Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,wh...Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,which underpin their broad applicability across diverse domains.Within the cosmetics industry,MOFs exhibit significant application potential owing to their high thermal and chemical stability,substantial loading capacity,low biological toxicity,favorable luminescent characteristics,and robust catalytic activity,leading to their increasing deployment in various cosmetic-related applications.This article systematically outlines the structural features and functional properties of MOFs,emphasizing their suitability for integration into cosmetic systems.Furthermore,it provides a comprehensive review of recent advances in the utilization of MOFs in cosmetics,encompassing the detection of organic contaminants and metal ions,ultraviolet protection,encapsulation,and controlled release of volatile active ingredients,as well as targeted delivery of dermatological therapeutic agents.The structure-property-application relationships of MOFs are critically examined.Building upon the foundation of existing research,this study offers a comprehensive outlook on the future development of MOFs in the field of cosmetics.It presents several strategic perspectives,including an in-depth analysis of current application studies,the expansion of MOFs applications into additional cosmetic domains,the integration of multifunctional MOFs systems,the development of MOFs-based composite materials,and the scale-up of synthesis processes from laboratory-scale research to industrial production.It is expected that the present piece of paper can contribute valuable guidance for further exploration and practical implementation in this emerging field of cosmetics.展开更多
This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the u...This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.展开更多
With the improvement of people’s living standards and the demand for their own health,plant-derived cosmetics containing plant extracts or plant active ingredients are also more and more favored by consumers.In fact,...With the improvement of people’s living standards and the demand for their own health,plant-derived cosmetics containing plant extracts or plant active ingredients are also more and more favored by consumers.In fact,the research on plant-derived cosmetics has a history of centuries and even over 1,000 years both domestically and internationally.In order to further analyze the domestic and international research hotspots and future trends in the research field of plant-derived cosmetics,the relevant literatures from China National Knowledge Infrastructure(CNKI)database,Wanfang database,Vip database and Web of Science Core Collection(WoSCC)database from January 1994 to June 2024 were chosen as research objects in this paper.The authors,countries,research institutions and key words of the selected 1,415 Chinese papers and 1,927 English papers were visually analysed using the bibliometric software CiteSpace and VOSviewer.The results show that the number of publications shows an increasing trend;the communication and cooperation between core authors and between research institutions of the publicationare are both weak;the research hotspots mainly focus on natural plants,Chinese herbs,active ingredients,and whitening;and future research trends may include green synthesis,efficacy application,health and safety,etc.This study aims to grasp the hot spots and trends in the field of plant-derived cosmetics,and to provide ideas and references for the relevant research in China in the future.展开更多
Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antio...Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antioxidant properties that can improve skin tone and skin health.Previous studies also reported that volatile organic compounds(VOCs)in skincare cosmetics could have beneficial effects on human skin.Objective:This research aims to evaluate the antioxidant properties of CHARMS^(TM)skincare cosmetics as well as to investigate the presence of VOCs that could influence their skin tone improvement properties.Material and methods:The CHARMS^(TM)products used were cleanser,toner,essence,serum,moisturizer,scrub,and night cream.The skin tone improvement was assessed on 20 female volunteers’facial skin by using a colorimeter.The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical scavenging assay,total phenolic content(TPC),and total flavonoid content(TFC).Meanwhile,the VOCs were measured using an electronic nose based on gas chromatography(e-nose-GC).Results:The findings show that skin tone was improved significantly by 3.23%in which the skin becomes lighter while skin redness was reduced by 5.75%after using the CHARMS^(TM)skincare cosmetics.The results also show that the cleanser(21.55±0.23%)and the serum(23.60±0.19%)had the highest DPPH radical scavenging activity.Contrarily,the moisturizer exhibited the highest TPC value(324.14±17.47 mg GAE/g),and the cleanser had the highest TFC value(24.68±1.57 mg QE/g).The VOCs detected in these skincare cosmetics such as limonene andγ-terpinene may have skin-lightening effects.Conclusion:It can be concluded that the tested products from CHARMS^(TM)skincare cosmetics comply with the standard regulations and guidelines for Control of Cosmetic Products in Malaysia and can be used effectively as a daily skincare routine.展开更多
