为探究鳞杯伞子实体多糖(Clitocybe squamulosa fruiting body polysaccharide,CSFP)对玉米淀粉理化及结构特性影响,分别向玉米淀粉中加入基于干基质0、2%、4%、6%、8%的CSFP,研究其糊化特性、流变性能、微观结构、红外光谱和质构特性...为探究鳞杯伞子实体多糖(Clitocybe squamulosa fruiting body polysaccharide,CSFP)对玉米淀粉理化及结构特性影响,分别向玉米淀粉中加入基于干基质0、2%、4%、6%、8%的CSFP,研究其糊化特性、流变性能、微观结构、红外光谱和质构特性。结果表明:CSFP能够延缓玉米淀粉的糊化,具体表现为随着CSFP添加量的增加,玉米淀粉糊化的峰值黏度、最低黏度、最终黏度、崩解黏度、回生黏度均下降,而糊化温度有所升高。静态流变结果显示玉米淀粉糊和复配体系均呈现剪切稀释的假塑性流体,且流体指数(n)和稠度系数(K)分别出现随CSFP添加量的增加而上升和下降的趋势;动态流变结果显示玉米淀粉糊和复配体系呈弱凝胶行为。通过扫描电镜对样品的微观结构进行观察,发现CSFP的加入使得样品内部结构逐渐松散,空隙变大。红外光谱扫描结果表明,形成的复配体系中未形成新的基团,添加CSFP后,淀粉结构的短程有序程度上升。研究结果表明,CSFP使得玉米淀粉糊的硬度、弹性、内聚性、咀嚼性和胶黏性均有所下降,以期为当前易吞咽食品的开发提供参考。展开更多
Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particular...Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particularly in high-risk AMI patients,is limited,leading to significant clinical concerns.This study aims to compare the efficacy and safety of DCBs versus standard drug-eluting stents(DESs)in AMI patients and explore their efficacy differences in patients with ST-segment elevation myocardial infarction(STEMI),non-ST-segment elevation myocardial infarction(NSTEMI),and different risk stratifications.Methods:A single-center,retrospective cohort study was conducted,involving 86 patients who underwent percutaneous coronary intervention(PCI)for AMI between January 2023 and July 2025.Patients were divided into a DCB group(n=26)and a DES group(n=60)based on the treatment modality.According to the Killip classification of myocardial infarction at admission,patients were categorized into a low-risk group(Killip Class I,n=68)and a high-risk group(Killip Classes II-IV,n=18).The primary efficacy endpoint was targeting lesion restenosis as shown by coronary angiography follow-up(6-12 months).Safety endpoints included acute in-stent thrombosis during hospitalization(ARC criteria)and long-term coronary slow flow.A multivariate logistic regression model was used to evaluate the associations between intervention modality,risk stratification,infarction type,and endpoint events,and to test for interactions.Results:The DCB and DES groups were generally balanced in terms of baseline traditional risk factors.During hospitalization,three cases(5.0%)of acute in-stent thrombosis occurred in the DES group,all requiring urgent re-intervention,while no such events occurred in the DCB group(0%).Acute in-stent thrombosis formation was significantly associated with high-risk stratification(χ2 test,p=0.047).The overall restenosis rate was 22.1%(19/86).Multivariate analysis showed no statistically significant difference in restenosis risk between the intervention modalities(DCB vs.DES)(adjusted odds ratio[OR]=1.07,95%confidence interval[CI]0.27-4.21,p=0.920),and no statistical differences were found in subgroups based on risk stratification(p=0.382)or infarction type(p=0.484).There was a trend toward increased restenosis risk in high-risk patients(OR=12.34),but the difference was not statistically significant(95%CI 0.28-542.75,p=0.193).The incidence of long-term coronary slow flow was significantly higher in the DES group than in the DCB group(16.7%vs.3.8%,Fisher’s exact test,p=0.048),with a statistically significant difference.Conclusion:For AMI patients,DCBs demonstrate similar efficacy to DESs in preventing restenosis.However,DESs are associated with a higher risk of acute thrombosis during hospitalization,especially in high-risk patients,and a higher risk of long-term slow coronary flow.DCBs exhibit superior perioperative and long-term safety compared to DESs.Given the limited sample size,particularly the small number of high-risk patients and those treated with DCBs,the conclusions require validation through larger-scale prospective studies.展开更多
Brain computer interface (BCI) aims at creating new communication channels without depending on brain’s normal output channels of peripheral nerves and muscles. However,natural and sophisticated interactions manner b...Brain computer interface (BCI) aims at creating new communication channels without depending on brain’s normal output channels of peripheral nerves and muscles. However,natural and sophisticated interactions manner between brain and computer still remain challenging. In this paper,we investigate how the duration of event-related desynchronization/synchronization (ERD/ERS) caused by motor im-agery (MI) can be modulated and used as an additional control parameter beyond simple binary deci-sions. Furthermore,using the non-time-locked properties of sustained (de)synchronization,we have developed an asynchronous BCI system for driving a car in 3D virtual reality environment (VRE) based on cumulative incremental control strategy. The extensive real time experiments confirmed that our new approach is able to drive smoothly a virtual car within challenging VRE only by the MI tasks with-out involving any muscular activities.展开更多
