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Plasma SCF/c-kit Levels in Patients with Dipper and Non-Dipper Hypertension 被引量:1
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作者 Hailan Zhong Chongli Xu +1 位作者 Guangsheng Chen Xiumei Chen 《Chinese Medical Sciences Journal》 CAS CSCD 2017年第4期232-238,共7页
Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.Methods Th... Objective The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.Methods This cross-sectional study included newly diagnosed hypertensive patients who underwent 24-hour ambulatory blood pressure monitor (ABPM) between January 2009 and 2012 in Jiangning city. Patients were divided into the dipper group and the non-dipper group according to ABPM measurements. The levels of SCF and its receptor c-kit, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in peripheral blood were measured via enzyme-linked immunosorbent assays. The serum levels of glucose and lipid were examined as well. The levels of SCF/c-kit were compared between the dippers and the non-dippers; and their correlation with 24-hour mean systolic blood pressure (MSBP), 24-hour mean diastolic blood pressure (MDBP), TNF-αand IL-6 were investigated using linear regression analyses statistically.Results A total of 247 patients with newly diagnosed hypertension were recruited into the study, including 116 non-dippers and 131 dippers. The levels of peripheral plasma SCF were higher in non-dipper group (907.1±52.7 ng/L vs. 778.7±44.6 ng/L; t=2.837, P<0.01), and the levels of c-kit were higher in non-dipper group too (13.2±1.7 μg/L vs 9.57±1.4 μg/L; t=2.831, P<0.01). Linear regression analysis revealed that SCF/ckit levels were significantly positively correlated with MSBP, MDBP, plasma TNF-α, and IL-6 levels (all P<0.01).Conclusions Peripheral plasma SCF/c-kit levels are higher in patients with non-dipper hypertension than those with dipper one, and significantly correlate with 24-hour MSBP, 24-hour MDBP, serum TNF-α and IL-6 levels. 展开更多
关键词 AMBULATORY BLOOD pressure monitor dipper HYPERTENSION NON-dipper HYPERTENSION stem cell factor C-KIT
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Hybrid Dipper Throated and Grey Wolf Optimization for Feature Selection Applied to Life Benchmark Datasets 被引量:2
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作者 Doaa Sami Khafaga El-Sayed M.El-kenawy +4 位作者 Faten Khalid Karim Mostafa Abotaleb Abdelhameed Ibrahim Abdelaziz A.Abdelhamid D.L.Elsheweikh 《Computers, Materials & Continua》 SCIE EI 2023年第2期4531-4545,共15页
Selecting the most relevant subset of features from a dataset is a vital step in data mining and machine learning.Each feature in a dataset has 2n possible subsets,making it challenging to select the optimum collectio... Selecting the most relevant subset of features from a dataset is a vital step in data mining and machine learning.Each feature in a dataset has 2n possible subsets,making it challenging to select the optimum collection of features using typical methods.As a result,a new metaheuristicsbased feature selection method based on the dipper-throated and grey-wolf optimization(DTO-GW)algorithms has been developed in this research.Instability can result when the selection of features is subject to metaheuristics,which can lead to a wide range of results.Thus,we adopted hybrid optimization in our method of optimizing,which allowed us to better balance exploration and harvesting chores more equitably.We propose utilizing the binary DTO-GW search approach we previously devised for selecting the optimal subset of attributes.In the proposed method,the number of features selected is minimized,while classification accuracy is increased.To test the proposed method’s performance against eleven other state-of-theart approaches,eight datasets from the UCI repository were used,such as binary grey wolf search(bGWO),binary hybrid grey wolf,and particle swarm optimization(bGWO-PSO),bPSO,binary stochastic fractal search(bSFS),binary whale optimization algorithm(bWOA),binary modified grey wolf optimization(bMGWO),binary multiverse optimization(bMVO),binary bowerbird optimization(bSBO),binary hysteresis optimization(bHy),and binary hysteresis optimization(bHWO).The suggested method is superior 4532 CMC,2023,vol.74,no.2 and successful in handling the problem of feature selection,according to the results of the experiments. 展开更多
