During the whole operation life of Bratsk and Ust-Ilimsk hydroelectric plants, chemical analysis of water filtering through the pressure front of the concrete dams was under systematic monitoring by sampling in places...During the whole operation life of Bratsk and Ust-Ilimsk hydroelectric plants, chemical analysis of water filtering through the pressure front of the concrete dams was under systematic monitoring by sampling in places of concemrated outcome in the inspection galleries of a dam. Long-term cumulative observations made up a basis for study of the indicated dams concrete corrosion caused by the Angara water in the process of its filtration through the cracks formed in the period of the dam erection, through construction joims and other defects. Mathematical-statistical analysis allowed the classification the processes of corrosion from the point of view of their time dynamics and divided them correspondingly into stationary （stable） and non-stationary. On the basis of a calculation of the cement stone componem removal along with the ideas of the process dynamics the pressure from filtration developmem forecast has been made and their danger level has been estimated. The developed conception is of rather a general character and can be used when analyzing the state of concrete dams of the Angara cascade and other similar cases.展开更多
Developing advanced tissue-engineered membranes with biocompatibility,suitable mechanical qualities,and anti-fibrotic and anti-inflammatory actions is important for tympanic membrane(TM)repair.Here,we present a novel ...Developing advanced tissue-engineered membranes with biocompatibility,suitable mechanical qualities,and anti-fibrotic and anti-inflammatory actions is important for tympanic membrane(TM)repair.Here,we present a novel acoustically transmitted decellularized fish swim bladder(DFB)loaded with mesenchymal stem cells(DFB@MSCs)for TM perforation(TMP)repair.The DFB scaffolds are obtained by removing the cellular components from the original FB,which retains the collagen composition that favors cell proliferation.Benefitting from their spatially porous structures and excellent mechanical properties,the DFB scaffolds can provide a suitable microenvironment and mechanical support for cell growth and tissue regeneration.In addition,by loading mesenchymal stem cells on the DFB scaffolds,the resultant DFB@MSCs system exhibits remarkable anti-fibrotic and anti-inflammatory effects,together with the ability to promote cell migration and angiogenesis.In vivo experiments confirm that the prepared DFB@MSCs scaffolds can not only alleviate inflammatory response caused by TMP but also promote new vessel formation,TM repair,and hearing improvement.These features indicate that our proposed DFB@MSCs stent is a prospective tool for the clinical repair of TM.展开更多
文摘During the whole operation life of Bratsk and Ust-Ilimsk hydroelectric plants, chemical analysis of water filtering through the pressure front of the concrete dams was under systematic monitoring by sampling in places of concemrated outcome in the inspection galleries of a dam. Long-term cumulative observations made up a basis for study of the indicated dams concrete corrosion caused by the Angara water in the process of its filtration through the cracks formed in the period of the dam erection, through construction joims and other defects. Mathematical-statistical analysis allowed the classification the processes of corrosion from the point of view of their time dynamics and divided them correspondingly into stationary （stable） and non-stationary. On the basis of a calculation of the cement stone componem removal along with the ideas of the process dynamics the pressure from filtration developmem forecast has been made and their danger level has been estimated. The developed conception is of rather a general character and can be used when analyzing the state of concrete dams of the Angara cascade and other similar cases.
基金supported by the National Natural Science Foundation of China(82171145,82371156,82401365,82192862,and 823B2021)the Key Research&Development Topics in Jiangsu Province(BE2023653)+1 种基金the Jiangsu Provincial Medical Key Discipline Laboratory(ZDXK202243)the Nanjing Medical Science and Technique Development Foundation(YKK24100).
文摘Developing advanced tissue-engineered membranes with biocompatibility,suitable mechanical qualities,and anti-fibrotic and anti-inflammatory actions is important for tympanic membrane(TM)repair.Here,we present a novel acoustically transmitted decellularized fish swim bladder(DFB)loaded with mesenchymal stem cells(DFB@MSCs)for TM perforation(TMP)repair.The DFB scaffolds are obtained by removing the cellular components from the original FB,which retains the collagen composition that favors cell proliferation.Benefitting from their spatially porous structures and excellent mechanical properties,the DFB scaffolds can provide a suitable microenvironment and mechanical support for cell growth and tissue regeneration.In addition,by loading mesenchymal stem cells on the DFB scaffolds,the resultant DFB@MSCs system exhibits remarkable anti-fibrotic and anti-inflammatory effects,together with the ability to promote cell migration and angiogenesis.In vivo experiments confirm that the prepared DFB@MSCs scaffolds can not only alleviate inflammatory response caused by TMP but also promote new vessel formation,TM repair,and hearing improvement.These features indicate that our proposed DFB@MSCs stent is a prospective tool for the clinical repair of TM.
