The Federal Railroad Administration (FRA)’s Web Based Accident Prediction System (WBAPS) is used by federal, state and local agencies to get a preliminary idea on safety at a rail-highway grade crossing. It is an int...The Federal Railroad Administration (FRA)’s Web Based Accident Prediction System (WBAPS) is used by federal, state and local agencies to get a preliminary idea on safety at a rail-highway grade crossing. It is an interactive and user-friendly tool used to make funding decisions. WBAPS is almost three decades old and involves a three-step approach making it difficult to interpret the contribution of the variables included in the model. It also does not directly account for regional/local developments and technological advancements pertaining to signals and signs implemented at rail-highway grade crossings. Further, characteristics of a rail-highway grade crossing vary by track class which is not explicitly considered by WBAPS. This research, therefore, examines and develops a method and models to estimate crashes at rail-highway grade crossings by track class using regional/local level data. The method and models developed for each track class as well as considering all track classes together are based on data for the state of North Carolina. Linear, as well as count models based on Poisson and Negative Binomial (NB) distributions, was tested for applicability. Negative binomial models were found to be the best fit for the data used in this research. Models for each track class have better goodness of fit statistics compared to the model considering data for all track classes together. This is primarily because traffic, design, and operational characteristics at rail-highway grade crossings are different for each track class. The findings from statistical models in this research are supported by model validation.展开更多
Graded teaching divides students into classes in which students are at the same level.Graded teaching is the variant and development of traditional methods.This article makes some introduction of graded teaching,has a...Graded teaching divides students into classes in which students are at the same level.Graded teaching is the variant and development of traditional methods.This article makes some introduction of graded teaching,has a review of the theoretical development and tries to analyses its advantages and disadvantages.Lastly,we have some specific requirements for teachers.展开更多
Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have tr...Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas,oligodendrogliomas,or oligoastrocytomas.Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century,it suffers from high intra-and inter-observer variability and does not adequately predict clinical outcomes.Based on integrated analysis of multiplatform genomic data from The Cancer Genome Atlas,lower-grade gliomas have been found to segregate into three cohesive,clinically relevant molecular classes.Molecular classes were closely aligned with the status of isocitrate dehydrogenase(IDH)mutations,tumor protein 53 mutations and the co-deletion of chromosome arms 1 p and 19q,but were not closely aligned with histologic classes.These findings emphasize the potential for improved definition of clinically relevant disease subsets using integrated molecular approaches and highlight the importance of biomarkers for brain tumor classification.展开更多
Jiang Shaohong is my best friend.He is 14years old and he is in Class 1,Grade 8.He is clever and can learn things quickly.He works hard at all his subjects.He has many hobbies,such as reading,singing,dancing,and playi...Jiang Shaohong is my best friend.He is 14years old and he is in Class 1,Grade 8.He is clever and can learn things quickly.He works hard at all his subjects.He has many hobbies,such as reading,singing,dancing,and playing sports.He loves animals,so he keeps a small dog as a pet and takes good care of it at home.He is kind and helpful.He often helps his classmates with their studies.展开更多
极地低温环境下,船体结构选材是极地船舶设计的关键环节。目前,各船级社船体结构选材规范要求既相互关联又存在差异,并且缺乏统一的设计温度定义,给极地低温环境下的船体结构选材设计带来较大挑战。通过对极地低温环境下船体结构选材规...极地低温环境下,船体结构选材是极地船舶设计的关键环节。目前,各船级社船体结构选材规范要求既相互关联又存在差异,并且缺乏统一的设计温度定义,给极地低温环境下的船体结构选材设计带来较大挑战。通过对极地低温环境下船体结构选材规范的系统梳理,按照规范基础和设计温度定义等方面的差异,可将其归纳为三大类,包括国际船级社协会统一要求S6(IACS UR S6)及船级社防寒规范、极地船级(POLAR CLASS)规范、俄罗斯船级社(RMRS)规范。文中对三大类规范之间的差异进行了对比分析,包括适用范围、设计温度和钢级选取等,提出有价值的结论和建议,以期为极地低温环境下船体结构选材设计提供参考。展开更多
