Tropospheric ozone pollution has been worsened over most regions of China,adversely affecting human health and ecosystems.The long-term ozone concentration depends largely upon atmospheric circulations.Here,we conduct...Tropospheric ozone pollution has been worsened over most regions of China,adversely affecting human health and ecosystems.The long-term ozone concentration depends largely upon atmospheric circulations.Here,we conducted meteorological adjustment to quantitatively assess the influences of meteorological factors on the ozone evolution in China's seven city clusters during thewarm season(April to October)from 2013 to 2020.Our analysis indicated that northern and eastern regions experienced ozone increases driven by emission changes.Southern regions,particularly the Pearl River Delta(PRD),exhibited ozone rise primarily due to meteorological conditions despite emission changes.In the Sichuan Basin(SCB)and Central Yangtze River Plain(CYP),where ozone levels decreased,meteorological conditions played a significant role in suppressing the ascent of ozone.Empirical orthogonal functions(EOF)analyses suggested that the spatiotemporal trend ofmeteorologyassociated ozone was strongly correlated with the variation of East Asian Trough(EAT),South Asian High(SAH)and the western Pacific subtropical high(WPSH).The top three EOF patterns explained 33.4%,21.8%,and 16.0%of the total variance inmeteorology-associated ozone.Absolute principal component scores-multiple linear regression(APCS-MLR)analyse quantitatively identified that enhanced EAT and SAH with a northward location of WPSH were favourable to surface ozone formation in central and eastern regions,but unfavourable to ozone formation in edge regions such as SCB.展开更多
Aiming at the global design issue of transpiration cooling thermal protection system,a self-driven circulation loop is proposed as the internal coolant flow passage for the transpiration cooling structure to achieve a...Aiming at the global design issue of transpiration cooling thermal protection system,a self-driven circulation loop is proposed as the internal coolant flow passage for the transpiration cooling structure to achieve adaptive cooling.To enhance the universality of this internal cooling pipe design and facilitate its application,numerical studies are conducted on this systemwith four commonly used cooling mediums as coolant.Firstly,the accuracy of the numerical method is verified through an established experimental platform.Then,transient numerical simulations are performed on the flow states of different cooling mediums in the new self-circulation system.Based on the numerical result,the flow,phase change,and heat transfer characteristics of different cooling mediums are analyzed.Differences in fluid velocity and latent heat of phase change result in significant variation in heat exchange capacity among different coolingmediums,with the maximumdifference reaching up to 3 times.Besides,faster circulation speed leads to greater heat transfer capacity,with a maximum of 7600 W/m^(2).Consequently,the operating mechanism and cooling laws of the natural circulation system is further investigated,providing a reference for the practical application of this system.展开更多
In terms of the characteristic topology parameters of climate complex networks, the spatial connection structural complexity of the circulation system and the influence of four teleconnection patterns are quantitative...In terms of the characteristic topology parameters of climate complex networks, the spatial connection structural complexity of the circulation system and the influence of four teleconnection patterns are quantitatively described. Results of node degrees for the Northern Hemisphere （NH） mid-high latitude （30° N-90°N） circulation system （NHS） networks with and without the Arctic Oscillations （AO）, the North Atlantic Oscillations （NAO） and the Pacific-North American pattern （PNA） demonstrate that the teleconnections greatly shorten the mean shortest path length of the networks, thus being advantageous to the rapid transfer of local fluctuation information over the network and to the stability of the NHS. The impact of the AO on the NHS connection structure is most important and the impact of the NAO is the next important. The PNA is a relatively independent teleconnection, and its role in the NHS is mainly manifested in the connection between the NHS and the tropical circulation system （TRS）. As to the Southern Hemisphere mid-high latitude （30°S-90°S） circulation system （SHS）, the impact of the Antarctic Arctic Oscillations （AAO） on the structural stability of the system is most important. In addition, there might be a stable correlation dipole （AACD） in the SHS, which also has important influence on the structure of the SHS networks.展开更多
Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processe...Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processes. In humans, there are different vehicles to contain water and its constituents. Our objective is to find out whether there is an overall water-base circulation system in the human body by analyzing the updated findings of different research groups on the physiological functions of various seemingly isolated fluid systems. By 1963, there were five separate fluid systems discovered in mammalians: (i) The Primo Vasculature Fluid (PVF) with protein precursors and micro cells held in the Primo Vasculature System (PVS). (ii) Blood with its constituents held in the cardio vasculature. (iii) Extracranial interstitial fluid (ISF) whose vehicle had a very irregular structure—the interstitium all over the body. (iv) The cerebrospinal fluid had been considered to be within the brain ventricles and spinal canal. (v) The extra-cranial lymphatic system which drained ISF, and had been known to join the subclavian vein. Fluid (i) was first reported in 1963 and fluids (ii) to (v) have been known for many decades, but the failure to detect a lymphatic system inside the skull has also been a mystery for many decades. The intra-cranial ISF (which we name as BISF) has drawn little attention, apart from discussing the mechanism of the blood-brain-barrier. During the past decade, there has been direct evidence indicating that CSF and BISF are actually mixed. After that, the intracranial lymphatic system was discovered and confirmed in animal models only slightly over one year back, and we called such fluid as glymphatic-fluid. After reviewing the stated “classical” five fluid systems together with the new findings in Sections 2 - 7, we propose, for the first time, that the PVF, the blood, ISF, a mixture of CSF-BISF, and a mixture of glymphatic-fluid and lymph form an integrative circulation system in water base in the human and other mammalian bodies, as schematically represented in the last section. In this paper, we point out the positive correlation of chronic neuro degenerative diseases such as Alzheimer’s disease, Parkinson’s diseases and the insufficient brain wastes clearance by the glymphatic system. We also discuss the role played by the venous vessels as part of such clearance in upright posture. Moreover, simple non-invasive maneuver techniques are introduced here, as one example of enhancement of glymphatic fluid flow out of the skull to join the lymphatic system. A series of questions are raised in Section 8, the answers to which would help us to understand the transition from physio- to pathological states in the development of many diseases. Detailed analysis of this paper leads us to consider that research in understanding this integrative circulation system is only at the infancy stage, and fluid dynamics investigation seems to be the plausible modality of approach in the near future.展开更多
An ocean-atmosphere and land-air coupled numerical model system is used to study the basic properties and the monthly time variations of the summer quasi-stationary circulation systems. It is found that either at the ...An ocean-atmosphere and land-air coupled numerical model system is used to study the basic properties and the monthly time variations of the summer quasi-stationary circulation systems. It is found that either at the upper or at the lower levels of the atmosphere, the circulation patterns have a two-wave structure in the zonal direction at the mid and high latitudes of the Northern Hemisphere. Such a structure of circulation is totally matchable to that of the land-sea distribution there. It is proved, hence, that the land-sea distributive pattern is the fundamental cause for the summer quasi-stationary circulation pattern. The topography in the globe is the secondary factor for circulation systems. The circulation centres of the quasi-stationary systems are always located in certain areas due to the thermodynamic contrast between land and sea.From the time evolutions of the circulation systems it is seen that the change is larger at the beginning period of the time integration, it is because of using the zonally averaged mean fields as the initial values of the model. As long as the basic simulated pattern of circulations reaches the state similar to that of the real climatic fields resulting from the coeffects of the land-sea distribution and the topography, the circulation systems modelled will change slowly and tend to a quasi-stationary state. Therefore, the time integration does not need to last for a very long time, if the purpose of numerical modellings is to test sensitivities of some factors influencing the climate, 20 model days may be enough for sensitive experiments.展开更多
Three Cenozoic basins—the Qaidam basin, the Weihe graben-type basin and the North China plain—which are different in climatic conditions, geological settings and run—off types, are selected for the study. Based on ...Three Cenozoic basins—the Qaidam basin, the Weihe graben-type basin and the North China plain—which are different in climatic conditions, geological settings and run—off types, are selected for the study. Based on an analysis of background information of the transect along the middle-latitude region, studies of groundwater dynamics, geochemistry, simulation of water circulation of the main elements as well as isotopic chronology, the information on global changes is collected, the formation of groundwater circulation systems and their evolution under stacked impacts of natural conditions and human activities are discussed, and a correlation is made between the evolutionary features of the above systems in these basins since 25 ka B.P. All these have laid a good foundation for further generalizing the evolutionary model of land water in northern China.展开更多
