Fast and accurate transient stability analysis is crucial to power system operation.With high penetration level of wind power resources,practical dynamic security region(PDSR)with hyper plane expression has outstandin...Fast and accurate transient stability analysis is crucial to power system operation.With high penetration level of wind power resources,practical dynamic security region(PDSR)with hyper plane expression has outstanding advantages in situational awareness and series of optimization problems.The precondition of obtaining accurate PDSR boundary is to locate sufficient points around the boundary(critical points).Therefore,this paper proposes a space division and Wasserstein generative adversarial network with gra-dient penalty(WGAN-GP)based fast generation method of PDSR boundary.First,the typical differential topological characterizations of dynamic security region(DSR)provide strong theoretical foundation that the interior of DSR is hole-free and the boundaries of DSR are tight and knot-free.Then,the space division method is proposed to calculate critical operation area where the PDSR boundary is located,tremen-dously compressing the search space to locate critical points and improving the confidence level of boundary fitting result.Furthermore,the WGAN-GP model is utilized to fast obtain large number of criti-cal points based on learning the data distribution of the small training set aforementioned.Finally,the PDSR boundary with hyperplanes is fitted by the least square method.The case study is tested on the Institute of Electrical and Electronics Engineers(IEEE)39-bus system and the results verify the accuracy and efficiency of the proposed method.展开更多
Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our pr...Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our previous study confirmed that inhalation of hydrogen gas can reduce the acute lung injury of ARDS,but the application of hydrogen has flammable and explosive safety concerns.Drinking hydrogen-rich liquid or inhaling hydrogen gas has been shown to play an important role in scavenging reactive oxygen species and maintaining mitochondrial quality control balance,thus improving ARDS in patients and animal models.Coral calcium hydrogenation(CCH)is a new solid molecular hydrogen carrier prepared from coral calcium(CC).Whether and how CCH affects acute lung injury in ARDS remains unstudied.In this study,we observed the therapeutic effect of CCH on lipopolysaccharide(LPS)induced acute lung injury in ARDS mice.The survival rate of mice treated with CCH and hydrogen inhalation was found to be comparable,demonstrating a significant improvement compared to the untreated ARDS model group.CCH treatment significantly reduced pulmonary hemorrhage and edema,and improved pulmonary function and local microcirculation in ARDS mice.CCH promoted mitochondrial peripheral division in the early course of ARDS by activating mitochondrial thioredoxin 2(Trx2),improved lung mitochondrial dysfunction induced by LPS,and reduced oxidative stress damage.The results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation.展开更多
The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor di...The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor division system covering vertical integration and horizontal complementarity of industrial chains.From the V-shaped development model in the twentieth century to the East Asian production network in the twenty-first century,the intra-industry and intra-product division of labor in the Asia-Pacific region has been ever deepening.However,due to the region’s high dependence on the U.S.market,the division of labor model in the Asia-Pacific suffers structural problems and is relatively fragile.Under the shock of Trump 1.0,countries in the Asia-Pacific region were forced to make adaptive adjustments,causing short-term turmoil in the regional economic order.Trump’s strong return in 2025,driven by the“America First”principle,brought forth a series of policies with strong unilateralism,isolationism and protectionism tendencies within just a few months。展开更多
Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane...Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.展开更多
WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphol...WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.展开更多