建设区域医疗中心是国家“十四五”规划的重要内容,是协同推进公立医院医、教、研、防、管整体水平提升的重要途径。深入了解全国区域医疗中心申报和建设情况,探讨其申报和建设过程中面临的困境及解决方案,积极推动地级市三甲医院高质...建设区域医疗中心是国家“十四五”规划的重要内容,是协同推进公立医院医、教、研、防、管整体水平提升的重要途径。深入了解全国区域医疗中心申报和建设情况,探讨其申报和建设过程中面临的困境及解决方案,积极推动地级市三甲医院高质量发展。采用态势分析法(strengths,weaknesses,opportunities and threats analysis,SWTO),从4个维度分析案例医院的内部优势、劣势、外部机会、挑战,探索地级市公立医院成功申报国家区域医疗中心的路径策略。地级市三甲医院申报区域医疗中心面临诸多困难和挑战,医院申报积极性高,牵头医院在人才、技术等方面做了充分准备,但也存在申报和建设等诸多问题,层次和结构需进一步优化、运行机制有待进一步健全、医疗服务同质化水平有待进一步提高等问题。建议政府做好资源规划,引导医院重视申报工作,强化人才培养和专科诊疗能力水平,发挥信息化支撑作用,顺利实现国家区域医疗中心的成功申报。展开更多
文摘The Federal Railroad Administration (FRA)’s Web Based Accident Prediction System (WBAPS) is used by federal, state and local agencies to get a preliminary idea on safety at a rail-highway grade crossing. It is an interactive and user-friendly tool used to make funding decisions. WBAPS is almost three decades old and involves a three-step approach making it difficult to interpret the contribution of the variables included in the model. It also does not directly account for regional/local developments and technological advancements pertaining to signals and signs implemented at rail-highway grade crossings. Further, characteristics of a rail-highway grade crossing vary by track class which is not explicitly considered by WBAPS. This research, therefore, examines and develops a method and models to estimate crashes at rail-highway grade crossings by track class using regional/local level data. The method and models developed for each track class as well as considering all track classes together are based on data for the state of North Carolina. Linear, as well as count models based on Poisson and Negative Binomial (NB) distributions, was tested for applicability. Negative binomial models were found to be the best fit for the data used in this research. Models for each track class have better goodness of fit statistics compared to the model considering data for all track classes together. This is primarily because traffic, design, and operational characteristics at rail-highway grade crossings are different for each track class. The findings from statistical models in this research are supported by model validation.
文摘Graded teaching divides students into classes in which students are at the same level.Graded teaching is the variant and development of traditional methods.This article makes some introduction of graded teaching,has a review of the theoretical development and tries to analyses its advantages and disadvantages.Lastly,we have some specific requirements for teachers.
文摘Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas,oligodendrogliomas,or oligoastrocytomas.Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century,it suffers from high intra-and inter-observer variability and does not adequately predict clinical outcomes.Based on integrated analysis of multiplatform genomic data from The Cancer Genome Atlas,lower-grade gliomas have been found to segregate into three cohesive,clinically relevant molecular classes.Molecular classes were closely aligned with the status of isocitrate dehydrogenase(IDH)mutations,tumor protein 53 mutations and the co-deletion of chromosome arms 1 p and 19q,but were not closely aligned with histologic classes.These findings emphasize the potential for improved definition of clinically relevant disease subsets using integrated molecular approaches and highlight the importance of biomarkers for brain tumor classification.
文摘Jiang Shaohong is my best friend.He is 14years old and he is in Class 1,Grade 8.He is clever and can learn things quickly.He works hard at all his subjects.He has many hobbies,such as reading,singing,dancing,and playing sports.He loves animals,so he keeps a small dog as a pet and takes good care of it at home.He is kind and helpful.He often helps his classmates with their studies.
文摘极地低温环境下,船体结构选材是极地船舶设计的关键环节。目前,各船级社船体结构选材规范要求既相互关联又存在差异,并且缺乏统一的设计温度定义,给极地低温环境下的船体结构选材设计带来较大挑战。通过对极地低温环境下船体结构选材规范的系统梳理,按照规范基础和设计温度定义等方面的差异,可将其归纳为三大类,包括国际船级社协会统一要求S6(IACS UR S6)及船级社防寒规范、极地船级(POLAR CLASS)规范、俄罗斯船级社(RMRS)规范。文中对三大类规范之间的差异进行了对比分析,包括适用范围、设计温度和钢级选取等,提出有价值的结论和建议,以期为极地低温环境下船体结构选材设计提供参考。
文摘建设区域医疗中心是国家“十四五”规划的重要内容,是协同推进公立医院医、教、研、防、管整体水平提升的重要途径。深入了解全国区域医疗中心申报和建设情况,探讨其申报和建设过程中面临的困境及解决方案,积极推动地级市三甲医院高质量发展。采用态势分析法(strengths,weaknesses,opportunities and threats analysis,SWTO),从4个维度分析案例医院的内部优势、劣势、外部机会、挑战,探索地级市公立医院成功申报国家区域医疗中心的路径策略。地级市三甲医院申报区域医疗中心面临诸多困难和挑战,医院申报积极性高,牵头医院在人才、技术等方面做了充分准备,但也存在申报和建设等诸多问题,层次和结构需进一步优化、运行机制有待进一步健全、医疗服务同质化水平有待进一步提高等问题。建议政府做好资源规划,引导医院重视申报工作,强化人才培养和专科诊疗能力水平,发挥信息化支撑作用,顺利实现国家区域医疗中心的成功申报。