A high-performance liquid chromatography(HPLC)method has been developed using a CAPCELL PAK ADME(150 mm×4.6 mm,5μm)as analytical column and a gradient elution with 15 min using acetonitrile and 0.1%(in volume fr...A high-performance liquid chromatography(HPLC)method has been developed using a CAPCELL PAK ADME(150 mm×4.6 mm,5μm)as analytical column and a gradient elution with 15 min using acetonitrile and 0.1%(in volume fraction)phosphoric acid water(pH=2.2)as the mobile phase.Three active substances in cosmetics were quantitatively detected simultaneously at a detection wavelength of 265 nm.The linear ranges of β-nicotinamide mononucleotides,ergothioneine and nicotinamide are 10~200 mg/L,5~100 mg/L and 5~100 mg/L respectively and the detection limits of three components are 3.0 mg/L,1.5 mg/L and 1.5 mg/L respectively.The recovery rate is 97.1~104.9%,with RSD≤2.0%.The method was applied to quantitative analysis of five samples of cosmetics toner,lotion,cream,essence and gel and three samples of raw materials.The results showed that the results of β-nicotinamide mononucleotide and ergothioneine in five cosmetics were consistent with the product label,while nicotinamide was inconsistent with the label.The purity of the three raw material samples was 99.5%,99.7% and 100.8%respectively.This method offers high precision,accuracy and short analysis time,making it a reliable approach for studying three active ingredients in cosmetics and suitable for quality control of related functional ingredients.展开更多
With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,pa...With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,particularly in aligning with the holistic education model,which emphasizes moral,intellectual,physical,aesthetic,and labor development.To bridge this gap,Guangdong Pharmaceutical University has implemented a comprehensive reform of its holistic education system,aiming to cultivate well-rounded cosmetics professionals.Key initiatives include integrating professional ethics into moral education,strengthening the integration of theory and practice in intellectual training,emphasizing skin health management in physical education,enhancing aesthetic appreciation and creative thinking,and promoting labor spirit and practical skills through hands-on experiences.These reform efforts have yielded significant results,contributing high-quality talent to the cosmetics industry and offering a valuable model for other institutions seeking to align education with industry demands.展开更多
This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And a...This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And also based on the Regulation on Supervision and Administration of Cosmetics(Draft),and so on.This article will briefly discuss the influence of the new trend of Chinese cosmetics regulations on the development of the cosmetics industry.According to data analysis,the pre-market approval process for cosmetics is closely related to the annual increase in the new product registrations quantity.Since March 1st,2017,the reform of the imported non-special-use cosmetics registration was first initiated in Pudong New Area in Shanghai,the imported cosmetics registration quantity has increased significantly,so as the non-special-use children’s registration.Under the background of no obvious change in the pre-marketing approval process of imported special-use cosmetics,there is no significant increase in the quantity of annual registration.Among the nine categories of special-use cosmetics,sunscreen and whitening cosmetics accounted for the highest proportion,followed by hair dyeing.For the hair-growing,breast beauty,fitness categories of special-use cosmetics,the registration quantity each year was very low due to the low approval rate,long approval process and high testing costs,etc.According to the new trend of Chinese cosmetics regulations,the idea of cosmetics supervision and administration is changing from focusing on pre-market approval procedures to focusing on post-market surveillance.展开更多
Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the s...Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the skin layers.These nano-sized emulsions allow skincare products,like moisturizers,anti-aging creams,and sunscreens,to penetrate the skin more deeply and be absorbed better.They can also release their active ingredients gradually,which enhances the product's effectiveness.Additionally,nanoemulsions are more stable,meaning they protect ingredients from breaking down or losing their effectiveness,which helps extend the shelf life of the products.However,despite their advantages,nanoemulsions come with challenges,such as difficulties in producing them on a large scale,meeting safety regulations,and ensuring they remain stable over time.Future research will likely focus on improving how these formulations are made,making sure they are safe to use,and exploring more environmentally friendly and personalized solutions for skincare.As this technology develops,nanoemulsions have the potential to transform cosmetic formulations by offering more innovative and effective skincare options.展开更多
This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory syst...This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory system of adverse event reporting and the registration of voluntary changes to mandatory,and analyzed the new regulatory requirements in depth,and put forward some suggestions for enterprises to cope with the strategy,so as to help enterprises adapt to the new policy more smoothly when exporting cosmetics.展开更多