From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then...From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then proposes future prospects for them. The integration of theory and practice of "Production-Living-Ecology" Spaces is currently in a stage of in-depth exploration and practical application. Future research should fully recognize the importance and necessity of theoretical research on "Production-Living-Ecology" Spaces under the new situation, and consolidate the theoretical foundation for research on the development and protection of territorial space in the new era.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleoti...BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase(GTPase)and is implicated in various cancers.However,the role of RCC1 in HCC remains unex-plored.AIM To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.METHODS Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy.The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells.Furthermore,quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.RESULTS Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients.Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells,especially the proliferation of HCC cells,whereas RCC1 knockdown had the opposite effect.Mechanistically,we identied cell division cycle-associated(CDCA)8 as a downstream target of RCC1 in HCC.RCC1 overexpression markedly increased CDCA8 levels,consequently enhancing cell proliferation and survival in HCC cells.Additionally,we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.CONCLUSION Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target.展开更多
Using data from the 2022 China Family Panel Studies(CFPS),this study selects 11,375 dual-spouse households as the research sample and constructs a comprehensive housework division index via the entropy weight method.T...Using data from the 2022 China Family Panel Studies(CFPS),this study selects 11,375 dual-spouse households as the research sample and constructs a comprehensive housework division index via the entropy weight method.The index integrates four dimensions:participation subject,time allocation,content type,and fairness perception,aiming to explore the fairness level of housework division and group differences in Chinese households.The results show that the overall fairness of housework division in Chinese households is relatively low:the mean value of the index(after 10,000-fold linear expansion)is 0.0632,showing a significant right-skewed distribution,with most households concentrated in the"low-fairness"range and only a few achieving relatively balanced division.Significant group differences exist:rural households have a slightly higher housework division index(0.0659)than urban households(0.0608);male respondents have a higher index(0.0660)than female respondents(0.0603);and the high-education group has a significantly lower index(0.0501)than the low-education group(0.0653).The fairness of housework division is jointly influenced by structural factors and perceptual factors,with an obvious"concept-action gap":74.02%of respondents perceive housework division as"fair",but the low index level indicates this perception mostly stems from normative adaptation rather than objective balance.This study provides empirical evidence for optimizing family labor allocation and promoting gender equality.展开更多
As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division...As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division gene, are involved in plastid division process of plant cells. Antisense and sense expression constructions were employed to investigate the functions of the two ftsZ genes, NtFtsZ1 and NtFtsZ2, in transgenic Nicotiana tabacum L. plants. Although antisense expression of,NtFtsZs reduced the native protein level obviously, the size and number of chloroplasts in transgenic tobacco plants had no effect. In contrast, overexpression of NtFtsZs in transgenic plants strikingly changed the number and morphology of chloroplasts. Even only 1 - 2 huge chloroplasts could be seen in the mesophyll cells of some overexpression transgenic plants. Analyses of chloroplast ultrastructures and chlorophyll content of different transgenic plants suggested that NtFtsZs gene have no direct influence on the normal development and function of chloroplasts. ne changes in chloroplast morphology must be a compensation for the change in chloroplast number. The different phenotypes of chloroplasts in antisense and sense transgenic plants implied that different members from the same ftsZ gene family may have similar function in controlling plastid division. Meanwhile, the changes of chloroplast morphology in sense transgenic plants represented the possible plastoskeleton function of ftsZ in higher plant.展开更多
Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method w...Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method will not be effective when the ground roll wave and the effective signal have the same frequency bands because of overlapping. The radial trace transform （RTT） considers the apparent velocity difference between the effective signal and the ground roll wave to suppress the latter, but affects the low-frequency components of the former. This study proposes a ground roll wave suppression method by combining the wavelet frequency division and the RTT based on the difference between the ground roll wave velocity and the effective signal and their energy difference in the wavelet domain, thus making full use of the advantages of both methods. First, we decompose the seismic data into different frequency bands through wavelet transform. Second, the RTT and low-cut filtering are applied to the low-frequency band, where the ground roll waves are appearing. Third, we reconstruct the seismic record without ground roll waves by using the inverse RTT and the remaining frequency bands. The proposed method not only improves the ground roll wave suppression, but also protects the signal integrity. The numerical simulation and real seismic data processing results suggest that the proposed method has a strong ability to denoise while preserving the amplitude.展开更多