Recently, the increasing concern about the environmental quality of human settlements makes people realize that the attractive environment given by natural ecology also deficiently needs the feedback and protection of...Recently, the increasing concern about the environmental quality of human settlements makes people realize that the attractive environment given by natural ecology also deficiently needs the feedback and protection of nature in some forms so that the natural ecology can be endlessly cycled on its own. Taking the project of German Enterprise Center in Qingdao Sino-German Ecopark as an example, this paper discussed construction of outdoor environment water circulation system using the landscape building method.展开更多
In this study, a full-scale internal circulation（IC） reactor coupled with an external circulation system was developed to treat high-strength leachate from a municipal solid waste（MSW）incineration plant, in which ...In this study, a full-scale internal circulation（IC） reactor coupled with an external circulation system was developed to treat high-strength leachate from a municipal solid waste（MSW）incineration plant, in which anaerobic sludge granulation was intensively investigated. Results showed that the IC reactor achieved excellent treatment performance under high organic loading rates（OLR） of 21.06–25.16 kg chemical oxygen demand（COD）/（m3？ day）. The COD removal efficiency and biogas yield respectively reached 89.4%–93.4% and 0.42–0.50 m3/kg COD.The formation of extracellular polymeric substances（EPS） was closely associated with sludge granulation. Protein was the dominant component in sludge EPS, and its content was remarkably increased from 21.6 to 99.7 mg/g Volatile Suspended Solid（VSS） during the reactor operation. The sludge Zeta potential and hydrophobicity positively correlated with the protein/polysaccharide ratio in EPS, and they were respectively increased from-26.2 m V and 30.35% to-10.6 m V and 78.67%, which was beneficial to microbial aggregation. Three-dimensional fluorescence spectroscopy（3 D-EEM） and Fourier transform infrared spectroscopy（FT-IR）analysis further indicated the importance of protein-like EPS substances in the sludge granulation. Moreover, it was also found that the secondary structures of EPS proteins varied during the reactor operation.展开更多
In order to solve water resources problems in the North China Plain, this paper explored human-nature compound water circulation system from three aspects including urban flood control, surface drainage and saline wat...In order to solve water resources problems in the North China Plain, this paper explored human-nature compound water circulation system from three aspects including urban flood control, surface drainage and saline water in the central and eastern of the North China Plain. Results show that:(1) The technical methods have achieved zero increase in rainwater runoff in urban areas,(2) surface drainage depletion problems can be solved through abandoned water and river water separation method,(3) and technical method through promoting rainwater infiltration would be used to solve problem of saline water in the central and eastern parts. This research provides a new perspective to the ultimate solutions to water resources problems in the North China Plain, and a fresh research direction for the development of hydro-geological science.展开更多
This paper firstly described current development situation of China's rural circulation system. In the process of accelerating modernization,the supply and marketing cooperative is always an essential force,but th...This paper firstly described current development situation of China's rural circulation system. In the process of accelerating modernization,the supply and marketing cooperative is always an essential force,but the gap between urban and rural circulation system is still expanding. On the basis of current development situation,it analyzed functions of supply and marketing cooperatives in rural logistics system. Finally,it came up with recommendations for improving China's rural circulation system. In the new period,it is recommended to bring into play advantages of supply and marketing cooperatives,expand the coverage,gradually promote industry upgrade of renewable resource recycling,and constantly strengthen functions of supply and marketing cooperatives in building the rural modern circulation system,to build supply and marketing cooperatives into new forces and comprehensive platform for farmers' production and living services.展开更多
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both g...Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.展开更多
This paper aims to demonstrate some characteristics of the 20-50 day oscillations of certain circulation systems in low latitudes during the northern summer seasons.The teleconnection between the variations of the Mas...This paper aims to demonstrate some characteristics of the 20-50 day oscillations of certain circulation systems in low latitudes during the northern summer seasons.The teleconnection between the variations of the Mascarene high and the Northwest Pacific high and its physical mechanism are studied.How the Mas- carene high plays an important role in the interaction between the atmospheric circulations of both hemispheres is discussed.展开更多
By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentratio...By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.展开更多
