Based on the theory of all-for-one tourism,a multi-scale analysis method is adopted to systematically evaluate red tourism resources.At the micro level,red tourism resources are analyzed from five evaluation dimension...Based on the theory of all-for-one tourism,a multi-scale analysis method is adopted to systematically evaluate red tourism resources.At the micro level,red tourism resources are analyzed from five evaluation dimensions:attention,supporting degree,accessibility,relevance,and differentiation;at the macro level,taking districts and counties as the basic units,indicators such as the quantity of red tourism resources in districts and counties,the number of red tourism resources at or above the provincial level,road network density and coverage density of red tourism resources,the average value of individual indicators in five dimensions within districts and counties,economic level,population,and fiscal expenditure are selected.Using entropy weight method,the weight coefficients of each indicator are calculated,and then the development potential of red tourism resources in Nanchang City is scientifically evaluated.At the individual scale,the most important indicators that affect development potential are attention,relevance,and supporting degree.At the global scale,the most important indicators that affect development potential are attention,differentiation,and relevance.The red tourism resources in Nanchang City with the highest comprehensive score are Mao Zedong Thought Victory Museum,Bayi Square,Fang Zhimin Patriotic Theme Education Exhibition Hall,Fang Zhimin Martyrs Cemetery,and Bayi Uprising Memorial Hall.The counties and districts with the highest comprehensive score are Donghu District,Xihu District,and Qingshanhu District.Among the red tourism resources in Nanchang City,only a small portion have a high level of development potential,while the development potential of most individuals and counties is at a moderate level.Moreover,individuals and counties adjacent to the city center generally show more significant development advantages.展开更多
Chemically defined medium is widely used for culturing mouse embryonic stem cells(mESCs),in which N2B27 works as a substitution for serum,and GSK3βand MEK inhibitors(2i)help to promote ground-state pluripo-tency.Howe...Chemically defined medium is widely used for culturing mouse embryonic stem cells(mESCs),in which N2B27 works as a substitution for serum,and GSK3βand MEK inhibitors(2i)help to promote ground-state pluripo-tency.However,recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs.Here,we demon-strated the deficient bone morphogenetic protein(BMP)signal in the chemically defined condition is one of the main causes for the impaired pluripotency.Mechanisti-cally,activating the BMP signal pathway by BMP4 could safeguard the chromosomal integrity and proliferation capacity of mESCs through regulating downstream tar-gets Ube2s and Chmp4b.More importantly,BMP4 pro-motes a distinct in vivo developmental potential and a long-term pluripotency preservation.Besides,the pluripotent improvements driven by BMP4 are superior to those by attenuating MEK suppression.Taken together,our study shows appropriate activation of BMP signal is essential for regulating functional pluripotency and reveals that BMP4 should be applied in the serum-free culture system.展开更多
In the traditional views on developmental biology, the process of a mammal from a zygote to. an adult individual follows continuous changes of space and time environments and is the result of different expressions of ...In the traditional views on developmental biology, the process of a mammal from a zygote to. an adult individual follows continuous changes of space and time environments and is the result of different expressions of target genes. It has long been known that this process is irreversible and the terminal differentiated adult cells, such as cardiac myocytes and neurons, will not divide and differentiate. But recent reports on the two hottest fields - cloning medicine and stem cell biology doubted these concepts. This may lead to a further understanding of the potentiality of mammal development and may provide great chances for commercial and clinical practice.展开更多
To investigate the relationship between the ATP content in human oocytes and the deve-lopmental potential of human oocytes, unfertilized oocytes from clinical IVF and immature oocytes unsuitable for ICSI were collecte...To investigate the relationship between the ATP content in human oocytes and the deve-lopmental potential of human oocytes, unfertilized oocytes from clinical IVF and immature oocytes unsuitable for ICSI were collected. The ATP content of these unfertilized and in vitro matured eggs were determined quantitatively by measuring the luminescence using an ATP-dependent bioluminescence assay. The result showed that the ATP content of unfertilized oocytes was higher than in vitro matured ones (2.20±0.67 pmol vs 1.72±0.49 pmol, P<0.05 ). In unfertilized oocytes, the ATP content of those whose fertilization rates (FR) was higher than 50 % was 2.43±0.60 pmol, which was significantly different from those whose FR was less than 50 % (1.72±0.56 pmol), while in in vitro matured oocytes, the ATP content of those whose FR more than 50 % was 1.8±0.44 pmol, slightly higher than those less than 50 % (1.55±0.40 pmol), without statistical significance. There was a tendency that the ATP content of oocytes of pregnant patients was higher than those of controls, but the sample number was too small to show any significance in statistics. Briefly, there was positive correlation between the ATP content in oocytes and developmental potential of oocytes.展开更多
The containerized traffic has come into being for over forty years and has become the most important mode of sea transportation. Although containerized traffic trade has been developed in port cities of Dalian, Yingko...The containerized traffic has come into being for over forty years and has become the most important mode of sea transportation. Although containerized traffic trade has been developed in port cities of Dalian, Yingkou, Dandong and Jinzhou in Liaoning Province, yet their development sped are obviously slower than the entire national development pace. In the article, the authors make a systematic study on the current situation and the potential developmental possibility of containerized traffic in Liaoning Province. It is held that the relative low proportion of the supply of goods in hinterland is relative low which will restrict directly the development potentiality of the container harbors in Liaoning. Three countermeasures of the containerized traffic development were given accordingly.展开更多
