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Durability of SAP-modified Fully Recycled Concrete under Freeze-Thaw Cycles
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作者 XING Zhengguang PENG Erxing +3 位作者 ZHANG Mingyi PEI Wansheng HU Xiaoying SUN Haoyue 《Journal of Wuhan University of Technology(Materials Science)》 2026年第1期179-188,共10页
This study introduces superabsorbent polymers(SAP)into recycled concrete and,through freeze-thaw cycle tests,unconfined compressive strength tests,and nuclear magnetic resonance(NMR)analysis,evaluates the freeze-thaw ... This study introduces superabsorbent polymers(SAP)into recycled concrete and,through freeze-thaw cycle tests,unconfined compressive strength tests,and nuclear magnetic resonance(NMR)analysis,evaluates the freeze-thaw resistance and durability of recycled concrete samples under varying freeze-thaw cycles.The results indicate that an appropriate addition of SAP significantly enhances the freeze-thaw resistance of recycled concrete.After 200 freeze-thaw cycles,the RS0.6 sample retained good surface integrity,demonstrating the best performance.Compared to NAC,its mass loss decreased by 1.16%,the relative dynamic modulus improved by 7.01%,and the compressive strength loss rate decreased by 5.41%.Additionally,T2 spectrum analysis revealed that adding SAP optimized the pore structure of recycled concrete and mitigated pore development during freeze-thaw cycles.As the number of freeze-thaw cycles increased,the RS0.3 and RS0.6 samples demonstrated superior frost resistance compared to NAC.However,an excessive amount of SAP increased pore expansion during subsequent freeze-thaw cycles,ultimately weakening frost resistance. 展开更多
关键词 Recycled concrete SAP freeze-thaw cycle pore structure DURABILITY
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Aerothermal performance of turbine during flight cycle based on fluid-thermal-structure multidisciplinary coupling method
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作者 Yunda ZHANG Zhengping ZOU +2 位作者 Chao FU Yifan WANG Jun ZENG 《Chinese Journal of Aeronautics》 2026年第1期35-54,共20页
The coupling effects among the flow field,temperature distribution and structural deformation in a turbine cannot be ignored,particularly during flight cycles when the turbine experiences varied operational states.Rel... The coupling effects among the flow field,temperature distribution and structural deformation in a turbine cannot be ignored,particularly during flight cycles when the turbine experiences varied operational states.Relying solely on steady-state solutions cannot predict the detrimental effects caused by hysteresis.Consequently,this paper employs a quasi-steady-state fluid-thermalstructure multidisciplinary coupling solution method,integrating transient solid heat conduction with steady-state flow field and static structural deformation solutions.After conducting a numerical simulation of a three-dimensional,five-stage,low-pressure turbine air system,the following conclusions are drawn:when boundary conditions attain high-power states through processes that are numerically identical but in opposite directions,slight variations in solid deformation significantly impact the flow field;when boundary conditions attain high-power states through processes that are directionally consistent but have different numerical values,the influence of the boundary condition change rate on the flow field surpasses that of solid deformation.In terms of turbine design parameters,a large difference in stage-reaction between adjacent stages at the lower radius of the turbine can lead to significant changes in the disc cavity flow field during flight cycles.The difference in the stage-reaction of 0.23 at 10%blade height in adjacent stages may induce severe gas ingress in the stator disc cavity.Thus,it is crucial to minimize this difference and to appropriately extend the duration of the deceleration phase to ensure the turbine's safe operation. 展开更多
关键词 Flight cycle Fluid-thermal-structure Multidisciplinary coupling Quasi-steady-state TURBINE
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Life cycle environmental impacts and emission reduction pathways of wind power in western China:A scenario-based assessment
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作者 Ning Su Xiaobing Li +3 位作者 Xin Lyu Dongliang Dang Siyu Liu Chenhao Zhang 《Geography and Sustainability》 2026年第1期54-65,共12页