关键词 Metaheuristics dipper throated optimization grey wolf optimization binary optimizer feature selection
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Transfer Learning for Chest X-rays Diagnosis Using Dipper Throated Algorithm
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作者 Hussah Nasser AlEisa El-Sayed M.El-kenawy +3 位作者 Amel Ali Alhussan Mohamed Saber Abdelaziz A.Abdelhamid Doaa Sami Khafaga 《Computers, Materials & Continua》 SCIE EI 2022年第11期2371-2387,共17页
Most children and elderly people worldwide die from pneumonia,which is a contagious illness that causes lung ulcers.For diagnosing pneumonia from chest X-ray images,many deep learning models have been put forth.The go... Most children and elderly people worldwide die from pneumonia,which is a contagious illness that causes lung ulcers.For diagnosing pneumonia from chest X-ray images,many deep learning models have been put forth.The goal of this research is to develop an effective and strong approach for detecting and categorizing pneumonia cases.By varying the deep learning approach,three pre-trained models,GoogLeNet,ResNet18,and DenseNet121,are employed in this research to extract the main features of pneumonia and normal cases.In addition,the binary dipper throated optimization(DTO)algorithm is utilized to select the most significant features,which are then fed to the K-nearest neighbor(KNN)classifier for getting the final classification decision.To guarantee the best performance of KNN,its main parameter(K)is optimized using the continuous DTO algorithm.To test the proposed approach,six evaluation metrics were employed namely,positive and negative predictive values,accuracy,specificity,sensitivity,and F1-score.Moreover,the proposed approach is compared with other traditional approaches,and the findings confirmed the superiority of the proposed approach in terms of all the evaluation metrics.The minimum accuracy achieved by the proposed approach is(98.5%),and the maximum accuracy is(99.8%)when different test cases are included in the evaluation experiments. 展开更多
关键词 METAHEURISTIC PNEUMONIA dipper throated optimization KNN
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Hybrid Grey Wolf and Dipper Throated Optimization in Network Intrusion Detection Systems
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作者 Reem Alkanhel Doaa Sami Khafaga +5 位作者 El-Sayed M.El-kenawy Abdelaziz A.Abdelhamid Abdelhameed Ibrahim Rashid Amin Mostafa Abotaleb B.M.El-den 《Computers, Materials & Continua》 SCIE EI 2023年第2期2695-2709,共15页
The Internet of Things(IoT)is a modern approach that enables connection with a wide variety of devices remotely.Due to the resource constraints and open nature of IoT nodes,the routing protocol for low power and lossy... The Internet of Things(IoT)is a modern approach that enables connection with a wide variety of devices remotely.Due to the resource constraints and open nature of IoT nodes,the routing protocol for low power and lossy(RPL)networks may be vulnerable to several routing attacks.That’s why a network intrusion detection system(NIDS)is needed to guard against routing assaults on RPL-based IoT networks.The imbalance between the false and valid attacks in the training set degrades the performance of machine learning employed to detect network attacks.Therefore,we propose in this paper a novel approach to balance the dataset classes based on metaheuristic optimization applied to locality-sensitive hashing and synthetic minority oversampling technique(LSH-SMOTE).The proposed optimization approach is based on a new hybrid between the grey wolf and dipper throated optimization algorithms.To prove the effectiveness of the proposed approach,a set of experiments were conducted to evaluate the performance of NIDS for three cases,namely,detection without dataset balancing,detection with SMOTE balancing,and detection with the proposed optimized LSHSOMTE balancing.Experimental results showed that the proposed approach outperforms the other approaches and could boost the detection accuracy.In addition,a statistical analysis is performed to study the significance and stability of the proposed approach.The conducted experiments include seven different types of attack cases in the RPL-NIDS17 dataset.Based on the 2696 CMC,2023,vol.74,no.2 proposed approach,the achieved accuracy is(98.1%),sensitivity is(97.8%),and specificity is(98.8%). 展开更多