The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was...The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was equal to or greater than the rate of 3% was taken as standards to define wheat drought disaster years.The average reduction ratio of production in the wheat drought years in Hebei-Shandong-Henan was calculated.The frequency distribution rule of wheat in different drought disaster strength of winter wheat in Hebei-Shandong-Henan was analyzed.According to the conception and calculation method of drought disaster risk index of winter wheat,the regional distribution law of drought disaster risk index of winter wheat was analyzed.The division technical methods of winter wheat drought disaster risk zones in Hebei-Shandong-Henan under the irrigated conditions were put forward.Taking the average reduction rate of production in drought years,drought disaster risk index and precipitation of winter wheat in growth periods as indices,using the statistical analysis and overlay function of GIS,the production reduction risk of winter wheat caused by drought disaster in winter wheat zones of Hebei-Shandong-Henan was divided and evaluated.The risk evaluation of production reduction of winter wheat in different risk zones under different climate conditions was realized.The disaster prevention and mitigation measures of winter wheat drought were given.展开更多
Two plastid division genes, NtFtsZ1 and NtFtsZ2 isolated from Nicotiana tabacum L. were fused with gfp and expressed in Escherichia coli . The regular localizations of full length NtFtsZs∶GFP along the fil...Two plastid division genes, NtFtsZ1 and NtFtsZ2 isolated from Nicotiana tabacum L. were fused with gfp and expressed in Escherichia coli . The regular localizations of full length NtFtsZs∶GFP along the filamentous bacteria indicated that the NtFtsZs could recognize the potential division sites in E. coli and be polymerized with heterogeneous FtsZ from bacteria. The overexpression of NtFtsZs ∶ gfp inhibited the division of host strain cells and resulted in the long filamentous bacterial morphology. These results suggested that eukaryotic ftsZs have similar function to their prokaryotic homologs. Meanwhile, the different deletions of motifs of NtFtsZs are also employed to investigate the functions of these proteins in E. coli . The results showed that the C_terminal domains of NtFtsZs were related to the correct localization of NtFtsZs in E. coli and the N_terminal domains of NtFtsZs were responsible for the polymerization of homogeneous and heterogeneous FtsZ proteins. The significance of these results in understanding the functions of NtFtsZs in plastid division were discussed.展开更多
Using the meteorological data and geographical information during January-March（1961-2010） accumulated by 18 stations of Hainan,a suitability zoning map for thermo-sensitive genetic male sterility（TGMS） rice was m...Using the meteorological data and geographical information during January-March（1961-2010） accumulated by 18 stations of Hainan,a suitability zoning map for thermo-sensitive genetic male sterility（TGMS） rice was made by GIS technology based on temperature indicators required by TGMS rice during fertility sensitive period and heading-flowering period,aiming to provide reasonable layout and scientific basis for sustainable development of TGMS rice in Hainan Island under the background of global warming.The results indicated that the suitable planting zones covered the south regions of Wuzhishan,Jianfengling and Diaoluoshan;subordinate suitable zones expanded northward to central parts of Wuzhishan,Dongfang,Changjiang,Qiongzhong and southern parts of Wanning;the other regions were unsuitable for breeding.展开更多
With the aim to improve the level of monitoring and warning as well as the comprehensive control of rice blast disease, and to feasibly reduce the disease threat in Nanchong City, the methods of GPS and GIS, systemati...With the aim to improve the level of monitoring and warning as well as the comprehensive control of rice blast disease, and to feasibly reduce the disease threat in Nanchong City, the methods of GPS and GIS, systematical monitoring and field survey, rice blast resistance identification, physiologic races of rice blast monitoring, and meteorological data analysis were performed to study the occurrence and epidemic region division, precise demarcation and occurrence and epidemic regularity of rice blast in Nanchong City. This study first completed the epidemic region