commercial software.A computer program based on this method has been developed, and a calculation example of semi-submersible platform was illustrated.Analysis results show that this method is a satisfying approach of wave loads computation for this kind of platform.展开更多
A direct linear discriminant analysis algorithm based on economic singular value decomposition （DLDA/ESVD） is proposed to address the computationally complex problem of the conventional DLDA algorithm, which directl...A direct linear discriminant analysis algorithm based on economic singular value decomposition （DLDA/ESVD） is proposed to address the computationally complex problem of the conventional DLDA algorithm, which directly uses ESVD to reduce dimension and extract eigenvectors corresponding to nonzero eigenvalues. Then a DLDA algorithm based on column pivoting orthogonal triangular （QR） decomposition and ESVD （DLDA/QR-ESVD） is proposed to improve the performance of the DLDA/ESVD algorithm by processing a high-dimensional low rank matrix, which uses column pivoting QR decomposition to reduce dimension and ESVD to extract eigenvectors corresponding to nonzero eigenvalues. The experimental results on ORL, FERET and YALE face databases show that the proposed two algorithms can achieve almost the same performance and outperform the conventional DLDA algorithm in terms of computational complexity and training time. In addition, the experimental results on random data matrices show that the DLDA/QR-ESVD algorithm achieves better performance than the DLDA/ESVD algorithm by processing high-dimensional low rank matrices.展开更多
A kernel-based discriminant analysis method called kernel direct discriminant analysis is employed, which combines the merit of direct linear discriminant analysis with that of kernel trick. In order to demonstrate it...A kernel-based discriminant analysis method called kernel direct discriminant analysis is employed, which combines the merit of direct linear discriminant analysis with that of kernel trick. In order to demonstrate its better robustness to the complex and nonlinear variations of real face images, such as illumination, facial expression, scale and pose variations, experiments are carried out on the Olivetti Research Laboratory, Yale and self-built face databases. The results indicate that in contrast to kernel principal component analysis and kernel linear discriminant analysis, the method can achieve lower （7%） error rate using only a very small set of features. Furthermore, a new corrected kernel model is proposed to improve the recognition performance. Experimental results confirm its superiority （1% in terms of recognition rate） to other polynomial kernel models.展开更多
To analyze the security of two-step quantum direct communication protocol （QDCP） by using Einstein-Podolsky Rosen pair proposed by Deng et al. [Phys. Rev. A 68 （2003）042317] in collective-rotation noise channel, a...To analyze the security of two-step quantum direct communication protocol （QDCP） by using Einstein-Podolsky Rosen pair proposed by Deng et al. [Phys. Rev. A 68 （2003）042317] in collective-rotation noise channel, an excellent model of noise analysis is proposed. In the security analysis, the method of the entropy theory is introduced, and is compared with QDCP, an error rate point Qo（M ： （Q0, 1.0）） is given. In different noise levels, if Eve wants to obtain the same amount of information, the error rate Q is distinguishable. The larger the noise level ~ is, the larger the error rate Q is. When the noise level ~ is lower than 11%, the high error rate is 0.153 without eavesdropping. Lastly, the security of the proposed protocol is discussed. It turns out that the quantum channel will be safe when Q 〈 0.153. Similarly, if error rate Q〉 0.153 = Q0, eavesdropping information I 〉 1, which means that there exist eavesdroppers in the quantum channel, and the quantum channel will not be safe anymore.展开更多
Secondary structures of RNAs are the basis of understanding their tertiary structures and functions and so their predictions are widely needed due to increasing discovery of noncoding RNAs.In the last decades,a lot of...Secondary structures of RNAs are the basis of understanding their tertiary structures and functions and so their predictions are widely needed due to increasing discovery of noncoding RNAs.In the last decades,a lot of methods have been proposed to predict RNA secondary structures but their accuracies encountered bottleneck.Here we present a method for RNA secondary structure prediction using direct coupling analysis and a remove-and-expand algorithm that shows better performance than four existing popular multiple-sequence methods.We further show that the results can also be used to improve the prediction accuracy of the single-sequence methods.展开更多
The recently proposed method of our research group named as directional Lyapunov exponents（DLEs） is presented. Then, DLEs are used to analyze the eigenstructure of the output phase space around the equilibrium point...The recently proposed method of our research group named as directional Lyapunov exponents（DLEs） is presented. Then, DLEs are used to analyze the eigenstructure of the output phase space around the equilibrium points. Finally, the impacts of the superlattice parameter changes on the characteristics of the output chaotic signal are analyzed. The experimental results show that parameter changes of the superlattice will affect the eigenstructure around the equilibrium points in the output phase space, and DLEs are sensitive to these changes.展开更多
