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Enhanced Cross-Phase Modulation via Phase Control in a Quantum dot Nanostructure 被引量:2
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作者 郝向英 郑安寿 +1 位作者 王英 李小刚 《Communications in Theoretical Physics》 SCIE CAS CSCD 2012年第5期866-872,共7页
A four-level quantum dot (QD) nanostructure interacting with four fields (two weak near-infrared (NIR) pulses and two control fields) forms the well-known double-cascade configuration.We investigate the cross-phase mo... A four-level quantum dot (QD) nanostructure interacting with four fields (two weak near-infrared (NIR) pulses and two control fields) forms the well-known double-cascade configuration.We investigate the cross-phase modulation (XPM) between the two NIR pulses.The results show,in such a closed-loop scheme,that the XPM can be greatly enhanced,while the linear absorption and two-photon absorption (gain) can be efficiently depressed by tuning the relative phase among the applied fields.This protocol may have potential applications in NIR all-optical switch design and quantum information processing with the solid-state materials. 展开更多
关键词 cross-phase modulation (XPM) phase control quantum dot (QD)
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Effects of walk-off on cross-phase modulation induced modulation instability in an optical fibre with high-order dispersion 被引量:1
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作者 钟先琼 向安平 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第6期1683-1688,共6页
This paper investigates the effects of walk-off among optical pulses on cross-phase modulation induced modulation instability in the normal dispersion region of an optical fibre with high-order dispersion. The results... This paper investigates the effects of walk-off among optical pulses on cross-phase modulation induced modulation instability in the normal dispersion region of an optical fibre with high-order dispersion. The results indicate that, in the case of high-order dispersion, the walk-off effect takes on new characteristics and will influence considerably the shape, position and especially the number of the spectral regions of the gain spectra of modulation instability. Not only the group-velocity mismatch, but also the difference of the third-order dispersion of two optical waves will alter the gain spectra of modulation instability but in different ways. Depending on the values of the walk-off parameters, the number of the spectral regions may increase from two to at most four, and the spectral shape and position may change too. 展开更多
关键词 modulation instability cross-phase modulation walk-off effect the difference ofthe third-order dispersion
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Supercontinuum Generation Enhanced by Cross-phase Modulation in Dispersion-flattened and Decreasing Fiber 被引量:1
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作者 XUWen-cheng XUYong-zhao YUBing-tao CUIHu CHENYong-zhu LIUSong-hao 《Semiconductor Photonics and Technology》 CAS 2005年第2期116-121,共6页
Supercontinuum spectrum generation in a dispersion-flattened and decreasing fiber with two orthogonally polarized pulses was simulated and calculated. The research results indicated that the supercontinuum spectrum ge... Supercontinuum spectrum generation in a dispersion-flattened and decreasing fiber with two orthogonally polarized pulses was simulated and calculated. The research results indicated that the supercontinuum spectrum generated by two orthogonally polarized pulses is wider and flatter than that generated by single polarized pulse due to cross-phase modulation. The cross-phase modulation effect can enhance the supercontinuum spectrum generation. When the pump power of the input pulse is lower, the enhancement of supercontinuum spectrum generation by cross-phase modulation effect is more significant. 展开更多
关键词 fiber optics supercontinuum spectrum dispersion-flattened and decreasingfiber cross-phase modulation soliton trapping
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Cross-phase modulation instability in optical fibres with exponential saturable nonlinearity and high-order dispersion
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作者 钟先琼 向安平 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第6期356-361,共6页
Utilizing the linear-stability analysis, this paper analytically investigates and calculates the condition and gain spectra of cross-phase modulation instability in optical fibres in the ease of exponential saturable ... Utilizing the linear-stability analysis, this paper analytically investigates and calculates the condition and gain spectra of cross-phase modulation instability in optical fibres in the ease of exponential saturable nonlinearity and high-order dispersion. The results show that, the modulation instability characteristics here are similar to those of conventional saturable nonlinearity and Kerr nonlinearity. That is to say, when the fourth-order dispersion has the same sign as that of the second-order one, a new gain spectral region called the second one which is far away from the zero point may appear. The existence of the exponential saturable nonlinearity will make the spectral width as well as the peak gain of every spectral region increase with the input powers before decrease. Namely, for every spectral regime, this may lead to a unique value of peak gain and spectral width for two different input powers. In comparison with the case of conventional saturable nonlinearity, however, when the other parameters are the same, the variations of the spectral width and the peak gain with the input powers will be faster in case of exponential saturable nonlinearity. 展开更多