division and precise demarcation; first clarified the initial affection（beginning period） locations, occurrence characteristics, epidemic trends and characteristics; explicated the existence of four epidemic peak periods of rice blast in the field, where the damage areas of first peak period played a decisive role during the blast epidemic years; in late May, the cumulative occurrence areas and annual occurrence areas presented higher positive correlation with the correlation coefficient of 0.817;and established a prediction model of occurrence areas per year based on the disease field rate at the end of boot stages and the diseased plant rate at dough stages. The results of investigation on the impact factors investigation of blast disease in Nanchong in recent years suggested that the internal causes were the decrease or loss of blast resistance of the rice cultivars, as well as the increase of physiological races with strong resistance to rice blast and the emergence of new virulent physiologic varieties; the external causes were suitable temperature, too much rainy, and sunlight shortage. Between 2010 and 2015, the short-term forecast accuracy for rice blast in Nanchong was up to 100%, and medium-and long-term forecast accuracy was also up to 98% and 95%, respectively, which increased by 5-15% than that before 1997, thereby making the control effect of rice blast in Nanchong increased by 15-30%.展开更多
Mitochondrial division inhibitor 1（Mdivi-1） is a selective cell-permeable inhibitor of dynamin-related protein-1（Drp1） and mitochondrial division.To investigate the effect of Mdivi-1 on cells treated with glutamat...Mitochondrial division inhibitor 1（Mdivi-1） is a selective cell-permeable inhibitor of dynamin-related protein-1（Drp1） and mitochondrial division.To investigate the effect of Mdivi-1 on cells treated with glutamate,cerebral cortex neurons isolated from neonatal rats were treated with 10 m M glutamate for 24 hours.Normal cultured cells and dimethyl sulfoxide-cultured cells were considered as controls.Apoptotic cells were detected by flow cytometry.Changes in mitochondrial morphology were examined by electron microscopy.Drp1,Bax,and casp ase-3 expression was evaluated by western blot assays and immunocytochemistry.Mitochondrial membrane potential was detected using the JC-1 probe.Twenty-four hours after 10 m M glutamate treatment,Drp1,Bax and caspase-3 expression was upregulated,Drp1 and Bax were translocated to mitochondria,mitochondrial membrane potential was decreased and the rate of apoptosis was increased.These effects were inhibited by treatment with 50 μM Mdivi-1 for 2 hours.This finding indicates that Mdivi-1 is a candidate neuroprotective drug that can potentially mitigate against neuronal injury caused by glutamate-induced excitotoxicity.展开更多
基金funded in part by the National Key Research and Development Program of China(2020YFB0905900)in part by Science and Technology Project of State Grid Corporation of China(SGCC)The Key Technologies for Electric Internet of Things(SGTJDK00DWJS2100223).
文摘Fast and accurate transient stability analysis is crucial to power system operation.With high penetration level of wind power resources,practical dynamic security region(PDSR)with hyper plane expression has outstanding advantages in situational awareness and series of optimization problems.The precondition of obtaining accurate PDSR boundary is to locate sufficient points around the boundary(critical points).Therefore,this paper proposes a space division and Wasserstein generative adversarial network with gra-dient penalty(WGAN-GP)based fast generation method of PDSR boundary.First,the typical differential topological characterizations of dynamic security region(DSR)provide strong theoretical foundation that the interior of DSR is hole-free and the boundaries of DSR are tight and knot-free.Then,the space division method is proposed to calculate critical operation area where the PDSR boundary is located,tremen-dously compressing the search space to locate critical points and improving the confidence level of boundary fitting result.Furthermore,the WGAN-GP model is utilized to fast obtain large number of criti-cal points based on learning the data distribution of the small training set aforementioned.Finally,the PDSR boundary with hyperplanes is fitted by the least square method.The case study is tested on the Institute of Electrical and Electronics Engineers(IEEE)39-bus system and the results verify the accuracy and efficiency of the proposed method.
基金supported by the Nanjing Medical Science and Technology Development Project,China(Project No.:YKK23221)Open Project of Immune Cell Translational Research Center of Jiangning Hospital,Nanjing Medical University,China(Project No.:JNYYZXKY202216)+1 种基金General Project of Medical Education Collaborative Innovation Fund of Jiangsu University,China(Project No.:JDYY2023094)China Red Cross Foundation Medical Empowerment Charity Special Fund Project(Project No.:CRCF-YXFN-202302028).
