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前列腺素D_(2)对大肠杆菌诱导的奶牛骨髓源巨噬细胞中细胞因子分泌及吞噬杀伤功能的影响
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作者 龚鹏飞 杨效林 +6 位作者 郭莉莉 王钰 吴敬泽 张双翼 刘博 毛伟 曹金山 《中国兽医学报》 北大核心 2025年第1期107-114,共8页
为了研究前列腺素D_(2)(prostaglandin D_(2),PGD_(2))对大肠杆菌诱导的奶牛骨髓源巨噬细胞的影响,以体外培养的奶牛骨髓源巨噬细胞为研究对象,分析内源性和外源性PGD_(2)对大肠杆菌诱导的巨噬细胞促炎性细胞因子(IL-1β、IL-6和TNF-α... 为了研究前列腺素D_(2)(prostaglandin D_(2),PGD_(2))对大肠杆菌诱导的奶牛骨髓源巨噬细胞的影响,以体外培养的奶牛骨髓源巨噬细胞为研究对象,分析内源性和外源性PGD_(2)对大肠杆菌诱导的巨噬细胞促炎性细胞因子(IL-1β、IL-6和TNF-α)的分泌和吞噬杀伤功能的影响。结果显示,由大肠杆菌诱导的巨噬细胞中PGD_(2)的合成依赖于天然模式识别受体TLR2、TLR4和NLRP3。抑制内源性PGD_(2)能够下调大肠杆菌诱导的巨噬细胞中促炎性细胞因子(IL-1β、IL-6和TNF-α)的分泌(P<0.001),并可以在一定程度上增强巨噬细胞的杀伤功能(P<0.01)。此外,外源性PGD_(2)能够上调大肠杆菌刺激后巨噬细胞中促炎性细胞因子(IL-1β、IL-6和TNF-α)的分泌(P<0.01),一定浓度范围内的外源性PGD_(2)能够减弱巨噬细胞的杀伤功能(P<0.01)。结果表明,PGD_(2)对大肠杆菌诱导的巨噬细胞细胞因子的分泌和吞噬杀伤功能均具有一定的影响。 展开更多
关键词 大肠杆菌 前列腺素D_(2) 奶牛骨髓源巨噬细胞 模式识别受体 吞噬杀伤
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MIPS64指令集模拟器的细化动态翻译技术
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作者 蔡启先 郭森 +1 位作者 裴锋 谭平 《广西工学院学报》 CAS 2010年第4期1-4,12,共5页
随着指令集模拟器在嵌入式开发中的作用日益增大,对于指令集模拟器模拟速度的要求也越来越高.本文提出了一种细化的动态翻译技术,即把指令在编译阶段翻译成伪指令.虽然在编译阶段花费时间较多一些,但使得译码阶段消耗的时间大量减少.实... 随着指令集模拟器在嵌入式开发中的作用日益增大,对于指令集模拟器模拟速度的要求也越来越高.本文提出了一种细化的动态翻译技术,即把指令在编译阶段翻译成伪指令.虽然在编译阶段花费时间较多一些,但使得译码阶段消耗的时间大量减少.实验结果证明:使用该技术能够准确模拟MIPS 64的指令,并且模拟速度显著提高. 展开更多
关键词 指令集模拟器 动态翻译 伪指令 d2模式 MIPS64
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An Easy Calibration Method for Central Catadioptric Cameras 被引量:12
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作者 DENG Xiao-Ming WU Fu-Chao WU Yi-Hong 《自动化学报》 EI CSCD 北大核心 2007年第8期801-808,共8页
Central catadioptric cameras are widely used in virtual reality and robot navigation,and the camera calibration is a prerequisite for these applications.In this paper,we propose an easy calibration method for central ... Central catadioptric cameras are widely used in virtual reality and robot navigation,and the camera calibration is a prerequisite for these applications.In this paper,we propose an easy calibration method for central catadioptric cameras with a 2D calibration pattern.Firstly,the bounding ellipse of the catadioptric image and field of view(FOV)are used to obtain the initial estimation of the intrinsic parameters.Then,the explicit relationship between the central catadioptric and the pinhole model is used to initialize the extrinsic parameters.Finally,the intrinsic and extrinsic parameters are refined by nonlinear optimization.The proposed method does not need any fitting of partial visible conic,and the projected images of 2D calibration pattern can easily cover the whole image,so our method is easy and robust.Experiments with simulated data as well as real images show the satisfactory performance of our proposed calibration method. 展开更多
关键词 Central catadioptric camera CALIBRATION 2D calibration pattern computer vision
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AI-driven generative and reinforcement learning for mechanical optimization of 2D patterned hollow structures
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作者 Yicheng Shan Leitao Cao +4 位作者 Yu Wang Jing Ren Chen Huang Wenli Gao Shengjie Ling 《Materials Futures》 2025年第3期426-442,共17页
2D patterned hollow structures have emerged as advanced materials with exceptional mechanical properties and lightweight characteristics,making them ideal for high-performance applications in aerospace and automotive ... 2D patterned hollow structures have emerged as advanced materials with exceptional mechanical properties and lightweight characteristics,making them ideal for high-performance applications in aerospace and automotive industries.However,optimizing their structural design to achieve uniform stress distribution and minimize stress concentration remains a significant challenge due to the complex interplay between geometric patterns and mechanical performance.In this study,we develop an integrated framework combining conditional generative adversarial networks(cGANs)and deep Q-networks(DQNs)to predict and optimize the stress fields of 2D-PHS.We generated a comprehensive dataet comprising 1000 samples across five distinct density classes using a custom grid pattern generation algorithm,ensuring a wide range of structural variations.The cGAN accurately predicts stress distributions,achieving a high correlation with finite element analysis(FEA)results while reducing computational time from approximately 40 s(FEA)to just 1-2 s per prediction.Concurrently,the DQN optimizes design parameters through scaling and rotation operations,enhancing structural performance based on predicted stress metrics.Our approach resulted in a 4.3%improvement in average stress uniformity and a 23.1%reduction in maximum stress concentration.These improvements were validated through FEA simulations and experimental tensile tests on 3D-printed thermoplastic polyurethane samples.The tensile strength of the optimized samples increased from an initial average of 5.9-6.6 MPa under 100%strain,demonstrating enhanced mechanical resilience.This study demonstrates the efficacy of combining advanced AI techniques for rapid and precise material design optimization,providing a scalable and cost-effective solution for developing superior lightweight materials with tailored mechanical properties for critical engineering applications. 展开更多