关键词 Metaheuristics grey wolf optimization dipper throated optimization dataset balancing locality sensitive hashing SMOTE
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Adaptive Dynamic Dipper Throated Optimization for Feature Selection in Medical Data
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作者 Ghada Atteia El-Sayed M.El-kenawy +7 位作者 Nagwan Abdel Samee Mona M.Jamjoom Abdelhameed Ibrahim Abdelaziz A.Abdelhamid Ahmad Taher Azar Nima Khodadadi Reham A.Ghanem Mahmoud Y.Shams 《Computers, Materials & Continua》 SCIE EI 2023年第4期1883-1900,共18页
The rapid population growth results in a crucial problem in the early detection of diseases inmedical research.Among all the cancers unveiled,breast cancer is considered the second most severe cancer.Consequently,an e... The rapid population growth results in a crucial problem in the early detection of diseases inmedical research.Among all the cancers unveiled,breast cancer is considered the second most severe cancer.Consequently,an exponential rising in death cases incurred by breast cancer is expected due to the rapid population growth and the lack of resources required for performing medical diagnoses.Utilizing recent advances in machine learning could help medical staff in diagnosing diseases as they offer effective,reliable,and rapid responses,which could help in decreasing the death risk.In this paper,we propose a new algorithm for feature selection based on a hybrid between powerful and recently emerged optimizers,namely,guided whale and dipper throated optimizers.The proposed algorithm is evaluated using four publicly available breast cancer datasets.The evaluation results show the effectiveness of the proposed approach from the accuracy and speed perspectives.To prove the superiority of the proposed algorithm,a set of competing feature selection algorithms were incorporated into the conducted experiments.In addition,a group of statistical analysis experiments was conducted to emphasize the superiority and stability of the proposed algorithm.The best-achieved breast cancer prediction average accuracy based on the proposed algorithm is 99.453%.This result is achieved in an average time of 3.6725 s,the best result among all the competing approaches utilized in the experiments. 展开更多
关键词 Medical dataset breast cancer guided whale optimizer dipper throated optimizer feature selection META-HEURISTICS
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Dipper Throated Optimization for Detecting Black-Hole Attacks inMANETs
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作者 Reem Alkanhel El-Sayed M.El-kenawy +3 位作者 Abdelaziz A.Abdelhamid Abdelhameed Ibrahim Mostafa Abotaleb Doaa Sami Khafaga 《Computers, Materials & Continua》 SCIE EI 2023年第1期1905-1921,共17页
In terms of security and privacy,mobile ad-hoc network(MANET)continues to be in demand for additional debate and development.As more MANET applications become data-oriented,implementing a secure and reliable data tran... In terms of security and privacy,mobile ad-hoc network(MANET)continues to be in demand for additional debate and development.As more MANET applications become data-oriented,implementing a secure and reliable data transfer protocol becomes a major concern in the architecture.However,MANET’s lack of infrastructure,unpredictable topology,and restricted resources,as well as the lack of a previously permitted trust relationship among connected nodes,contribute to the attack detection burden.A novel detection approach is presented in this paper to classify passive and active black-hole attacks.The proposed approach is based on the dipper throated optimization(DTO)algorithm,which presents a plausible path out of multiple paths for statistics transmission to boost MANETs’quality of service.A group of selected packet features will then be weighed by the DTO-based multi-layer perceptron(DTO-MLP),and these features are collected from nodes using the Low Energy Adaptive