The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by phy...The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by physical attacks,EMP(electromagnetic pulse)events,or cyberattacks,such disruptions could cripple essential services like water supply,healthcare,communication,and transportation.Research indicates that an attack on just nine key substations could result in a coast-to-coast blackout lasting up to 18 months,leading to economic collapse,civil unrest,and a breakdown of public order.This paper explores the key vulnerabilities of the grid,the potential impacts of prolonged blackouts,and the role of AI(artificial intelligence)and ML(machine learning)in mitigating these threats.AI-driven cybersecurity measures,predictive maintenance,automated threat response,and EMP resilience strategies are discussed as essential solutions to bolster grid security.Policy recommendations emphasize the need for hardened infrastructure,enhanced cybersecurity,redundant power systems,and AI-based grid management to ensure national resilience.Without proactive measures,the nation remains exposed to a catastrophic power grid failure that could have dire consequences for society and the economy.展开更多
This study exploressimilarities and differences between American and Chinese colleges' crisis communication strategies.Italso examines how American and Chinese colleges use social media in crisis communication.The...This study exploressimilarities and differences between American and Chinese colleges' crisis communication strategies.Italso examines how American and Chinese colleges use social media in crisis communication.The in-depth interviews focus on the com-parison of the crisis communication strategies in both American and Chinese universities.展开更多
This paper explores the concept of crisis from a critical and interdisciplinary perspective,arguing that many contemporary crises-such as the coronavirus crisis and the climate crisis-are socially constructed and misu...This paper explores the concept of crisis from a critical and interdisciplinary perspective,arguing that many contemporary crises-such as the coronavirus crisis and the climate crisis-are socially constructed and misunderstood.Drawing from Thomas Kuhn’s paradigm shift theory,Nassim Nicholas Taleb’s Black Swan concept,and complexity science,it contends that crises are a normal part of systemic evolution rather than extraordinary disruptions.The paper critiques the shift in agency from individuals to macro-level institutions,which has led to crises being perceived as indefinite rather than finite.The work also examines how crises are often framed through memetics rather than physical reality.By analyzing historical and contemporary crises,the paper illustrates how crisis narratives shape societal behavior and policy.The role of antifragility,memetic warfare,and evolutionary stable strategies(ESS)is discussed,demonstrating how resilience emerges through localized,rather than globalized,responses.The study concludes by advocating for a shift away from progressivist macro-level interventions and toward individual agency as the fundamental unit of societal adaptation.This perspective reframes crises as necessary transitions within evolutionary progress,arguing that societal sustainability depends on decentralization and adaptation rather than centralized control and panic-driven reactions.展开更多
The territorial and maritime disputes in the South China Sea have been a significant and persistent factor affecting China’s bilateral relations with some member states of the Association of Southeast Asian Nations(A...The territorial and maritime disputes in the South China Sea have been a significant and persistent factor affecting China’s bilateral relations with some member states of the Association of Southeast Asian Nations(ASEAN).While a resolution to these disputes appears unlikely in the near future,it is important to properly manage differences and prevent conflicts from escalating into crises,which is essential for maintaining peace and stability in the region.Since 2023,the tensions between China and the Philippines over Ren’ai Jiao,Huangyan Dao,Tiexian Jiao,and Xianbin Jiao,along with their adjacent waters have once again highlighted the significance and urgency of crisis management in the South China Sea.展开更多
The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 k...The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 key-informants were surveyed, including water-well owners, well-digging companies, water-trucking suppliers, agricultural pharmacies, and service offices within local councils. The surveys covered all nine districts in northwestern Syria across the Aleppo and the Idleb governorates. The survey findings reveal significant shifts in water sources, an almost halving in water availability and per capita consumption, and a notable decrease in water quality. Coping mechanisms include random well drilling and reduced hygiene practices. Water pumping stations face challenges with functionality, and there is a shift towards clean energy sources, particularly solar energy. Challenges identified by the survey respondents include drought, fuel costs, and damaged water networks. The study highlights the urgency of addressing the potable water crisis in Northwest Syria and suggests specific interventions to enhance water sustainability and governance.展开更多
