Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were co...Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were confirmed according to the relevant diagnostic criteria of schizophrenia and underwent CT examination including the CT detection rate, CT typing, age distribution and disease course distribution of the patients. Results: after the 60 schizophrenia patients were selected for a CT scan, forty-one patients were found to have structural brain abnormalities. The CT classification was: 5 cases of diffuse cerebral atrophy, 12.19%), 25 (60.97%) and 11 (26.83%) respectively;at the same time, Schizophrenic patients with structural brain abnormalities are mainly 21-55 years old;for 85.36% (35 / 41), the disease duration is mainly 10 years, accounting for 53.66% (22 / 41);the CT value of the left frontal CT was lower than that of the healthy group. Statistical significance was observed (P 0.05). Conclusion: using CT examination can evaluate the brain structure of schizophrenia patients. This study found that the most common clinical symptoms of schizophrenia is brain atrophy in the elderly compared with age. CT can provide more reliable information for clinical diagnosis and treatment of schizophrenia. But because of abnormal brain structure, there is no high specificity, so patients with schizophrenia will not have significant performance, clinical to do further research in this aspect.展开更多
BACKGROUND Corrosive ingestion remains an important global pathology with high morbidity and mortality.Data on the acute management of adult corrosive injuries from sub-Saharan Africa is scarce,with international inve...BACKGROUND Corrosive ingestion remains an important global pathology with high morbidity and mortality.Data on the acute management of adult corrosive injuries from sub-Saharan Africa is scarce,with international investigative algorithms,relying heavily on computed tomography(CT),having limited availability in this setting.AIM To investigate the corrosive injury spectrum in a low-resource setting and the applicability of parameters for predicting full-thickness(FT)necrosis and mortality.METHODS A retrospective analysis of a prospective corrosive injury registry(March 1,2017–October 31,2023)was performed to include all adult patients with acute corrosive ingestion managed at a single,academic referral centre in Cape Town,South Africa.Patient demographics,corrosive ingestion details,initial investigations,management,and short-term outcomes were described using descriptive statistics while multivariate analysis with receiver operator characteristic area under the curve graphs(ROC AUC)were used to identify factors predictive of FT necrosis and 30-day mortality.RESULTS One-hundred patients were included,with a mean age of 32 years(SD:11.2 years)and a male predominance(65.0%).The majority(73.0%)were intentional suicide attempts.Endoscopy on admission was the most frequent initial investigation performed(95 patients),while only 17 were assessed with CT.Seventeen patients had full thickness necrosis at surgery,of which eleven underwent emergency resection and six were palliated.Thirty-day morbidity and mortality were 27.0%and 14.0%,respectively.Patients with full thickness necrosis and those with an established perforation had a 30-day mortality of 58.8%and 91.0%,respectively.Full thickness necrosis was associated with a cumulative 2-year survival of only 17.6%.Multivariate analyses with ROC AUC showed admission endoscopy findings,CT findings,and blood gas findings(pH,base excess,lactate),to all have significant predictive value for full thickness necrosis,with endoscopy proving to have the best predictive value(AUC 0.850).CT and endoscopy findings were the only factors predictive of early mortality,with CT performing better than endoscopy(AUC 0.798 vs 0.759).CONCLUSION Intentional corrosive injuries result in devastating morbidity and mortality.Locally,early endoscopy remains the mainstay of severity assessment,but referral for CT imaging should be considered especially when blood gas findings are abnormal.展开更多
文摘Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were confirmed according to the relevant diagnostic criteria of schizophrenia and underwent CT examination including the CT detection rate, CT typing, age distribution and disease course distribution of the patients. Results: after the 60 schizophrenia patients were selected for a CT scan, forty-one patients were found to have structural brain abnormalities. The CT classification was: 5 cases of diffuse cerebral atrophy, 12.19%), 25 (60.97%) and 11 (26.83%) respectively;at the same time, Schizophrenic patients with structural brain abnormalities are mainly 21-55 years old;for 85.36% (35 / 41), the disease duration is mainly 10 years, accounting for 53.66% (22 / 41);the CT value of the left frontal CT was lower than that of the healthy group. Statistical significance was observed (P 0.05). Conclusion: using CT examination can evaluate the brain structure of schizophrenia patients. This study found that the most common clinical symptoms of schizophrenia is brain atrophy in the elderly compared with age. CT can provide more reliable information for clinical diagnosis and treatment of schizophrenia. But because of abnormal brain structure, there is no high specificity, so patients with schizophrenia will not have significant performance, clinical to do further research in this aspect.
文摘BACKGROUND Corrosive ingestion remains an important global pathology with high morbidity and mortality.Data on the acute management of adult corrosive injuries from sub-Saharan Africa is scarce,with international investigative algorithms,relying heavily on computed tomography(CT),having limited availability in this setting.AIM To investigate the corrosive injury spectrum in a low-resource setting and the applicability of parameters for predicting full-thickness(FT)necrosis and mortality.METHODS A retrospective analysis of a prospective corrosive injury registry(March 1,2017–October 31,2023)was performed to include all adult patients with acute corrosive ingestion managed at a single,academic referral centre in Cape Town,South Africa.Patient demographics,corrosive ingestion details,initial investigations,management,and short-term outcomes were described using descriptive statistics while multivariate analysis with receiver operator characteristic area under the curve graphs(ROC AUC)were used to identify factors predictive of FT necrosis and 30-day mortality.RESULTS One-hundred patients were included,with a mean age of 32 years(SD:11.2 years)and a male predominance(65.0%).The majority(73.0%)were intentional suicide attempts.Endoscopy on admission was the most frequent initial investigation performed(95 patients),while only 17 were assessed with CT.Seventeen patients had full thickness necrosis at surgery,of which eleven underwent emergency resection and six were palliated.Thirty-day morbidity and mortality were 27.0%and 14.0%,respectively.Patients with full thickness necrosis and those with an established perforation had a 30-day mortality of 58.8%and 91.0%,respectively.Full thickness necrosis was associated with a cumulative 2-year survival of only 17.6%.Multivariate analyses with ROC AUC showed admission endoscopy findings,CT findings,and blood gas findings(pH,base excess,lactate),to all have significant predictive value for full thickness necrosis,with endoscopy proving to have the best predictive value(AUC 0.850).CT and endoscopy findings were the only factors predictive of early mortality,with CT performing better than endoscopy(AUC 0.798 vs 0.759).CONCLUSION Intentional corrosive injuries result in devastating morbidity and mortality.Locally,early endoscopy remains the mainstay of severity assessment,but referral for CT imaging should be considered especially when blood gas findings are abnormal.