Compared with traditional energy sources,wind power has a lower environmental impact.However,emissions are still generated across the life cycle of wind turbines,from production to recycling.As wind power rapidly deve... Compared with traditional energy sources,wind power has a lower environmental impact.However,emissions are still generated across the life cycle of wind turbines,from production to recycling.As wind power rapidly develops and deployment increases,these impacts are becoming increasingly evident.A comprehensive understanding of these impacts is crucial for sustainable development.Based on the harmonization of previous detailed life cycle assessment(LCA)studies,this study develops a simplified LCA model that estimates the life cycle environmental impacts of wind turbines based on their nominal power.Using this simplified LCA model,we assess the global warming potential(GWP),acidification potential(AP),and cumulative energy demand(CED)of wind power at the regional scale for 2022 and under three future scenarios(high-power wind turbine promotion,reduced wind curtailment,and a comprehensive development scenario).The results indicate that in 2022,the life cycle GWP,AP,and CED of wind power in western China were 10.76 g CO_(2) eq/kWh,0.177 g SO_(2) eq/kWh,and 17.6 kJ/kWh,respectively.Scenario simulations suggest that reducing wind curtailment is the most effective approach for reducing emissions in Inner Mongolia,Gansu,Qinghai,Ningxia,and Xinjiang,producing average decreases of 8.64%in GWP,8.39%in AP,and 9.26%in CED.In contrast,for Guangxi,Chongqing,Sichuan,Guizhou,Yunnan,Xizang,and Shaanxi,the promotion of high-power wind turbines provides greater environmental benefits than reducing curtailment,producing average decreases of 3.45%,3.09%,and 4.29%in GWP,AP,and CED,respectively.These findings help clarify the environmental impact of wind power across its life cycle at the regional scale and provide theoretical references for the direction of future wind power development and the formulation of related policies. 展开更多
关键词 Wind energy Life cycle assessment Environmental impact Scenario simulation Western China
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Forecasting solar cycles using the time-series dense encoder deep learning model
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作者 Cui Zhao Shangbin Yang +1 位作者 Jianguo Liu Shiyuan Liu 《Astronomical Techniques and Instruments》 2026年第1期43-54,共12页
The solar cycle(SC),a phenomenon caused by the quasi-periodic regular activities in the Sun,occurs approximately every 11 years.Intense solar activity can disrupt the Earth’s ionosphere,affecting communication and na... The solar cycle(SC),a phenomenon caused by the quasi-periodic regular activities in the Sun,occurs approximately every 11 years.Intense solar activity can disrupt the Earth’s ionosphere,affecting communication and navigation systems.Consequently,accurately predicting the intensity of the SC holds great significance,but predicting the SC involves a long-term time series,and many existing time series forecasting methods have fallen short in terms of accuracy and efficiency.The Time-series Dense Encoder model is a deep learning solution tailored for long time series prediction.Based on a multi-layer perceptron structure,it outperforms the best previously existing models in accuracy,while being efficiently trainable on general datasets.We propose a method based on this model for SC forecasting.Using a trained model,we predict the test set from SC 19 to SC 25 with an average mean absolute percentage error of 32.02,root mean square error of 30.3,mean absolute error of 23.32,and R^(2)(coefficient of determination)of 0.76,outperforming other deep learning models in terms of accuracy and training efficiency on sunspot number datasets.Subsequently,we use it to predict the peaks of SC 25 and SC 26.For SC 25,the peak time has ended,but a stronger peak is predicted for SC 26,of 199.3,within a range of 170.8-221.9,projected to occur during April 2034. 展开更多
关键词 Solar cycle Forecasting TIDE Deep learning
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Fluid mechanics approach to assess airflow dynamics during the respiratory cycle in a child nasal airway with adenoid hypertrophy
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作者 Zahid Ullah Khan Xizhuo Jiang +1 位作者 Jingliang Dong Xiaodong Wang 《Acta Mechanica Sinica》 2026年第1期162-177,共16页
The airflow mechanics in adult nasal airways,whether healthy or abnormal,are extensively studied and investigated,but the flow mechanics in child nasal airways remain underexplored.This study investigates the airflow ... The airflow mechanics in adult nasal airways,whether healthy or abnormal,are extensively studied and investigated,but the flow mechanics in child nasal airways remain underexplored.This study investigates the airflow mechanics in the child’s nasal upper airway with adenoid hypertrophy,with an adenoid nasopharyngeal ratio(AN of 0.9),under cyclic inhalation and exhalation.An inlet respiratory cycle with three different flow rates(3.2 L/min calm breathing,8.6 L/min normal breathing,and 19.3 L/min intensive breathing)was simulated by using the computational fluid dynamics approach.To better capture the interaction between airflow and the flexible airway tissue,fluid-structure interaction analysis was performed at the normal breathing rate.Comparing the airflow dynamics during inhalation and exhalation,the pressure drops,nasal resistance,and wall shear stress show significant differences in the nasopharyngeal region for all different flow rates.This observation suggests that the inertial effect associated with the transient flow is important during exhalation and inhalation.Furthermore,the considerable temporal variation in flow rate distribution across a specific cross-section of the nasal airway highlights the critical role of transient data in virtual surgery planning and data for clinical decisions. 展开更多