The risk of new pathogen emergence is constantly increasing due to several factors,including the expansion and exploration of previously uninhabited regions,increased global trade,tourism,climate change and others.Rec...The risk of new pathogen emergence is constantly increasing due to several factors,including the expansion and exploration of previously uninhabited regions,increased global trade,tourism,climate change and others.Recently,monkeypox(mpox)cases have been increasing,causing alarm as the cases are reported from countries where the disease is not endemic.Mpox virus is an emerging pathogen responsible for human mpox.展开更多
Objective:To examine how emotional labor demands and strategies influence work engagement and occupational identity among Portuguese volunteer firefighters.Methods:Participants completed the Emotional Work Requirement...Objective:To examine how emotional labor demands and strategies influence work engagement and occupational identity among Portuguese volunteer firefighters.Methods:Participants completed the Emotional Work Requirements Scale,Emotional Labour Scale,Utrecht Work Engagement Scale,and Social Identity Scale.Multiple linear regression analyses were conducted to assess the predictive effects of emotional labor demands and strategies on work engagement and occupational identity.Results:Emotional labor explained 11.8%of the variance in work engagement and 10.9%in occupational identity.Positive emotion expression significantly predicted higher work engagement and a stronger occupational identity,while the suppression of negative emotions predicted a weaker occupational identity.Other emotional labor dimensions were not significant.Conclusions:Findings underscore the dual role of emotional labor—as a resource when positive emotions are expressed and as a strain when negative emotions are habitually suppressed.Targeted interventions to promote authentic positive expression and effective emotional processing may enhance firefighters’well-being,strengthen crisis team performance,and benefit the communities they serve.Further research is needed to deepen the understanding of emotional labor in crisis response contexts.展开更多
I.The Fentanyl Crisis in the U.S.The development and spread of the fentanyl crisis in the U.S.Recent years have seen a deteriorating narcotics situation in the U.S.and serious social problems arising therefrom.From 19...I.The Fentanyl Crisis in the U.S.The development and spread of the fentanyl crisis in the U.S.Recent years have seen a deteriorating narcotics situation in the U.S.and serious social problems arising therefrom.From 1999 to 2012,deaths from synthetic opioids(mainly fentanylrelated substances)overdose in the U.S.increased by 8%annually.展开更多
Sickle cell anemia (SCA) is a prevalent genetic disorder primarily affecting individuals of African descent and populations in malaria-endemic regions, with significant global public health implications. Sickle cell c...Sickle cell anemia (SCA) is a prevalent genetic disorder primarily affecting individuals of African descent and populations in malaria-endemic regions, with significant global public health implications. Sickle cell crises are their most common acute complication, characterized by episodes of intense pain and systemic manifestations that impair quality of life and impose a high healthcare burden. We present the case of a 19-year-old male diagnosed with SCA since the age of two, who developed a sickle cell crisis precipitated by right basal pneumonia. The patient exhibited sudden-onset, cyclic lumbar pain with progressive dyspnea. Initial management included multimodal pain control, volume optimization, and targeted antimicrobial therapy to achieve clinical stabilization. This case underscores the importance of a comprehensive approach to managing sickle cell crises, addressing both symptomatic relief and the prevention and treatment of complications. It also highlights the need for public health strategies promoting early diagnosis, access to disease-modifying therapies such as hydroxyurea, and interdisciplinary follow-up to mitigate the socioeconomic and clinical impact of SCA.展开更多
The recent Russian-Ukrainian crisis has had a substantial impact on the global natural gas supply landscape and brought major challenges to liquified natural gas(LNG)supply chain safety in many countries.However,acade...The recent Russian-Ukrainian crisis has had a substantial impact on the global natural gas supply landscape and brought major challenges to liquified natural gas(LNG)supply chain safety in many countries.However,academic research in this field remains scarce.This study aims to analyze the global LNG marine supply network changes during the recent Russian-Ukrainian crisis.Big data analytics are applied to the global vessel trajectory information recorded by automatic identification system(AIS).The weighted degree index indicates that global LNG marine supply is still primarily led by a few exporting countries,and the Middle East Port of Ras Laffan now occupies the central position.In 2022,the betweenness centrality and other indicators of the