文摘Acute respiratory distress syndrome(ARDS)is a common respiratory emergency,but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures.Our previous study confirmed that inhalation of hydrogen gas can reduce the acute lung injury of ARDS,but the application of hydrogen has flammable and explosive safety concerns.Drinking hydrogen-rich liquid or inhaling hydrogen gas has been shown to play an important role in scavenging reactive oxygen species and maintaining mitochondrial quality control balance,thus improving ARDS in patients and animal models.Coral calcium hydrogenation(CCH)is a new solid molecular hydrogen carrier prepared from coral calcium(CC).Whether and how CCH affects acute lung injury in ARDS remains unstudied.In this study,we observed the therapeutic effect of CCH on lipopolysaccharide(LPS)induced acute lung injury in ARDS mice.The survival rate of mice treated with CCH and hydrogen inhalation was found to be comparable,demonstrating a significant improvement compared to the untreated ARDS model group.CCH treatment significantly reduced pulmonary hemorrhage and edema,and improved pulmonary function and local microcirculation in ARDS mice.CCH promoted mitochondrial peripheral division in the early course of ARDS by activating mitochondrial thioredoxin 2(Trx2),improved lung mitochondrial dysfunction induced by LPS,and reduced oxidative stress damage.The results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation.
文摘The Asia-Pacific region is the most dynamic part of the global economy.After over 50 years of continuously expanding trade,investment and industrial cooperation,the region has formed a highly-tied multi-level labor division system covering vertical integration and horizontal complementarity of industrial chains.From the V-shaped development model in the twentieth century to the East Asian production network in the twenty-first century,the intra-industry and intra-product division of labor in the Asia-Pacific region has been ever deepening.However,due to the region’s high dependence on the U.S.market,the division of labor model in the Asia-Pacific suffers structural problems and is relatively fragile.Under the shock of Trump 1.0,countries in the Asia-Pacific region were forced to make adaptive adjustments,causing short-term turmoil in the regional economic order.Trump’s strong return in 2025,driven by the“America First”principle,brought forth a series of policies with strong unilateralism,isolationism and protectionism tendencies within just a few months。
基金support from the National Nat-ural Science Foundation of China(Grant No.12474199)the Fundamental Research Funds for Central Universities of China(Grant No.20720240144),and 111 Project(B16029).
文摘Cell division is a fundamental biological process in which a parent cell divides into two daughter cells.The cell cortex,a thin layer primarily composed of actin filaments and myosin motors beneath the plasma membrane,plays a critical role in ensuring proper cell division.In this study,we apply a hydrodynamic model to describe the actin cortex as an active nematic surface,incorporating orientational order arising from actin filament alignment and anisotropic active stress produced by myosin motors.By analyzing the linearized dynamics,we investigate how shape,flow,and stress regulators evolve over time when the surface deviates slightly from a sphere.Our findings reveal that the active alignment of actin filaments,often overlooked in previous studies,is crucial for successful division.Furthermore,we demonstrate that a cortical chiral flow naturally emerges as a consequence of this active alignment.Overall,our results provide a mechanistic explanation for key phenomena observed during cell division,offering new insights into the role of active stress and filament alignment in cortical dynamics.
文摘WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.
基金Supported by Open Experimental Project in 2024 of Chuzhou University"Construction of Land and Space Planning System under the Background of Ecological Civilization"Humanities and Social Sciences Research Project Key Project of Anhui University in 2023"Digital Enabling Anhui Rural Human Settlements Environment Comprehensive Renovation Promotion Mechanism and Policy Optimization Research"(2023AH051571)+1 种基金Scientific Research Project of Chuzhou University"Research on the Mode,Mechanism and Promotion Path of Coordinated Development of Villages and Towns in the Suburbs of Metropolis from the Perspective of Three-dimensional Structure"(2023qd63)Digital Technology and Rural Revitalization Anhui Key Laboratory of Philosophy and Social Sciences 2024 Open Fund"Research on the Development Path and Supporting System of Rural Industry Driven by Digital Technology"(ZSKF202408).