The magnetic property of soft magnetic metals and alloys depends strongly on the crystallo-graphic orientation. In automated equipment for orientation research, the intensity for drawing up the pole figure is measured...The magnetic property of soft magnetic metals and alloys depends strongly on the crystallo-graphic orientation. In automated equipment for orientation research, the intensity for drawing up the pole figure is measured in detail. The present research shows that the accurate pole figure can be drawn up without measuring concretely the intensity. For directional Si steel sheet the measuring step may be 4～5 degrees. In this paper the experimental equation for defo-cusing correction was derived from the experimental data in different specimens with random orientation.展开更多
Access to security and safe food is a basic human necessity and essential for a sustainable world. To perform hi-end rood safety analysis and risk assessment with state of the art technologies is of utmost importance ...Access to security and safe food is a basic human necessity and essential for a sustainable world. To perform hi-end rood safety analysis and risk assessment with state of the art technologies is of utmost importance thereof. With applications as exemplified by microfiuidic immunoassay, aptasensor, direct analysis in real time, high resolution mass spectrometry, benchmark dose and chemical specific adjustment factor, this review presents frontier food safety analysis and risk assessment technologies, from which both food quality and public health will benefit undoubtedly in a foreseeable future.展开更多
The fixed-time synchronization and preassigned-time synchronization are investigated for a class of quaternion-valued neural networks with time-varying delays and discontinuous activation functions. Unlike previous ef...The fixed-time synchronization and preassigned-time synchronization are investigated for a class of quaternion-valued neural networks with time-varying delays and discontinuous activation functions. Unlike previous efforts that employed separation analysis and the real-valued control design, based on the quaternion-valued signum function and several related properties, a direct analytical method is proposed here and the quaternion-valued controllers are designed in order to discuss the fixed-time synchronization for the relevant quaternion-valued neural networks. In addition, the preassigned-time synchronization is investigated based on a quaternion-valued control design, where the synchronization time is preassigned and the control gains are finite. Compared with existing results, the direct method without separation developed in this article is beneficial in terms of simplifying theoretical analysis, and the proposed quaternion-valued control schemes are simpler and more effective than the traditional design, which adds four real-valued controllers. Finally, two numerical examples are given in order to support the theoretical results.展开更多
Since peanut oil（PO） is more expensive than other seed oils, some PO is adulterated with other cheap seed oils, such as soybean oil, palm olein, cottonseed oil, corn oil and rapeseed oil. The conventional method for...Since peanut oil（PO） is more expensive than other seed oils, some PO is adulterated with other cheap seed oils, such as soybean oil, palm olein, cottonseed oil, corn oil and rapeseed oil. The conventional method for deter mining whether PO was adulterated is to detect the freezing point of oils. The proposed method for the determination of adulterants in PO was based on monitoring the change of absorbance when the sample was refrigerated. A special spectrophotometer was developed. A total of 10 kinds of POs from different suppliers were chosen and adulterated with other seed oils at the volume fraction levels ranging from 5% to 30%. A total of 150 samples were analyzed by the proposed method and the results were satisfactory.展开更多
A direct digital design method （DDDM） of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth ...A direct digital design method （DDDM） of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth contact analysis （LTCA） method is analyzed, in which the advanced surface to surface searching technique is included. The influence of misalignment errors and contact deformations on contact zone and transmission error （TE） is discussed. Combined modification approach on worm tooth surface is presented. By means of DDDM and LTCA, it is very conven- ient to verify the effect of worm-gear drive＇s modification approach. The analysis results show that, the modification in profile direction reduces the sensitivity of worm-gear drive to misalignment errors and the modification in longitudinal direction decreases the TE. Thus the optimization design of worm-gear drive can be achieved prior to the actual manufacturing process.展开更多