Hainan Island is located in the northwestern South China Sea at the boundary of two tectonic plates.Surface features and actual drilling have confirmed that there are rich geothermal resources in the area,with predict...Hainan Island is located in the northwestern South China Sea at the boundary of two tectonic plates.Surface features and actual drilling have confirmed that there are rich geothermal resources in the area,with predicted resources of 480 million GWh.On the basis of the 1:200,000 gravity and 1:10 aeromagnetic data and constrained by the well-explored Fushan Depression and Baocheng Rock Mass,we conducted a sys-tematic study of hot dry rocks and evaluated the development potential of the geothermal resources of the medium-depth and deep hot dry rocks in Hainan Island for thefirst time.The island is structurally active,with extensive granites,strong volcanic and earthquake activities,and many hot springs,indicating that the geothermal geological conditions are favorable.There are two types of hot dry rocks,sedimentary basin type and uplifted mountain type,on the island.The sedimentary basin-type hot dry rocks are mainly found in the north of the island and have an area of 2657 km^(2),an average depth of 2480 m,and an average heat reservoir temperature of 230℃ at 6000 m depth.Uplifted mountain-type hot dry rocks with a total area of 13,000 km^(2) mainly occur in Danzhou in the north of the island and Baocheng in the south.The heat reservoirs of these rocks are Yanshanian intrusive plutons and the average temperature is 236℃ at 6000 m depth.Nine favorable hot dry rock targets are identified,of whichfive are sedimentary basin types and four are uplifted mountain types.The Fushan and Eman depressions in north Hainan Island and the Baocheng Rock Mass in the south of the island are the preferred exploration targets.展开更多
The‘15-minute city’(15minC)concept,which aspires to bring essential services within reach via a 15-minute walk for all residents,represents a pivotal paradigm shift in sustainable urban development.However,the achie...The‘15-minute city’(15minC)concept,which aspires to bring essential services within reach via a 15-minute walk for all residents,represents a pivotal paradigm shift in sustainable urban development.However,the achievability of this concept for different cities varies considerably across diverse population distributions,urban contexts,and development priorities.In this study,we propose a robust method for evaluating a city’s 15minC potential-a city’s capability to achieve widespread 15-minute accessibility while maintaining an optimal balance between resource efficiency and resident accessibility.We employ the Location Set Covering Problem optimization model to analyze the resources required to achieve full coverage of 15-minute accessibility and the knee point detection algorithm to assess a city’s 15minC potential.Across 23 major Chinese cities,our method exhibits a sharp sensitivity to delineate distinct 15minC potentials.It reveals that cities’current 15minC development level doesn’t align with their inherent potential uniformly.Key determinants include how well current facility locations match population centers and the population density in remote areas.Further,reducing facility constructions by twothirds has only a marginal impact on accessibility,emphasizing the need for tailored,data-driven planning in effective and sustainable urban development based on the distinct potentials of cities.Our approach prioritizes resource efficiency,minimizing the inefficient use of facilities that serve only a small portion of residents while maximizing the benefits of the 15minC and therefore has significant implications for a sustainable urban future.展开更多
The developmental competence of porcine parthenotes cultured in porcine zygote medium-3 （PZM-3） and North Carolina State University-23 （NCSU-23） media was investigated. After in vitro maturation oocytes were elect...The developmental competence of porcine parthenotes cultured in porcine zygote medium-3 （PZM-3） and North Carolina State University-23 （NCSU-23） media was investigated. After in vitro maturation oocytes were electro-activated, and the subsequent developmental competence, rates of apoptotic, fragmented and arrested embryos from the two media were evaluated. Also, the ratio of mRNA expression of Bcl-2 and Bax gene was determined. Results demonstrated that cleavage, blastocyst, hatched blastocyst rates, and blastocyst cell numbers were significantly higher in PZM-3 than in NCSU-23. The rate of fragmented embryos in PZM-3 was lower than in NCSU-23 on d 1 and 3 （P〈0.05） while the percentage of arrested embryo was lower in PZM-3 than in NCSU-23 on d 4 and 5 （P〈0.05）. TUNEL positive signals were higher in NCSU-23 than in PZM-3 from d 3 to 7 （P〈0.05）. The ratios of Bcl-2 and Bax mRNA expression in embryos were higher on d 5 than on d 3 and 1 in PZM-3 （P〈0.05）. In contrast, the ratios of Bcl-2 and Bax mRNA expression in embryos on d 1 were higher than on d 3 and 5 in NCSU-23 （P〈0.05）. Additionally, the ratios of Bcl-2 and Bax mRNA expression in embryos in PZM-3 were higher than in NCSU-23 on d 3 and 5 （P〈0.05）. In conclusion, lower apoptotic embryo rates and down-regulating Bax together with up-regulating expression of Bcl-2 transcripts may be responsible for the better developmental competence of porcine parthenotes in PZM-3.展开更多
[Objective] The aim was to make analysis on natural condition,present situation,and potential of rice production development in Angola.[Method] Conclusion and analysis of rice development in Angola were conducted from...[Objective] The aim was to make analysis on natural condition,present situation,and potential of rice production development in Angola.[Method] Conclusion and analysis of rice development in Angola were conducted from natural condition,production status,present problem and development potential.[Result] In Angola,about 30 million hectares agricultural lands enjoy fresh water,temperature,and light resources which are requirement for rice development.Presently,however,some disadvantages have harassed the nation,such as outdated production mode and technology,small cultivated area and low level of per unit yield.In addition,about 98% of consumed rice was imported from other countries.The government has attached high importance to food production,and rice production was a priority of national investment.Per unit rice yield would achieve 7 500 kg/hm2 if Angola introduces hybrid rice species and high-yield cultivation techniques from China.[Conclusion] The research provided technical reference for enterprises or individuals ready to invest in rice development in Angola.展开更多
Based on the characteristics of agricultural resources and social resources in Shandong Province, the approaches of developing farming system potential were discussed, which provide important references for sustainabl...Based on the characteristics of agricultural resources and social resources in Shandong Province, the approaches of developing farming system potential were discussed, which provide important references for sustainable development of modern farming system.展开更多
