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Glucocorticoid-insulin like growth factor 1 axis programming might be involved in pancreaticβ-cell dysplasia and dysfunction in female offspring rats exposed to caffeine prenatally
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作者 Shuxia Gui Xiaoling Guo +2 位作者 Yongguo Dai Hao Kou Hui Wang 《Food Science and Human Wellness》 2025年第10期4262-4277,共16页
Prenatal caffeine exposure(PCE)leads to intrauterine growth retardation and altered glucose homeostasis after birth,but the underlying mechanism remains unclear.This study aims to investigate the alteration of pancrea... Prenatal caffeine exposure(PCE)leads to intrauterine growth retardation and altered glucose homeostasis after birth,but the underlying mechanism remains unclear.This study aims to investigate the alteration of pancreatic development and insulin biosynthesis in the PCE female offspring and explore the intrauterine programming mechanism.Pregnant rats were orally treated with 120 mg/(kg·day)of caffeine from gestational day(GD)9 to 20.Results showed that fetal pancreaticβ-cells in the PCE group exhibited reduced mass and impaired insulin synthesis function,as evidenced by decreased expression of developmental and functional genes and reduced pancreatic insulin content.At postnatal week(PW)12,the PCE offspring exhibited glucose intolerance,diminishedβ-cell mass,and lower blood insulin levels.However,by PW28,glucose tolerance showed some improvement.Both in vivo and in vitro findings collectively indicated that excessive serum corticosterone(CORT)levels of the PCE fetuses may act through the activation of the pancreatic glucocorticoid receptor(GR)and recruitment of histone deacetylase 9(HDAC9),leading to H3K9 deacetylation in promoter and downregulation of insulin-like growth factor 1(IGF1),thereby inhibiting pancreatic islet morphogenesis and insulin synthesis in fetal rats.Furthermore,the PCE offspring after birth exhibited decreased blood CORT levels,increased H3K9 acetylation in promoter and upregulated gene expression of the pancreatic IGF1 promoter region,accompanied by elevated insulin biosynthesis.However,when exposed to chronic stress,the above changes were totally reversed.Conclusively,“glucocorticoid-insulin like growth factor 1(GC-IGF1)axis”programming may be involved in pancreaticβ-cell dysplasia and dysfunction in the PCE female offspring. 展开更多
关键词 Prenatal caffeine exposure Pancreatic development GLUCOCORTICOIDS Insulin-like growth factor 1 Intrauterine programming
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Stage-specific nutritional management and developmental programming to optimize meat production 被引量:2
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作者 Liang Zhao Xiangdong Liu +5 位作者 Noe A Gomez Yao Gao Jun Seok Son Song Ah Chae Mei‑Jun Zhu Min Du 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第2期451-464,共14页
Over the past few decades,genetic selection and refined nutritional management have extensively been used to increase the growth rate and lean meat production of livestock.However,the rapid growth rates of modern bree... Over the past few decades,genetic selection and refined nutritional management have extensively been used to increase the growth rate and lean meat production of livestock.However,the rapid growth rates of modern breeds are often accompanied by a reduction in intramuscular fat deposition and increased occurrences of muscle abnor‑malities,impairing meat quality and processing functionality.Early stages of animal development set the long‑term growth trajectory of offspring.However,due to the seasonal reproductive cycles of ruminant livestock,gestational nutrient deficiencies caused by seasonal variations,frequent droughts,and unfavorable geological locations nega‑tively affect fetal development and their subsequent production efficiency and meat quality.Therefore,enrolling live‑stock in nutritional intervention strategies during gestation is effective for improving the body composition and meat quality of the offspring at harvest.These crucial early developmental stages include embryonic,fetal,and postnatal stages,which have stage‑specific effects on subsequent offspring development,body composition,and meat quality.This review summarizes contemporary research in the embryonic,fetal,and neonatal development,and the impacts of maternal nutrition on the early development and programming effects on the long‑term growth performance of livestock.Understanding the developmental and metabolic characteristics of skeletal muscle,adipose,and fibrotic tissues will facilitate the development of stage‑specific nutritional management strategies to optimize production efficiency and meat quality. 展开更多
关键词 Adipose tissue Embryonic development Fetal programming Fibro/adipogenic progenitors MARBLING Nutritional regulations Skeletal muscle
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Research and Review on the Java Multi-thread Programming and Its Further Development Tendency
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作者 Jiangtao Geng 《International Journal of Technology Management》 2016年第5期4-6,共3页