Clustering Hierarchical(LEACH)clustering technique.MLP is a powerful classifier and the DTO weight optimization method has a significant impact on improving the classification process by strengthening the weights of key features while suppressing the weights ofminor features.This hybridmethod is primarily designed to combat active black-hole assaults.Using the LEACH clustering phase,however,can also detect passive black-hole attacks.The effect of mobility variation on detection error and routing overhead is explored and evaluated using the suggested approach.For diverse mobility situations,the results demonstrate up to 97%detection accuracy and faster execution time.Furthermore,the suggested approach uses an adjustable threshold value to make a correct conclusion regarding whether a node is malicious or benign. 展开更多
关键词 Black-hole attack mobile ad-hoc network OPTIMIZATION dipper throated optimization
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Optimized Weighted Ensemble Using Dipper Throated Optimization Algorithm in Metamaterial Antenna
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作者 Doaa Sami Khafaga El-Sayed M.El-kenawy +3 位作者 Faten Khalid Karim Sameer Alshetewi Abdelhameed Ibrahim Abdelaziz AAbdelhamid 《Computers, Materials & Continua》 SCIE EI 2022年第12期5771-5788,共18页
Metamaterial Antennas are a type of antenna that uses metamaterial to enhance performance.The bandwidth restriction associated with small antennas can be solved using metamaterial antennas.Machine learning is gaining ... Metamaterial Antennas are a type of antenna that uses metamaterial to enhance performance.The bandwidth restriction associated with small antennas can be solved using metamaterial antennas.Machine learning is gaining popularity as a way to improve solutions in a range of fields.Machine learning approaches are currently a big part of current research,and they’re likely to be huge in the future.The model utilized determines the accuracy of the prediction in large part.The goal of this paper is to develop an optimized ensemble model for forecasting the metamaterial antenna’s bandwidth and gain.The basic models employed in the developed ensemble are Support Vector Regression(SVR),K-NearestRegression(KNR),Multi-Layer Perceptron(MLP),Decision Trees(DT),and Random Forest(RF).The percentages of contribution of these models in the ensemble model are weighted and optimized using the dipper throated optimization(DTO)algorithm.To choose the best features from the dataset,the binary(bDTO)algorithm is exploited.The proposed ensemble model is compared to the base models and results are recorded and analyzed statistically.In addition,two other ensembles are incorporated in the conducted experiments for comparison.These ensembles are average ensemble and K-nearest neighbors(KNN)-based ensemble.The comparison is performed in terms of eleven evaluation criteria.The evaluation results confirmed the superiority of the proposed model when compared with the basic models and the other ensemble models. 展开更多
关键词 Metamaterial antenna dipper throated optimization feature selection parameters prediction
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Optimization of Electrocardiogram Classification Using Dipper Throated Algorithm and Differential Evolution
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作者 Doaa Sami Khafaga El-Sayed M.El-kenawy +4 位作者 Faten Khalid Karim Sameer Alshetewi Abdelhameed Ibrahim Abdelaziz A.Abdelhamid D.L.Elsheweikh 《Computers, Materials & Continua》 SCIE EI 2023年第2期2379-2395,共17页
Electrocardiogram(ECG)signal is a measure of the heart’s electrical activity.Recently,ECG detection and classification have benefited from the use of computer-aided systems by cardiologists.The goal of this paper is ... Electrocardiogram(ECG)signal is a measure of the heart’s electrical activity.Recently,ECG detection and classification have benefited from the use of computer-aided systems by cardiologists.The goal of this paper is to improve the accuracy of ECG classification by combining the Dipper Throated Optimization(DTO)and Differential Evolution Algorithm(DEA)into a unified algorithm to optimize the hyperparameters of neural network(NN)for boosting the ECG classification accuracy.In addition,we proposed a new feature selection method for selecting the significant feature that can improve the overall performance.To prove the superiority of the proposed approach,several experimentswere conducted to compare the results achieved by the proposed approach and other competing approaches.Moreover,statistical analysis is performed to study the significance and stability of the proposed approach using Wilcoxon and ANOVA tests.Experimental results confirmed the superiority and effectiveness of the proposed approach.The classification accuracy achieved by the proposed approach is(99.98%). 展开更多