With the advent of the era of big data and artificial intelligence, new infrastructure construction(NIC) has attracted the attention of many countries. The development of NIC provides an opportunity to bridge the digi...With the advent of the era of big data and artificial intelligence, new infrastructure construction(NIC) has attracted the attention of many countries. The development of NIC provides an opportunity to bridge the digital divide and narrow the regional gap,providing continuous impetus to further promote economic development. Here, we considered 31 provincial-level administrative units in China(not including Hong Kong, Macao, and Taiwan of China due to data unavailable) and established comprehensive evaluation indicators for the development potential of NIC. Afterward, we used the entropy-weight TOPSIS model to determine the development potential of NIC and analyze its spatio-temporal evolution characteristics. Furthermore, the GeoDetector model was applied to explore the driving mechanism of the NIC development potential. The conclusions were as follows: (1) The Chinese NIC development potential is generally low. The eastern China was the region with the highest development potential year by year, while the development potential in the central China was found to be in an accelerating phase. (2) The evolution of the Chinese NIC development potential’s spatial pattern has been characterized by an inland extension and coastal agglomeration. Moreover, we identified a superior development zone, a rising development zone, an inferior development zone, and a declining development zone. (3) The scope of Chinese NIC development potential agglomeration areas has gradually expanded and its degree has gradually deepened. The range of high-value agglomeration in eastern area gradually expanded and its degree gradually deepened. (4) Investment in innovative talents appears as the core factor affecting the Chinese NIC development potential. Whether acting alone or synergistically with other factors, its promoting effect on Chinese NIC development potential is the strongest.展开更多
With the objectives to acquire the fundamental dat a of the territorial resource, understand the impacts of human activit ies on the land use and cover patterns and evaluate the potential of the future exploitation, a...With the objectives to acquire the fundamental dat a of the territorial resource, understand the impacts of human activit ies on the land use and cover patterns and evaluate the potential of the future exploitation, an intensive land cover classification with an accuracy of 93% has been completed for North Ningxia by remote sen sing technique based on the adoption of a combination method composed o f texture training, maximum likelihood classification and post-processing such as re-allocation and aggregation. This classification result was incorporated with the contemporaneous socio-economic and meteorological d ata for cross-sectional regression modelling to reveal the spatial dete rminants of the land cover patterns and understand the human-environmen tal relationships. A tentative evaluation on the potential of soil exp loitation in the near future was carried out in combination with our land use and cover change detection results aiming at supplying some useful references for the central and local governments in their sustainable l and use planning.展开更多
Based on an investigation of the meaning of development, the neo-classical economic approach to development, and the post-welfarist theory of development, this paper proposes a conceptual framework for understanding h...Based on an investigation of the meaning of development, the neo-classical economic approach to development, and the post-welfarist theory of development, this paper proposes a conceptual framework for understanding human development potentials, while undertaking empirical analysis using cross-sectional and time series data on human development. Human development is associated with basic necessities for subsistence, the quality of life, and political and civil rights, in addition to income indicators. Our analysis suggests that the concept of human development potentials has two dimensions: the rights of development and limits to human development. Both are largely ignored in the neoclassical theory of development. However, human development is not unbounded, which approaches to a relatively fixed constant at given economic, technological and institutional conditions. This conceptual understanding is supported by results from the empirical examination of the relationships between demands for carbon展开更多
Traditional music is an important component of cultural heritage.However,studies have scarcely explored the tourism development potential and the obstacle factors of traditional music.This study takes Xiangxi as the r...Traditional music is an important component of cultural heritage.However,studies have scarcely explored the tourism development potential and the obstacle factors of traditional music.This study takes Xiangxi as the research site,constructs an evaluation index system,and utilizes survey and geographical methods.The major research results are as follows:First,the average potential of resource endowment,tourism industry development,and socio-economic conditions are 0.28,0.36,and 0.24,respectively.The potential of resource endowment is higher in the west and lower in the east,that of tourism industry development is higher in the north and south and lower in the center,and that of socio-economic conditions is higher in the south and lower in the north.Second,the comprehensive potential is 0.29,which is higher in the northwest and southwest regions.Coordination in most administrative units is at a medium level,and most regions have obvious advantages in resource endowment.Third,the primary obstacle factor is socio-economic conditions(39.21%),followed by resource endowment(30.73%)and tourism industry development(30.06%).The administrative units can be classified into four groups:socio-economic condition obstacle,resource endowment and tourism industry development obstacles,resource endowment and socio-economic condition obstacles,and tourism industry development and socio-economic condition obstacles.The highest priority goals for Xiangxi involve economic development and the integration of modern technologies to stimulate passenger flow.For reg traditional music items(eastern area of Xiangxi),tourism development should be restrained and other resources with stronger inherent advantages should be exploited.This study explored the quantification of traditional music tourism potential,representing a novel breakthrough in this field of research.The indicator system and research methods used in this study can provide guidance and methodological references for cultural heritage research.The suggestions proposed in this article contribute to the rational development and effective protection of cultural heritage resources and the healthy development of the tourism industry.展开更多