关键词 nonlinear optics cross-phase modulation instability exponential saturable nonlinearity high-order dispersion
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Transverse manipulation of particles using Bessel beam of tunable size generated by cross-phase modulation
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作者 乔响来 程雪梅 +3 位作者 张倩 张文定 任兆玉 白晋涛 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期747-753,共7页
We report on a method to achieve multiple microscopic particles being trapped and manipulated transversely by using a size-tunable Bessel beam generated by cross-phase modulation(XPM)based on the thermal nonlinear opt... We report on a method to achieve multiple microscopic particles being trapped and manipulated transversely by using a size-tunable Bessel beam generated by cross-phase modulation(XPM)based on the thermal nonlinear optical effect.The results demonstrate that multiple polystyrene particles can be stably trapped simultaneously,and the number of the trapped particles can be controlled by varying the trapping beam power.In addition,the trapped particles can be manipulated laterally with micron-level precision by changing the size of J_(0)Bessel beam.This work provides a simple but efficient way to trap and manipulate multiple particles simultaneously,which would have potential applications in many fields such as cell sorting and transportation. 展开更多
关键词 optical manipulation optical trapping J_(0)Bessel beam cross-phase modulation
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Channel Capacity of DWDM Networks with Cross-phase Modulation Effect
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作者 QI Jun-xuan WEN Shuang-cun 《Semiconductor Photonics and Technology》 CAS 2006年第1期51-53,共3页
In dense wavelength division multiplexing(DWDM) optical transmission systems, cross phase modulation(XPM) due to Kerr effect causes phase shift and intensity modulation in each channel, which will lead the channel cap... In dense wavelength division multiplexing(DWDM) optical transmission systems, cross phase modulation(XPM) due to Kerr effect causes phase shift and intensity modulation in each channel, which will lead the channel capacity to be a random variable. An expression of the channel capacity dealing with XPM effect is presented, and the correctness and accuracy of this method are demonstrated by numerical simulation. 展开更多
关键词 Fiber nonlinearity Information theory Optical fiber communication systems cross-phase modulation
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Evolution of Hyperbolic-Secant Pulses Towards Cross-Phase Modulation Induced Optical Wave Breaking and Soliton or Soliton Trains Generation in Quintic Nonlinear Fibers
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作者 钟先琼 张晓霞 +2 位作者 杜仙童 刘永 程科 《Communications in Theoretical Physics》 SCIE CAS CSCD 2015年第10期447-463,共17页
The approximate analytical frequency chirps and the critical distances for cross-phase modulation induced optical wave breaking(OWB) of the initial hyperbolic-secant optical pulses propagating in optical fibers with q... The approximate analytical frequency chirps and the critical distances for cross-phase modulation induced optical wave breaking(OWB) of the initial hyperbolic-secant optical pulses propagating in optical fibers with quintic nonlinearity(QN) are presented. The pulse evolutions in terms of the frequency chirps, shapes and spectra are numerically calculated in the normal dispersion regime. The results reveal that, depending on different QN parameters, the traditional OWB or soliton or soliton pulse trains may occur. The approximate analytical critical distances are found to be in good agreement with the numerical ones only for the traditional OWB whereas the approximate analytical frequency chirps accords well with the numerical ones at the initial evolution stages of the pulses. 展开更多
关键词 OPTICAL wave BREAKING cross-phase modulation quint
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Nonlinear Pulse Compression and Reshaping Using Cross-Phase Modulation in a Dispersion-Shifted Fiber
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作者 S. W. Chan K. K. Chow C. Shu 《光学学报》 EI CAS CSCD 北大核心 2003年第S1期395-396,共2页
Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to... Nonlinear pulse compression has been demonstrated by cross-phase modulation in a dispersion-shifted fiber. The output is obtained from filtering of the broadened optical spectrum and a pulse width reduction from 61 to 28 ps is achieved. 展开更多
关键词 DSF of line on IEEE as in Nonlinear Pulse Compression and Reshaping Using cross-phase modulation in a Dispersion-Shifted Fiber EDFA XPM DBM
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Analytical Assessment of the Q-Factor due to Cross-Phase Modulation (XPM)
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作者 Stephan Pachnicke Edgar Voges 《光学学报》 EI CAS CSCD 北大核心 2003年第S1期542-543,共2页
The paper describes the impact of cross-phase modulation on NRZ modulated WDM systems. The impairments due to XPM will be related to a Q-factor and the effects of dispersion management will be covered.