文摘From the concept of the "Production-Living-Ecology" Spaces, this paper sorts out the theoretical basis, division principles, and division methods of the "Production-Living-Ecology" Spaces, and then proposes future prospects for them. The integration of theory and practice of "Production-Living-Ecology" Spaces is currently in a stage of in-depth exploration and practical application. Future research should fully recognize the importance and necessity of theoretical research on "Production-Living-Ecology" Spaces under the new situation, and consolidate the theoretical foundation for research on the development and protection of territorial space in the new era.
基金Supported by the National Natural Science Foundation of China,No.82002940 and No.82203336Shaanxi Natural Science Foundation,No.2023-JC-YB-166.
文摘BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase(GTPase)and is implicated in various cancers.However,the role of RCC1 in HCC remains unex-plored.AIM To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.METHODS Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy.The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells.Furthermore,quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.RESULTS Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients.Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells,especially the proliferation of HCC cells,whereas RCC1 knockdown had the opposite effect.Mechanistically,we identied cell division cycle-associated(CDCA)8 as a downstream target of RCC1 in HCC.RCC1 overexpression markedly increased CDCA8 levels,consequently enhancing cell proliferation and survival in HCC cells.Additionally,we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.CONCLUSION Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target.
文摘Using data from the 2022 China Family Panel Studies(CFPS),this study selects 11,375 dual-spouse households as the research sample and constructs a comprehensive housework division index via the entropy weight method.The index integrates four dimensions:participation subject,time allocation,content type,and fairness perception,aiming to explore the fairness level of housework division and group differences in Chinese households.The results show that the overall fairness of housework division in Chinese households is relatively low:the mean value of the index(after 10,000-fold linear expansion)is 0.0632,showing a significant right-skewed distribution,with most households concentrated in the"low-fairness"range and only a few achieving relatively balanced division.Significant group differences exist:rural households have a slightly higher housework division index(0.0659)than urban households(0.0608);male respondents have a higher index(0.0660)than female respondents(0.0603);and the high-education group has a significantly lower index(0.0501)than the low-education group(0.0653).The fairness of housework division is jointly influenced by structural factors and perceptual factors,with an obvious"concept-action gap":74.02%of respondents perceive housework division as"fair",but the low index level indicates this perception mostly stems from normative adaptation rather than objective balance.This study provides empirical evidence for optimizing family labor allocation and promoting gender equality.
文摘As an important group of plant cellular organelles, the molecular mechanism of plastid division is poorly understood. Recent studies have revealed that the homologs of ftsZ gene, an essential prokaryotic cell division gene, are involved in plastid division process of plant cells. Antisense and sense expression constructions were employed to investigate the functions of the two ftsZ genes, NtFtsZ1 and NtFtsZ2, in transgenic Nicotiana tabacum L. plants. Although antisense expression of,NtFtsZs reduced the native protein level obviously, the size and number of chloroplasts in transgenic tobacco plants had no effect. In contrast, overexpression of NtFtsZs in transgenic plants strikingly changed the number and morphology of chloroplasts. Even only 1 - 2 huge chloroplasts could be seen in the mesophyll cells of some overexpression transgenic plants. Analyses of chloroplast ultrastructures and chlorophyll content of different transgenic plants suggested that NtFtsZs gene have no direct influence on the normal development and function of chloroplasts. ne changes in chloroplast morphology must be a compensation for the change in chloroplast number. The different phenotypes of chloroplasts in antisense and sense transgenic plants implied that different members from the same ftsZ gene family may have similar function in controlling plastid division. Meanwhile, the changes of chloroplast morphology in sense transgenic plants represented the possible plastoskeleton function of ftsZ in higher plant.
