Background: Toxoplasmosis is a worldwide disease that severely affects the fetuses and immunocompromised patients and results in many critical and life threatening conditions. The present study aimed to evaluate the a...Background: Toxoplasmosis is a worldwide disease that severely affects the fetuses and immunocompromised patients and results in many critical and life threatening conditions. The present study aimed to evaluate the awareness of toxoplasmosis and its preventive behaviors among female students in King Faisal University in Al-Ahssa. Subjects and methods: A cross sectional study was conducted in April 2014 among female students in KFU. The data were collected by a questionnaire from 88 participants. Results: Results showed that 65.4% were not aware of toxoplasmosis, and only 28.2% were aware of its complications or risk factors. This study showed that some people are at risk to get toxoplasmosis as they do not wash their hands with water and soap before eating (48.8%), do not wash the fruits and vegetables with water and soap (78.2%), drink tank water (51.3%) and cat owners don’t follow the proper measures for their cats. However, some people practice some of the preventive behaviors as they do not raise the cats (93.6%) and do not consume unpasteurized or unboiled milk (100%) or undercooked meat (92.3%). Conclusion: The current study proved the low awareness of toxoplasmosis which emphasized the need to educate the people in Al-Ahssa about the preventive methods, especially the pregnant women to prevent the severe complications of congenital infections.展开更多
Aluminium(Al)toxicity is one of the key factors limiting crop output in acidic soils,but until now little has been known about how Al is regulated transcriptionally in plants.This study identified Arabidopsis NAC tran...Aluminium(Al)toxicity is one of the key factors limiting crop output in acidic soils,but until now little has been known about how Al is regulated transcriptionally in plants.This study identified Arabidopsis NAC transcription factor ANAC050 in the regulation of Al tolerance.ANAC050 was located in the nucleus and displayed constitutive expression in the silique,flower,leaf,stem,and root,despite the fact that Al stress decreased its expression and protein accumulation.When compared with the Columbia ecotype wild-type,anac050 mutants that lacked function of ANAC050 exhibited Al sensitivity phenotype,while transgenic lines that overexpressed ANAC050 showed an Al-resistant phenotype,indicating the favorable influence of ANAC050 on preserving Al tolerance in plants.Further analysis indicated that anac050 mutants accumulated more Al in roots,implying that ANAC050 may confer a potential operation of an Al exclusion mechanism.Interestingly,anac050 mutants had down-regulated the expression of the genes encoding MULTIDRUG AND TOXIC COMPOUND EXTRUSION(MATE)and AL-ACTIVATED MALATE TRANSPORTER(ALMT1),which were involved in the secretion of citrate and malate,even though there was no evidence of a direct interaction between them,suggesting ANAC050 may mediate the secretion of citrate and malate indirectly.Together with the decreased hemicellulose content,lower Al content was also discovered in root cell walls and hemicelluloses of anac050 mutants,pointing to a potential interaction between ANAC017 and XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE(XTH).Although there was no evidence of a direct interaction between ANAC050 and XTH31,it is worth mentioning that the expression of XTH31,which is essential for xyloglucan modification,was down-regulated in anac050 mutants irrespective of the amount of Al given.In conclusion,our findings showed that ANAC050 contributed to Al resistance by indirect control of the release of organic acids and the accumulation of cell wall hemicelluloses.展开更多
文摘Background: Toxoplasmosis is a worldwide disease that severely affects the fetuses and immunocompromised patients and results in many critical and life threatening conditions. The present study aimed to evaluate the awareness of toxoplasmosis and its preventive behaviors among female students in King Faisal University in Al-Ahssa. Subjects and methods: A cross sectional study was conducted in April 2014 among female students in KFU. The data were collected by a questionnaire from 88 participants. Results: Results showed that 65.4% were not aware of toxoplasmosis, and only 28.2% were aware of its complications or risk factors. This study showed that some people are at risk to get toxoplasmosis as they do not wash their hands with water and soap before eating (48.8%), do not wash the fruits and vegetables with water and soap (78.2%), drink tank water (51.3%) and cat owners don’t follow the proper measures for their cats. However, some people practice some of the preventive behaviors as they do not raise the cats (93.6%) and do not consume unpasteurized or unboiled milk (100%) or undercooked meat (92.3%). Conclusion: The current study proved the low awareness of toxoplasmosis which emphasized the need to educate the people in Al-Ahssa about the preventive methods, especially the pregnant women to prevent the severe complications of congenital infections.
基金supported by the Key Project of the National Natural Science Foundation of China(No.42230711)。
文摘Aluminium(Al)toxicity is one of the key factors limiting crop output in acidic soils,but until now little has been known about how Al is regulated transcriptionally in plants.This study identified Arabidopsis NAC transcription factor ANAC050 in the regulation of Al tolerance.ANAC050 was located in the nucleus and displayed constitutive expression in the silique,flower,leaf,stem,and root,despite the fact that Al stress decreased its expression and protein accumulation.When compared with the Columbia ecotype wild-type,anac050 mutants that lacked function of ANAC050 exhibited Al sensitivity phenotype,while transgenic lines that overexpressed ANAC050 showed an Al-resistant phenotype,indicating the favorable influence of ANAC050 on preserving Al tolerance in plants.Further analysis indicated that anac050 mutants accumulated more Al in roots,implying that ANAC050 may confer a potential operation of an Al exclusion mechanism.Interestingly,anac050 mutants had down-regulated the expression of the genes encoding MULTIDRUG AND TOXIC COMPOUND EXTRUSION(MATE)and AL-ACTIVATED MALATE TRANSPORTER(ALMT1),which were involved in the secretion of citrate and malate,even though there was no evidence of a direct interaction between them,suggesting ANAC050 may mediate the secretion of citrate and malate indirectly.Together with the decreased hemicellulose content,lower Al content was also discovered in root cell walls and hemicelluloses of anac050 mutants,pointing to a potential interaction between ANAC017 and XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE(XTH).Although there was no evidence of a direct interaction between ANAC050 and XTH31,it is worth mentioning that the expression of XTH31,which is essential for xyloglucan modification,was down-regulated in anac050 mutants irrespective of the amount of Al given.In conclusion,our findings showed that ANAC050 contributed to Al resistance by indirect control of the release of organic acids and the accumulation of cell wall hemicelluloses.