The directional spectrum is one of the basic characteristics of sea waves. The observations of directional spectrum of sea waves were successfully conducted at platform Bohai 8 during 1991 and 1992 using a wave gage a...The directional spectrum is one of the basic characteristics of sea waves. The observations of directional spectrum of sea waves were successfully conducted at platform Bohai 8 during 1991 and 1992 using a wave gage array for the first time in China. Based on the field data, the directional spectrum which depends on the wave growth is given in this paper. Before observations, the effects of the type of gage array, the distance between the gages and the platform itself on the measured results and the precision of some methods for estimating the directional spectrum were investigated and compared with the methods of numerical simulations and model tests of multi-direcitonal irregular waves. This ensures the quality of the observations and estimations of the directional spectrum.展开更多
The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneit...The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging.Herein,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 NTs.We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision.Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy.In addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy.Our results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.展开更多
Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cer...Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region.展开更多
Design of a very large floating structure(VLFS)deployed near islands and reefs,different from those in the open sea,inevitably faces new technical challenges including numerical analysis methods.In this paper,a direct...Design of a very large floating structure(VLFS)deployed near islands and reefs,different from those in the open sea,inevitably faces new technical challenges including numerical analysis methods.In this paper,a direct coupling analysis method(DCAM)has been established based on the Boussinesq equations and the three-dimensional hydroelasisity theory with Rankine source method to analyze the responses of a VLFS in shallow sea with complicated geographical environment.Model tests have been carried out to validate the DCAM.To further verify the numerical methods and investigate the performance of such a VLFS,a“Scientific Research and Demonstration Platform(SRDP)”was built and deployed in 2019 at the site about 1000 m off an island with water depth around 40m in South China Sea.It is a simplified small model of a two-module semi-submersible-type VLFS.The numerical simulation of its responses on severe waves with focus on motions and connector forces is conduct by DCAM,and compared with the on-site measurements.Good agreement has been achieved.This approves the DCAM as a feasible tool for design and safety assessment of a VLFS deployed near islands and reefs.展开更多
It has been extensively recognized that the engineering structures are becoming increasingly precise and complex,which makes the requirements of design and analysis more and more rigorous.Therefore the uncertainty eff...It has been extensively recognized that the engineering structures are becoming increasingly precise and complex,which makes the requirements of design and analysis more and more rigorous.Therefore the uncertainty effects are indispensable during the process of product development.Besides,iterative calculations,which are usually unaffordable in calculative efforts,are unavoidable if we want to achieve the best design.Taking uncertainty effects into consideration,matrix perturbation methodpermits quick sensitivity analysis and structural dynamic re-analysis,it can also overcome the difficulties in computational costs.Owing to the situations above,matrix perturbation method has been investigated by researchers worldwide recently.However,in the existing matrix perturbation methods,correlation coefficient matrix of random structural parameters,which is barely achievable in engineering practice,has to be given or to be assumed during the computational process.This has become the bottleneck of application for matrix perturbation method.In this paper,we aim to develop an executable approach,which contributes to the application of matrix perturbation method.In the present research,the first-order perturbation of structural vibration eigenvalues and eigenvectors is derived on the basis of the matrix perturbation theory when structural parameters such as stiffness and mass have changed.Combining the first-order perturbation of structural vibration eigenvalues and eigenvectors with the probability theory,the variance of structural random eigenvalue is derived from the perturbation of stiffness matrix,the perturbation of mass matrix and the eigenvector of baseline-structure directly.Hence the Direct-VarianceAnalysis(DVA)method is developed to assess the variation range of the structural random eigenvalues without correlation coefficient matrix being involved.The feasibility of the DVA method is verified with two numerical examples(one is trusssystem and the other is wing structure of MA700 commercial aircraft),in which the DVA method also shows superiority in computational efficiency when compared to the Monte-Carlo method.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.21275012 and 21175008).