LNG shipping network showed a high middle and low end,indicating that the network has a certain degree of resilience.After the Russian-Ukrainian crisis happened,LNG exports from Qatar,the United States,and Russia increased.Resource flows have reshaped the competitive standing of countries.The European LNG market witnessed a significant intensification in the export competition between Russia and the United States.Despite the ongoing crisis,Russia's LNG export competitiveness remained resilient and displayed no indications of weakening.The results show new evidence for the changes in global natural resources marine supply influenced by the geopolitical events among countries.This has important implications for policymaking of LNG supply safety to the countries that rely heavily on imports.展开更多
Objective:To analyze the preventive and management effects of the 4R crisis management theory on incontinence-associated dermatitis(IAD)in ICU patients with fecal incontinence.Methods:A hundred patients with fecal inc...Objective:To analyze the preventive and management effects of the 4R crisis management theory on incontinence-associated dermatitis(IAD)in ICU patients with fecal incontinence.Methods:A hundred patients with fecal incontinence who were admitted to the ICU for treatment between January 2024 and December 2024 were selected and randomly divided into two groups using a random number table.The observation group received 4R crisis management theory,while the control group received routine management.The IAD risk score,incidence of IAD,severity of IAD,and formation and healing time of IAD were compared between the two groups.Results:After management,the IAD risk score of the observation group was lower than that of the control group(P<0.05).The incidence of IAD in the observation group was lower than that in the control group,the proportion of mild IAD was higher than that in the control group,the formation time of IAD was later than that in the control group,and the healing time was shorter than that in the control group(P<0.05).Conclusion:Adopting the 4R crisis management theory for ICU patients with fecal incontinence can reduce the risk of IAD occurrence,effectively prevent IAD,reduce its severity,delay its formation time,and promote good healing.展开更多
In the poem“Asides on the Oboe,”Wallace Stevens depicts a world rife with war,chaos,and a lack of faith,where old fictions no longer hold credibility,and it is time to create a new one.By crafting“the central man”...In the poem“Asides on the Oboe,”Wallace Stevens depicts a world rife with war,chaos,and a lack of faith,where old fictions no longer hold credibility,and it is time to create a new one.By crafting“the central man”as an embodiment of poetic fiction,Stevens argues for the possibility that poetry can bring poetic redemption to people in this era of war and crisis of faith.The frequent use of imagery,allusion,and other techniques in the poem together constitute the deep connotations of the text,reflecting Stevens’s equal attention to the aesthetics of poetry and humanism.展开更多
BACKGROUND Although chronic-phase chronic myeloid leukemia(CP-CML)is treatable and nearly curable in about 50%of patients,accelerated-phase chronic myeloid leukemia(AP-CML)shows concerning drug resistance,while blast ...BACKGROUND Although chronic-phase chronic myeloid leukemia(CP-CML)is treatable and nearly curable in about 50%of patients,accelerated-phase chronic myeloid leukemia(AP-CML)shows concerning drug resistance,while blast crisis chronic myeloid leukemia(BC-CML)is highly lethal.Advances in whole exome sequencing(WES)reveal pan-cancer mutations in BC-CML,supporting mutation-guided therapies beyond Breakpoint cluster region-Abelson.Artificial intelligence(AI)and machine learning(ML)enable genomic stratification and drug repurposing,addressing overlooked actionable mutations.AIM To stratify BC-CML into molecular subtypes using WES,ML,and AI for precision drug repurposing.METHODS Included 123 CML patients(111 CP-CML,5 AP-CML,7 BC-CML).WES identified pan-cancer mutations.Variants annotated via Ensembl Variant Effect Predictor and Catalogue of Somatic Mutations in Cancer(COSMIC).ML(principal component analysis,K-means)stratified BC-CML.COSMIC signatures and PanDrugs prioritized drugs.Analysis of variance/Kruskal-Wallis validated differences(P<0.05).RESULTS In this exploratory,hypothesis-generating study of BC-CML patients(n=7),we detected over 2500 somatic mutations.ML identified three BC-CML clusters:(1)Cluster 1[breast cancer susceptibility gene 2(BRCA2),TP53];(2)Cluster 2[isocitrate dehydrogenase(IDH)1/2,ten-eleven translocation 2];and(3)Cluster 3[Janus kinase(JAK)2,colony-stimulating factor 3 receptor],with distinct COSMIC signatures.Therapies:(1)Polyadenosinediphosphate-ribose polymerase inhibitors(olaparib);(2)IDH inhibitors(ivosidenib);and(3)JAK inhibitors(ruxolitinib).Mutational burden,signatures,and targets varied significantly across clusters,supporting precision stratification.CONCLUSION This WES-AI-ML framework provides mutation-guided therapies for BC-CML,enabling real-time stratification and Food and Drug Administration-approved drug repurposing.While this exploratory study is limited by its small sample size(n=7),it establishes a methodological framework for precision oncology stratification that warrants validation in larger,multi-center cohorts.展开更多