The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by ce...The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by central government" which played the main role while making the local government subsidiary. Yet, the whole process of auto production and circulation had been controlled by both central and local governments. Therefore, strictly speaking,展开更多
5 Former circulation enterprises finding new market position Those large-sized auto circulation enterprises, which used to lead the circulation system, have been suffering the twist and turns from the new system orien...5 Former circulation enterprises finding new market position Those large-sized auto circulation enterprises, which used to lead the circulation system, have been suffering the twist and turns from the new system oriented by automakers. Their market shares shapely fell down and have emerged into chaos. Parts of them that are powerful enough have established new sales companies controlled by the展开更多
1. The sales and circulation system, taking by automakers in the lead, basically formed. The jointly managed and joint companies, established in the mid-1980%, have become gradually dominant element in the system. Alo...1. The sales and circulation system, taking by automakers in the lead, basically formed. The jointly managed and joint companies, established in the mid-1980%, have become gradually dominant element in the system. Along with the steady growth of auto production in the coming years, these companies will be getting stronger and stronger, with their sales and circulation networks being further perfected.展开更多
The passive containment heat removal system(PCS)is one of the key passive safety systems of China’s third-generation advanced pressurized water reactor-Hua-long Pressurized Reactor(HPR1000),used to prevent overpressu...The passive containment heat removal system(PCS)is one of the key passive safety systems of China’s third-generation advanced pressurized water reactor-Hua-long Pressurized Reactor(HPR1000),used to prevent overpressure of large concrete containment under severe accident scenarios.This paper provides an overview of the development of the HPR1000 passive containment heat removal system,including its operating principles and configuration,internal heat exchanger design,feasibility tests,engineering-scale PCS verification tests,comprehensive tests on PCS-containment coupling characteristics,among other key supporting studies.These extensive studies demonstrated that the PCS of HPR1000,which is designed based on flashing-driven open natural circulation and efficient condensation heat transfer theory,can work effectively and ensure the integrity of the containment under various accident scenarios.The system has been applied to Fuqing No.5 and No.6 nuclear power units and Zhangzhou No.1 and No.2 units of China’s first million-kilowatt third-generation nuclear power HPR1000.It is also applied to K-2/K-3 units of Karachi Nuclear Power Plant in Pakistan.展开更多
In this study, a group of indices were defined regarding intensity （P）, area （S） and central position （λc, Фc） of the Aleutian low （AL） in the Northern Hemisphere in winter, using seasonal and monthly mean h...In this study, a group of indices were defined regarding intensity （P）, area （S） and central position （λc, Фc） of the Aleutian low （AL） in the Northern Hemisphere in winter, using seasonal and monthly mean height field at 1000-hPa. These indices were calculated over 60 winter seasons from 1948/1949 to 2007/2008 using reanalysis data. Climatic and anomalous characteristics of the AL were analyzed based on these indices and relationships between the AL, and general circulations were explored using correlations between indicesP, λc, and Pacific SST, as well as Northern Hemisphere temperature and precipitation. The main results are these： （1） AL is the strongest in January, when the center shifts to the south and west of its climatological position, and it is the weakest in December when the center shifts to the north and east. （2） AL intensity （P） is negatively correlated with its longitude （λc）： a deeper low occurs toward the east and a shallower low occurs toward the west. On a decadal scale, the AL has been persistently strong and has shifted eastward since the 1970s, but reversal signs have been observed in recent years. （3） The AL is stronger and is located toward the east during strong E1 Nifio winters and vice versa during strong La Nifia years; this tendency is particularly evident after 1975. The AL is also strongly correlated with SST in the North Pacific. It intensifies and moves eastward with negative SST anomalies, and it weakens and moves westward with positive SST anomalies. （4） Maps of significance correlation between AL intensity and Northern Hemisphere temperature and rainfall resemble the PNA teleconnection pattern in mid-latitudes in the North Pacific and across North America. The AL and the Mongolian High are two permanent atmospheric pressure systems adjacent to each other during boreal winter over the middle and high latitudes in the Northern Hemisphere, but their relationships with the E1 Nifio/La Nifia events and with temperature and precipitation in the Northern Hemisphere are significantly different.展开更多
基金supported by the National Natural Science Foundation of China(No.42377095)the Open Research Fund Program of Plateau Atmosphere and Environment Key Laboratory of Sichuan Province(No.PAEKL-2024-K01)Xianyang Key Research and Development Program(No.L2022ZDYFSF040).