关键词 Computational fluid dynamics Child nasal airway Nasal breathing cycle Flow mechanics Nasal resistance Pressure drop Wall shear stress
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The extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro
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作者 Yunwei Hu Keke Hu +4 位作者 Jiaying Liang Xingjiang Zhang Huijuan Li Jianxin Wu Qing Huang 《Chinese Journal of Natural Medicines》 2026年第2期203-214,共12页
Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chin... Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chinese medicine used for various ailments,has not been evaluated for efficacy in treating hair loss.This study presents the first comprehensive assessment of the hair growth-promoting effects of ethanol extract from CR on mouse primary dermal papilla cells(MDPCs)and human immortalized hair DPCs(IHHDPCs),employing cell counting kit-8(CCK-8),scratch assay,reverse transcription-quantitative polymerase chain reaction(RT-q PCR),and Western blot(WB).CR treatment activated the Wnt/β-Catenin signaling pathway by upregulating Wnt10b,increasingβ-Catenin protein levels and promoting its nuclear translocation,while simultaneously downregulating transforming growth factor-beta 1(TGF-β1),BMP4,and dickkopf-related protein 1(DKK1)in MDPCs.These molecular changes enhanced cell proliferation and increased secretion of key growth factors—insulin-like growth factor 1(IGF1),keratinocyte growth factor(KGF),and vascular endothelial growth factor(VEGF)—thereby stimulating hair growth and prolonging the anagen phase,which was confirmed in an ex vivo hair follicle(HF)organ culture model.Chromatographic analysis identified the petroleum ether fraction(CRP),enriched in sesquiterpenes,as the primary bioactive component.Both CR and CRP promoted IHHDPC proliferation,migration,and growth factor expression through activation of the Wnt/β-Catenin pathway,with CRP exhibiting superior bioactivity.Furthermore,both treatments stimulated HF cycling,increased follicular density,and upregulated Ki67 andβ-Catenin expression in the dorsal skin of C57BL/6 mice.Collectively,these findings demonstrate that CR and CRP promote hair growth and modulate the hair cycle via enhancement of Wnt/β-Catenin signaling,providing a scientific basis for the potential clinical application of C.rotundus rhizomes in hair loss therapy and the development of related pharmaceuticals or cosmetics. 展开更多
关键词 Cyperus rotundus Hair growth Hair cycle WNT/Β-CATENIN
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Study on the strength deterioration characteristics and microscopic mechanisms of moraine soil under freeze-thaw cycles
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作者 Peng-fei Wang Ming-li Li +3 位作者 Ming Chang Jun-lin Jiang Fan Yang Zhi-qiang Zuo 《Journal of Groundwater Science and Engineering》 2026年第1期15-31,共17页
To investigate the strength degradation characteristics and microscopic damage mechanisms of moraine soil under hydro-thermo-mechanical coupling conditions,a series of X-ray Diffraction(XRD),standard triaxial testing,... To investigate the strength degradation characteristics and microscopic damage mechanisms of moraine soil under hydro-thermo-mechanical coupling conditions,a series of X-ray Diffraction(XRD),standard triaxial testing,Scanning Electron Microscopy(SEM),and Nuclear Magnetic Resonance(NMR)experiments were conducted.The mechanical property degradation laws and evolution characteristics of the microscopic pore structure of moraine soil under Freeze-Thaw(F-T)conditions were revealed.After F-T cycles,the stress-strain curves of moraine soil showed a strain-softening trend.In the early stage of F-T cycles(0–5 cycles),the shear strength and elastic modulus exhibited damage rate of approximately 10.33%±0.8%and 16.60%±1.2%,respectively.In the later stage(10–20 cycles),the strength parameters fluctuated slightly and tended to stabilize.The number of F-T cycles was negatively exponentially correlated with cohesion,while showing only slight fluctuation in the internal friction angle,thereby extending the Mohr-Coulomb strength criterion for moraine soil under F-T cycles.The NMR experiments quantitatively characterized the evolution of the internal pore structure of moraine soil under F-T cycles.As the number of F-T cycles increased,fine and micro pores gradually expanded and merged due to the frost-heaving effect during the water-ice phase transition,forming larger pores.The proportion of large and medium pores increased to 59.55%±2.1%(N=20),while that of fine and micro pores decreased to 40.45%±2.1%(N=20).The evolution of pore structure characteristics was essentially completed in the later stage of F-T cycles(10–20 cycles).This study provides a theoretical foundation and technical support for major engineering construction and disaster prevention in the Qinghai-Xizang Plateau. 展开更多