文摘Ambient mass spectrometry facilitates surface detection under ambient conditions and has quickly found its applications in various areas.However,the sensitivity of AMS methods is usually not as good as that of encapsulated ion sources due to less efficient ion transmission.In this work,a briefly machined external ion funnel(threepole electrostatic lens)was adopted and installed between direct analysis in real time and the mass spectrometer inlet to increase detection sensitivity.Software investigation with SIMION version 8.0 was employed to calculate electric fields and to simulate the trajectories of charged particles in the electric field.Both the geometrical parameters of the ion funnel and the electric parameters were studied to obtain the optimal ion focusing results,which demonstrated the ion funnel equipment would greatly improve the ion transmission efficiency.The equipment showed good prospect in direct analysis in real time-mass spectrometry analysis in the future.
基金This work was supported by ERAN I-21-18,Key Program of Tianjin Municipal Natural Science Foundation(19JCZDJC40500)Key Program of National Center for Occupational Safety and Health(2021-ZD-06).
文摘Objective:To establish a rapid analysis method for the activity concentration of carbon-14(14C)in urine,in order to estimate the internal dose of 14C exposure,and to protect the health of occupational population.Methods:Liquid scintillation counting(LSC)combined with the function of transformed spectral index of the external standard spectrum(tSIE)was used to measure the quenching level and counting rate,and the spiked urine samples with different shades of color were measured by LSC.After establishing the efficiency-quenching curve,the quenching correction and activity concentration analysis of the actual samples were carried out.Results:By LSC and the data fitting,the relationship between efficiency and quenching index could be represented using the equation y=0.0013x-0.0177(R^(2)=0.978).Three actual spiked samples were tested to verify this method,with recoveries of 97%,102%,and 89%,respectively.14C activity concentration of 4 actual urine samples were 0.12,0.11,0.10 and 0.08 Bq/mL,respectively,while the corresponding extended relative uncertainties were 0.0652,0.0929,0.0893 and 0.1043,respectively.Conclusion:The direct analysis method of 14C activity concentration in urine samples was established using LSC.The recovery of 14C activity concentration in urine samples showed that the proposed method had relatively high accuracy.By studying on the source of uncertainty,the uncertainty of the analysis results mainly came from the statistical error of LSC,and the uncertainty component of counting efficiency.
基金support from National Natural Science Foundation of China(Nos.21172250 and 21275155).
文摘A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act(CPSIA),European Union legislations and Chinese national standards(GB)were analyzed.By a combined solid-phase micro-extraction(SPME)and direct analysis in real time mass spectrometry(DART-MS)approach,phthalates at sub-ng•mL^(−1)levels can be qualitatively and quantitatively analyzed in a short time.The use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or preparations.The limits of quantification(LOQs)were estimated to be at 0.3-5.0 ng•mL^(−1),lower than the Maximum Residue Limit(MRL)regulated by the European Union legislations(2007/19/EC)in foods,beverages,food packaging and toys(0.3-30 ng•mL^(−1)).This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety.
基金This research was supported by the Project for Strengthening the Police Force with Science and Technology(project number 2018GABJC29).
文摘We aimed to establish for the rapid detection of morphine,O6‑monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin in human blood and urine by direct analysis in real‑time coupled with tandem mass spectrometry(DART‑MS/MS).These samples were extracted by acetonitrile‑methanol(V/V=4:1),using DART 12 Dip‑it automatic sampling system.They were injected at 400℃,and analyzed by positive ion and multiple reaction monitoring mode.The detection limits of morphine,O6‑Monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin were 100,50,50,100,20,20,10,1,and 0.01 ng/mL,respectively.The practical cases contained methamphetamine,codeine,cocaine,and O6‑monoacetylmorphine were detected accurately and rapidly.The method has the advantages of high sensitivity and good accuracy.The sample processing is simple and can be analyzed in a short time.This method is suitable for the analysis of morphine,O6‑monoacetylmorphine,heroin,codeine,cocaine,methamphetamine,ketamine,methadone,and dolantin in some practical cases.