文摘Tropospheric ozone pollution has been worsened over most regions of China,adversely affecting human health and ecosystems.The long-term ozone concentration depends largely upon atmospheric circulations.Here,we conducted meteorological adjustment to quantitatively assess the influences of meteorological factors on the ozone evolution in China's seven city clusters during thewarm season(April to October)from 2013 to 2020.Our analysis indicated that northern and eastern regions experienced ozone increases driven by emission changes.Southern regions,particularly the Pearl River Delta(PRD),exhibited ozone rise primarily due to meteorological conditions despite emission changes.In the Sichuan Basin(SCB)and Central Yangtze River Plain(CYP),where ozone levels decreased,meteorological conditions played a significant role in suppressing the ascent of ozone.Empirical orthogonal functions(EOF)analyses suggested that the spatiotemporal trend ofmeteorologyassociated ozone was strongly correlated with the variation of East Asian Trough(EAT),South Asian High(SAH)and the western Pacific subtropical high(WPSH).The top three EOF patterns explained 33.4%,21.8%,and 16.0%of the total variance inmeteorology-associated ozone.Absolute principal component scores-multiple linear regression(APCS-MLR)analyse quantitatively identified that enhanced EAT and SAH with a northward location of WPSH were favourable to surface ozone formation in central and eastern regions,but unfavourable to ozone formation in edge regions such as SCB.
基金funded by Fei He,National Natural Science Foundation of China(contract no.52376154)Anhui Provincial Natural Science Foundation(contract no.2308085J21).
文摘Aiming at the global design issue of transpiration cooling thermal protection system,a self-driven circulation loop is proposed as the internal coolant flow passage for the transpiration cooling structure to achieve adaptive cooling.To enhance the universality of this internal cooling pipe design and facilitate its application,numerical studies are conducted on this systemwith four commonly used cooling mediums as coolant.Firstly,the accuracy of the numerical method is verified through an established experimental platform.Then,transient numerical simulations are performed on the flow states of different cooling mediums in the new self-circulation system.Based on the numerical result,the flow,phase change,and heat transfer characteristics of different cooling mediums are analyzed.Differences in fluid velocity and latent heat of phase change result in significant variation in heat exchange capacity among different coolingmediums,with the maximumdifference reaching up to 3 times.Besides,faster circulation speed leads to greater heat transfer capacity,with a maximum of 7600 W/m^(2).Consequently,the operating mechanism and cooling laws of the natural circulation system is further investigated,providing a reference for the practical application of this system.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.40930952 and 40705031)the Special Scientific Research Project for Public Interest,China (Grant Nos.GYHY201006021 and GYHY201106016)the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grant No.2007BAC29B01)
文摘In terms of the characteristic topology parameters of climate complex networks, the spatial connection structural complexity of the circulation system and the influence of four teleconnection patterns are quantitatively described. Results of node degrees for the Northern Hemisphere （NH） mid-high latitude （30° N-90°N） circulation system （NHS） networks with and without the Arctic Oscillations （AO）, the North Atlantic Oscillations （NAO） and the Pacific-North American pattern （PNA） demonstrate that the teleconnections greatly shorten the mean shortest path length of the networks, thus being advantageous to the rapid transfer of local fluctuation information over the network and to the stability of the NHS. The impact of the AO on the NHS connection structure is most important and the impact of the NAO is the next important. The PNA is a relatively independent teleconnection, and its role in the NHS is mainly manifested in the connection between the NHS and the tropical circulation system （TRS）. As to the Southern Hemisphere mid-high latitude （30°S-90°S） circulation system （SHS）, the impact of the Antarctic Arctic Oscillations （AAO） on the structural stability of the system is most important. In addition, there might be a stable correlation dipole （AACD） in the SHS, which also has important influence on the structure of the SHS networks.