文摘为探究鳞杯伞子实体多糖(Clitocybe squamulosa fruiting body polysaccharide,CSFP)对玉米淀粉理化及结构特性影响,分别向玉米淀粉中加入基于干基质0、2%、4%、6%、8%的CSFP,研究其糊化特性、流变性能、微观结构、红外光谱和质构特性。结果表明:CSFP能够延缓玉米淀粉的糊化,具体表现为随着CSFP添加量的增加,玉米淀粉糊化的峰值黏度、最低黏度、最终黏度、崩解黏度、回生黏度均下降,而糊化温度有所升高。静态流变结果显示玉米淀粉糊和复配体系均呈现剪切稀释的假塑性流体,且流体指数(n)和稠度系数(K)分别出现随CSFP添加量的增加而上升和下降的趋势;动态流变结果显示玉米淀粉糊和复配体系呈弱凝胶行为。通过扫描电镜对样品的微观结构进行观察,发现CSFP的加入使得样品内部结构逐渐松散,空隙变大。红外光谱扫描结果表明,形成的复配体系中未形成新的基团,添加CSFP后,淀粉结构的短程有序程度上升。研究结果表明,CSFP使得玉米淀粉糊的硬度、弹性、内聚性、咀嚼性和胶黏性均有所下降,以期为当前易吞咽食品的开发提供参考。
基金Social Development Science and Technology Project of Dongguan Science and Technology Bureau(Project No.:20221800905302)。
文摘Background:Drug-coated balloons(DCBs)are receiving increasing attention in interventional therapy for coronary artery disease.However,evidence regarding their application in acute myocardial infarction(AMI),particularly in high-risk AMI patients,is limited,leading to significant clinical concerns.This study aims to compare the efficacy and safety of DCBs versus standard drug-eluting stents(DESs)in AMI patients and explore their efficacy differences in patients with ST-segment elevation myocardial infarction(STEMI),non-ST-segment elevation myocardial infarction(NSTEMI),and different risk stratifications.Methods:A single-center,retrospective cohort study was conducted,involving 86 patients who underwent percutaneous coronary intervention(PCI)for AMI between January 2023 and July 2025.Patients were divided into a DCB group(n=26)and a DES group(n=60)based on the treatment modality.According to the Killip classification of myocardial infarction at admission,patients were categorized into a low-risk group(Killip Class I,n=68)and a high-risk group(Killip Classes II-IV,n=18).The primary efficacy endpoint was targeting lesion restenosis as shown by coronary angiography follow-up(6-12 months).Safety endpoints included acute in-stent thrombosis during hospitalization(ARC criteria)and long-term coronary slow flow.A multivariate logistic regression model was used to evaluate the associations between intervention modality,risk stratification,infarction type,and endpoint events,and to test for interactions.Results:The DCB and DES groups were generally balanced in terms of baseline traditional risk factors.During hospitalization,three cases(5.0%)of acute in-stent thrombosis occurred in the DES group,all requiring urgent re-intervention,while no such events occurred in the DCB group(0%).Acute in-stent thrombosis formation was significantly associated with high-risk stratification(χ2 test,p=0.047).The overall restenosis rate was 22.1%(19/86).Multivariate analysis showed no statistically significant difference in restenosis risk between the intervention modalities(DCB vs.DES)(adjusted odds ratio[OR]=1.07,95%confidence interval[CI]0.27-4.21,p=0.920),and no statistical differences were found in subgroups based on risk stratification(p=0.382)or infarction type(p=0.484).There was a trend toward increased restenosis risk in high-risk patients(OR=12.34),but the difference was not statistically significant(95%CI 0.28-542.75,p=0.193).The incidence of long-term coronary slow flow was significantly higher in the DES group than in the DCB group(16.7%vs.3.8%,Fisher’s exact test,p=0.048),with a statistically significant difference.Conclusion:For AMI patients,DCBs demonstrate similar efficacy to DESs in preventing restenosis.However,DESs are associated with a higher risk of acute thrombosis during hospitalization,especially in high-risk patients,and a higher risk of long-term slow coronary flow.DCBs exhibit superior perioperative and long-term safety compared to DESs.Given the limited sample size,particularly the small number of high-risk patients and those treated with DCBs,the conclusions require validation through larger-scale prospective studies.
基金Supported by the National High-Tech Research Program of China (Grant No.2006AA01Z125)the National Basic Research Program of China (Grant No.2005CB724301)
文摘Brain computer interface (BCI) aims at creating new communication channels without depending on brain’s normal output channels of peripheral nerves and muscles. However,natural and sophisticated interactions manner between brain and computer still remain challenging. In this paper,we investigate how the duration of event-related desynchronization/synchronization (ERD/ERS) caused by motor im-agery (MI) can be modulated and used as an additional control parameter beyond simple binary deci-sions. Furthermore,using the non-time-locked properties of sustained (de)synchronization,we have developed an asynchronous BCI system for driving a car in 3D virtual reality environment (VRE) based on cumulative incremental control strategy. The extensive real time experiments confirmed that our new approach is able to drive smoothly a virtual car within challenging VRE only by the MI tasks with-out involving any muscular activities.