In this paper, we conduct research on the Java multi-thread programming and its further development tendency. Multithreading mechanisms can run several programs at the same time, make the program run effi ciency becom... In this paper, we conduct research on the Java multi-thread programming and its further development tendency. Multithreading mechanisms can run several programs at the same time, make the program run effi ciency becomes higher that also can overcome the problem of basic traditional programming language design while its design is the key to the realization of the synchronous thread. Multithreading is a mechanism that allows concurrent execution of multiple instruction stream in the program, each instruction stream is called a thread, independent from each other between each other. Thread is also known as a lightweight process, it have independent execution and process control. Our research starts from the analysis of the corresponding mechanism to enhance the performance that is innovative and meaningful. 展开更多
关键词 REVIEW MULTI-THREAD development TENDENCY programming COMPUTER SCIENCE
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Research and Development on NC System of Gear-hobbing Machine based on Zero-programming Technology
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作者 HUANG He LIU Fu-hua +2 位作者 FENG Guo-qun LIU Liang CHEN Qing-lin 《International Journal of Plant Engineering and Management》 2016年第4期241-254,共14页
By the analysis of roller gear processing technology, combining with gear meshing mechanism and motion relationship, models for rolling gear machining parameter and zero-programming are established. In this paper, the... By the analysis of roller gear processing technology, combining with gear meshing mechanism and motion relationship, models for rolling gear machining parameter and zero-programming are established. In this paper, the automatic generation technology of NC program for CNC gear machining process has been studied and the zero-programming system architecture of open CNC gear-hobbing machine has been presented. In the design and development of the system, human computer interaction, programming algorithm and the design of each function module have bean done. Application test shows that the expected design requirements have been achieved. 展开更多
关键词 CNC gear-hobbing machine zero-programming open CNC system development
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Developing a school-based drug prevention program to overcome barriers to effective program implementation: The CLIMATE schools: Alcohol module 被引量:1
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作者 Laura E. Vogl Maree Teesson +1 位作者 Nicola C. Newton Gavin Andrews 《Open Journal of Preventive Medicine》 2012年第3期410-422,共13页
Although effective school-based alcohol prevention programs do exist, the overall efficacy of these programs has been compromised by implementation failure. The CLIMATE Schools: Alcohol Module was developed to overcom... Although effective school-based alcohol prevention programs do exist, the overall efficacy of these programs has been compromised by implementation failure. The CLIMATE Schools: Alcohol Module was developed to overcome some of the obstacles to high fidelity program implementation. This paper details this development of the CLIMATE Schools: Alcohol Module. The development involved two stages, both of which were considered essential. The first stage, involved reviewing the literature to ensure the program was based on the most effecttive pedagogy and health promotion practice and the second stage involved collaborating with teachers, students and specialists in the area of alcohol and other drugs, to ensure these goals were realised. The final CLIMATE Schools: Alcohol Module consists of computer-driven harm minimisation program which is based on a social influence approach. The program consists of six lessons, each with two components. The first component involves students completing an interactive computer-based program, with the second consisting of a variety of individual, small group and class-based activities. This program was developed to provide an innovative new platform for the delivery of drug education and has proven to be both feasible and effective in the school environment. The success of this program is considered to be testament to this collaborative development approach. 展开更多
关键词 program development Implementation SCHOOL-BASED DRUG Prevention ALCOHOL
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Global optimality conditions for quadratic 0-1 programming with inequality constraints 被引量:1
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作者 张连生 陈伟 姚奕荣 《Journal of Shanghai University(English Edition)》 CAS 2010年第2期150-154,共5页
Quadratic 0-1 problems with linear inequality constraints are briefly considered in this paper.Global optimality conditions for these problems,including a necessary condition and some sufficient conditions,are present... Quadratic 0-1 problems with linear inequality constraints are briefly considered in this paper.Global optimality conditions for these problems,including a necessary condition and some sufficient conditions,are presented.The necessary condition is expressed without dual variables.The relations between the global optimal solutions of nonconvex quadratic 0-1 problems and the associated relaxed convex problems are also studied. 展开更多
关键词 quadratic 0-1 programming optimality condition nonconvex optimization integer programming convex duality
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A Tabu Search Algorithm for Quadratic 0-1 Programming Problem 被引量:2
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作者 周贤伟 王远允 +1 位作者 田新现 郭瑞强 《Chinese Quarterly Journal of Mathematics》 CSCD 1997年第4期98-102, ,共5页
In this paper,quadratic 0-1 programming problem (I) is considered, in terms of its features quadratic 0-1 programming problem is solved by linear approxity heurstic algrothm and a developed tabu search ahgrothm .