关键词 ELECTROCARDIOGRAM differential evolution algorithm dipper throated optimization neural networks
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Dipper Throated Algorithm for Feature Selection and Classification in Electrocardiogram
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作者 Doaa Sami Khafaga Amel Ali Alhussan +3 位作者 Abdelaziz A.Abdelhamid Abdelhameed Ibrahim Mohamed Saber El-Sayed M.El-kenawy 《Computer Systems Science & Engineering》 SCIE EI 2023年第5期1469-1482,共14页
Arrhythmia has been classified using a variety of methods.Because of the dynamic nature of electrocardiogram(ECG)data,traditional handcrafted approaches are difficult to execute,making the machine learning(ML)solution... Arrhythmia has been classified using a variety of methods.Because of the dynamic nature of electrocardiogram(ECG)data,traditional handcrafted approaches are difficult to execute,making the machine learning(ML)solutions more appealing.Patients with cardiac arrhythmias can benefit from competent monitoring to save their lives.Cardiac arrhythmia classification and prediction have greatly improved in recent years.Arrhythmias are a category of conditions in which the heart's electrical activity is abnormally rapid or sluggish.Every year,it is one of the main reasons of mortality for both men and women,worldwide.For the classification of arrhythmias,this work proposes a novel technique based on optimized feature selection and optimized K-nearest neighbors(KNN)classifier.The proposed method makes advantage of the UCI repository,which has a 279-attribute high-dimensional cardiac arrhythmia dataset.The proposed approach is based on dividing cardiac arrhythmia patients into 16 groups based on the electrocardiography dataset’s features.The purpose is to design an efficient intelligent system employing the dipper throated optimization method to categorize cardiac arrhythmia patients.This method of comprehensive arrhythmia classification outperforms earlier methods presented in the literature.The achieved classification accuracy using the proposed approach is 99.8%. 展开更多
关键词 Feature selection ELECTROCARDIOGRAM metaheuristics dipper throated algorithm
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Using Polaris and the Big Dipper to approximate local standard time
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作者 Edwin H. Kaufman Jr Corey R. Page Casey R. Watson 《Natural Science》 2012年第12期1042-1055,共14页
In this paper we introduce methods for approximating local standard time in the Northern Hemisphere using Polaris and the Big Dipper as well as alternative reference stars, and describe in detail how to construct a de... In this paper we introduce methods for approximating local standard time in the Northern Hemisphere using Polaris and the Big Dipper as well as alternative reference stars, and describe in detail how to construct a device we call a dipperclock to facilitate this process. An alternative method which does not require a dipperclock is also discussed. Ways of constructing dipperclocks which glow in the dark are presented. The accuracy of dipperclocks is examined, both theoretically and through field testing. A java program is provided for creating dipperclocks customized to a particular year-long time period and place to get improved accuracy. Basic astronomical definitions and justifications of the results are provided. We also discuss the use of dipperclocks to find longitude and latitude. 展开更多
关键词 POLARIS BIG dipper TIME LONGITUDE LATITUDE
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Forecasting Energy Consumption Using a Novel Hybrid Dipper Throated Optimization and Stochastic Fractal Search Algorithm