The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries ...The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries of the past decade.Data shows that the Chinese cosmetics market was US$60 billion in 2021.It is expected to be the world’s number one consumer cosmetics market by 2050,with a size of approximately US$450 billion.The influence of social media and the internet has raised awareness of the risks associated with the usage of many chemicals in cosmetics and the health benefits of natural products derived from plants and other natural resources.As a result,the cosmetic industry is now paying more attention to natural products.The present review focus on the possible applications of natural products from various biological sources in skin care cosmetics,including topical care products,fragrances,moisturizers,UV protective,and anti-wrinkle products.In addition,the mechanisms of targets for evaluation of active ingredients in cosmetics and the possible benefits of these bioactive compounds in rejuvenation and health,and their potential role in cosmetics are also discussed.展开更多
Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purifi...Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purified bee venom （PBV） has been proposed as a promising candidate for that purpose. The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris. METHODS： The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit （CFU） assay. The mechanism of PBV employed in killing P. acnes was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. In addition, a total of 12 subjects were randomized in a double-blind, controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks. Evaluations included lesion counts and skin microorganism. RESULTS： PBV exhibited antimicrobial activity in a concentration-dependent manner, reducing the number of P. acnes CFU by approximately 6 logs at a concentration of 0.5 mg. When PBV concentration was higher than 1.0 mg, no P. acnes colonies were spotted on an agar. TEM and SEM of untreated P. acnes illustrated the normal pleomorphic structure, whereas the PBV- treated bacterium lost the integrity of surface architecture. Significant difference （P=0.027） in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group. In terms of average decrement of skin microorganism, subjects receiving cosmetics containing PBV experienced a significant 57.5% decrease of adenosine triphosphate levels, whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%. CONCLUSION： These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo. Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris. PBV may be a good candidate compound for developing therapeutic drua for the treatment of acne vulaaris.展开更多
A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar el...A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar electrokinetic capillary chromatography with amperometric detection （MECC-AD）. Effects of several factors, such as the pH value and concentration of running buffer, potential applied to the working electrode, separation voltage, and injection time were investigated to obtain optimum conditions for separation and detection. With a 75 cm long fused-silica capillary tube, well-defined separation of six phenolic compounds was achieved in 10 mmol/L SDS/40 mmol/L H3BO3-Na2B407 running buffer （pH 9.0）. Good linear relationship was obtained for each analyte over three orders of magnitude with correlation coefficients （r2） between 0.9985 and 0.9994, and the detection limit （S/N = 3） ranged from 0.04 p^g/mL to 0.45 p^g/mL. The proposed method has been successfully applied for the determination of phenolic whitening agents in real cosmetic samples with satisfactory results, providing an alternative monitoring method for cosmetics safety regulation.展开更多
An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the d...An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the determination of nine hormones including three glucocorticoids, one androgen and five progestogens in cosmetics. Several factors that affect the extraction efficiency, such as the kinds and volume of ionic liquid, salt concentration, ultrasonic power and time, and centrifugation time were investigated and optimized. Under the optimum extraction condition, the recoveries of analytes ranged from 85.97% to 108.84% except prednisolone (62.30%). The intraday and interday precision was below 2.51% and 3.30%, respectively.展开更多
As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, li...As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, liposomes, dendrimers, nano-emulsions are now becoming regular ingredients in the cosmetic space. These nanoparticle-based cosmetics or nano-cosmeceuticals have extended the boundaries of the applications of cosmetics in managing conditions of wrinkling, dehydrated and inelastic skin associated with aging and dispersed hyperpigmentation. With so many claims by giant cosmetic manufacturers on the several possibilities achievable by such products containing these, there remain valid questions needing answers. Such includes: what are the actual facts as opposed to unfounded expectations on use of nano-materials in cosmetics? What are the peculiar properties of Nano-sized structures? Any potential or actual health risks associated with nanoparticle-incorporated cosmetic products? What roles are the regulating authorities and academic researchers playing in the light of all these developments? This review attempts to answer these questions, taking a look at the updates on nano-sized materials used in cosmetics, while presenting actual advances made in nano-cosmetics amidst the seemingly not too obvious hidden risks.展开更多