关键词 Moraine soil in the Qinghai-Xizang Plateau F-T cycle Standard triaxial tests soil strength degradation Mohr-Coulomb criterion Microscopic pore structure
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Oxygen-Pressure Protocol Breaking Cycle Limit of Continuously Reversible Lithium-Oxygen Batteries
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作者 Xinhang Cui Fenglong Xiao +10 位作者 Guoliang Zhang Zhangliu Tian Qingshan Bao Yanlu Li Deliang Cui Qilong Wang Feng Dang Wei Chen Haohai Yu Huaijin Zhang Gang Lian 《Nano-Micro Letters》 2026年第5期391-404,共14页
Lithium-oxygen(Li-O_(2))battery is favored among“beyond lithiumion”technologies for sustainability because of its exceptional energy density.Major impediments are the poor cycle stability and grievous capacity degra... Lithium-oxygen(Li-O_(2))battery is favored among“beyond lithiumion”technologies for sustainability because of its exceptional energy density.Major impediments are the poor cycle stability and grievous capacity degradation at high current densities.We address these issues by a“killing two birds with one stone”O_(2)-pressure protocol.It first resolves efficient O_(2) mass transport at high rates..The accelerated reaction kinetics optimizes the composition and growth pathway of discharge products.This protocol secondly achieves protection of Li anodes via densifying corrosion layers on them.Consequently,the battery delivers both ultrahigh discharge capacity(>9,000 mAh g^(-1))at 3,000 mA g^(-1) and excellent cycling stability.Under a dual-strategy effect of high-pressure O_(2) and artificial protection layers,the battery actualizes over 11-fold increase in cycle life of 5,170 h(2,585 cycles).The strategy opens avenues for advancing Li-O_(2) batteries towards practical application and confers the extension to other gas-based batteries. 展开更多
关键词 Li-O_(2)batteries O_(2)pressure cycle life Li anode protection Rate performance
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Experimental study on damage evolution and failure precursor characteristics of granite under thermal shock cycles
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作者 Zhenjiang Huang Mingxuan Shen +5 位作者 Yu Zhao Chaolin Wang Jing Bi Yongfa Zhang Shuang Dang Yuhang Zhao 《International Journal of Mining Science and Technology》 2026年第1期125-148,共24页
Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens un... Investigating the damage evolution of surrounding rock under thermal shock cycles is crucial for ensuring the stability of engineering rock masses.This study performed Brazilian splitting tests on granite specimens under varying temperature and cycle conditions,employing acoustic emission monitoring,digital image correlation,and three-dimensional scanning technology.A systematic analysis was conducted on the patterns of damage evolution,failure precursor,and response mechanisms under combined thermal and cyclic loading.Experimental results show that both P-wave velocity and tensile strength degrade significantly with increasing temperature and cycle count,with temperature having a more pronounced effect than cycle count.Notably,damage evolution exhibits a dual-threshold behavior in which degradation accelerates markedly above 400℃ and stabilizes after 5 thermal cycles.Fracture surfaces evolve from initially planar to rugged morphologies,with peak-valley height differences at 600℃ being approximately three times greater than those at 200℃.Furthermore,based on acoustic emission energy entropy analysis,we introduce a novel failure precursor indicator where the sustained increase and critical surge in average entropy serve as reliable early-warning signals for impending rock failure.These findings establish a solid theoretical basis and practical methodology for damage assessment and instability early-warning systems in high-temperature rock engineering. 展开更多
关键词 GRANITE Thermal shock cycles Acoustic emission Thermal damage Failure precursor
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Effects of freeze-thaw cycles on aggregate stability of sandy loam on the Eastern Qinghai-Tibet Plateau
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作者 FENG Xiao DUN Yaoquan +2 位作者 QU Jianjun TIAN Qin DONG Lili 《Journal of Mountain Science》 2026年第1期417-433,共17页