关键词 XPM Analytical Assessment of the Q-Factor due to cross-phase modulation in In of OSNR
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Memory-enhanced noiseless cross-phase modulation
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作者 Mahdi Hosseini Stojan Rebic +3 位作者 Ben M Sparkes Jason Twamley Ben C Buchler Ping K Lam 《Light: Science & Applications》 SCIE EI CAS 2012年第1期6-10,共5页
Large nonlinearity at the single-photon level can pave the way for the implementation of universal quantum gates.However,realizing large and noiseless nonlinearity at such low light levels has been a great challenge f... Large nonlinearity at the single-photon level can pave the way for the implementation of universal quantum gates.However,realizing large and noiseless nonlinearity at such low light levels has been a great challenge for scientists in the past decade.Here,we propose a scheme that enables substantial nonlinear interaction between two light fields that are both stored in an atomic memory.Semiclassical and quantum simulations demonstrate the feasibility of achieving large cross-phase modulation(XPM)down to the single-photon level.The proposed scheme can be used to implement parity gates from which CNOT gates can be constructed.Furthermore,we present a proof of principle experimental demonstration of XPM between two optical pulses:one stored and one freely propagating through the memory medium. 展开更多
关键词 CNOT gate cross-phase modulation electromagnetically induced transparency parity gate quantum memory
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Peak current reduction in presence of RF phase modulationin the dual RF system
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作者 Jiang Bocheng Zhang Yao Tsai Cheng-Ying 《强激光与粒子束》 北大核心 2026年第1期160-165,共6页
[Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau... [Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau damping,which is particularly important for storage rings operating with ultra-low emittance or atlow beam energy.[Purpose]To further increase the bunch length without additional hardware costs,the phasemodulation in a dual-RF system is considered.[Methods]In this paper,turn-by-turn simulations incorporating randomsynchrotron radiation excitation are conducted,and a brief analysis is presented to explain the bunch lengtheningmechanism.[Results]Simulation results reveal that the peak current can be further reduced,thereby mitigating IBSeffects and enhancing the Touschek lifetime.Although the energy spread increases,which tends to reduce thebrightness of higher-harmonic radiation from the undulator,the brightness of the fundamental harmonic can,in fact,beimproved. 展开更多
关键词 dual high-frequency system phase modulation beam bunch stretching intra-beam scattering
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Evaluation of Reinforcement Learning-Based Adaptive Modulation in Shallow Sea Acoustic Communication
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作者 Yifan Qiu Xiaoyu Yang +1 位作者 Feng Tong Dongsheng Chen 《哈尔滨工程大学学报(英文版)》 2026年第1期292-299,共8页
While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance re... While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance remains underexplored in field investigations.To evaluate the practical applicability of this emerging technique in adverse shallow sea channels,a field experiment was conducted using three communication modes:orthogonal frequency division multiplexing(OFDM),M-ary frequency-shift keying(MFSK),and direct sequence spread spectrum(DSSS)for reinforcement learning-driven adaptive modulation.Specifically,a Q-learning method is used to select the optimal modulation mode according to the channel quality quantified by signal-to-noise ratio,multipath spread length,and Doppler frequency offset.Experimental results demonstrate that the reinforcement learning-based adaptive modulation scheme outperformed fixed threshold detection in terms of total throughput and average bit error rate,surpassing conventional adaptive modulation strategies. 展开更多
关键词 Adaptive modulation Shallow sea underwater acoustic modulation Reinforcement learning
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Unlocking Wavelength-Selective Modulations of Open-Circuit Voltage in Metal Halide Perovskite Solar Cells
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作者 Younsuk Hu Jibeom Hong +3 位作者 Kyounguk Cho Wanseung Yoo Doo Hyun Ko Inchan Hwang 《Energy & Environmental Materials》 2026年第1期329-340,共12页