关键词 2D patterned hollow structures mechanical property generative adversarial networks deep reinforcement learning
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Simultaneous 2D in-plane deformation measurement using electronic speckle pattern interferometry with double phase modulations 被引量:1
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作者 朱云龙 Julien Vaillant +3 位作者 Guillaume Montay Manuel Fran?ois Yassine Hadjar Aurélien Bruyant 《Chinese Optics Letters》 SCIE EI CAS CSCD 2018年第7期40-44,共5页
Electronic speckle pattern interferometry(ESPI) and digital speckle pattern interferometry are wellestablished non-contact measurement methods. They have been widely used to carry out precise deformation mapping. Ho... Electronic speckle pattern interferometry(ESPI) and digital speckle pattern interferometry are wellestablished non-contact measurement methods. They have been widely used to carry out precise deformation mapping. However, the simultaneous two-dimensional(2D) or three-dimensional(3D) deformation measurements using ESPI with phase shifting usually involve complicated and slow equipment. In this Letter, we solve these issues by proposing a modified ESPI system based on double phase modulations with only one laser and one camera. In-plane normal and shear strains are obtained with good quality. This system can also be developed to measure 3D deformation, and it has the potential to carry out faster measurements with a highspeed camera. 展开更多
关键词 Simultaneous 2D in-plane deformation measurement using electronic speckle pattern interferometry with double phase modulations
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Drought-induced desiccation cracking in surface soil:Two-dimensional characterization by FEM-OFDR framework
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作者 Jinjian XU Chaosheng TANG +4 位作者 Zhaojun ZENG Lin LI Junzheng ZHANG Tengfei GAO Bin SHI 《Science China(Technological Sciences)》 2025年第3期278-297,共20页
Drought-induced desiccation cracking can trigger several weakening mechanisms in surface soils,potentially precipitating instability and failure of slopes and earthen structures.To investigate the potential applicatio... Drought-induced desiccation cracking can trigger several weakening mechanisms in surface soils,potentially precipitating instability and failure of slopes and earthen structures.To investigate the potential application of distributed fibre optical sensing(DFOS)based on optical frequency domain reflectometry(OFDR)technology in characterizing the twodimensional(2D)desiccation cracking processes of surface soils,a comprehensive test device is utilized to conduct soil evaporation tests,continuously record water content changes,desiccation cracking evolution,and FO sensing strain status.A deep learning-based quantitative analysis method is employed to meticulously examine the relationship between 2D cracking geometric parameters and strain status.The comprehensive analysis not only reveals the mutual feedback response mechanism between the strain status and the soil evaporation-shrinkage-cracking processes,but also clarifies the early detection distance of OFDR technology for 2D desiccation cracking.Specifically,OFDR technology can detect the propagation of horizontal desiccation cracks up to 23 mm in advance with a strain measurement accuracy of 1με.To address the spatial continuity issue in OFDR sensing strain data,an innovative high-resolution characterization framework is proposed by combining the finite element method(FEM)and OFDR technology,referred to as the FEM-OFDR framework.Comparative results indicate that the proposed FEM significantly surpasses both the kriging and radial basis function(RBF)methods in inferring missing OFDR sensing strain data.Notably,during the drying process,reaching a critical water content causes the local decoupling between the uncracked clods and the substrate,resulting in a decreasing trend in the sensing strain at the crack position.This study provides crucial technical means and theoretical support for a deeper understanding of the mechanisms driving 2D desiccation-induced shrinkage and cracking in surface soils. 展开更多
关键词 soil desiccation cracking distributed fibre optical sensing optical frequency domain reflectometry finite element method 2D crack patterns monitoring mechanism
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