Countries have to pre-evaluate threats and risks that may incur their national security and national interests, take the necessary preventive measures timely, and pursue decisive policies within the limits of the poss...Countries have to pre-evaluate threats and risks that may incur their national security and national interests, take the necessary preventive measures timely, and pursue decisive policies within the limits of the possibilities of their national power, by keeping a close watch on ongoing and conceivable crises and new developments. Like statesmen, also the international security organizations have to foresee the coming or anticipated threats and opportunities, take the necessary precautions and when necessary even to react by using force. Starting from time of peace, all these require an effective crisis management system that would warn and manage the threats that would create such crises. There are, however, crisis management centers and situation rooms in the focal points of the physical substructure of the crisis management system. In this article, by looking at the attributions of an effective crisis management system, structure of the crisis management centers and situation rooms will be questioned at international and national levels.展开更多
The mortgage loan has evolved from a local lending instrument into a major global security and its role is unparallel to other financial instruments in the process of financial globalization. This paper explains how t...The mortgage loan has evolved from a local lending instrument into a major global security and its role is unparallel to other financial instruments in the process of financial globalization. This paper explains how technology and financial innovation transformed the mortgage loan from a local security into a premier global security traded worldwide. It examines the fundamental flaws of this process and why it does not work in regards to mortgage lending and the re-securitization products that were created through financial innovation. The findings show that regulation was unable to keep pace with financial innovation, which created an environment where actors in the financial service sector were able to behave geographically irresponsibly by using information asymmetries to their advantage by par- ticipating in moral hazard activities and engaging in other immoral and unethical business practices that were centered around localized geography, which ultimately contributed to the global financial crisis. It also examines the roll of financial innovation in regard to the Lehman Brothers Mini-Bond in Hung and its role as a driving force behind China＇s newly emerging shadow banking sector. It concludes with a policy recommendation and its implication for China＇s continued economic development.展开更多
Public emergencies exert a significant impact on the mental health of the people,while psychological crisis intervention can efficiently improve the level of the mental health. The existing psychological crisis interv...Public emergencies exert a significant impact on the mental health of the people,while psychological crisis intervention can efficiently improve the level of the mental health. The existing psychological crisis intervention in China has weakness in organization system,budget input,human resources,social cognition,and other aspects. The psychological crisis intervention work in the future can be performed by actively perfecting the organization management system of psychological crisis intervention,increasing the budget input,strengthening the construction of psychological intervention teams,improving the level of social cognition,and so on.展开更多
The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological c...The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological crisis.The research mainly adopts case study and interview methods.Through scientific analysis of psychological crisis cases in four grades of X College in ethnic regions,it summarizes the current situation of crisis psychology among X College students,hoping to provide some first-hand data and research ideas for relevant researchers.展开更多
The commencement of China–Pakistan Economic Corridor has led to the appreciation of Pakistan’s economic outlook from 5.4%to 5.8%by the World Bank.The upgraded outlook is a welcome sign but it is still trivial,essent...The commencement of China–Pakistan Economic Corridor has led to the appreciation of Pakistan’s economic outlook from 5.4%to 5.8%by the World Bank.The upgraded outlook is a welcome sign but it is still trivial,essentially attributable to the electric power crisis,which approximately trims 2%of Pakistan’s economic growth annually.Almost 60%of the CPEC(China–Pakistan Economic Corridor)funds are directed at Pakistan’s energy sector,hence,demanding careful attention of both researchers and policy analysts alike.The study is based upon a meta-analytic review of literature concerning CPEC and Pakistan’s energy sector.The results of the study demonstrate that CPEC is an easing agent for Pakistan’s energy crisis(82.30%).The results also highlight points of concern,including inadequate planning(47%),dilapidated electricity distribution system causing losses(64.7%),and an unsustainable energy mix(64.7%).The study further validates the findings via Spearman’s Rho-Correlation.The rρvalue for the possible“resolution of Pakistan’s energy crisis”is 0.5426 achieving a significance level of 98%and a corresponding p-value of 0.0252.The significant negative rρvalue attained is−0.4894 which establishes the fact that lack of planning can hinder the energy crisis resolution.展开更多