The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and m...The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.展开更多
Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide ad...Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.展开更多
Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency.As a highly active substance in nature,natural polysaccharides have been reported in recent years to have ...Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency.As a highly active substance in nature,natural polysaccharides have been reported in recent years to have various cosmetic activities such as moisturizing,whitening,anti-aging and repairing skin,and are becoming a hot research topic in the cosmetics industry.At present,the mechanism of polysaccharide exerting cosmetic activity has been widely studied,but the relationship between polysaccharide’s chemical structure and cosmetic activity has not been effectively analyzed,which leads to the limitation of polysaccharide development.In this review,the mechanism of polysaccharides exerting cosmetic activities such as moisturizing,whitening,anti-aging and skin repair was introduced.The potential relationship between the structure and activity of polysaccharides was summarized by analyzing the influence of physical and chemical properties of polysaccharides,such as extraction method,molecular weight,monosaccharide composition,functional group and structural modification,etc.,which laid a foundation for the analysis of the structure-activity relationship of polysaccharides and improved its cosmetic value.展开更多
The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, th...The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.展开更多
文摘Metal-organic frameworks(MOFs)represent a class of multifunctional hybrid materials distinguished by their tunable structural architectures,adjustable pore dimensions,and tailorable surface chemical functionalities,which underpin their broad applicability across diverse domains.Within the cosmetics industry,MOFs exhibit significant application potential owing to their high thermal and chemical stability,substantial loading capacity,low biological toxicity,favorable luminescent characteristics,and robust catalytic activity,leading to their increasing deployment in various cosmetic-related applications.This article systematically outlines the structural features and functional properties of MOFs,emphasizing their suitability for integration into cosmetic systems.Furthermore,it provides a comprehensive review of recent advances in the utilization of MOFs in cosmetics,encompassing the detection of organic contaminants and metal ions,ultraviolet protection,encapsulation,and controlled release of volatile active ingredients,as well as targeted delivery of dermatological therapeutic agents.The structure-property-application relationships of MOFs are critically examined.Building upon the foundation of existing research,this study offers a comprehensive outlook on the future development of MOFs in the field of cosmetics.It presents several strategic perspectives,including an in-depth analysis of current application studies,the expansion of MOFs applications into additional cosmetic domains,the integration of multifunctional MOFs systems,the development of MOFs-based composite materials,and the scale-up of synthesis processes from laboratory-scale research to industrial production.It is expected that the present piece of paper can contribute valuable guidance for further exploration and practical implementation in this emerging field of cosmetics.
文摘This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.
文摘With the improvement of people’s living standards and the demand for their own health,plant-derived cosmetics containing plant extracts or plant active ingredients are also more and more favored by consumers.In fact,the research on plant-derived cosmetics has a history of centuries and even over 1,000 years both domestically and internationally.In order to further analyze the domestic and international research hotspots and future trends in the research field of plant-derived cosmetics,the relevant literatures from China National Knowledge Infrastructure(CNKI)database,Wanfang database,Vip database and Web of Science Core Collection(WoSCC)database from January 1994 to June 2024 were chosen as research objects in this paper.The authors,countries,research institutions and key words of the selected 1,415 Chinese papers and 1,927 English papers were visually analysed using the bibliometric software CiteSpace and VOSviewer.The results show that the number of publications shows an increasing trend;the communication and cooperation between core authors and between research institutions of the publicationare are both weak;the research hotspots mainly focus on natural plants,Chinese herbs,active ingredients,and whitening;and future research trends may include green synthesis,efficacy application,health and safety,etc.This study aims to grasp the hot spots and trends in the field of plant-derived cosmetics,and to provide ideas and references for the relevant research in China in the future.