Freeze-thaw cycles(FTCs)have an important effect on soil aggregate stability by altering soil structures,thereby influencing soil wind and water erosion on the eastern Qinghai-Tibet Plateau.However,the effects of FTCs... Freeze-thaw cycles(FTCs)have an important effect on soil aggregate stability by altering soil structures,thereby influencing soil wind and water erosion on the eastern Qinghai-Tibet Plateau.However,the effects of FTCs on the stability of these soils remain unclear.Here,we conducted freeze-thaw simulations in laboratory to investigate the effects of FTCs(0 to 15 cycles)on the wet-and dry-sieving aggregate stability of undisturbed sandy loam from Maqu county,which was treated with different initial soil moisture contents(1%to 25%in increments of 4%)and initial aggregate diameters(<2,2-5,5-10,and 10-15 mm).Results show that soil aggregates with initial diameters larger than 2 mm exhibit higher soil organic carbon contents(1.45%-1.57%)and silt contents(34.63%-35.52%)than those smaller than 2 mm(0.93%and 31.38%,respectively).The stability of both wet-and dry-sieving aggregates increases with larger initial diameters.Increasing initial soil moisture content from 1%to 25%reduces aggregate stability,with reductions of 2.4%-88.0%for wet-sieving aggregates and 2.1%-25.5%for dry-sieving aggregates(>2 mm).With increasing FTCs,wet-sieving aggregate(>2 mm)stability exhibits a fluctuating upward trend,with increases of 79.2%-87.4%after 15 FTCs,while dry-sieving aggregate(>2 mm)stability decreases significantly(5.7%-21.7%)upon the first FTC and remains unchanged thereafter.The stability of both the wet-and dry-sieving aggregates smaller than 2 mm remains unchanged with increasing FTCs(p>0.05).SOC content decreases by 22.3%on average with increasing FTCs from 1 to 15 and shows no significant correlations with wet-and dry-sieving aggregate stability.Higher silt content(r=0.39,p<0.05)and lower sand content(r=-0.38,p<0.05)enhances the wet-sieving aggregate stability of sandy loam.Frequent FTCs tend to improve wet-sieving aggregate stability but reduce dry-sieving aggregate stability in the sandy loam.The findings provide certain guidance for preventing freeze-thaw-induced wind erosion. 展开更多
关键词 Freeze-thaw cycles Sandy loam Soil aggregate stability Initial aggregate diameter Soil erosion Soil organic carbon
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Mechanical and microstructural properties of schist exposed to freezethaw cycles,dry-wet cycles,and alternating actions 被引量:2
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作者 Jiajia Gao Jiajian Jin +5 位作者 Daguo Wang Shaogang Lei Jianguo Lu Huan Xiao Jinhe Li Huadong Li 《International Journal of Mining Science and Technology》 2025年第5期783-800,共18页
In cold regions,slope rocks are inevitably impacted by freeze-thaw,dry-wet cycles and their alternating actions,leading to strength weakening and pore degradation.In this study,the mechanical and microstructural prope... In cold regions,slope rocks are inevitably impacted by freeze-thaw,dry-wet cycles and their alternating actions,leading to strength weakening and pore degradation.In this study,the mechanical and microstructural properties of schist subjected to four conditions were investigated:freeze-thaw cycles in air(FTA),freeze-thaw cycles in water(FTW),dry-wet cycles(DW),and dry-wet-freeze-thaw cycles(DWFT).Uniaxial compressive strength(UCS),water absorption,ultrasonication,low-field nuclear magnetic resonance,and scanning electron microscopy analyses were conducted.The integrity attenuation characteristics of the longitudinal wave velocity,UCS,and elastic modulus were analyzed.The results showed that liquid water emerged as a critical factor in reducing the brittleness of schist.The attenuation function model accurately described the peak stress and static elastic modulus of schist in various media(R2>0.97).Different media affected the schist deterioration and half-life,with the FTW-immersed samples having a half-life of 28 cycles.Furthermore,the longitudinal wave velocity decreased as the number of cycles increased,with the FTW showing the most significant reduction and having the shortest half-life of 208 cycles.Moreover,the damage variables of compressive strength and elastic modulus increased with the number of cycles.After 40 cycles,the schist exposed to FTW exhibited the highest damage variables and saturated water content. 展开更多
关键词 SCHIST Mechanical property Microstructure Freeze-thaw cycles Dry-wet cycles
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Optimizing Efficiency and Performance in a Rankine Cycle Power Plant Analysis
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作者 Ramesh Kumar Abdullah Bin Queyam +2 位作者 Manish Kumar Singla Mohamed Louzazni Mishra Dipak Kumar 《Energy Engineering》 2025年第4期1373-1386,共14页