文摘The national grid and other life-sustaining critical infrastructures face an unprecedented threat from prolonged blackouts,which could last over a year and pose a severe risk to national security.Whether caused by physical attacks,EMP(electromagnetic pulse)events,or cyberattacks,such disruptions could cripple essential services like water supply,healthcare,communication,and transportation.Research indicates that an attack on just nine key substations could result in a coast-to-coast blackout lasting up to 18 months,leading to economic collapse,civil unrest,and a breakdown of public order.This paper explores the key vulnerabilities of the grid,the potential impacts of prolonged blackouts,and the role of AI(artificial intelligence)and ML(machine learning)in mitigating these threats.AI-driven cybersecurity measures,predictive maintenance,automated threat response,and EMP resilience strategies are discussed as essential solutions to bolster grid security.Policy recommendations emphasize the need for hardened infrastructure,enhanced cybersecurity,redundant power systems,and AI-based grid management to ensure national resilience.Without proactive measures,the nation remains exposed to a catastrophic power grid failure that could have dire consequences for society and the economy.
文摘This study exploressimilarities and differences between American and Chinese colleges' crisis communication strategies.Italso examines how American and Chinese colleges use social media in crisis communication.The in-depth interviews focus on the com-parison of the crisis communication strategies in both American and Chinese universities.
文摘This paper explores the concept of crisis from a critical and interdisciplinary perspective,arguing that many contemporary crises-such as the coronavirus crisis and the climate crisis-are socially constructed and misunderstood.Drawing from Thomas Kuhn’s paradigm shift theory,Nassim Nicholas Taleb’s Black Swan concept,and complexity science,it contends that crises are a normal part of systemic evolution rather than extraordinary disruptions.The paper critiques the shift in agency from individuals to macro-level institutions,which has led to crises being perceived as indefinite rather than finite.The work also examines how crises are often framed through memetics rather than physical reality.By analyzing historical and contemporary crises,the paper illustrates how crisis narratives shape societal behavior and policy.The role of antifragility,memetic warfare,and evolutionary stable strategies(ESS)is discussed,demonstrating how resilience emerges through localized,rather than globalized,responses.The study concludes by advocating for a shift away from progressivist macro-level interventions and toward individual agency as the fundamental unit of societal adaptation.This perspective reframes crises as necessary transitions within evolutionary progress,arguing that societal sustainability depends on decentralization and adaptation rather than centralized control and panic-driven reactions.
文摘The territorial and maritime disputes in the South China Sea have been a significant and persistent factor affecting China’s bilateral relations with some member states of the Association of Southeast Asian Nations(ASEAN).While a resolution to these disputes appears unlikely in the near future,it is important to properly manage differences and prevent conflicts from escalating into crises,which is essential for maintaining peace and stability in the region.Since 2023,the tensions between China and the Philippines over Ren’ai Jiao,Huangyan Dao,Tiexian Jiao,and Xianbin Jiao,along with their adjacent waters have once again highlighted the significance and urgency of crisis management in the South China Sea.
文摘The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 key-informants were surveyed, including water-well owners, well-digging companies, water-trucking suppliers, agricultural pharmacies, and service offices within local councils. The surveys covered all nine districts in northwestern Syria across the Aleppo and the Idleb governorates. The survey findings reveal significant shifts in water sources, an almost halving in water availability and per capita consumption, and a notable decrease in water quality. Coping mechanisms include random well drilling and reduced hygiene practices. Water pumping stations face challenges with functionality, and there is a shift towards clean energy sources, particularly solar energy. Challenges identified by the survey respondents include drought, fuel costs, and damaged water networks. The study highlights the urgency of addressing the potable water crisis in Northwest Syria and suggests specific interventions to enhance water sustainability and governance.