基金funded by Universiti Tun Hussein Onn Malaysia(UTHM)under Industrial Grant,M066 together with Matching Grant,Q003.
文摘Background:The use of skincare cosmetics can enhance human skin integrity,appearance,and conditions.However,consumers nowadays are quite concerned about the efficacy of skincare cosmetics,particularly those with antioxidant properties that can improve skin tone and skin health.Previous studies also reported that volatile organic compounds(VOCs)in skincare cosmetics could have beneficial effects on human skin.Objective:This research aims to evaluate the antioxidant properties of CHARMS^(TM)skincare cosmetics as well as to investigate the presence of VOCs that could influence their skin tone improvement properties.Material and methods:The CHARMS^(TM)products used were cleanser,toner,essence,serum,moisturizer,scrub,and night cream.The skin tone improvement was assessed on 20 female volunteers’facial skin by using a colorimeter.The antioxidant properties were evaluated by 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical scavenging assay,total phenolic content(TPC),and total flavonoid content(TFC).Meanwhile,the VOCs were measured using an electronic nose based on gas chromatography(e-nose-GC).Results:The findings show that skin tone was improved significantly by 3.23%in which the skin becomes lighter while skin redness was reduced by 5.75%after using the CHARMS^(TM)skincare cosmetics.The results also show that the cleanser(21.55±0.23%)and the serum(23.60±0.19%)had the highest DPPH radical scavenging activity.Contrarily,the moisturizer exhibited the highest TPC value(324.14±17.47 mg GAE/g),and the cleanser had the highest TFC value(24.68±1.57 mg QE/g).The VOCs detected in these skincare cosmetics such as limonene andγ-terpinene may have skin-lightening effects.Conclusion:It can be concluded that the tested products from CHARMS^(TM)skincare cosmetics comply with the standard regulations and guidelines for Control of Cosmetic Products in Malaysia and can be used effectively as a daily skincare routine.
文摘A high-performance liquid chromatography(HPLC)method has been developed using a CAPCELL PAK ADME(150 mm×4.6 mm,5μm)as analytical column and a gradient elution with 15 min using acetonitrile and 0.1%(in volume fraction)phosphoric acid water(pH=2.2)as the mobile phase.Three active substances in cosmetics were quantitatively detected simultaneously at a detection wavelength of 265 nm.The linear ranges of β-nicotinamide mononucleotides,ergothioneine and nicotinamide are 10~200 mg/L,5~100 mg/L and 5~100 mg/L respectively and the detection limits of three components are 3.0 mg/L,1.5 mg/L and 1.5 mg/L respectively.The recovery rate is 97.1~104.9%,with RSD≤2.0%.The method was applied to quantitative analysis of five samples of cosmetics toner,lotion,cream,essence and gel and three samples of raw materials.The results showed that the results of β-nicotinamide mononucleotide and ergothioneine in five cosmetics were consistent with the product label,while nicotinamide was inconsistent with the label.The purity of the three raw material samples was 99.5%,99.7% and 100.8%respectively.This method offers high precision,accuracy and short analysis time,making it a reliable approach for studying three active ingredients in cosmetics and suitable for quality control of related functional ingredients.
基金Guangdong Provincial Graduate Education Innovation Program Project in 2024(Project No.:2024XSLT-039)。
文摘With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,particularly in aligning with the holistic education model,which emphasizes moral,intellectual,physical,aesthetic,and labor development.To bridge this gap,Guangdong Pharmaceutical University has implemented a comprehensive reform of its holistic education system,aiming to cultivate well-rounded cosmetics professionals.Key initiatives include integrating professional ethics into moral education,strengthening the integration of theory and practice in intellectual training,emphasizing skin health management in physical education,enhancing aesthetic appreciation and creative thinking,and promoting labor spirit and practical skills through hands-on experiences.These reform efforts have yielded significant results,contributing high-quality talent to the cosmetics industry and offering a valuable model for other institutions seeking to align education with industry demands.