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作者 Doaa Sami Khafaga El-Sayed M.El-kenawy +1 位作者 Amel Ali Alhussan Marwa M.Eid 《Intelligent Automation & Soft Computing》 SCIE 2023年第8期2117-2132,共16页
The accurate prediction of energy consumption has effective role in decision making and risk management for individuals and governments.Meanwhile,the accurate prediction can be realized using the recent advances in ma... The accurate prediction of energy consumption has effective role in decision making and risk management for individuals and governments.Meanwhile,the accurate prediction can be realized using the recent advances in machine learning and predictive models.This research proposes a novel approach for energy consumption forecasting based on a new optimization algorithm and a new forecasting model consisting of a set of long short-term memory(LSTM)units.The proposed optimization algorithm is used to optimize the parameters of the LSTM-based model to boost its forecasting accuracy.This optimization algorithm is based on the recently emerged dipper-throated optimization(DTO)and stochastic fractal search(SFS)algo-rithm and is referred to as dynamic DTOSFS.To prove the effectiveness and superiority of the proposed approach,five standard benchmark algorithms,namely,stochastic fractal search(SFS),dipper throated optimization(DTO),whale optimization algorithm(WOA),particle swarm optimization(PSO),and grey wolf optimization(GWO),are used to optimize the parameters of the LSTM-based model,and the results are compared with that of the proposed approach.Experimental results show that the proposed DDTOSFS+LSTM can accurately forecast the energy consumption with root mean square error RMSE of 0.00013,which is the best among the recorded results of the other methods.In addition,statistical experiments are conducted to prove the statistical difference of the proposed model.The results of these tests confirmed the expected outcomes. 展开更多
关键词 Stochastic fractal search dipper throated optimization energy consumption long short-term memory prediction models
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The Making of a Renowned Doctor:The Early Experiences of Edmund Dipper(1871-1919)
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作者 HUANG Tian WANG Yi 《Chinese Annals of History of Science and Technology》 2024年第2期91-121,共31页
Dr.Edmund Dipper,a distinguished German doctor practicing in China during the tumultuous decades of the 1920s and 1930s,rose to near-legendary status during the Republican era.Yet,the historical trajectory leading to ... Dr.Edmund Dipper,a distinguished German doctor practicing in China during the tumultuous decades of the 1920s and 1930s,rose to near-legendary status during the Republican era.Yet,the historical trajectory leading to his acclaim remains shrouded in conflicting narratives.Dipper’s formative years demonstrate that his success in China stemmed from a multifaceted background encompassing education,religion,and military service.This was coupled with an unwavering commitment to excellence in medical practice and adaptability and resourcefulness in navigating cross-cultural settings.These factors allowed him to successfully avoid strife between church factions when managing the Faber Hospital.Furthermore,Dipper’s remarkable intercultural acumen enabled him to seize a crucial historical opportunity.By adeptly navigating the German Hospital through the repatriation of German citizens after China declared war on Germany in 1917,he not only preserved his own standing but also safeguarded the hospital’s key personnel.This strategic maneuvering laid the groundwork for his illustrious career trajectory.Dipper epitomizes a subset of Western doctors in China during this era,underscoring the imperative to further explore their nuanced historical contributions. 展开更多
关键词 dipper distinguished German doctor Faber Hospital German Hospital
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Virtual simulation analysis and verification of seed-filling mechanism for dipper hill-drop precision direct rice seeder 被引量:8