关键词 Tabu search linear approximate quaratic 0-1 programming
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The Construction of Linux System and Network Programming Course to Develop Engineering Ability 被引量:1
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作者 Haitao Dong GuoBing Ma 《计算机教育》 2020年第12期107-113,共7页
To meet society’s needs for undergraduate students to have engineering skills and to develop students’ability to operate Linux and engage in network software development,this paper proposes the construction of a new... To meet society’s needs for undergraduate students to have engineering skills and to develop students’ability to operate Linux and engage in network software development,this paper proposes the construction of a new specialized course for network engineering major--Linux system and network programming.This paper analyzes the course’s advantages,presents the contents of this course,designs a series of teaching methods aimed at improving students’engineering ability,proposes a course assessment method that will encourage students to practice,lists the development requirements for an examination software designed for this course,and finally,presents the results of our practice in teaching this course. 展开更多
关键词 Linux teaching Linux network programming development of engineering ability course construction.
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Redefining the Programmer:Human-AI Collaboration,LLMs,and Security in Modern Software Engineering
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作者 Elyson De La Cruz Hanh Le +2 位作者 Karthik Meduri Geeta Sandeep Nadella Hari Gonaygunta 《Computers, Materials & Continua》 2025年第11期3569-3582,共14页
The rapid integration of artificial intelligence(AI)into software development,driven by large language models(LLMs),is reshaping the role of programmers from traditional coders into strategic collaborators within Indu... The rapid integration of artificial intelligence(AI)into software development,driven by large language models(LLMs),is reshaping the role of programmers from traditional coders into strategic collaborators within Industry 4.0 ecosystems.This qualitative study employs a hermeneutic phenomenological approach to explore the lived experiences of Information Technology(IT)professionals as they navigate a dynamic technological landscape marked by intelligent automation,shifting professional identities,and emerging ethical concerns.Findings indicate that developers are actively adapting to AI-augmented environments by engaging in continuous upskilling,prompt engineering,interdisciplinary collaboration,and heightened ethical awareness.However,participants also voiced growing concerns about the reliability and security of AI-generated code,noting that these tools can introduce hidden vulnerabilities and reduce critical engagement due to automation bias.Many described instances of flawed logic,insecure patterns,or syntactically correct but contextually inappropriate suggestions,underscoring the need for rigorous human oversight.Additionally,the study reveals anxieties around job displacement and the gradual erosion of fundamental coding skills,particularly in environments where AI tools dominate routine development tasks.These findings highlight an urgent need for educational reforms,industry standards,and organizational policies that prioritize both technical robustness and the preservation of human expertise.As AI becomes increasingly embedded in software engineering workflows,this research offers timely insights into how developers and organizations can responsibly integrate intelligent systems to promote accountability,resilience,and innovation across the software development lifecycle. 展开更多
关键词 Human-AI collaboration large language models AI security developer identity ethical AI in software development AI-assisted programming
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Subdynamic Programming Optimization Model on Oil Field Development Program
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作者 沙聚桢 艾文国 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 1995年第3期88-94,共7页
Taking the formulation of the Daqing Oil. fived five-year development plan as the background, this paper puts forward the concept of dynamic programming with aftereffects and gives the principle of suboptimality as it... Taking the formulation of the Daqing Oil. fived five-year development plan as the background, this paper puts forward the concept of dynamic programming with aftereffects and gives the principle of suboptimality as its approximate solution. By using this principle an oil field development subdynamic programming model has been made and the oil field development program based on this model has achieved obvious economic benefits. 展开更多
关键词 ss:Subdynamic programming OIL FIELD developMENT