Enhancing the efficiency of Rankine cycles is crucial for improving the performance of thermal power plants,as it directly impacts operational costs and emissions in light of energy transition goals.This study sets it... Enhancing the efficiency of Rankine cycles is crucial for improving the performance of thermal power plants,as it directly impacts operational costs and emissions in light of energy transition goals.This study sets itself apart from existing research by applying a novel optimization technique to a basic ideal Rankine cycle,focusing on a specific power plant that has not been previously analyzed.Currently,this cycle operates at 41%efficiency and a steam quality of 76%,constrained by fixed operational parameters.The primary objectives are to increase thermal efficiency beyond 46%and raise steam quality above 85%,while adhering to operational limits:a boiler pressure not exceeding 15 MPa,condenser pressure not dropping below 10 kPa,and turbine temperature not surpassing 500℃.This study utilizes numerical simulations to model the effects of varying boiler pressure(Pb)and condenser pressure(Pc)within the ranges of 12MPa<Pb<15 MPa and 5 kPa<Pc<10 kPa.By systematically adjusting these parameters,the proposed aimto identify optimal conditions that maximize efficiency and performance within specified constraints.The findings will provide valuable insights for power plant operators seeking to optimize performance under real-world conditions,contributing to more efficient and sustainable power generation. 展开更多
关键词 Rankine cycle thermal efficiency steamquality boiler pressure condenser pressure cycle performance operational constraints efficiency improvement
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Latent-Factorization-of-Tensors-Incorporated Battery Cycle Life Prediction
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作者 Minzhi Chen Li Tao +1 位作者 Jungang Lou Xin Luo 《IEEE/CAA Journal of Automatica Sinica》 2025年第3期633-635,共3页
Dear Editor,This letter presents a latent-factorization-of-tensors(LFT)-incorporated battery cycle life prediction framework.Data-driven prognosis and health management(PHM)for battery pack(BP)can boost the safety and... Dear Editor,This letter presents a latent-factorization-of-tensors(LFT)-incorporated battery cycle life prediction framework.Data-driven prognosis and health management(PHM)for battery pack(BP)can boost the safety and sustainability of a battery management system(BMS),which relies heavily on the quality of the measured BP data like the voltage(V),current(I),and temperature(T). 展开更多
关键词 health management battery pack bp can latent factorization tensors battery cycle life prediction health management phm battery cycle battery pack battery management system bms which
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Cell cycle proteins:Linking the cell cycle to tumors
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作者 JIE ZHONG JUE LIU +9 位作者 XING TANG WENCHAO ZHOU GUANGMING SONG YUHUAN ZENG XIAODI ZHANG JIANBIN ZHOU JieZhou LU CAO QUNFENG ZHANG YUKUN LI 《Oncology Research》 2025年第6期1335-1346,共12页
The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate.Cyclin-dependent kinases(CDKs)play crucial roles in the cell cycle by enabling cells to transition between different phase... The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate.Cyclin-dependent kinases(CDKs)play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated.Cell cycle proteins enhance the activity of CDKs,while natural CDK inhibitors(CDKIs)suppress them.The cell cycle continues in cycles under normal conditions,but when conditions change,cells halt or terminate the cell cycle.Tumors are tissues that grow out of control,and the mechanisms of various types of tumors are different;however,almost all tumor cells share several common characteristics,including proliferation,prevention of apoptosis and genomic instability.Cellular division is essential in the progression of cancer.A key characteristic of cancer is the uncontrolled growth of tumor cells,which is due to the erratic behavior of several proteins during the cell cycle.Therefore,cell cycle regulators are considered attractive targets for the treatment of cancer.The present analysis highlights proteins that play a direct role in controlling the tumor cell cycle,such as CDKs,and provides a brief overview of checkpoint kinases.The present review also discusses how cell cycle proteins contribute to cancer and describes some of the antitumor drugs that are being researched. 展开更多
关键词 Cell cycle CYCLIN Cyclin dependent kinase Cell cycle checkpoint TUMORS
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On the Occurrence of Different Classes of Solar Flares during the Solar Cycles 23 and 24
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作者 Longo Wilfried Sanon Wendpuiré Ousmane Compaoré +1 位作者 Somaïla Koala Jean Louis Zerbo 《Journal of High Energy Physics, Gravitation and Cosmology》 2025年第1期28-38,共11页