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作者 Wang Jinwu Zhou Wenqi +2 位作者 Tian Liquan Li Shuwei Zhang Zhao 《International Journal of Agricultural and Biological Engineering》 SCIE EI CAS 2017年第6期77-85,共9页
In order to improve the seeder’seed-filling ability of the dipper hill-drop precision direct rice seeder,and to meet the mechanization requirement of high speed operation,the self-designed seeder was taken as the obj... In order to improve the seeder’seed-filling ability of the dipper hill-drop precision direct rice seeder,and to meet the mechanization requirement of high speed operation,the self-designed seeder was taken as the objective to explore its seed-filling mechanism and the movement status of rice seed in seed box from the perspective of mechanics.The force models of seed-filling process by dipper were established,and the influential regularity of its rotation speed to compressive resistance of seed population was analyzed as well.The image processing Module-Clipping of discrete element simulation software EDEM was used in the virtual simulation analysis for the process of the seed filling into the dipper,and the velocity relation curve and the force changing curve between rotation speed and seeds were obtained.According to the virtual experiment,the composite filling force of seeds,i.e.the qualified rate on filled rice seed amounts was the largest when rotation speed was at 40 r/min.The performance test bed of seeder was used to verify the simulation results,in which the qualified rate on scooped rice seed amounts was taken as the index,and six rotation speeds of seed-filling dipper were also selected for analysis of seed-filling ability of the device.The results are as follows:with the increase of working speed,the qualified rate on filled rice seed amounts fluctuated with a trend of cosine curve,the largest value was 94.16%occurred when the rotation speed of seed-filling dipper was at 40 r/min.The variation trend of simulation value was approximately consistent with that of verification value.The study can provide a reference for the research and development of mechanical seeder. 展开更多
关键词 precision direct rice seeding rice seed dipper seeder seed-filling performance EDEM force model
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羟苯磺酸钙联合依那普利治疗非杓型高血压合并2型糖尿病的疗效
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作者 崔寿波 籍国军 李晓东 《中国药物应用与监测》 2026年第2期202-206,共5页
目的探讨羟苯磺酸钙联合依那普利治疗非杓型高血压合并2型糖尿病(T2DM)患者的疗效。方法采用前瞻性对照研究设计,选取2022年12月至2024年12月于寿光市人民医院就诊的80例非杓型高血压合并T2DM患者,通过随机数字表法将其分为两组,对照组... 目的探讨羟苯磺酸钙联合依那普利治疗非杓型高血压合并2型糖尿病(T2DM)患者的疗效。方法采用前瞻性对照研究设计,选取2022年12月至2024年12月于寿光市人民医院就诊的80例非杓型高血压合并T2DM患者,通过随机数字表法将其分为两组,对照组(40例)接受基础用药+依那普利治疗,观察组(40例)接受基础用药+依那普利+羟苯磺酸钙治疗,两组维持治疗6个月。比较两组临床疗效、血压昼夜节律变化、血糖水平、胰岛功能、血管内皮功能以及不良反应发生情况。结果治疗后,观察组总有效率为92.50%(37/40),高于对照组的75.00%(30/40)(χ^(2)=4.501,P<0.05)。治疗后,观察组日间血压(收缩压、舒张压)、夜间血压(收缩压、舒张压)[分别为(126.03±6.31)、(81.31±6.29)、(115.62±6.40)、(75.65±5.65)mmHg(1 mmHg=0.133 kPa)]低于对照组[分别为(141.36±6.94)、(87.54±6.27)、(124.33±6.38)、(80.31±5.40)mmHg](t=10.337、4.437、6.096、3.771,均P<0.05),夜间血压下降率为(12.02±2.18)%,高于对照组的(7.53±1.79)%(t=10.067,P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平[分别为(6.08±0.57)mmol/L、(9.57±0.56)mmol/L、(6.12±0.51)%]低于对照组[分别为(6.95±0.67)mmol/L、(10.28±0.91)mmol/L、(7.43±0.96)%](t=6.255、4.203、7.622,均P<0.05)。治疗后,观察组空腹胰岛素水平、胰岛素抵抗指数[分别为(11.22±1.63)mU/L、(3.36±0.35)]低于对照组[分别为(13.01±1.76)mU/L、(3.91±0.38)](t=4.719、6.733,均P<0.05)。治疗后,观察组内皮素1水平为(44.74±6.82)pg/mL,低于对照组的(55.89±6.75)pg/mL(t=7.349,P<0.05),一氧化氮水平为(86.11±11.52)μmol/L,高于对照组的(71.25±10.86)μmol/L(t=5.936,P<0.05)。观察组和对照组不良反应发生率为15.00%(6/40)和12.50%(5/40)(χ^(2)=0.105,P>0.05)。结论羟苯磺酸钙联合依那普利治疗非杓型高血压合并T2DM具有良好疗效,可有效改善患者的血压昼夜节律变化、调节血糖水平、改善胰岛素抵抗并促进血管内皮功能的修复,且安全性良好。 展开更多
关键词 羟苯磺酸钙 依那普利 非杓型高血压 2型糖尿病 昼夜节律
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4100XPC电铲竖销固定方铁的改造研究
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作者 高启林 贺栋 徐治中 《煤矿机械》 2026年第3期144-147,共4页
为了减少4100XPC电铲竖销固定方铁故障、提高设备可用率,针对4100XPC电铲竖销固定方铁存在的磨损过限和开裂问题,对竖销固定方铁进行了受力分析和计算,合理选择了竖销固定方铁的材质,同时对竖销固定方铁结构进行了优化设计,对竖销固定... 为了减少4100XPC电铲竖销固定方铁故障、提高设备可用率,针对4100XPC电铲竖销固定方铁存在的磨损过限和开裂问题,对竖销固定方铁进行了受力分析和计算,合理选择了竖销固定方铁的材质,同时对竖销固定方铁结构进行了优化设计,对竖销固定方铁的现场安装进行了指导。结果表明,通过改造不仅解决了竖销固定方铁的开裂和磨损问题,而且取得了较好的经济效益和社会效益。 展开更多
关键词 4100XPC电铲 竖销固定方铁 斗门 受力 焊缝
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原发性高血压患者异常血压昼夜节律的影响因素分析