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Changing HIV Epidemic in North-Eastern India and Its Relationship with Development and Programmatic Indicators
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作者 Chiranjeev Bhattacharjya Sangram Kishor Patel +1 位作者 Samiran Panda Alok Kr. Deb 《World Journal of AIDS》 2015年第3期265-274,共10页
Background: Although there has been significant reduction in HIV prevalence and new HIV infections in India, some of the low/moderate prevalence states have been showing long term increase in HIV prevalence and new HI... Background: Although there has been significant reduction in HIV prevalence and new HIV infections in India, some of the low/moderate prevalence states have been showing long term increase in HIV prevalence and new HIV infections. Assam, a state in northeast India is one such low HIV prevalence state where HIV prevalence and new HIV infections have almost doubled in the last few years. This study examined the trend of HIV prevalence across districts/regions of Assam and its association with developmental and program indicators. Materials and Methods: A retrospective descriptive analysis of secondary data from the National AIDS Control Program, Census of India-2011, and District Level Household and Facility Survey-3 was conducted. The time period covered under the secondary data analysis was 2007 to 2012. Correlation and Chi-square for trend tests were also used in this paper. Results: During 2007 and 2012, HIV positivity (%) increased relatively in North Assam (46.9%) followed by South Assam (11.5%) while there has been a relative decline in West Assam (﹣51.5%). Correlation analysis showed statistically significant association between HIV prevalence and female literacy, population using mobile phone, population using internet, women (15 - 49 years) seeking treatment for any STI/RTI, proportion of brothel based FSWs, FSWs having <5 clients per week and proportion of condom utilized annually. Conclusion: Program efforts in the state should be focus on the districts with increasing HIV prevalence. Emphasis should be given in planning strategies to address the program gaps among the high risk and vulnerable populations in the state. 展开更多
关键词 HIV EPIDEMIC program and developMENT Indicator North-Eastern India
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Program for the Development of Chinese Women (2001-2010)
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《China Population Today》 2001年第6期2-6,共5页
关键词 program for the development of Chinese Women 2010
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Program for the Development of Chinese Women(2001-2010)
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《China Population Today》 2001年第5期2-5,共4页
关键词 program for the development of Chinese Women 2010
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Exploration on Interesting and Skill Programming of WEB Software Development
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作者 Yuan Chunping 《International Journal of Technology Management》 2017年第6期56-59,共4页
Although the WEB software development has some difficulty,but as long as the programming skills to find,in the practice ofoperation will find programming fun,this will stimulate the enthusiasm of students programming.... Although the WEB software development has some difficulty,but as long as the programming skills to find,in the practice ofoperation will find programming fun,this will stimulate the enthusiasm of students programming.Exploration of interesting skills programmingof WEB software development is aimed at developers who initial contact with WEB software,through the practice of operation to make themget some fun of WEB programming,from simple to difficult gradually let students master WEB programming skills,improve students' interestin programming.By adding some special effects of webpages to enhance the students' interest in programming,through the key practice ofdatabase,let the students out of fear of programming of database connection. 展开更多
关键词 WEB development JSP special effects of webpages INTERESTING programming
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China's Biotech Achievements——Development of China's 863 Program in the Ninth Five-Year Plan Period
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《China's Foreign Trade》 2002年第6期44-45,共2页
Modern biotechnology booms in the molecular life science. It brings about a promising future for improving human health, foodstuff, environment and energy and is of significance to improve traditional agriculture, dru... Modern biotechnology booms in the molecular life science. It brings about a promising future for improving human health, foodstuff, environment and energy and is of significance to improve traditional agriculture, druamakins and other 展开更多