The photovoltaic performance of metal halide perovskite solar cells often respond divergently to environmental conditions during storage.In particular,light exposure can either enhance or degrade device efficiency,yet... The photovoltaic performance of metal halide perovskite solar cells often respond divergently to environmental conditions during storage.In particular,light exposure can either enhance or degrade device efficiency,yet the mechanisms underlying these antithetical behaviors are still under investigation.In this study,we explore the modulation of the open-circuit voltage(Voc)in triple-cation mixed-halide perovskite solar cells by systematically controlling storage environments.While light intensity exhibits minimal impact during storage,the spectral composition of illumination selectively enhances Voc comprising reversible and irreversible contributions.Structural characterization reveals that prolonged storage degrades the quality of perovskite crystals in the upper region of the perovskite layer,whereas light storage promotes the relaxation of microstrain at the buried interface with a p-type organic layer.This structural reorganization at the interface,accompanied by lattice expansion,accounts for suppressed nonradiative recombination and a corresponding increase in quasi-Fermi level splitting.Consequently,devices fabricated without chemical defect passivation achieve a power conversion efficiency of higher than 40%under indoor lighting conditions after preconditioned by continuous exposure to ambient light during storage.These findings highlight the critical role of controlled light exposure during storage not only in enhancing efficiency,but also in ensuring reproducibility of perovskite solar cell characterization. 展开更多
关键词 indoor photovoltaics light-induced modulations perovskite solar cells REPRODUCIBILITY strain relaxation
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Lattice-oxygen modulation for redox stabilization and multi-electron transfer in lithium-rich cathodes
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作者 Mingche Huang Ruian Fan +5 位作者 Chenkai Sun Aoshen Duan Hao Cheng Ruguang Ma Erhong Song Jianjun Liu 《Materials Reports(Energy)》 2026年第1期94-102,共9页
Lithium-rich layered oxides(LRLOs)are promising cathode materials due to their high specific capacity,energy density,and operating voltage.However,their performance is hindered by the limited redox activity of transit... Lithium-rich layered oxides(LRLOs)are promising cathode materials due to their high specific capacity,energy density,and operating voltage.However,their performance is hindered by the limited redox activity of transition metals,leading to oxygen redox instability,oxygen release,and capacity degradation.To address these issues,we propose an innovative lattice-oxygen modulation(LOM)strategy that incorporates Mn^(3+)and Ti^(4+)into the Li_(1.2)Cr_(0.3)Mn_(0.4)Ti_(0.1)O_(2) system,effectively mitigating Cr migration,stabilizing oxygen redox reactions,and reinforcing structural integrity.This results in improved electrochemical performance,as demonstrated by a 56.5 mAh g^(−1) increase in initial discharge capacity to 364.2 mAh g^(−1),with 71.3%capacity retention after 30 cycles,reflecting a 20.2%improvement in cycling stability.Density functional theory(DFT)calculations confirm enhanced Cr redox reversibility and reduced oxygen evolution,further strengthening structural stability.These synergistic effects highlight the pivotal role of the LOM strategy in optimizing both electrochemical performance and structural integrity,offering a scalable pathway to improve capacity and cycling stability in lithium-rich cathodes. 展开更多
关键词 Lithium-rich cathodes Oxygen modulation Redox stabilization Multi-electron transfer enhancement Lattice reinforcement
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Tea polyphenol polymer film enables broadband optical modulation for hybrid mode-locked ultrafast fiber lasers
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作者 Wei Chen Kang Li +4 位作者 Cheng Gao Qingping Hu Zhengfan Li Yi Xiong Yunzhou Sun 《Chinese Physics B》 2026年第2期442-450,共9页
Materials exhibiting broadband nonlinear optical responses are critically important for ultrafast photonics applications,particularly as saturable absorbers(SAs)that facilitate broadband optical pulse generation.In th... Materials exhibiting broadband nonlinear optical responses are critically important for ultrafast photonics applications,particularly as saturable absorbers(SAs)that facilitate broadband optical pulse generation.In this study,tea polyphenolpolyvinyl alcohol(TP-PVA)composite films are synthesized via a polymer embedding method and employed as SAs to initiate ultrafast pulse operation in fiber lasers.The TP-PVA SA film exhibits excellent broadband saturable absorption performance at wavelengths of 1.0μm,1.5μm,and 2.0μm,with modulation depths of 54.21%,41.41%,and 51.16%,respectively.Stable passively mode-locked pulses with pulse widths of 588 fs,419 fs,and 743 fs are generated in Yb-,Er-,and Tm-doped fiber lasers,respectively.This work confirms the effective performance of TP-PVA as a broadband SA,and establishes a foundation for the integration of novel and sustainable materials within ultrafast photonic systems.The approach paves the way for developing compact broadband ultrafast laser systems operating in the near-infrared spectral region. 展开更多