In this study we review the occurrence of different types (A, B, C, M, and X classes) of solar flares during different solar cycle phases from 1996 to 2019 covering the solar cycles 23 and 24. During this period, a to... In this study we review the occurrence of different types (A, B, C, M, and X classes) of solar flares during different solar cycle phases from 1996 to 2019 covering the solar cycles 23 and 24. During this period, a total of 19,126 solar flares were observed regardless the class: 3548 flares in solar cycle 23 (SC23) and 15,668 flares in solar cycle 24 (SC24). Our findings show that the cycle 23 has observed the highest occurrences of M-class and X-class flares, whereas cycle 24 has pointed out a predominance of B-class and C-class flares throughout its different phases. The results indicate that the cycle 23 was magnetically more intense than cycle 24, leading to more powerful solar flares and more frequent geomagnetic storms, capable of generating significant electromagnetic emissions that can affect satellites and GPS signals. The decrease in intense solar flares during cycle 24 compared to cycle 23 reflects an evolution in solar activity patterns over time. 展开更多
关键词 Solar Flare Solar cycle Solar cycle Phase Solar Flare Class OCCURRENCE
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Life Cycle Assessment of Wood as a Sustainable Material:Greenhouse Gas Emissions and Life Cycle Costs
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作者 Mingjia Liu 《Journal of Architectural Research and Development》 2025年第3期1-7,共7页
With the increasingly serious environmental problems,the use of sustainable materials is particularly important.This study focuses on the greenhouse gas emissions and economic costs of wood over its life cycle as a su... With the increasingly serious environmental problems,the use of sustainable materials is particularly important.This study focuses on the greenhouse gas emissions and economic costs of wood over its life cycle as a sustainable resource.We use a systematic life cycle assessment(LCA)approach to assess the entire process from raw material collection,processing,use to disposal.The study found that using wood can significantly reduce greenhouse gas emissions compared to traditional building materials such as steel and concrete.In addition,although the initial procurement costs of wood may be higher,its maintenance costs are lower in the long run,making the life cycle costs generally more economical.The results of this study highlight the environmental and economic advantages of wood in the selection of sustainable building materials,and provide a scientific basis for promoting the use of wood. 展开更多
关键词 WOOD Sustainable materials Life cycle assessment Greenhouse gas emissions Life cycle cost
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Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling
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作者 Ya-Tao Wang Yu-Le Yong +3 位作者 Ze-Kun Liu Yi-Xuan Shen Xiang-Min Yang Zhi-Nan Chen 《World Journal of Gastrointestinal Oncology》 2025年第6期405-422,共18页
BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleoti... BACKGROUND Hepatocellular carcinoma(HCC)ranks among the most prevalent and deadly malignancies,characterized by a high recurrence rate.Regulator of chromosome condensation 1(RCC1)serves as a principal guanine nucleotide exchange factor for ras-related nuclear protein guanosine triphosphatase(GTPase)and is implicated in various cancers.However,the role of RCC1 in HCC remains unex-plored.AIM To elucidate the functional significance and molecular mechanisms of RCC1 in HCC.METHODS Bioinformatics were to examine the expression levels of RCC1 in HCC and to assess its impact on the prognosis of this malignancy.The cell counting kit-8 assay and flow cytometry were utilized to evaluate the cell viability and cell cycle of HCC cells.Furthermore,quantitative reverse transcription and immunoblotting were to investigate the influence of RCC1 on cyclin associated proteins.RESULTS Bioinformatics analysis revealed that RCC1 was highly expressed in HCC and correlated with poor prognosis in HCC patients.Functional studies showed that RCC1 overexpression promoted the malignant phenotype of HCC cells,especially the proliferation of HCC cells,whereas RCC1 knockdown had the opposite effect.Mechanistically,we identied cell division cycle-associated(CDCA)8 as a downstream target of RCC1 in HCC.RCC1 overexpression markedly increased CDCA8 levels,consequently enhancing cell proliferation and survival in HCC cells.Additionally,we discovered that RCC1 contributed to the development and progression of HCC by activating the phosphoinositide 3-kinase/protein kinase B/cyclin-dependent kinase inhibitor 1a pathway through CDCA8.CONCLUSION Our study provides profound insights into the pivotal role of RCC1 in HCC and its potential as a therapeutic target. 展开更多
关键词 Hepatocellular carcinoma Regulator of chromosome condensation 1 PROLIFERATION Cell cycle Cell division cycleassociated 8 Phosphoinositide 3-kinase/protein kinase B pathway