This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas prod...This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas production between regions/countries,and the development potentials of oil and gas fields unproduced and to be produced in 2023.On this basis,the situation and characteristics of global oil and gas development are expounded,and the trend of global oil and gas development is summarized.In 2023,upstream oil and gas production landscape is expanding,and the number of oil and gas fields in production is increasing significantly;oil and gas recoverable reserves increased year-on-year,driven by significant contributions from new discoveries and reserve re-estimates;the overall oil and gas production grew continuously,with notable contributions from new projects coming online and capacity expansion efforts;and the oil and gas fields unproduced or to be produced,especially large onshore conventional oil fields and economically challenging offshore gas fields,host abundant recoverable reserves.From the perspectives of reshaping oil and gas production areas due to the pandemic and Russia-Ukraine conflicts,geopolitical crises,capital expenditure structures in petroleum exploration and development,and the proactive layout of oil and gas associated resources,the trend of global oil and gas development in 2023 was analyzed systematically.The enlightenment and suggestions in four aspects are proposed for Chinese oil companies to focus on core businesses and clarify development strategies in the post-pandemic era and the context of energy transition:The global oil and gas landscape is undergoing profound adjustments,and it is essential to grasp development trends,especially in core businesses;upstream business exhibits a strong potential,and emerging fields are considered as new growth poles;the prospects for tight/shale oil and gas are promising,and new pathways to ensure national energy security are explored;cutting-edge breakthroughs are achieved in emerging industries of strategic importance,and a comprehensive energy collaboration system for supply security is established.展开更多
Western Guizhou is a favorable region for coalbed methane(CBM)exploration and development in Guizhou Province.Affected by complex geological conditions,the heterogeneity of middle-high rank coal reservoirs is strong,a...Western Guizhou is a favorable region for coalbed methane(CBM)exploration and development in Guizhou Province.Affected by complex geological conditions,the heterogeneity of middle-high rank coal reservoirs is strong,and the geological and engineering control effects on enrichment and high productivity of CBM are significantly different.This paper comparatively analyzes the characteristics of middle-and high-rank coal reservoirs in the western Guizhou region,revealing the productivity characteristics and gas/water production rules of typical middle-high rank CBM high-yield wells.Moreover,it establishes a geological-engineering control model for the enrichment and high productivity of CBM in middle-high-rank coal seams in the western Guizhou region and analyzes the exploration and development potential and direction of middle-high-rank CBM in the region.The results are as follows.First,the middle-rank coal in the western Guizhou region is represented by the Liupanshui coalfield,where cleats and fractures are well developed,the content of macropores and mesopores is relatively high,the permeability is good,and the adsorption capacity is relatively weak.The high-rank coal is represented by the Zhina coalfield,where micropores are well developed,the permeability is greatly affected by burial depth,and the adsorption capacity is strong.Second,the difference in the characteristics of middle-rank and high-rank coal reservoirs in the western Guizhou region is mainly reflected in the pore-permeability conditions and adsorption capacity.The porosity and permeability of middle-rank coal samples are both greater than those of high-rank coal samples,and the development of secondary microfractures is the main reason for the relatively high permeability of middle-rank coal,while the well-developed micropores in high-rank coal provide more space for CBM preservation.Third,the CBM highyield wells in middle-rank coal seams in the western Guizhou region have the characteristics of“relatively high water production and high gas production,”while those of high-rank coal seams have the characteristics of“low water production and high gas production”or“high water production and low gas production.”The gas content and permeability of the coal reservoirs are the common constraints on whether CBM in middle-high rank coal seams can be highly productive under complex geological conditions.Fourth,the enrichment and high productivity of CBM in middle-high rank coal seams under complex geological conditions is the result of the synergistic matching of depth structure hydrology and adaptive fracturing production techniques.The CBM enrichment model,reservoir reformability,and gas/water production characteristics under geological and engineering synergistic control are unique and complex.Fifth,the middle-high rank coal seams in the western Guizhou region exhibit the basic resource characteristics of high gas content and high CBM resource abundance.Carrying out a precise evaluation of the CBM dual sweet spot system and reservoir volume stimulation are important guarantees for the efficient exploration and development of CBM in the western Guizhou region.展开更多
Cultural heritage in the Yellow River Basin,as the product of harmonious human-land co-existence,is an important component of both the linear natural ecological landscape and the historic corridor.Focusing on the line...Cultural heritage in the Yellow River Basin,as the product of harmonious human-land co-existence,is an important component of both the linear natural ecological landscape and the historic corridor.Focusing on the linear historic space in the Shaanxi section of the Yellow River Basin,this study employs quantitative analysis methods to assess the development potential of cultural heritage resources in the river basin,based on surveys,identification,and selection of cultural heritage sites in this region.The assessment considers multiple dimensions,including resource endowment,spatial distribution,economic-industrial foundation,transportation accessibility,and ecological environment.On this basis,the paper proposes protection and development strategies for the basin's cultural heritage from five perspectives:settlement heritage protection,spatial structure delineation,transportation and touring route planning,tourism system construction,and ecological protection and governance,in the hope of providing new insights for the high-quality development of the Yellow River National Cultural Park.展开更多
Urban fringe areas are faced with remarkable contradictions between land supply and demand due to a lack of scientific planning.Rural hollowing is accompanied by a shortage of urban land,resulting in a loss of both la...Urban fringe areas are faced with remarkable contradictions between land supply and demand due to a lack of scientific planning.Rural hollowing is accompanied by a shortage of urban land,resulting in a loss of both land and employment for farmers as well as a destruction to the distinctive features of urban fringe villages.Therefore,it is necessary to explore a set of planning methods for urban fringe villages to satisfy the needs of urban and rural development.Firstly,this paper carries out a literature review on the evaluation of village development potential and the main factors affecting the development of urban fringe villages.Based on previous studies,the paper establishes a development potential evaluation system for urban fringe villages,employing the Analytic Hierarchy Process(AHP)method.In the end,taking the Shenshan Special Cooperation Zone as an example,the paper presents the types of village development and the corresponding planning strategies based on the results of village development potential evaluation.展开更多
基金Sponsored by the Humanities and Social Sciences Research Project in Jiangxi Province’s Universities(YS23104).