基金supported by the National Science and Technology Major Project(No.2011ZX05007-006)the 973 Program of China(No.2013CB228604)the major Project of Petrochina(No.2014B-0610)
文摘Ground roll waves interfere with seismic data. The suppression of ground roll waves based on the division of wavelet frequencies considers the low-frequency characteristics of ground roll waves. However, this method will not be effective when the ground roll wave and the effective signal have the same frequency bands because of overlapping. The radial trace transform （RTT） considers the apparent velocity difference between the effective signal and the ground roll wave to suppress the latter, but affects the low-frequency components of the former. This study proposes a ground roll wave suppression method by combining the wavelet frequency division and the RTT based on the difference between the ground roll wave velocity and the effective signal and their energy difference in the wavelet domain, thus making full use of the advantages of both methods. First, we decompose the seismic data into different frequency bands through wavelet transform. Second, the RTT and low-cut filtering are applied to the low-frequency band, where the ground roll waves are appearing. Third, we reconstruct the seismic record without ground roll waves by using the inverse RTT and the remaining frequency bands. The proposed method not only improves the ground roll wave suppression, but also protects the signal integrity. The numerical simulation and real seismic data processing results suggest that the proposed method has a strong ability to denoise while preserving the amplitude.
基金Supported by The Ministry of Finance,Meteorological Industry Spe-cific(GYHY200706030)China Meteorological Administration 2009 Budget Item(CMATG2009M32)~~
文摘The average rainfall in whole growth period of winter wheat to plus or minus several times of sample variance was used to define different grades of drought.The reduction rate of production in meteorological which was equal to or greater than the rate of 3% was taken as standards to define wheat drought disaster years.The average reduction ratio of production in the wheat drought years in Hebei-Shandong-Henan was calculated.The frequency distribution rule of wheat in different drought disaster strength of winter wheat in Hebei-Shandong-Henan was analyzed.According to the conception and calculation method of drought disaster risk index of winter wheat,the regional distribution law of drought disaster risk index of winter wheat was analyzed.The division technical methods of winter wheat drought disaster risk zones in Hebei-Shandong-Henan under the irrigated conditions were put forward.Taking the average reduction rate of production in drought years,drought disaster risk index and precipitation of winter wheat in growth periods as indices,using the statistical analysis and overlay function of GIS,the production reduction risk of winter wheat caused by drought disaster in winter wheat zones of Hebei-Shandong-Henan was divided and evaluated.The risk evaluation of production reduction of winter wheat in different risk zones under different climate conditions was realized.The disaster prevention and mitigation measures of winter wheat drought were given.
文摘Two plastid division genes, NtFtsZ1 and NtFtsZ2 isolated from Nicotiana tabacum L. were fused with gfp and expressed in Escherichia coli . The regular localizations of full length NtFtsZs∶GFP along the filamentous bacteria indicated that the NtFtsZs could recognize the potential division sites in E. coli and be polymerized with heterogeneous FtsZ from bacteria. The overexpression of NtFtsZs ∶ gfp inhibited the division of host strain cells and resulted in the long filamentous bacterial morphology. These results suggested that eukaryotic ftsZs have similar function to their prokaryotic homologs. Meanwhile, the different deletions of motifs of NtFtsZs are also employed to investigate the functions of these proteins in E. coli . The results showed that the C_terminal domains of NtFtsZs were related to the correct localization of NtFtsZs in E. coli and the N_terminal domains of NtFtsZs were responsible for the polymerization of homogeneous and heterogeneous FtsZ proteins. The significance of these results in understanding the functions of NtFtsZs in plastid division were discussed.