文摘A wave load computation approach in direct strength analysis of semi-submersible platform structures was presented in this paper. Considering the differences in shape of pontoon, column and beam, the combination of accumulative chord length cubic parameter spline theory and analytic method was adopted for generating the wet surface mesh of platform. The hydrodynamic coefficients of platform were calculated by the three-dimensional potential flow theory of the linear hydrodynamic problem for platform with low forward speed. The equation of platform motions was established and solved in frequency domain, and the responses of wave-induced loads on the platform can be obtained. With the interpolation method being utilized, the pressure loads on shell elements for finite element analysis (FEA) were converted from those on the hydrodynamic computation mesh, which pave the basis for FEA with commercial software.A computer program based on this method has been developed, and a calculation example of semi-submersible platform was illustrated.Analysis results show that this method is a satisfying approach of wave loads computation for this kind of platform.
基金The National Natural Science Foundation of China (No.61374194)
文摘A direct linear discriminant analysis algorithm based on economic singular value decomposition （DLDA/ESVD） is proposed to address the computationally complex problem of the conventional DLDA algorithm, which directly uses ESVD to reduce dimension and extract eigenvectors corresponding to nonzero eigenvalues. Then a DLDA algorithm based on column pivoting orthogonal triangular （QR） decomposition and ESVD （DLDA/QR-ESVD） is proposed to improve the performance of the DLDA/ESVD algorithm by processing a high-dimensional low rank matrix, which uses column pivoting QR decomposition to reduce dimension and ESVD to extract eigenvectors corresponding to nonzero eigenvalues. The experimental results on ORL, FERET and YALE face databases show that the proposed two algorithms can achieve almost the same performance and outperform the conventional DLDA algorithm in terms of computational complexity and training time. In addition, the experimental results on random data matrices show that the DLDA/QR-ESVD algorithm achieves better performance than the DLDA/ESVD algorithm by processing high-dimensional low rank matrices.
文摘A kernel-based discriminant analysis method called kernel direct discriminant analysis is employed, which combines the merit of direct linear discriminant analysis with that of kernel trick. In order to demonstrate its better robustness to the complex and nonlinear variations of real face images, such as illumination, facial expression, scale and pose variations, experiments are carried out on the Olivetti Research Laboratory, Yale and self-built face databases. The results indicate that in contrast to kernel principal component analysis and kernel linear discriminant analysis, the method can achieve lower （7%） error rate using only a very small set of features. Furthermore, a new corrected kernel model is proposed to improve the recognition performance. Experimental results confirm its superiority （1% in terms of recognition rate） to other polynomial kernel models.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61472048,61402058,61272511,61472046,61202082 and 61370194the Beijing Natural Science Foundation under Grant No 4152038the China Postdoctoral Science Foundation Funded Project under Grant No 2014M561826
文摘To analyze the security of two-step quantum direct communication protocol （QDCP） by using Einstein-Podolsky Rosen pair proposed by Deng et al. [Phys. Rev. A 68 （2003）042317] in collective-rotation noise channel, an excellent model of noise analysis is proposed. In the security analysis, the method of the entropy theory is introduced, and is compared with QDCP, an error rate point Qo（M ： （Q0, 1.0）） is given. In different noise levels, if Eve wants to obtain the same amount of information, the error rate Q is distinguishable. The larger the noise level ~ is, the larger the error rate Q is. When the noise level ~ is lower than 11%, the high error rate is 0.153 without eavesdropping. Lastly, the security of the proposed protocol is discussed. It turns out that the quantum channel will be safe when Q 〈 0.153. Similarly, if error rate Q〉 0.153 = Q0, eavesdropping information I 〉 1, which means that there exist eavesdroppers in the quantum channel, and the quantum channel will not be safe anymore.
基金Project supported by the National Natural Science Foundation of China(Grant No.31570722).
文摘Secondary structures of RNAs are the basis of understanding their tertiary structures and functions and so their predictions are widely needed due to increasing discovery of noncoding RNAs.In the last decades,a lot of methods have been proposed to predict RNA secondary structures but their accuracies encountered bottleneck.Here we present a method for RNA secondary structure prediction using direct coupling analysis and a remove-and-expand algorithm that shows better performance than four existing popular multiple-sequence methods.We further show that the results can also be used to improve the prediction accuracy of the single-sequence methods.