文摘The risk of new pathogen emergence is constantly increasing due to several factors,including the expansion and exploration of previously uninhabited regions,increased global trade,tourism,climate change and others.Recently,monkeypox(mpox)cases have been increasing,causing alarm as the cases are reported from countries where the disease is not endemic.Mpox virus is an emerging pathogen responsible for human mpox.
基金funded by national funds through FCT-Fundação para a Ciência e a TecnologiaI.P.(Foundation for Science and Technology,I.P.) under project UIDB/05037/2020.
文摘Objective:To examine how emotional labor demands and strategies influence work engagement and occupational identity among Portuguese volunteer firefighters.Methods:Participants completed the Emotional Work Requirements Scale,Emotional Labour Scale,Utrecht Work Engagement Scale,and Social Identity Scale.Multiple linear regression analyses were conducted to assess the predictive effects of emotional labor demands and strategies on work engagement and occupational identity.Results:Emotional labor explained 11.8%of the variance in work engagement and 10.9%in occupational identity.Positive emotion expression significantly predicted higher work engagement and a stronger occupational identity,while the suppression of negative emotions predicted a weaker occupational identity.Other emotional labor dimensions were not significant.Conclusions:Findings underscore the dual role of emotional labor—as a resource when positive emotions are expressed and as a strain when negative emotions are habitually suppressed.Targeted interventions to promote authentic positive expression and effective emotional processing may enhance firefighters’well-being,strengthen crisis team performance,and benefit the communities they serve.Further research is needed to deepen the understanding of emotional labor in crisis response contexts.
文摘I.The Fentanyl Crisis in the U.S.The development and spread of the fentanyl crisis in the U.S.Recent years have seen a deteriorating narcotics situation in the U.S.and serious social problems arising therefrom.From 1999 to 2012,deaths from synthetic opioids(mainly fentanylrelated substances)overdose in the U.S.increased by 8%annually.
文摘Sickle cell anemia (SCA) is a prevalent genetic disorder primarily affecting individuals of African descent and populations in malaria-endemic regions, with significant global public health implications. Sickle cell crises are their most common acute complication, characterized by episodes of intense pain and systemic manifestations that impair quality of life and impose a high healthcare burden. We present the case of a 19-year-old male diagnosed with SCA since the age of two, who developed a sickle cell crisis precipitated by right basal pneumonia. The patient exhibited sudden-onset, cyclic lumbar pain with progressive dyspnea. Initial management included multimodal pain control, volume optimization, and targeted antimicrobial therapy to achieve clinical stabilization. This case underscores the importance of a comprehensive approach to managing sickle cell crises, addressing both symptomatic relief and the prevention and treatment of complications. It also highlights the need for public health strategies promoting early diagnosis, access to disease-modifying therapies such as hydroxyurea, and interdisciplinary follow-up to mitigate the socioeconomic and clinical impact of SCA.
基金Under the auspices of the National Natural Science Foundation of China(No.42130402)Shenzhen Science and Technology Program(No.JCYJ20220818100810024,KQTD20221101093604016)。
文摘The recent Russian-Ukrainian crisis has had a substantial impact on the global natural gas supply landscape and brought major challenges to liquified natural gas(LNG)supply chain safety in many countries.However,academic research in this field remains scarce.This study aims to analyze the global LNG marine supply network changes during the recent Russian-Ukrainian crisis.Big data analytics are applied to the global vessel trajectory information recorded by automatic identification system(AIS).The weighted degree index indicates that global LNG marine supply is still primarily led by a few exporting countries,and the Middle East Port of Ras Laffan now occupies the central position.In 2022,the betweenness centrality and other indicators of the LNG shipping network showed a high middle and low end,indicating that the network has a certain degree of resilience.After the Russian-Ukrainian crisis happened,LNG exports from Qatar,the United States,and Russia increased.Resource flows have reshaped the competitive standing of countries.The European LNG market witnessed a significant intensification in the export competition between Russia and the United States.Despite the ongoing crisis,Russia's LNG export competitiveness remained resilient and displayed no indications of weakening.The results show new evidence for the changes in global natural resources marine supply influenced by the geopolitical events among countries.This has important implications for policymaking of LNG supply safety to the countries that rely heavily on imports.