文摘Based on the theory of all-for-one tourism,a multi-scale analysis method is adopted to systematically evaluate red tourism resources.At the micro level,red tourism resources are analyzed from five evaluation dimensions:attention,supporting degree,accessibility,relevance,and differentiation;at the macro level,taking districts and counties as the basic units,indicators such as the quantity of red tourism resources in districts and counties,the number of red tourism resources at or above the provincial level,road network density and coverage density of red tourism resources,the average value of individual indicators in five dimensions within districts and counties,economic level,population,and fiscal expenditure are selected.Using entropy weight method,the weight coefficients of each indicator are calculated,and then the development potential of red tourism resources in Nanchang City is scientifically evaluated.At the individual scale,the most important indicators that affect development potential are attention,relevance,and supporting degree.At the global scale,the most important indicators that affect development potential are attention,differentiation,and relevance.The red tourism resources in Nanchang City with the highest comprehensive score are Mao Zedong Thought Victory Museum,Bayi Square,Fang Zhimin Patriotic Theme Education Exhibition Hall,Fang Zhimin Martyrs Cemetery,and Bayi Uprising Memorial Hall.The counties and districts with the highest comprehensive score are Donghu District,Xihu District,and Qingshanhu District.Among the red tourism resources in Nanchang City,only a small portion have a high level of development potential,while the development potential of most individuals and counties is at a moderate level.Moreover,individuals and counties adjacent to the city center generally show more significant development advantages.
基金This work was supported by the National Key R&D Program of China(2020YFA0112500 and 2021YFA1100300)the National Natural Science Foundation of China(31721003,31820103009,92168205,32070857 and 31871446)+3 种基金the Young Elite Scientist Sponsorship Program by CAST(2018QNRC001)the key project of the Science and Technology of Shanghai Municipality(19JC1415300)the Shanghai Rising-Star Program(19QA1409600)the Shanghai municipal medical and health discipline construction projects(no.2017ZZ02015).
文摘Chemically defined medium is widely used for culturing mouse embryonic stem cells(mESCs),in which N2B27 works as a substitution for serum,and GSK3βand MEK inhibitors(2i)help to promote ground-state pluripo-tency.However,recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs.Here,we demon-strated the deficient bone morphogenetic protein(BMP)signal in the chemically defined condition is one of the main causes for the impaired pluripotency.Mechanisti-cally,activating the BMP signal pathway by BMP4 could safeguard the chromosomal integrity and proliferation capacity of mESCs through regulating downstream tar-gets Ube2s and Chmp4b.More importantly,BMP4 pro-motes a distinct in vivo developmental potential and a long-term pluripotency preservation.Besides,the pluripotent improvements driven by BMP4 are superior to those by attenuating MEK suppression.Taken together,our study shows appropriate activation of BMP signal is essential for regulating functional pluripotency and reveals that BMP4 should be applied in the serum-free culture system.
基金This work was supported by the "973" Project (Grant No. G1999054205).
文摘In the traditional views on developmental biology, the process of a mammal from a zygote to. an adult individual follows continuous changes of space and time environments and is the result of different expressions of target genes. It has long been known that this process is irreversible and the terminal differentiated adult cells, such as cardiac myocytes and neurons, will not divide and differentiate. But recent reports on the two hottest fields - cloning medicine and stem cell biology doubted these concepts. This may lead to a further understanding of the potentiality of mammal development and may provide great chances for commercial and clinical practice.
文摘To investigate the relationship between the ATP content in human oocytes and the deve-lopmental potential of human oocytes, unfertilized oocytes from clinical IVF and immature oocytes unsuitable for ICSI were collected. The ATP content of these unfertilized and in vitro matured eggs were determined quantitatively by measuring the luminescence using an ATP-dependent bioluminescence assay. The result showed that the ATP content of unfertilized oocytes was higher than in vitro matured ones (2.20±0.67 pmol vs 1.72±0.49 pmol, P<0.05 ). In unfertilized oocytes, the ATP content of those whose fertilization rates (FR) was higher than 50 % was 2.43±0.60 pmol, which was significantly different from those whose FR was less than 50 % (1.72±0.56 pmol), while in in vitro matured oocytes, the ATP content of those whose FR more than 50 % was 1.8±0.44 pmol, slightly higher than those less than 50 % (1.55±0.40 pmol), without statistical significance. There was a tendency that the ATP content of oocytes of pregnant patients was higher than those of controls, but the sample number was too small to show any significance in statistics. Briefly, there was positive correlation between the ATP content in oocytes and developmental potential of oocytes.
文摘The containerized traffic has come into being for over forty years and has become the most important mode of sea transportation. Although containerized traffic trade has been developed in port cities of Dalian, Yingkou, Dandong and Jinzhou in Liaoning Province, yet their development sped are obviously slower than the entire national development pace. In the article, the authors make a systematic study on the current situation and the potential developmental possibility of containerized traffic in Liaoning Province. It is held that the relative low proportion of the supply of goods in hinterland is relative low which will restrict directly the development potentiality of the container harbors in Liaoning. Three countermeasures of the containerized traffic development were given accordingly.
基金Research on Exploration and Evaluation of hot dry rock Resources and Target Area Preference(No.2023-HNKT-001)This article is sponsored by the New Energy Technology Development and Application Research Project No.2022DJ5503.