文摘Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processes. In humans, there are different vehicles to contain water and its constituents. Our objective is to find out whether there is an overall water-base circulation system in the human body by analyzing the updated findings of different research groups on the physiological functions of various seemingly isolated fluid systems. By 1963, there were five separate fluid systems discovered in mammalians: (i) The Primo Vasculature Fluid (PVF) with protein precursors and micro cells held in the Primo Vasculature System (PVS). (ii) Blood with its constituents held in the cardio vasculature. (iii) Extracranial interstitial fluid (ISF) whose vehicle had a very irregular structure—the interstitium all over the body. (iv) The cerebrospinal fluid had been considered to be within the brain ventricles and spinal canal. (v) The extra-cranial lymphatic system which drained ISF, and had been known to join the subclavian vein. Fluid (i) was first reported in 1963 and fluids (ii) to (v) have been known for many decades, but the failure to detect a lymphatic system inside the skull has also been a mystery for many decades. The intra-cranial ISF (which we name as BISF) has drawn little attention, apart from discussing the mechanism of the blood-brain-barrier. During the past decade, there has been direct evidence indicating that CSF and BISF are actually mixed. After that, the intracranial lymphatic system was discovered and confirmed in animal models only slightly over one year back, and we called such fluid as glymphatic-fluid. After reviewing the stated “classical” five fluid systems together with the new findings in Sections 2 - 7, we propose, for the first time, that the PVF, the blood, ISF, a mixture of CSF-BISF, and a mixture of glymphatic-fluid and lymph form an integrative circulation system in water base in the human and other mammalian bodies, as schematically represented in the last section. In this paper, we point out the positive correlation of chronic neuro degenerative diseases such as Alzheimer’s disease, Parkinson’s diseases and the insufficient brain wastes clearance by the glymphatic system. We also discuss the role played by the venous vessels as part of such clearance in upright posture. Moreover, simple non-invasive maneuver techniques are introduced here, as one example of enhancement of glymphatic fluid flow out of the skull to join the lymphatic system. A series of questions are raised in Section 8, the answers to which would help us to understand the transition from physio- to pathological states in the development of many diseases. Detailed analysis of this paper leads us to consider that research in understanding this integrative circulation system is only at the infancy stage, and fluid dynamics investigation seems to be the plausible modality of approach in the near future.
基金Supported by National Fundamental Key Research Project:"Studies on dynamic climate and climate prediction theory".
文摘An ocean-atmosphere and land-air coupled numerical model system is used to study the basic properties and the monthly time variations of the summer quasi-stationary circulation systems. It is found that either at the upper or at the lower levels of the atmosphere, the circulation patterns have a two-wave structure in the zonal direction at the mid and high latitudes of the Northern Hemisphere. Such a structure of circulation is totally matchable to that of the land-sea distribution there. It is proved, hence, that the land-sea distributive pattern is the fundamental cause for the summer quasi-stationary circulation pattern. The topography in the globe is the secondary factor for circulation systems. The circulation centres of the quasi-stationary systems are always located in certain areas due to the thermodynamic contrast between land and sea.From the time evolutions of the circulation systems it is seen that the change is larger at the beginning period of the time integration, it is because of using the zonally averaged mean fields as the initial values of the model. As long as the basic simulated pattern of circulations reaches the state similar to that of the real climatic fields resulting from the coeffects of the land-sea distribution and the topography, the circulation systems modelled will change slowly and tend to a quasi-stationary state. Therefore, the time integration does not need to last for a very long time, if the purpose of numerical modellings is to test sensitivities of some factors influencing the climate, 20 model days may be enough for sensitive experiments.
基金This study was supported by the National Natural Science Foundation of China Grant 49672185.