基金Exploration of the Preventive Effect of Skin Management Program Based on 4R Crisis Management Theory on Incontinence-Associated Dermatitis in ICU Patients with Fecal Incontinence(Project No.:YK202335)。
文摘Objective:To analyze the preventive and management effects of the 4R crisis management theory on incontinence-associated dermatitis(IAD)in ICU patients with fecal incontinence.Methods:A hundred patients with fecal incontinence who were admitted to the ICU for treatment between January 2024 and December 2024 were selected and randomly divided into two groups using a random number table.The observation group received 4R crisis management theory,while the control group received routine management.The IAD risk score,incidence of IAD,severity of IAD,and formation and healing time of IAD were compared between the two groups.Results:After management,the IAD risk score of the observation group was lower than that of the control group(P<0.05).The incidence of IAD in the observation group was lower than that in the control group,the proportion of mild IAD was higher than that in the control group,the formation time of IAD was later than that in the control group,and the healing time was shorter than that in the control group(P<0.05).Conclusion:Adopting the 4R crisis management theory for ICU patients with fecal incontinence can reduce the risk of IAD occurrence,effectively prevent IAD,reduce its severity,delay its formation time,and promote good healing.
文摘In the poem“Asides on the Oboe,”Wallace Stevens depicts a world rife with war,chaos,and a lack of faith,where old fictions no longer hold credibility,and it is time to create a new one.By crafting“the central man”as an embodiment of poetic fiction,Stevens argues for the possibility that poetry can bring poetic redemption to people in this era of war and crisis of faith.The frequent use of imagery,allusion,and other techniques in the poem together constitute the deep connotations of the text,reflecting Stevens’s equal attention to the aesthetics of poetry and humanism.
文摘BACKGROUND Although chronic-phase chronic myeloid leukemia(CP-CML)is treatable and nearly curable in about 50%of patients,accelerated-phase chronic myeloid leukemia(AP-CML)shows concerning drug resistance,while blast crisis chronic myeloid leukemia(BC-CML)is highly lethal.Advances in whole exome sequencing(WES)reveal pan-cancer mutations in BC-CML,supporting mutation-guided therapies beyond Breakpoint cluster region-Abelson.Artificial intelligence(AI)and machine learning(ML)enable genomic stratification and drug repurposing,addressing overlooked actionable mutations.AIM To stratify BC-CML into molecular subtypes using WES,ML,and AI for precision drug repurposing.METHODS Included 123 CML patients(111 CP-CML,5 AP-CML,7 BC-CML).WES identified pan-cancer mutations.Variants annotated via Ensembl Variant Effect Predictor and Catalogue of Somatic Mutations in Cancer(COSMIC).ML(principal component analysis,K-means)stratified BC-CML.COSMIC signatures and PanDrugs prioritized drugs.Analysis of variance/Kruskal-Wallis validated differences(P<0.05).RESULTS In this exploratory,hypothesis-generating study of BC-CML patients(n=7),we detected over 2500 somatic mutations.ML identified three BC-CML clusters:(1)Cluster 1[breast cancer susceptibility gene 2(BRCA2),TP53];(2)Cluster 2[isocitrate dehydrogenase(IDH)1/2,ten-eleven translocation 2];and(3)Cluster 3[Janus kinase(JAK)2,colony-stimulating factor 3 receptor],with distinct COSMIC signatures.Therapies:(1)Polyadenosinediphosphate-ribose polymerase inhibitors(olaparib);(2)IDH inhibitors(ivosidenib);and(3)JAK inhibitors(ruxolitinib).Mutational burden,signatures,and targets varied significantly across clusters,supporting precision stratification.CONCLUSION This WES-AI-ML framework provides mutation-guided therapies for BC-CML,enabling real-time stratification and Food and Drug Administration-approved drug repurposing.While this exploratory study is limited by its small sample size(n=7),it establishes a methodological framework for precision oncology stratification that warrants validation in larger,multi-center cohorts.