文摘The recently proposed method of our research group named as directional Lyapunov exponents（DLEs） is presented. Then, DLEs are used to analyze the eigenstructure of the output phase space around the equilibrium points. Finally, the impacts of the superlattice parameter changes on the characteristics of the output chaotic signal are analyzed. The experimental results show that parameter changes of the superlattice will affect the eigenstructure around the equilibrium points in the output phase space, and DLEs are sensitive to these changes.
文摘The magnetic property of soft magnetic metals and alloys depends strongly on the crystallo-graphic orientation. In automated equipment for orientation research, the intensity for drawing up the pole figure is measured in detail. The present research shows that the accurate pole figure can be drawn up without measuring concretely the intensity. For directional Si steel sheet the measuring step may be 4～5 degrees. In this paper the experimental equation for defo-cusing correction was derived from the experimental data in different specimens with random orientation.
基金financially supported by the Beijing Municipal Science and Technology Project, China (Z131110000613066)the Educational and Teaching Reform Project for Graduate Students, China (G-JG-XJ201408)the Beijing Key Laboratory of Bioprocess, China
文摘Access to security and safe food is a basic human necessity and essential for a sustainable world. To perform hi-end rood safety analysis and risk assessment with state of the art technologies is of utmost importance thereof. With applications as exemplified by microfiuidic immunoassay, aptasensor, direct analysis in real time, high resolution mass spectrometry, benchmark dose and chemical specific adjustment factor, this review presents frontier food safety analysis and risk assessment technologies, from which both food quality and public health will benefit undoubtedly in a foreseeable future.
基金supported by the National Natural Science Foundation of China (61963033, 61866036, 62163035)the Key Project of Natural Science Foundation of Xinjiang (2021D01D10)+1 种基金the Xinjiang Key Laboratory of Applied Mathematics (XJDX1401)the Special Project for Local Science and Technology Development Guided by the Central Government (ZYYD2022A05)。
文摘The fixed-time synchronization and preassigned-time synchronization are investigated for a class of quaternion-valued neural networks with time-varying delays and discontinuous activation functions. Unlike previous efforts that employed separation analysis and the real-valued control design, based on the quaternion-valued signum function and several related properties, a direct analytical method is proposed here and the quaternion-valued controllers are designed in order to discuss the fixed-time synchronization for the relevant quaternion-valued neural networks. In addition, the preassigned-time synchronization is investigated based on a quaternion-valued control design, where the synchronization time is preassigned and the control gains are finite. Compared with existing results, the direct method without separation developed in this article is beneficial in terms of simplifying theoretical analysis, and the proposed quaternion-valued control schemes are simpler and more effective than the traditional design, which adds four real-valued controllers. Finally, two numerical examples are given in order to support the theoretical results.
基金Supported by the Fund of Changchun Jilin University Little Swan Instrument Co., Ltd., China(No.GDYQ 2009-201SP)
文摘Since peanut oil（PO） is more expensive than other seed oils, some PO is adulterated with other cheap seed oils, such as soybean oil, palm olein, cottonseed oil, corn oil and rapeseed oil. The conventional method for deter mining whether PO was adulterated is to detect the freezing point of oils. The proposed method for the determination of adulterants in PO was based on monitoring the change of absorbance when the sample was refrigerated. A special spectrophotometer was developed. A total of 10 kinds of POs from different suppliers were chosen and adulterated with other seed oils at the volume fraction levels ranging from 5% to 30%. A total of 150 samples were analyzed by the proposed method and the results were satisfactory.
基金This project is supported by National Natural Science Foundation of China (No.E50575234).
文摘A direct digital design method （DDDM） of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth contact analysis （LTCA） method is analyzed, in which the advanced surface to surface searching technique is included. The influence of misalignment errors and contact deformations on contact zone and transmission error （TE） is discussed. Combined modification approach on worm tooth surface is presented. By means of DDDM and LTCA, it is very conven- ient to verify the effect of worm-gear drive＇s modification approach. The analysis results show that, the modification in profile direction reduces the sensitivity of worm-gear drive to misalignment errors and the modification in longitudinal direction decreases the TE. Thus the optimization design of worm-gear drive can be achieved prior to the actual manufacturing process.
基金This Project is supported by National Natural Science Foundation of China.