文摘This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And also based on the Regulation on Supervision and Administration of Cosmetics(Draft),and so on.This article will briefly discuss the influence of the new trend of Chinese cosmetics regulations on the development of the cosmetics industry.According to data analysis,the pre-market approval process for cosmetics is closely related to the annual increase in the new product registrations quantity.Since March 1st,2017,the reform of the imported non-special-use cosmetics registration was first initiated in Pudong New Area in Shanghai,the imported cosmetics registration quantity has increased significantly,so as the non-special-use children’s registration.Under the background of no obvious change in the pre-marketing approval process of imported special-use cosmetics,there is no significant increase in the quantity of annual registration.Among the nine categories of special-use cosmetics,sunscreen and whitening cosmetics accounted for the highest proportion,followed by hair dyeing.For the hair-growing,breast beauty,fitness categories of special-use cosmetics,the registration quantity each year was very low due to the low approval rate,long approval process and high testing costs,etc.According to the new trend of Chinese cosmetics regulations,the idea of cosmetics supervision and administration is changing from focusing on pre-market approval procedures to focusing on post-market surveillance.
文摘Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the skin layers.These nano-sized emulsions allow skincare products,like moisturizers,anti-aging creams,and sunscreens,to penetrate the skin more deeply and be absorbed better.They can also release their active ingredients gradually,which enhances the product's effectiveness.Additionally,nanoemulsions are more stable,meaning they protect ingredients from breaking down or losing their effectiveness,which helps extend the shelf life of the products.However,despite their advantages,nanoemulsions come with challenges,such as difficulties in producing them on a large scale,meeting safety regulations,and ensuring they remain stable over time.Future research will likely focus on improving how these formulations are made,making sure they are safe to use,and exploring more environmentally friendly and personalized solutions for skincare.As this technology develops,nanoemulsions have the potential to transform cosmetic formulations by offering more innovative and effective skincare options.
文摘This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory system of adverse event reporting and the registration of voluntary changes to mandatory,and analyzed the new regulatory requirements in depth,and put forward some suggestions for enterprises to cope with the strategy,so as to help enterprises adapt to the new policy more smoothly when exporting cosmetics.
基金funding from the National Natural Science Foundation of China (Grant Numbers 21961142008,22177138).
文摘The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023,at around a 7%annual growth rate.The cosmetics industry is emerging as one of the fastest-growing industries of the past decade.Data shows that the Chinese cosmetics market was US$60 billion in 2021.It is expected to be the world’s number one consumer cosmetics market by 2050,with a size of approximately US$450 billion.The influence of social media and the internet has raised awareness of the risks associated with the usage of many chemicals in cosmetics and the health benefits of natural products derived from plants and other natural resources.As a result,the cosmetic industry is now paying more attention to natural products.The present review focus on the possible applications of natural products from various biological sources in skin care cosmetics,including topical care products,fragrances,moisturizers,UV protective,and anti-wrinkle products.In addition,the mechanisms of targets for evaluation of active ingredients in cosmetics and the possible benefits of these bioactive compounds in rejuvenation and health,and their potential role in cosmetics are also discussed.
基金supported by a grant from BioGreen21 Program, Rural Development Administration (Code#:PJ009519), Republic of Korea
文摘Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purified bee venom （PBV） has been proposed as a promising candidate for that purpose. The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris. METHODS： The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit （CFU） assay. The mechanism of PBV employed in killing P. acnes was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. In addition, a total of 12 subjects were randomized in a double-blind, controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks. Evaluations included lesion counts and skin microorganism. RESULTS： PBV exhibited antimicrobial activity in a concentration-dependent manner, reducing the number of P. acnes CFU by approximately 6 logs at a concentration of 0.5 mg. When PBV concentration was higher than 1.0 mg, no P. acnes colonies were spotted on an agar. TEM and SEM of untreated P. acnes illustrated the normal pleomorphic structure, whereas the PBV- treated bacterium lost the integrity of surface architecture. Significant difference （P=0.027） in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group. In terms of average decrement of skin microorganism, subjects receiving cosmetics containing PBV experienced a significant 57.5% decrease of adenosine triphosphate levels, whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%. CONCLUSION： These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo. Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris. PBV may be a good candidate compound for developing therapeutic drua for the treatment of acne vulaaris.