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Precise Control of the Recollision Dynamics in Nonsequential Double Ionization by Spatially Inhomogeneous Few-Cycle Negatively Chirped Laser Pulses
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作者 Yingbin Li Fengrun Wu +10 位作者 Fanfei Liu Shuaijie Kang Zhengfa Li Ke Zhang Yifan Liu Kuo Li Chunyang Zhai Jingkun Xu Pu Wang Qiming Zhao Benhai Yu 《Chinese Physics Letters》 2025年第5期26-32,共7页
With a three-dimensional semiclassical ensemble method, we theoretically investigated the nonsequential double ionization of Ar driven by the spatially inhomogeneous few-cycle negatively chirped laser pulses. Our resu... With a three-dimensional semiclassical ensemble method, we theoretically investigated the nonsequential double ionization of Ar driven by the spatially inhomogeneous few-cycle negatively chirped laser pulses. Our results show that the recollision time window can be precisely controlled within an isolated time interval of several hundred attoseconds, which is useful for understanding the subcycle correlated electron dynamics. More interestingly, the correlated electron momentum distribution (CEMD) exhibits a strong dependence on laser intensity. That is, at lower laser intensity, CEMD is located in the first quadrant. As the laser intensity increases,CEMD shifts almost completely to the second and fourth quadrants, and then gradually to the third quadrant.The underlying physics governing the CEMD's dependence on laser intensity is explained. 展开更多
关键词 recollision time window recollision dynamics correlated electron momentum distribution nonsequential double ionization precise control understanding subcycle correlated electron dynamics three dimensional semiclassical ensemble method spatially inhomogeneous few cycle negatively chirped laser pulses
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一种带有比较器交错的2-bit/cycle高速SAR ADC
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作者 费秘 岳宏卫 韦善于 《微电子学》 北大核心 2025年第6期941-948,共8页
针对传统2-bit/cycle逐次逼近模数转换器(SAR ADC)中需要2^(N)个额外单位电容来提高速度的问题,基于CMOS 40 nm工艺提出了一种带有比较器交错的2-bit/cycle高速SAR ADC。该结构通过在最后一个比较周期自动切换不同尺寸大小的比较器来等... 针对传统2-bit/cycle逐次逼近模数转换器(SAR ADC)中需要2^(N)个额外单位电容来提高速度的问题,基于CMOS 40 nm工艺提出了一种带有比较器交错的2-bit/cycle高速SAR ADC。该结构通过在最后一个比较周期自动切换不同尺寸大小的比较器来等效减小参考电压的方法,将电容式数模转换器(CDAC)单位电容的使用量降低50%。此外,提出的比较器速度反馈系统能够在输入电压差较低时提高比较器的速度,并通过在采样保持电路中采用两段栅压自举和引入补偿电容的方法来降低噪声与失真。仿真结果表明,该ADC的分辨率为10 bit,采样频率为700 MS/s,在Nyquist输入频率下的SNDR为55.05 dB,SFDR为67.27 dB,整体功耗为2.91 mW,Walden FoM为9.20 fJ/conv.。 展开更多
关键词 2-bit/cycle 速度反馈 高速 SAR ADC 比较器交错
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Carbon emissions in China’s steel industry from a life cycle perspective:Carbon footprint insights 被引量:9
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作者 Xiaocong Song Shuai Du +5 位作者 Chenning Deng Peng Shen Minghui Xie Ci Zhao Chen Chen Xiaoyu Liu 《Journal of Environmental Sciences》 2025年第2期650-664,共15页
China is the most important steel producer in the world,and its steel industry is one of themost carbon-intensive industries in China.Consequently,research on carbon emissions from the steel industry is crucial for Ch... China is the most important steel producer in the world,and its steel industry is one of themost carbon-intensive industries in China.Consequently,research on carbon emissions from the steel industry is crucial for China to achieve carbon neutrality and meet its sustainable global development goals.We constructed a carbon dioxide(CO_(2))emission model for China’s iron and steel industry froma life cycle perspective,conducted an empirical analysis based on data from2019,and calculated the CO_(2)emissions of the industry throughout its life cycle.Key emission reduction factors were identified using sensitivity analysis.The results demonstrated that the CO_(2)emission intensity of the steel industry was 2.33 ton CO_(2)/ton,and the production and manufacturing stages were the main sources of CO_(2)emissions,accounting for 89.84%of the total steel life-cycle emissions.Notably,fossil fuel combustion had the highest sensitivity to steel CO_(2)emissions,with a sensitivity coefficient of 0.68,reducing the amount of fossil fuel combustion by 20%and carbon emissions by 13.60%.The sensitivities of power structure optimization and scrap consumption were similar,while that of the transportation structure adjustment was the lowest,with a sensitivity coefficient of less than 0.1.Given the current strategic goals of peak carbon and carbon neutrality,it is in the best interest of the Chinese government to actively promote energy-saving and low-carbon technologies,increase the ratio of scrap steel to steelmaking,and build a new power system. 展开更多
关键词 Iron and steel industry Life cycle Carbon dioxide(CO_(2))emissions Carbon footprint China
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