文摘Three Cenozoic basins—the Qaidam basin, the Weihe graben-type basin and the North China plain—which are different in climatic conditions, geological settings and run—off types, are selected for the study. Based on an analysis of background information of the transect along the middle-latitude region, studies of groundwater dynamics, geochemistry, simulation of water circulation of the main elements as well as isotopic chronology, the information on global changes is collected, the formation of groundwater circulation systems and their evolution under stacked impacts of natural conditions and human activities are discussed, and a correlation is made between the evolutionary features of the above systems in these basins since 25 ka B.P. All these have laid a good foundation for further generalizing the evolutionary model of land water in northern China.
基金Sponsored by the National Science and Technology Project in the Twelfth Five-Year Plan Period(2013BAJ02B04)
文摘Recently, the increasing concern about the environmental quality of human settlements makes people realize that the attractive environment given by natural ecology also deficiently needs the feedback and protection of nature in some forms so that the natural ecology can be endlessly cycled on its own. Taking the project of German Enterprise Center in Qingdao Sino-German Ecopark as an example, this paper discussed construction of outdoor environment water circulation system using the landscape building method.
基金supported by the National Natural Science Foundation of China(Nos.21506076,51678279 and 51508230)the National Science and Technological Support of China(No.2014BAC25B01)
文摘In this study, a full-scale internal circulation（IC） reactor coupled with an external circulation system was developed to treat high-strength leachate from a municipal solid waste（MSW）incineration plant, in which anaerobic sludge granulation was intensively investigated. Results showed that the IC reactor achieved excellent treatment performance under high organic loading rates（OLR） of 21.06–25.16 kg chemical oxygen demand（COD）/（m3？ day）. The COD removal efficiency and biogas yield respectively reached 89.4%–93.4% and 0.42–0.50 m3/kg COD.The formation of extracellular polymeric substances（EPS） was closely associated with sludge granulation. Protein was the dominant component in sludge EPS, and its content was remarkably increased from 21.6 to 99.7 mg/g Volatile Suspended Solid（VSS） during the reactor operation. The sludge Zeta potential and hydrophobicity positively correlated with the protein/polysaccharide ratio in EPS, and they were respectively increased from-26.2 m V and 30.35% to-10.6 m V and 78.67%, which was beneficial to microbial aggregation. Three-dimensional fluorescence spectroscopy（3 D-EEM） and Fourier transform infrared spectroscopy（FT-IR）analysis further indicated the importance of protein-like EPS substances in the sludge granulation. Moreover, it was also found that the secondary structures of EPS proteins varied during the reactor operation.
基金funded by National Key Basic Research Program of China(2010CB428800),Geological Survey(20023064)(12120113102400)
文摘In order to solve water resources problems in the North China Plain, this paper explored human-nature compound water circulation system from three aspects including urban flood control, surface drainage and saline water in the central and eastern of the North China Plain. Results show that:(1) The technical methods have achieved zero increase in rainwater runoff in urban areas,(2) surface drainage depletion problems can be solved through abandoned water and river water separation method,(3) and technical method through promoting rainwater infiltration would be used to solve problem of saline water in the central and eastern parts. This research provides a new perspective to the ultimate solutions to water resources problems in the North China Plain, and a fresh research direction for the development of hydro-geological science.
文摘This paper firstly described current development situation of China's rural circulation system. In the process of accelerating modernization,the supply and marketing cooperative is always an essential force,but the gap between urban and rural circulation system is still expanding. On the basis of current development situation,it analyzed functions of supply and marketing cooperatives in rural logistics system. Finally,it came up with recommendations for improving China's rural circulation system. In the new period,it is recommended to bring into play advantages of supply and marketing cooperatives,expand the coverage,gradually promote industry upgrade of renewable resource recycling,and constantly strengthen functions of supply and marketing cooperatives in building the rural modern circulation system,to build supply and marketing cooperatives into new forces and comprehensive platform for farmers' production and living services.
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2342210 and 42275043)the National Institute of Natural Hazards,Ministry of Emergency Management of China(Grant Nos.J2223806,ZDJ2024-25 and ZDJ2025-34)。
文摘Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.