文摘Hainan Island is located in the northwestern South China Sea at the boundary of two tectonic plates.Surface features and actual drilling have confirmed that there are rich geothermal resources in the area,with predicted resources of 480 million GWh.On the basis of the 1:200,000 gravity and 1:10 aeromagnetic data and constrained by the well-explored Fushan Depression and Baocheng Rock Mass,we conducted a sys-tematic study of hot dry rocks and evaluated the development potential of the geothermal resources of the medium-depth and deep hot dry rocks in Hainan Island for thefirst time.The island is structurally active,with extensive granites,strong volcanic and earthquake activities,and many hot springs,indicating that the geothermal geological conditions are favorable.There are two types of hot dry rocks,sedimentary basin type and uplifted mountain type,on the island.The sedimentary basin-type hot dry rocks are mainly found in the north of the island and have an area of 2657 km^(2),an average depth of 2480 m,and an average heat reservoir temperature of 230℃ at 6000 m depth.Uplifted mountain-type hot dry rocks with a total area of 13,000 km^(2) mainly occur in Danzhou in the north of the island and Baocheng in the south.The heat reservoirs of these rocks are Yanshanian intrusive plutons and the average temperature is 236℃ at 6000 m depth.Nine favorable hot dry rock targets are identified,of whichfive are sedimentary basin types and four are uplifted mountain types.The Fushan and Eman depressions in north Hainan Island and the Baocheng Rock Mass in the south of the island are the preferred exploration targets.
基金supported by grants from the Hong Kong Research Grants Council(General Research Fund Grants No.14605920,14611621,14606922,14603724Collaborative Research Fund Grant No.C4023-20GF+2 种基金Research Matching Grants No.8601219,8601242,3110156)a grant from the Research Committee on Research Sustainability of Major Research Grants Council Funding Schemes(Grant No.3133235)of the Chinese University of Hong Kongfunding from the Improvement on Competitiveness in Hiring New Faculties Funding Scheme of The Chinese University of Hong Kong.
文摘The‘15-minute city’(15minC)concept,which aspires to bring essential services within reach via a 15-minute walk for all residents,represents a pivotal paradigm shift in sustainable urban development.However,the achievability of this concept for different cities varies considerably across diverse population distributions,urban contexts,and development priorities.In this study,we propose a robust method for evaluating a city’s 15minC potential-a city’s capability to achieve widespread 15-minute accessibility while maintaining an optimal balance between resource efficiency and resident accessibility.We employ the Location Set Covering Problem optimization model to analyze the resources required to achieve full coverage of 15-minute accessibility and the knee point detection algorithm to assess a city’s 15minC potential.Across 23 major Chinese cities,our method exhibits a sharp sensitivity to delineate distinct 15minC potentials.It reveals that cities’current 15minC development level doesn’t align with their inherent potential uniformly.Key determinants include how well current facility locations match population centers and the population density in remote areas.Further,reducing facility constructions by twothirds has only a marginal impact on accessibility,emphasizing the need for tailored,data-driven planning in effective and sustainable urban development based on the distinct potentials of cities.Our approach prioritizes resource efficiency,minimizing the inefficient use of facilities that serve only a small portion of residents while maximizing the benefits of the 15minC and therefore has significant implications for a sustainable urban future.
基金funded by the National Natural Science Foundation of China (31072031)the Key Research Program of Ministry of Education of China(109018)
文摘The developmental competence of porcine parthenotes cultured in porcine zygote medium-3 （PZM-3） and North Carolina State University-23 （NCSU-23） media was investigated. After in vitro maturation oocytes were electro-activated, and the subsequent developmental competence, rates of apoptotic, fragmented and arrested embryos from the two media were evaluated. Also, the ratio of mRNA expression of Bcl-2 and Bax gene was determined. Results demonstrated that cleavage, blastocyst, hatched blastocyst rates, and blastocyst cell numbers were significantly higher in PZM-3 than in NCSU-23. The rate of fragmented embryos in PZM-3 was lower than in NCSU-23 on d 1 and 3 （P〈0.05） while the percentage of arrested embryo was lower in PZM-3 than in NCSU-23 on d 4 and 5 （P〈0.05）. TUNEL positive signals were higher in NCSU-23 than in PZM-3 from d 3 to 7 （P〈0.05）. The ratios of Bcl-2 and Bax mRNA expression in embryos were higher on d 5 than on d 3 and 1 in PZM-3 （P〈0.05）. In contrast, the ratios of Bcl-2 and Bax mRNA expression in embryos on d 1 were higher than on d 3 and 5 in NCSU-23 （P〈0.05）. Additionally, the ratios of Bcl-2 and Bax mRNA expression in embryos in PZM-3 were higher than in NCSU-23 on d 3 and 5 （P〈0.05）. In conclusion, lower apoptotic embryo rates and down-regulating Bax together with up-regulating expression of Bcl-2 transcripts may be responsible for the better developmental competence of porcine parthenotes in PZM-3.
基金Supportd by Science and Technology Cooperation Project of Anhui Science and Technology Department (11030603031)~~
文摘[Objective] The aim was to make analysis on natural condition,present situation,and potential of rice production development in Angola.[Method] Conclusion and analysis of rice development in Angola were conducted from natural condition,production status,present problem and development potential.[Result] In Angola,about 30 million hectares agricultural lands enjoy fresh water,temperature,and light resources which are requirement for rice development.Presently,however,some disadvantages have harassed the nation,such as outdated production mode and technology,small cultivated area and low level of per unit yield.In addition,about 98% of consumed rice was imported from other countries.The government has attached high importance to food production,and rice production was a priority of national investment.Per unit rice yield would achieve 7 500 kg/hm2 if Angola introduces hybrid rice species and high-yield cultivation techniques from China.[Conclusion] The research provided technical reference for enterprises or individuals ready to invest in rice development in Angola.
基金Supported by the Scientific Research Project of Public Welfare Industry(Agriculture)(201103001)the Domestic Visiting Scholar Program for Excellent Young Teachers of Shandong Province 2009~~
文摘Based on the characteristics of agricultural resources and social resources in Shandong Province, the approaches of developing farming system potential were discussed, which provide important references for sustainable development of modern farming system.