文摘Countries have to pre-evaluate threats and risks that may incur their national security and national interests, take the necessary preventive measures timely, and pursue decisive policies within the limits of the possibilities of their national power, by keeping a close watch on ongoing and conceivable crises and new developments. Like statesmen, also the international security organizations have to foresee the coming or anticipated threats and opportunities, take the necessary precautions and when necessary even to react by using force. Starting from time of peace, all these require an effective crisis management system that would warn and manage the threats that would create such crises. There are, however, crisis management centers and situation rooms in the focal points of the physical substructure of the crisis management system. In this article, by looking at the attributions of an effective crisis management system, structure of the crisis management centers and situation rooms will be questioned at international and national levels.
基金Under the auspices of International Centre for China Development Studies,the University of Hong Kong
文摘The mortgage loan has evolved from a local lending instrument into a major global security and its role is unparallel to other financial instruments in the process of financial globalization. This paper explains how technology and financial innovation transformed the mortgage loan from a local security into a premier global security traded worldwide. It examines the fundamental flaws of this process and why it does not work in regards to mortgage lending and the re-securitization products that were created through financial innovation. The findings show that regulation was unable to keep pace with financial innovation, which created an environment where actors in the financial service sector were able to behave geographically irresponsibly by using information asymmetries to their advantage by par- ticipating in moral hazard activities and engaging in other immoral and unethical business practices that were centered around localized geography, which ultimately contributed to the global financial crisis. It also examines the roll of financial innovation in regard to the Lehman Brothers Mini-Bond in Hung and its role as a driving force behind China＇s newly emerging shadow banking sector. It concludes with a policy recommendation and its implication for China＇s continued economic development.
基金supported by Specialist construction program of Jiading District Mental Health Center(No.:JDYXZDZK-3)Hospital-level program of Jiading District Mental Health Center(No.:2013-04)
文摘Public emergencies exert a significant impact on the mental health of the people,while psychological crisis intervention can efficiently improve the level of the mental health. The existing psychological crisis intervention in China has weakness in organization system,budget input,human resources,social cognition,and other aspects. The psychological crisis intervention work in the future can be performed by actively perfecting the organization management system of psychological crisis intervention,increasing the budget input,strengthening the construction of psychological intervention teams,improving the level of social cognition,and so on.
基金Self-funded project“Research on Intervention Pathways for Psychological Crisis of College Students in Ethnic Regions”by Sichuan Minzu College(Project number:XYZB2328SB)。
文摘The article discusses the significance of the research,and outlines the concepts of psychological crisis,its intervention,and psychological crisis among college students,as well as relevant theories on psychological crisis.The research mainly adopts case study and interview methods.Through scientific analysis of psychological crisis cases in four grades of X College in ethnic regions,it summarizes the current situation of crisis psychology among X College students,hoping to provide some first-hand data and research ideas for relevant researchers.
文摘The commencement of China–Pakistan Economic Corridor has led to the appreciation of Pakistan’s economic outlook from 5.4%to 5.8%by the World Bank.The upgraded outlook is a welcome sign but it is still trivial,essentially attributable to the electric power crisis,which approximately trims 2%of Pakistan’s economic growth annually.Almost 60%of the CPEC(China–Pakistan Economic Corridor)funds are directed at Pakistan’s energy sector,hence,demanding careful attention of both researchers and policy analysts alike.The study is based upon a meta-analytic review of literature concerning CPEC and Pakistan’s energy sector.The results of the study demonstrate that CPEC is an easing agent for Pakistan’s energy crisis(82.30%).The results also highlight points of concern,including inadequate planning(47%),dilapidated electricity distribution system causing losses(64.7%),and an unsustainable energy mix(64.7%).The study further validates the findings via Spearman’s Rho-Correlation.The rρvalue for the possible“resolution of Pakistan’s energy crisis”is 0.5426 achieving a significance level of 98%and a corresponding p-value of 0.0252.The significant negative rρvalue attained is−0.4894 which establishes the fact that lack of planning can hinder the energy crisis resolution.