关键词 In China’s Biotech Achievements development of China’s 863 program in the Ninth Five-Year Plan Period gene
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China's Biotechnology Development Program during the Tenth Five-Year Plan Period (2001-2005)
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《China's Foreign Trade》 2002年第6期46-46,共1页
Bioengineering TechnoIogy(Ⅰ)1. Crop molecular marker-assisted selection and pyramiding breeding technology2. Super hybrid
关键词 high China’s Biotechnology development program during the Tenth Five-Year Plan Period
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Rapid Prototype Development Approach for Genetic Programming
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作者 Pei He Lei Zhang 《Journal of Computer and Communications》 2024年第2期67-79,共13页
Genetic Programming (GP) is an important approach to deal with complex problem analysis and modeling, and has been applied in a wide range of areas. The development of GP involves various aspects, including design of ... Genetic Programming (GP) is an important approach to deal with complex problem analysis and modeling, and has been applied in a wide range of areas. The development of GP involves various aspects, including design of genetic operators, evolutionary controls and implementations of heuristic strategy, evaluations and other mechanisms. When designing genetic operators, it is necessary to consider the possible limitations of encoding methods of individuals. And when selecting evolutionary control strategies, it is also necessary to balance search efficiency and diversity based on representation characteristics as well as the problem itself. More importantly, all of these matters, among others, have to be implemented through tedious coding work. Therefore, GP development is both complex and time-consuming. To overcome some of these difficulties that hinder the enhancement of GP development efficiency, we explore the feasibility of mutual assistance among GP variants, and then propose a rapid GP prototyping development method based on πGrammatical Evolution (πGE). It is demonstrated through regression analysis experiments that not only is this method beneficial for the GP developers to get rid of some tedious implementations, but also enables them to concentrate on the essence of the referred problem, such as individual representation, decoding means and evaluation. Additionally, it provides new insights into the roles of individual delineations in phenotypes and semantic research of individuals. 展开更多
关键词 Genetic programming Grammatical Evolution Gene Expression programming Regression Analysis Mathematical Modeling Rapid Prototype development
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The Program for the Development of Chinese New and Renewable Energy (1996-2010) Worked Out
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《Electricity》 1996年第4期21-21,共1页
The State Science and Technology Commission, State Economic and Trade Commission, and State Planning Commission of China have jointly worked out the Program for the Development of Chinese New and Renewable Energy rece... The State Science and Technology Commission, State Economic and Trade Commission, and State Planning Commission of China have jointly worked out the Program for the Development of Chinese New and Renewable Energy recently. 展开更多
关键词 2010 The program for the development of Chinese New and Renewable Energy Worked Out
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Nondifferentiable Multiobjective Programming under Generalized d_I-G-Type I Invexity
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作者 闫春雷 《Journal of Donghua University(English Edition)》 EI CAS 2013年第4期293-297,共5页
To relax convexity assumptions imposed on the functions in theorems on sufficient conditions and duality,new concepts of generalized dI-G-type Ⅰ invexity were introduced for nondifferentiable multiobjective programmi... To relax convexity assumptions imposed on the functions in theorems on sufficient conditions and duality,new concepts of generalized dI-G-type Ⅰ invexity were introduced for nondifferentiable multiobjective programming problems.Based upon these generalized invexity,G-Fritz-John (G-F-J) and G-Karnsh-Kuhn-Tucker (G-K-K-T) types sufficient optimality conditions were established for a feasible solution to be an efficient solution.Moreover,weak and strict duality results were derived for a G-Mond-Weir type dual under various types of generalized dI-G-type Ⅰ invexity assumptions. 展开更多
关键词 nondifferentiable multiobjective program efficient solution generalized dI-G-type invexity sufficient optimality conditions dualityCLC number:O221.6Document code:AArticle ID:1672-5220(2013)04-0293-05
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