文摘The directional spectrum is one of the basic characteristics of sea waves. The observations of directional spectrum of sea waves were successfully conducted at platform Bohai 8 during 1991 and 1992 using a wave gage array for the first time in China. Based on the field data, the directional spectrum which depends on the wave growth is given in this paper. Before observations, the effects of the type of gage array, the distance between the gages and the platform itself on the measured results and the precision of some methods for estimating the directional spectrum were investigated and compared with the methods of numerical simulations and model tests of multi-direcitonal irregular waves. This ensures the quality of the observations and estimations of the directional spectrum.
基金supported by the National Natural Science Foundation of China(82273684)。
文摘The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging.Herein,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 NTs.We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision.Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy.In addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy.Our results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.
基金supported by the National Basic Research Program of China (973 Program 2009CB421605)the National Natural Science Foundation of China (20890111, 20921063 & 20931160427)the Ministry of Science and Technology of China (2008IM041300)
文摘Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region.
基金supported by the Ministry of Industry and Information Technology(Grant Nos.[2016]22,[2019]357)the Ministry of Science and Technology(Grant No.2013CB36102)+1 种基金supported by the National KeyResearch and Development Program of China(Grant No.2017YFBO202701)the Jiangsu Province ScienceFoundation for Youths(BK20190151).
文摘Design of a very large floating structure(VLFS)deployed near islands and reefs,different from those in the open sea,inevitably faces new technical challenges including numerical analysis methods.In this paper,a direct coupling analysis method(DCAM)has been established based on the Boussinesq equations and the three-dimensional hydroelasisity theory with Rankine source method to analyze the responses of a VLFS in shallow sea with complicated geographical environment.Model tests have been carried out to validate the DCAM.To further verify the numerical methods and investigate the performance of such a VLFS,a“Scientific Research and Demonstration Platform(SRDP)”was built and deployed in 2019 at the site about 1000 m off an island with water depth around 40m in South China Sea.It is a simplified small model of a two-module semi-submersible-type VLFS.The numerical simulation of its responses on severe waves with focus on motions and connector forces is conduct by DCAM,and compared with the on-site measurements.Good agreement has been achieved.This approves the DCAM as a feasible tool for design and safety assessment of a VLFS deployed near islands and reefs.
基金supported by the AVIC Research Project(Grant No.cxy2012BH07)the National Natural Science Foundation of China(Grant Nos.10872017,90816024,10876100)+1 种基金the Defense Industrial Technology Development Program(Grant Nos.A2120110001,B2120110011,A082013-2001)"111" Project(Grant No.B07009)
文摘It has been extensively recognized that the engineering structures are becoming increasingly precise and complex,which makes the requirements of design and analysis more and more rigorous.Therefore the uncertainty effects are indispensable during the process of product development.Besides,iterative calculations,which are usually unaffordable in calculative efforts,are unavoidable if we want to achieve the best design.Taking uncertainty effects into consideration,matrix perturbation methodpermits quick sensitivity analysis and structural dynamic re-analysis,it can also overcome the difficulties in computational costs.Owing to the situations above,matrix perturbation method has been investigated by researchers worldwide recently.However,in the existing matrix perturbation methods,correlation coefficient matrix of random structural parameters,which is barely achievable in engineering practice,has to be given or to be assumed during the computational process.This has become the bottleneck of application for matrix perturbation method.In this paper,we aim to develop an executable approach,which contributes to the application of matrix perturbation method.In the present research,the first-order perturbation of structural vibration eigenvalues and eigenvectors is derived on the basis of the matrix perturbation theory when structural parameters such as stiffness and mass have changed.Combining the first-order perturbation of structural vibration eigenvalues and eigenvectors with the probability theory,the variance of structural random eigenvalue is derived from the perturbation of stiffness matrix,the perturbation of mass matrix and the eigenvector of baseline-structure directly.Hence the Direct-VarianceAnalysis(DVA)method is developed to assess the variation range of the structural random eigenvalues without correlation coefficient matrix being involved.The feasibility of the DVA method is verified with two numerical examples(one is trusssystem and the other is wing structure of MA700 commercial aircraft),in which the DVA method also shows superiority in computational efficiency when compared to the Monte-Carlo method.