文摘With the advent of the era of big data and artificial intelligence, new infrastructure construction(NIC) has attracted the attention of many countries. The development of NIC provides an opportunity to bridge the digital divide and narrow the regional gap,providing continuous impetus to further promote economic development. Here, we considered 31 provincial-level administrative units in China(not including Hong Kong, Macao, and Taiwan of China due to data unavailable) and established comprehensive evaluation indicators for the development potential of NIC. Afterward, we used the entropy-weight TOPSIS model to determine the development potential of NIC and analyze its spatio-temporal evolution characteristics. Furthermore, the GeoDetector model was applied to explore the driving mechanism of the NIC development potential. The conclusions were as follows: (1) The Chinese NIC development potential is generally low. The eastern China was the region with the highest development potential year by year, while the development potential in the central China was found to be in an accelerating phase. (2) The evolution of the Chinese NIC development potential’s spatial pattern has been characterized by an inland extension and coastal agglomeration. Moreover, we identified a superior development zone, a rising development zone, an inferior development zone, and a declining development zone. (3) The scope of Chinese NIC development potential agglomeration areas has gradually expanded and its degree has gradually deepened. The range of high-value agglomeration in eastern area gradually expanded and its degree gradually deepened. (4) Investment in innovative talents appears as the core factor affecting the Chinese NIC development potential. Whether acting alone or synergistically with other factors, its promoting effect on Chinese NIC development potential is the strongest.
基金The Sino-Belgian co-operation project on Northwest China funded by the Federal Office for the Scientific, Technical and Cultural Affairs (OSTC) of the Belgium Government, No.BL/10/C15
文摘With the objectives to acquire the fundamental dat a of the territorial resource, understand the impacts of human activit ies on the land use and cover patterns and evaluate the potential of the future exploitation, an intensive land cover classification with an accuracy of 93% has been completed for North Ningxia by remote sen sing technique based on the adoption of a combination method composed o f texture training, maximum likelihood classification and post-processing such as re-allocation and aggregation. This classification result was incorporated with the contemporaneous socio-economic and meteorological d ata for cross-sectional regression modelling to reveal the spatial dete rminants of the land cover patterns and understand the human-environmen tal relationships. A tentative evaluation on the potential of soil exp loitation in the near future was carried out in combination with our land use and cover change detection results aiming at supplying some useful references for the central and local governments in their sustainable l and use planning.
文摘Based on an investigation of the meaning of development, the neo-classical economic approach to development, and the post-welfarist theory of development, this paper proposes a conceptual framework for understanding human development potentials, while undertaking empirical analysis using cross-sectional and time series data on human development. Human development is associated with basic necessities for subsistence, the quality of life, and political and civil rights, in addition to income indicators. Our analysis suggests that the concept of human development potentials has two dimensions: the rights of development and limits to human development. Both are largely ignored in the neoclassical theory of development. However, human development is not unbounded, which approaches to a relatively fixed constant at given economic, technological and institutional conditions. This conceptual understanding is supported by results from the empirical examination of the relationships between demands for carbon
基金Project of Hunan Provincial Social Science Achievement Evaluation Committee,No.XSP2023GLC023Excellent Youth Program of the Education Department of Hunan Province,No.22B0692+2 种基金National Natural Science Fundation of China,No.41971191,No.42171213Project of Hunan University of Arts and Science,No.22BSQD15Project of Henan Philosophy and Social Sciences,No.2022BJJ026。
文摘Traditional music is an important component of cultural heritage.However,studies have scarcely explored the tourism development potential and the obstacle factors of traditional music.This study takes Xiangxi as the research site,constructs an evaluation index system,and utilizes survey and geographical methods.The major research results are as follows:First,the average potential of resource endowment,tourism industry development,and socio-economic conditions are 0.28,0.36,and 0.24,respectively.The potential of resource endowment is higher in the west and lower in the east,that of tourism industry development is higher in the north and south and lower in the center,and that of socio-economic conditions is higher in the south and lower in the north.Second,the comprehensive potential is 0.29,which is higher in the northwest and southwest regions.Coordination in most administrative units is at a medium level,and most regions have obvious advantages in resource endowment.Third,the primary obstacle factor is socio-economic conditions(39.21%),followed by resource endowment(30.73%)and tourism industry development(30.06%).The administrative units can be classified into four groups:socio-economic condition obstacle,resource endowment and tourism industry development obstacles,resource endowment and socio-economic condition obstacles,and tourism industry development and socio-economic condition obstacles.The highest priority goals for Xiangxi involve economic development and the integration of modern technologies to stimulate passenger flow.For reg traditional music items(eastern area of Xiangxi),tourism development should be restrained and other resources with stronger inherent advantages should be exploited.This study explored the quantification of traditional music tourism potential,representing a novel breakthrough in this field of research.The indicator system and research methods used in this study can provide guidance and methodological references for cultural heritage research.The suggestions proposed in this article contribute to the rational development and effective protection of cultural heritage resources and the healthy development of the tourism industry.
