In this paper, we prove a common fixed point theorem for a pair of weakly compatible mappings in fuzzy metric space using the joint common limit in the range property of mappings called (JCLR) property. An example is ...In this paper, we prove a common fixed point theorem for a pair of weakly compatible mappings in fuzzy metric space using the joint common limit in the range property of mappings called (JCLR) property. An example is also furnished which demonstrates the validity of main result. We also extend our main result to two finite families of self mappings. Our results improve and generalize results of Cho et al. [Y. J. Cho, S. Sedghi and N. Shobe, “Generalized fixed point theorems for compatible mappings with some types in fuzzy metric spaces,” Chaos, Solitons & Fractals, Vol. 39, No. 5, 2009, pp. 2233-2244.] and several known results existing in the literature.展开更多
在SQL Server 2005中通过检查约束来实现一些复杂字符串的验证是比较困难的,由于在SQL Server 2005中集成了CLR,可以利用C#的正则表达式来解决这一问题,本文对CLR在SQL Server 2005中的应用做出了基本的阐述,详细给出了如何使用SQL CLR...在SQL Server 2005中通过检查约束来实现一些复杂字符串的验证是比较困难的,由于在SQL Server 2005中集成了CLR,可以利用C#的正则表达式来解决这一问题,本文对CLR在SQL Server 2005中的应用做出了基本的阐述,详细给出了如何使用SQL CLR集成来验证电子邮箱格式的关键步骤和代码,并通过实例进行了验证。展开更多
CGRP receptor（CLR） is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recent...CGRP receptor（CLR） is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recently. In the present study we designed and synthesized small molecular antagonists against CLR/RAMP1, resulting in a novel type of structure with acceptable high potency. The molecules were designed via virtual screening. Afterwards, a series of modification were conducted on the hit compounds, resulting in compound 8 as the best scored compound in docking, which was further validated in vitro by cell-based functional assay.展开更多
文摘In this paper, we prove a common fixed point theorem for a pair of weakly compatible mappings in fuzzy metric space using the joint common limit in the range property of mappings called (JCLR) property. An example is also furnished which demonstrates the validity of main result. We also extend our main result to two finite families of self mappings. Our results improve and generalize results of Cho et al. [Y. J. Cho, S. Sedghi and N. Shobe, “Generalized fixed point theorems for compatible mappings with some types in fuzzy metric spaces,” Chaos, Solitons & Fractals, Vol. 39, No. 5, 2009, pp. 2233-2244.] and several known results existing in the literature.
文摘在SQL Server 2005中通过检查约束来实现一些复杂字符串的验证是比较困难的,由于在SQL Server 2005中集成了CLR,可以利用C#的正则表达式来解决这一问题,本文对CLR在SQL Server 2005中的应用做出了基本的阐述,详细给出了如何使用SQL CLR集成来验证电子邮箱格式的关键步骤和代码,并通过实例进行了验证。
基金National Basic Research Program of China(Grant No.2012CB518000)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120001110010)
文摘CGRP receptor（CLR） is a B class GPCR that functions only when combined with RAMPs. CLR/RAMP1 has been regarded as a promising target for migraine treatment, as its antagonists have been proved to be effective recently. In the present study we designed and synthesized small molecular antagonists against CLR/RAMP1, resulting in a novel type of structure with acceptable high potency. The molecules were designed via virtual screening. Afterwards, a series of modification were conducted on the hit compounds, resulting in compound 8 as the best scored compound in docking, which was further validated in vitro by cell-based functional assay.