基金Supported by the Project of Meteorological Service Website Construction for HainanBreeding(Qiong Nong Ji Cai No.[2013]18 of Hainan Provincial Department of Agriculture)~~
文摘Using the meteorological data and geographical information during January-March（1961-2010） accumulated by 18 stations of Hainan,a suitability zoning map for thermo-sensitive genetic male sterility（TGMS） rice was made by GIS technology based on temperature indicators required by TGMS rice during fertility sensitive period and heading-flowering period,aiming to provide reasonable layout and scientific basis for sustainable development of TGMS rice in Hainan Island under the background of global warming.The results indicated that the suitable planting zones covered the south regions of Wuzhishan,Jianfengling and Diaoluoshan;subordinate suitable zones expanded northward to central parts of Wuzhishan,Dongfang,Changjiang,Qiongzhong and southern parts of Wanning;the other regions were unsuitable for breeding.
基金Supported by Notice on the First Batch of National Modern Agricultural Demonstration Zone by the Ministry of Agriculture([2010]22)the Research and Application Project for the Early Warning and Comprehensive Control of the Major Pests and Diseases for Main Grain and Oil Crops(N1997-ZC002)the Fundamental Research Funds for the Central Universities(XDJK2015C060,SWU114046,2362015xk04)~~
文摘With the aim to improve the level of monitoring and warning as well as the comprehensive control of rice blast disease, and to feasibly reduce the disease threat in Nanchong City, the methods of GPS and GIS, systematical monitoring and field survey, rice blast resistance identification, physiologic races of rice blast monitoring, and meteorological data analysis were performed to study the occurrence and epidemic region division, precise demarcation and occurrence and epidemic regularity of rice blast in Nanchong City. This study first completed the epidemic region division and precise demarcation; first clarified the initial affection（beginning period） locations, occurrence characteristics, epidemic trends and characteristics; explicated the existence of four epidemic peak periods of rice blast in the field, where the damage areas of first peak period played a decisive role during the blast epidemic years; in late May, the cumulative occurrence areas and annual occurrence areas presented higher positive correlation with the correlation coefficient of 0.817;and established a prediction model of occurrence areas per year based on the disease field rate at the end of boot stages and the diseased plant rate at dough stages. The results of investigation on the impact factors investigation of blast disease in Nanchong in recent years suggested that the internal causes were the decrease or loss of blast resistance of the rice cultivars, as well as the increase of physiological races with strong resistance to rice blast and the emergence of new virulent physiologic varieties; the external causes were suitable temperature, too much rainy, and sunlight shortage. Between 2010 and 2015, the short-term forecast accuracy for rice blast in Nanchong was up to 100%, and medium-and long-term forecast accuracy was also up to 98% and 95%, respectively, which increased by 5-15% than that before 1997, thereby making the control effect of rice blast in Nanchong increased by 15-30%.
基金supported by the National Natural Science Foundation of China,No.81371967 and 81401807a grant from the 5th Phase of "Project 333"of Jiangsu Province of China,No.BRA2016512a grant from the Six Talent Peaks Project of Jiangsu Province of China,No.2014-WSN-012
文摘Mitochondrial division inhibitor 1（Mdivi-1） is a selective cell-permeable inhibitor of dynamin-related protein-1（Drp1） and mitochondrial division.To investigate the effect of Mdivi-1 on cells treated with glutamate,cerebral cortex neurons isolated from neonatal rats were treated with 10 m M glutamate for 24 hours.Normal cultured cells and dimethyl sulfoxide-cultured cells were considered as controls.Apoptotic cells were detected by flow cytometry.Changes in mitochondrial morphology were examined by electron microscopy.Drp1,Bax,and casp ase-3 expression was evaluated by western blot assays and immunocytochemistry.Mitochondrial membrane potential was detected using the JC-1 probe.Twenty-four hours after 10 m M glutamate treatment,Drp1,Bax and caspase-3 expression was upregulated,Drp1 and Bax were translocated to mitochondria,mitochondrial membrane potential was decreased and the rate of apoptosis was increased.These effects were inhibited by treatment with 50 μM Mdivi-1 for 2 hours.This finding indicates that Mdivi-1 is a candidate neuroprotective drug that can potentially mitigate against neuronal injury caused by glutamate-induced excitotoxicity.