关键词 ultrafast fiber lasers saturable absorbers broadband modulators natural dyes tea polyphenol
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Double-side delay alignment modulation for multi-user millimeter wave and terahertz communications
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作者 Xingwei Wang Haiquan Lu +1 位作者 Jieni Zhang Yong Zeng 《Digital Communications and Networks》 2026年第1期11-24,共14页
Delay Alignment Modulation(DAM)is an innovative broadband modulation technique well-suited for millimeter Wave(mm Wave)and Terahertz(THz)massive Multiple-Input Multiple-Output(MIMO)communication systems.Leveraging the... Delay Alignment Modulation(DAM)is an innovative broadband modulation technique well-suited for millimeter Wave(mm Wave)and Terahertz(THz)massive Multiple-Input Multiple-Output(MIMO)communication systems.Leveraging the high spatial resolution and sparsity of multi-path channels,DAM effectively mitigates Inter-Symbol Interference(ISI)by aligning all multi-path components through a combination of delay pre-compensation(or post-compensation)and path-based beamforming.As such,ISI is eliminated while preserving multi-path power gains.In this paper,we investigate multi-user double-side DAM,which incorporates both delay pre-compensation at the transmitter and post-compensation at the receiver,in contrast to prior works that primarily focus on singleside DAM with only delay pre-compensation.Firstly,we derive the constraint on the number of introduced delays and formulate the corresponding delay pre/post-compensation vectors tailored for multi-user double-side DAM,given a specific number of delay compensations.Furthermore,we demonstrate that when the number of Base Stations(BSs)/User Equipment(UE)antennas is sufficiently large,single-side DAM—where delay compensation is performed only at the BS/UE—is preferable to double-side DAM,since the former results in less ISI to be spatially eliminated.Next,we propose two low-complexity path-based beamforming strategies based on the eigen-beamforming transmission and ISI-Zero Forcing(ZF),respectively.On this basis,we further analyze the achievable sum rates.Simulation results verify that with a sufficiently large number of BS/UE antennas,singleside DAM is adequate for ISI elimination.Moreover,compared to the benchmarking scheme of Orthogonal Frequency Division Multiplexing(OFDM),multi-user BS-side DAM achieves higher spectral efficiency and lower Peak-to-Average Power Ratio(PAPR). 展开更多
关键词 Delay alignment modulation Delay pre-compensation Delay post-compensation Path-based beamforming Fractional channel delay
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Dual-region synergistic modulation and (101) facet engineering for highly reversible zinc anodes
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作者 Shuai Zhang Kittima Lolupiman +5 位作者 Dongdong Zhang Zixuan Gao Rungroj Chanajaree Xinyu Zhang Jin Cao Jiaqian Qin 《Advanced Powder Materials》 2026年第1期99-111,共13页
Aqueous zinc-ion batteries(AZIBs)offer promising safety and affordability,but suffer from dendritic Zn growth and parasitic side reactions at the electrode-electrolyte interface.Herein,we construct a dual-region inter... Aqueous zinc-ion batteries(AZIBs)offer promising safety and affordability,but suffer from dendritic Zn growth and parasitic side reactions at the electrode-electrolyte interface.Herein,we construct a dual-region interfacial modulation framework by molecularly reconfiguring the Helmholtz double layer via trace methyl methacrylate(MMA).Exploiting its amphiphilic and functionally asymmetric architecture,MMA enables a coordinated interfacial reconstruction that disrupts Zn^(2+)solvation in the outer Helmholtz plane,builds a chemisorbed coordination layer in the inner plane,and modulates local interfacial chemistry with spatial precision.This dualregion regulation collectively suppresses water reactivity,facilitates Zn^(2+)desolvation,and drives crystallo-graphically preferred deposition along the(101)plane,promoting lateral growth and mitigating dendrite for-mation.As a result,symmetric Zn||Zn cells exhibit over 4200 h of stable cycling at 1 mA cm^(-2) and maintain 1100 h of operation at 2 mA cm^(-2),even at 0℃.Zn||Ti half-cells achieve a Coulombic efficiency of 99.83%,while Zn||NH_(4)V_(4)O_(10) full cells deliver 93.92%capacity retention after 400 cycles at 2 A g^(-1),and preserve 85.3%after 300 cycles at 0℃.This work demonstrates a scalable,mechanism-driven electrolyte design paradigm for dendrite-free and high-performance aqueous Zn metal batteries. 展开更多