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作者 曾雨 丁楠 《中国现代医生》 2026年第2期45-48,共4页
目的探讨原发性高血压患者群体中导致血压昼夜节律紊乱的影响因素。方法选取2020年1月1日至2025年9月1日中山大学附属第五医院诊治的181例原发性高血压患者作为研究对象。根据血压昼夜变化节律>10%为杓型组(n=39),血压昼夜变化节律&l... 目的探讨原发性高血压患者群体中导致血压昼夜节律紊乱的影响因素。方法选取2020年1月1日至2025年9月1日中山大学附属第五医院诊治的181例原发性高血压患者作为研究对象。根据血压昼夜变化节律>10%为杓型组(n=39),血压昼夜变化节律<10%为非杓型组(n=88),血压昼夜变化节律<0为反杓型组(n=54)。比较三组患者的临床资料、动态血压参数、心律失常指标及血清学生物标志物,采用多因素Logistic回归分析异常血压节律的影响因素。结果与杓型组比较,反杓型组患者的日间及夜间平均收缩压、舒张压均显著更高(P<0.05)。反杓型患者的夜间室性早搏总次数较非杓型显著升高(P<0.05)。多因素Logistic回归分析结果表明,纤维蛋白原、N末端B型利尿钠肽原及夜间室性早搏总次数是异常血压节律的独立危险因素。结论异常血压节律与夜间室性心律失常、炎症高凝状态及心肌应激密切相关。临床应重视血压的昼夜节律评估,对异常节律患者进行早期识别和综合干预。 展开更多
关键词 原发性高血压 反杓型血压 昼夜节律 心律失常 动态血压监测
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THE BIG DIPPER GUIDE China has high expectations for its domestically produced global positioning system
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作者 TANG YUANKAI 《Beijing Review》 2009年第27期20-21,共2页
China has high expectations for its domestically produced global positioning system When a catastrophic earthquake measuring 8.0 on the Richter scale rocked Wenchuan County in China’s
关键词 THE BIG dipper GUIDE
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基于营卫理论探讨益气活血通脉汤治疗气虚血瘀型反杓型高血压的临床研究 被引量:3
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作者 唐娜娜 徐媛媛 +2 位作者 缪慧慧 陈抒鹏 刘中勇 《江西中医药大学学报》 2025年第2期32-36,40,共6页
目的:探讨基于营卫理论指导下应用益气活血通脉汤治疗气虚血瘀型反杓型高血压的疗效。方法:选取2022年1—2月就诊于江西中医药大学附属医院心血管科的气虚血瘀型反杓型高血压患者60例,随机分为对照组和观察组,各30例。对照组给予苯磺酸... 目的:探讨基于营卫理论指导下应用益气活血通脉汤治疗气虚血瘀型反杓型高血压的疗效。方法:选取2022年1—2月就诊于江西中医药大学附属医院心血管科的气虚血瘀型反杓型高血压患者60例,随机分为对照组和观察组,各30例。对照组给予苯磺酸氨氯地平片治疗,观察组在对照组基础上给予益气活血通脉汤治疗,疗程为12周。观察2组患者临床疗效,治疗前后中医证候积分、血脂水平[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、动态血压水平[24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、日间平均收缩压(dSBP)、日间平均舒张压(dDBP)、夜间平均收缩压(n SBP)、夜间平均舒张压(n DBP)、夜间收缩压下降率(SBPF)、夜间舒张压下降率(DBPF)、收缩压负荷(SBPL)、舒张压负荷(DBPL)、晨峰血压(MBPS)、脉压差(PP)]、血压昼夜节律,并记录不良反应。结果:治疗后,观察组总有效率(96.67%)高于对照组(73.33%)(P<0.05);2组患者治疗后中医证候积分、血脂水平均较治疗前下降(P<0.05,P<0.01),且观察组中医证候积分及TC、TG水平均低于对照组(P<0.05);2组患者治疗后各动态血压水平均较治疗前降低,且观察组24 h SBP、n SBP、24 h DBP、dDBP、24 h SBPL、d SBPL、nSBPL、24 h DBPL、dDBPL、MBPS均低于对照组(P<0.05);治疗后观察组反杓型血压昼夜节律逆转率高于对照组(P<0.05);治疗期间2组患者的不良反应无显著差异。结论:营卫理论指导下的益气活血通脉汤能够缓解气虚血瘀型反杓型高血压患者临床症状,降低患者血压,恢复血压节律。 展开更多
关键词 营卫理论 益气活血通脉汤 气虚血瘀型 反杓型高血压 血压昼夜节律
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癫狂梦醒汤治疗非杓型高血压伴失眠的临床效果观察 被引量:1
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作者 靳曼曼 杨环玮 +2 位作者 王海涛 李权 张学新 《中外医药研究》 2025年第8期105-107,共3页
目的:观察癫狂梦醒汤治疗非杓型高血压伴失眠的临床效果。方法:选择2022年9月—2024年3月秦皇岛市中医医院心血管病科收治的60例非杓型高血压伴失眠患者作为研究对象,根据随机数字表法分为对照组和观察组,每组30例。对照组予以缬沙坦氢... 目的:观察癫狂梦醒汤治疗非杓型高血压伴失眠的临床效果。方法:选择2022年9月—2024年3月秦皇岛市中医医院心血管病科收治的60例非杓型高血压伴失眠患者作为研究对象,根据随机数字表法分为对照组和观察组,每组30例。对照组予以缬沙坦氢氯噻嗪片联合艾司唑仑片治疗,观察组予以缬沙坦氢氯噻嗪片联合癫狂梦醒汤治疗。比较两组治疗前后血压水平及睡眠质量。结果:治疗后,两组24 h平均收缩压、24 h平均舒张压、白昼平均收缩压、白昼平均舒张压、夜间平均收缩压、夜间平均舒张压水平降低,观察组较对照组低(P<0.05);治疗后,两组匹兹堡睡眠质量指数评分降低,观察组较对照组低(P<0.001)。结论:癫狂梦醒汤治疗非杓型高血压伴失眠的效果较好,可有效降低患者血压水平,改善睡眠质量。 展开更多
关键词 非杓型高血压 失眠 癫狂梦醒汤 睡眠质量
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基于网络药理学探讨益气活血通脉方治疗反杓型高血压的分子机制 被引量:1
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作者 缪慧慧 刘中勇 +1 位作者 唐娜娜 徐媛媛 《中西医结合心脑血管病杂志》 2025年第18期2721-2732,共12页
目的:基于网络药理学方法探讨益气活血通脉方治疗反杓型高血压的潜在作用机制。方法:应用中药系统药理学数据库与分析平台(TCMSP)、BATMAN-TCM数据库、PubChem数据库、Swiss Target Prediction数据库筛选益气活血通脉方药物的生物活性成... 目的:基于网络药理学方法探讨益气活血通脉方治疗反杓型高血压的潜在作用机制。方法:应用中药系统药理学数据库与分析平台(TCMSP)、BATMAN-TCM数据库、PubChem数据库、Swiss Target Prediction数据库筛选益气活血通脉方药物的生物活性成分,并预测其靶点。应用DisGeNET、GeneCards、OMIM数据库收集反杓型高血压的相关靶点。利用Venny 2.1软件对益气活血通脉方与反杓型高血压的靶点进行映射,获得药物-疾病共同靶点,并绘制韦恩图,构建“药物-成分-交集靶点”网络图,筛选获得核心活性成分。运用STRING数据库及Cytoscape 3.9.1软件构建蛋白-蛋白互作(PPI)网络,筛选获得核心靶点。应用DAVID数据库进行药物-疾病共有靶基因的基因本体(GO)功能注释、京都基因与基因组百科全书(KEGG)通路富集分析。结果:从益气活血通脉方中筛选出109个化合物、1256个靶点,反杓型高血压靶点1231个、交集靶点313个、关键靶点11个。GO富集分析获得生物过程1202个、细胞组分125个、分子功能225个;KEGG富集分析得到信号通路189条。益气活血通脉方干预反杓型高血压可能涉及的靶点包括胰岛素(INS)、白细胞介素-6(IL6)、肿瘤蛋白53(TP53)、转录激活因子3(STAT3)、酪氨酸激酶(SRC)等,涉及的信号通路包括糖尿病并发症中的糖基化终末产物及其受体(AGE-RAGE)信号通路、缺氧诱导因子1(HIF-1)信号通路、钙信号通路、磷脂酰肌醇3激酶-蛋白激酶B(PI3K-AKT)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、Rap1信号通路、催乳素信号通路、松弛素信号通路等。结论:益气活血通脉方治疗反杓型高血压具有多成分、多靶点、多途径的特点与优势,可作为进一步探讨益气活血通脉方治疗反杓型高血压的药效物质及作用机制重要的研究基础。 展开更多
关键词 反杓型高血压 益气活血通脉方 网络药理学 靶点 分子机制
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