文摘This paper aims to demonstrate some characteristics of the 20-50 day oscillations of certain circulation systems in low latitudes during the northern summer seasons.The teleconnection between the variations of the Mascarene high and the Northwest Pacific high and its physical mechanism are studied.How the Mas- carene high plays an important role in the interaction between the atmospheric circulations of both hemispheres is discussed.
文摘By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.
文摘The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by central government" which played the main role while making the local government subsidiary. Yet, the whole process of auto production and circulation had been controlled by both central and local governments. Therefore, strictly speaking,
文摘5 Former circulation enterprises finding new market position Those large-sized auto circulation enterprises, which used to lead the circulation system, have been suffering the twist and turns from the new system oriented by automakers. Their market shares shapely fell down and have emerged into chaos. Parts of them that are powerful enough have established new sales companies controlled by the
文摘1. The sales and circulation system, taking by automakers in the lead, basically formed. The jointly managed and joint companies, established in the mid-1980%, have become gradually dominant element in the system. Along with the steady growth of auto production in the coming years, these companies will be getting stronger and stronger, with their sales and circulation networks being further perfected.
基金supported by China Nuclear Power Engineering Co.,Ltd.and Harbin Engineering University,and granted financial resources by China’s National Energy Administration and China National Nuclear Corporation.
文摘The passive containment heat removal system(PCS)is one of the key passive safety systems of China’s third-generation advanced pressurized water reactor-Hua-long Pressurized Reactor(HPR1000),used to prevent overpressure of large concrete containment under severe accident scenarios.This paper provides an overview of the development of the HPR1000 passive containment heat removal system,including its operating principles and configuration,internal heat exchanger design,feasibility tests,engineering-scale PCS verification tests,comprehensive tests on PCS-containment coupling characteristics,among other key supporting studies.These extensive studies demonstrated that the PCS of HPR1000,which is designed based on flashing-driven open natural circulation and efficient condensation heat transfer theory,can work effectively and ensure the integrity of the containment under various accident scenarios.The system has been applied to Fuqing No.5 and No.6 nuclear power units and Zhangzhou No.1 and No.2 units of China’s first million-kilowatt third-generation nuclear power HPR1000.It is also applied to K-2/K-3 units of Karachi Nuclear Power Plant in Pakistan.
基金supported by National Key Technology Research and Development Program (Grant No. 2007BAC29B02)the National Basic Research Program of China’s 973 Program (Grant Nos.2010CB950502 and 2010CB428904)the project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘In this study, a group of indices were defined regarding intensity （P）, area （S） and central position （λc, Фc） of the Aleutian low （AL） in the Northern Hemisphere in winter, using seasonal and monthly mean height field at 1000-hPa. These indices were calculated over 60 winter seasons from 1948/1949 to 2007/2008 using reanalysis data. Climatic and anomalous characteristics of the AL were analyzed based on these indices and relationships between the AL, and general circulations were explored using correlations between indicesP, λc, and Pacific SST, as well as Northern Hemisphere temperature and precipitation. The main results are these： （1） AL is the strongest in January, when the center shifts to the south and west of its climatological position, and it is the weakest in December when the center shifts to the north and east. （2） AL intensity （P） is negatively correlated with its longitude （λc）： a deeper low occurs toward the east and a shallower low occurs toward the west. On a decadal scale, the AL has been persistently strong and has shifted eastward since the 1970s, but reversal signs have been observed in recent years. （3） The AL is stronger and is located toward the east during strong E1 Nifio winters and vice versa during strong La Nifia years; this tendency is particularly evident after 1975. The AL is also strongly correlated with SST in the North Pacific. It intensifies and moves eastward with negative SST anomalies, and it weakens and moves westward with positive SST anomalies. （4） Maps of significance correlation between AL intensity and Northern Hemisphere temperature and rainfall resemble the PNA teleconnection pattern in mid-latitudes in the North Pacific and across North America. The AL and the Mongolian High are two permanent atmospheric pressure systems adjacent to each other during boreal winter over the middle and high latitudes in the Northern Hemisphere, but their relationships with the E1 Nifio/La Nifia events and with temperature and precipitation in the Northern Hemisphere are significantly different.