关键词 Aqueous zinc-ion batteries Helmholtz plane engineering Dendrite suppression Solvation modulation Facet-selective Zn deposition
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Periodontitis-associated salivary microbiota exacerbates systemic osteoclastogenesis via gut modulation and tryptophan metabolism suppression in ovariectomized mice
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作者 Nannan Wang Jun Qian +7 位作者 Min Wang Lili Li Wenzheng Liao Rixin Chen Hua Nie Ruiyang Ge Fangfang Sun Fuhua Yan 《International Journal of Oral Science》 2026年第1期152-164,共13页
Epidemiological studies have highlighted an association between periodontitis and osteoporosis.However,the mechanism underlining this association remains unclear.Here,we revealed significant differences in the salivar... Epidemiological studies have highlighted an association between periodontitis and osteoporosis.However,the mechanism underlining this association remains unclear.Here,we revealed significant differences in the salivary microbiota between periodontally healthy individuals and periodontitis patients,with periodontitis patients exhibiting increased salivary microbiota diversity and an elevated abundance of pathogenic bacteria.Using an ovariectomized(OVX) mouse model,we demonstrated that the salivary microbiota from periodontitis patients exacerbated bone destruction by modulating the gut microbiota.Metabolomic analysis revealed that the periodontitis-associated salivary microbiota suppressed tryptophan metabolism.The tryptophan metabolite indole-3-lactic acid(ILA) directly inhibited osteoclast formation and differentiation.In OVX mice treated with periodontitis salivary microbiota,supplementation with ILA effectively suppressed osteoclastogenesis and alleviated the detrimental effects of periodontitis-associated salivary microbiota on systemic bones.In summary,our data demonstrate that periodontitis can affect systemic bone metabolism via the oral-gut axis and that ILA supplementation serves as a potential therapeutic option to mitigate these adverse effects. 展开更多
关键词 tryptophan metabolism salivary microbiota PERIODONTITIS OSTEOCLASTOGENESIS pathogenic bacteriausing epidemiological studies indole lactic acid gut modulation
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Complexity-Reduced Equalization for 200 Gbit/s PON Downstream Systems Based on SSB Modulation and Direct Detection
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作者 Yang Tao Huang Xingang +3 位作者 Ma Zhuang Zhong Yiming Huang Xiatao Liu Bo 《ZTE Communications》 2026年第1期56-64,共9页
The 200 Gbit/s passive optical network(PON)is most likely to be the next-generation scheme following 50G PON.The costeffective direct detection(DD)system is the economical choice.However,larger-capacity DD systems wil... The 200 Gbit/s passive optical network(PON)is most likely to be the next-generation scheme following 50G PON.The costeffective direct detection(DD)system is the economical choice.However,larger-capacity DD systems will face much more serious power fading caused by chromatic dispersion(CD)combined with square-law DD and thereby significantly increases the complexity of equalization algorithms.In this paper,a 200 Gbit/s Nyquist 4-level pulse amplitude modulation(PAM4)single side-band(SSB)modulation-DD downlink scheme is designed,and a low complexity quadratic-nonlinear equalizer is proposed for this system.The computational complexity of the quadratic nonlinear equalizer is about 28%of that of the conventional Volterra nonlinear equalizer,while still exhibiting excellent nonlinear equalization ability.Simulation results for the 200 Gbit/s system with 20 km fiber transmission show that it can achieve a power budget of 29 dB,while a 30.4 dB power budget is obtained in the 50 Gbit/s experimental transmission. 展开更多
关键词 200 Gbit/s passive optical network single side band modulation direct detection EQUALIZATION
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Modulation of mitochondrial dysfunction:Mechanisms and strategies for the use of natural products to treat stroke
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作者 Na Qin Rujuan Liu +3 位作者 Rong Deng Liuliu Shi Lei Wang Ting Zhu 《Neural Regeneration Research》 2026年第6期2215-2226,共12页
Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop... Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs. 展开更多
关键词 apoptosis AUTOPHAGY hemorrhagic stroke ischemic stroke mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction modulations mitochondrial transport natural products oxidative stress
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