基金supported by the Natural Science Foundation of China(No.21205042)the Special Funds for the Development of Major Scientific Instruments and Equipment(No. 2011YQ15007205)
文摘A sensitive method for simultaneous determination of six phenolic whitening agents, including arbutin, phenol, resorcinol, hydroquinone, kojic acid, and salicylic acid in cosmetics has been developed using micellar electrokinetic capillary chromatography with amperometric detection （MECC-AD）. Effects of several factors, such as the pH value and concentration of running buffer, potential applied to the working electrode, separation voltage, and injection time were investigated to obtain optimum conditions for separation and detection. With a 75 cm long fused-silica capillary tube, well-defined separation of six phenolic compounds was achieved in 10 mmol/L SDS/40 mmol/L H3BO3-Na2B407 running buffer （pH 9.0）. Good linear relationship was obtained for each analyte over three orders of magnitude with correlation coefficients （r2） between 0.9985 and 0.9994, and the detection limit （S/N = 3） ranged from 0.04 p^g/mL to 0.45 p^g/mL. The proposed method has been successfully applied for the determination of phenolic whitening agents in real cosmetic samples with satisfactory results, providing an alternative monitoring method for cosmetics safety regulation.
文摘An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the determination of nine hormones including three glucocorticoids, one androgen and five progestogens in cosmetics. Several factors that affect the extraction efficiency, such as the kinds and volume of ionic liquid, salt concentration, ultrasonic power and time, and centrifugation time were investigated and optimized. Under the optimum extraction condition, the recoveries of analytes ranged from 85.97% to 108.84% except prednisolone (62.30%). The intraday and interday precision was below 2.51% and 3.30%, respectively.
文摘As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, liposomes, dendrimers, nano-emulsions are now becoming regular ingredients in the cosmetic space. These nanoparticle-based cosmetics or nano-cosmeceuticals have extended the boundaries of the applications of cosmetics in managing conditions of wrinkling, dehydrated and inelastic skin associated with aging and dispersed hyperpigmentation. With so many claims by giant cosmetic manufacturers on the several possibilities achievable by such products containing these, there remain valid questions needing answers. Such includes: what are the actual facts as opposed to unfounded expectations on use of nano-materials in cosmetics? What are the peculiar properties of Nano-sized structures? Any potential or actual health risks associated with nanoparticle-incorporated cosmetic products? What roles are the regulating authorities and academic researchers playing in the light of all these developments? This review attempts to answer these questions, taking a look at the updates on nano-sized materials used in cosmetics, while presenting actual advances made in nano-cosmetics amidst the seemingly not too obvious hidden risks.
文摘The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.
文摘Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.
基金the“JUN-MA”High-level Talents Program of Inner Mongolia University(No.21300-5195112,No.21300-5205107)the funding from the Science&Technology Department of Inner Mongolia Autonomous Region(No.2021CG0029,No.15000021T000000020229)the funding from the Agriculture&Animal Husbandry Department of Inner Mongolia Autonomous Region(No.21300-5223323).
文摘Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency.As a highly active substance in nature,natural polysaccharides have been reported in recent years to have various cosmetic activities such as moisturizing,whitening,anti-aging and repairing skin,and are becoming a hot research topic in the cosmetics industry.At present,the mechanism of polysaccharide exerting cosmetic activity has been widely studied,but the relationship between polysaccharide’s chemical structure and cosmetic activity has not been effectively analyzed,which leads to the limitation of polysaccharide development.In this review,the mechanism of polysaccharides exerting cosmetic activities such as moisturizing,whitening,anti-aging and skin repair was introduced.The potential relationship between the structure and activity of polysaccharides was summarized by analyzing the influence of physical and chemical properties of polysaccharides,such as extraction method,molecular weight,monosaccharide composition,functional group and structural modification,etc.,which laid a foundation for the analysis of the structure-activity relationship of polysaccharides and improved its cosmetic value.
文摘The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.