基金Supported by the Petro China Scientific Research and Technology Development Project(2023SC0105)。
文摘This paper presents an analysis of four aspects,including the distribution and production of global oil and gas fields,the distribution and changes of remaining recoverable reserves,the differences in oil and gas production between regions/countries,and the development potentials of oil and gas fields unproduced and to be produced in 2023.On this basis,the situation and characteristics of global oil and gas development are expounded,and the trend of global oil and gas development is summarized.In 2023,upstream oil and gas production landscape is expanding,and the number of oil and gas fields in production is increasing significantly;oil and gas recoverable reserves increased year-on-year,driven by significant contributions from new discoveries and reserve re-estimates;the overall oil and gas production grew continuously,with notable contributions from new projects coming online and capacity expansion efforts;and the oil and gas fields unproduced or to be produced,especially large onshore conventional oil fields and economically challenging offshore gas fields,host abundant recoverable reserves.From the perspectives of reshaping oil and gas production areas due to the pandemic and Russia-Ukraine conflicts,geopolitical crises,capital expenditure structures in petroleum exploration and development,and the proactive layout of oil and gas associated resources,the trend of global oil and gas development in 2023 was analyzed systematically.The enlightenment and suggestions in four aspects are proposed for Chinese oil companies to focus on core businesses and clarify development strategies in the post-pandemic era and the context of energy transition:The global oil and gas landscape is undergoing profound adjustments,and it is essential to grasp development trends,especially in core businesses;upstream business exhibits a strong potential,and emerging fields are considered as new growth poles;the prospects for tight/shale oil and gas are promising,and new pathways to ensure national energy security are explored;cutting-edge breakthroughs are achieved in emerging industries of strategic importance,and a comprehensive energy collaboration system for supply security is established.
基金supported by the“Belt and Road”Innovation Cooperation Project of Jiangsu Province(Grant No.BZ2022015)the National Natural Science Foundation of China(No.42030810 and 42102207)Geological Exploration Foundation of Guizhou Province(No.52000021MGQSE7S7K6PRP).
文摘Western Guizhou is a favorable region for coalbed methane(CBM)exploration and development in Guizhou Province.Affected by complex geological conditions,the heterogeneity of middle-high rank coal reservoirs is strong,and the geological and engineering control effects on enrichment and high productivity of CBM are significantly different.This paper comparatively analyzes the characteristics of middle-and high-rank coal reservoirs in the western Guizhou region,revealing the productivity characteristics and gas/water production rules of typical middle-high rank CBM high-yield wells.Moreover,it establishes a geological-engineering control model for the enrichment and high productivity of CBM in middle-high-rank coal seams in the western Guizhou region and analyzes the exploration and development potential and direction of middle-high-rank CBM in the region.The results are as follows.First,the middle-rank coal in the western Guizhou region is represented by the Liupanshui coalfield,where cleats and fractures are well developed,the content of macropores and mesopores is relatively high,the permeability is good,and the adsorption capacity is relatively weak.The high-rank coal is represented by the Zhina coalfield,where micropores are well developed,the permeability is greatly affected by burial depth,and the adsorption capacity is strong.Second,the difference in the characteristics of middle-rank and high-rank coal reservoirs in the western Guizhou region is mainly reflected in the pore-permeability conditions and adsorption capacity.The porosity and permeability of middle-rank coal samples are both greater than those of high-rank coal samples,and the development of secondary microfractures is the main reason for the relatively high permeability of middle-rank coal,while the well-developed micropores in high-rank coal provide more space for CBM preservation.Third,the CBM highyield wells in middle-rank coal seams in the western Guizhou region have the characteristics of“relatively high water production and high gas production,”while those of high-rank coal seams have the characteristics of“low water production and high gas production”or“high water production and low gas production.”The gas content and permeability of the coal reservoirs are the common constraints on whether CBM in middle-high rank coal seams can be highly productive under complex geological conditions.Fourth,the enrichment and high productivity of CBM in middle-high rank coal seams under complex geological conditions is the result of the synergistic matching of depth structure hydrology and adaptive fracturing production techniques.The CBM enrichment model,reservoir reformability,and gas/water production characteristics under geological and engineering synergistic control are unique and complex.Fifth,the middle-high rank coal seams in the western Guizhou region exhibit the basic resource characteristics of high gas content and high CBM resource abundance.Carrying out a precise evaluation of the CBM dual sweet spot system and reservoir volume stimulation are important guarantees for the efficient exploration and development of CBM in the western Guizhou region.
基金funded by the Annual Special Program of Shaanxi Province Philosophy and Social Sciences Research(No.2025QN0638)the Fundamental Research Funds for the Central Universities(No.300102415107)。
文摘Cultural heritage in the Yellow River Basin,as the product of harmonious human-land co-existence,is an important component of both the linear natural ecological landscape and the historic corridor.Focusing on the linear historic space in the Shaanxi section of the Yellow River Basin,this study employs quantitative analysis methods to assess the development potential of cultural heritage resources in the river basin,based on surveys,identification,and selection of cultural heritage sites in this region.The assessment considers multiple dimensions,including resource endowment,spatial distribution,economic-industrial foundation,transportation accessibility,and ecological environment.On this basis,the paper proposes protection and development strategies for the basin's cultural heritage from five perspectives:settlement heritage protection,spatial structure delineation,transportation and touring route planning,tourism system construction,and ecological protection and governance,in the hope of providing new insights for the high-quality development of the Yellow River National Cultural Park.
基金funded by the projects of the National Social Science(No.20FGLB057)the Natural Science Foundation of Guangdong Province(No.17YJAZH059)the Shenzhen Philosophy and Social Sciences Planning Annual Project(No.SZ2024B005)。
文摘Urban fringe areas are faced with remarkable contradictions between land supply and demand due to a lack of scientific planning.Rural hollowing is accompanied by a shortage of urban land,resulting in a loss of both land and employment for farmers as well as a destruction to the distinctive features of urban fringe villages.Therefore,it is necessary to explore a set of planning methods for urban fringe villages to satisfy the needs of urban and rural development.Firstly,this paper carries out a literature review on the evaluation of village development potential and the main factors affecting the development of urban fringe villages.Based on previous studies,the paper establishes a development potential evaluation system for urban fringe villages,employing the Analytic Hierarchy Process(AHP)method.In the end,taking the Shenshan Special Cooperation Zone as an example,the paper presents the types of village development and the corresponding planning strategies based on the results of village development potential evaluation.
