目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of th...目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of the brief mental state examination,cMMSE)评估认知功能。使用R软件进行数据处理和分析,Bootstrap抽样法验证中介效应。结果校正多种协变量后,小腿围与认知障碍呈显著负相关(OR=0.951,95%CI:0.933~0.970),HCAR在其中起到中介作用(中介效应比例为0.022,95%CI:0.002~0.060)。结论小腿围与认知障碍之间存在负关联,HCAR起中介作用。该发现对预防和干预认知障碍有重要意义。展开更多
Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank...Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.展开更多
This paper uses the latest data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)of 2018 to report that the cognitive function and mental health sta-tus of elderly people in China.Elderly women and the old...This paper uses the latest data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)of 2018 to report that the cognitive function and mental health sta-tus of elderly people in China.Elderly women and the oldest-old(age over 80 years)tended to have higher risks of cognitive impairment and depressive symptoms than elderly men and younger elderly people.Respondents who continued to live at home in their communities(i.e.were not institutionalized in elderly care facilities,and were educated,married,without ADL disability and engaged in physical activities regularly appeared to have better cognitive function and mental health.Therefore,healthy lifestyles should be advocated and healthy interventions should focus more on the vulnerable elderly such as the oldest-old and women.展开更多
The 2018 Chinese Longitudinal Healthy Longevity Survey(CLHLS)presents infor-mation on both individual characteristics and family characteristics of China’s elderly population.It shows that only 1%of elderly men and 0...The 2018 Chinese Longitudinal Healthy Longevity Survey(CLHLS)presents infor-mation on both individual characteristics and family characteristics of China’s elderly population.It shows that only 1%of elderly men and 0.1%of elderly women never married.Older elderly people had more children than younger elderly people on average.Younger elderly had more years of schooling on average than did the older elderly population.Elderly women were more likely than elderly men to rely on their children as the main source of their income.Eighty-four point six percent of elderly people lived with household members,13.5%lived alone and 1.9%lived in institutions.Younger elderly people preferred to live alone(or with spouse only)more than did older elderly people.Family members offered the elderly the most in the way of emotional support and comfort,while people other than friends or neigh-bors play a very limited role.展开更多
文摘目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of the brief mental state examination,cMMSE)评估认知功能。使用R软件进行数据处理和分析,Bootstrap抽样法验证中介效应。结果校正多种协变量后,小腿围与认知障碍呈显著负相关(OR=0.951,95%CI:0.933~0.970),HCAR在其中起到中介作用(中介效应比例为0.022,95%CI:0.002~0.060)。结论小腿围与认知障碍之间存在负关联,HCAR起中介作用。该发现对预防和干预认知障碍有重要意义。
基金supported by grants from the National Key Research and Development Program of China(No.2023YFC3606300,No.2022YFC3600300)the National Natural Science Foundation of China(No.82325043)the National Key Research and Development Program of Hubei Province(2022BCA036)。
文摘Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.
基金This article was jointly supported by the National Natural Sciences Foundation of China(71490732,71873006)the National Key R&D Program of China(2018YFC2000400)the U.S.National Institute of Aging of the National Institute of Health(P01AG031719).
文摘This paper uses the latest data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)of 2018 to report that the cognitive function and mental health sta-tus of elderly people in China.Elderly women and the oldest-old(age over 80 years)tended to have higher risks of cognitive impairment and depressive symptoms than elderly men and younger elderly people.Respondents who continued to live at home in their communities(i.e.were not institutionalized in elderly care facilities,and were educated,married,without ADL disability and engaged in physical activities regularly appeared to have better cognitive function and mental health.Therefore,healthy lifestyles should be advocated and healthy interventions should focus more on the vulnerable elderly such as the oldest-old and women.
基金The data analyzed in this paper are from the Chinese Longitudinal Healthy Longevity Study(CLHLS)which was jointly supported by the National Natural Sciences Foundation of China(71490732)the National Key R&D Program of China(2018YFC2000400)the U.S.National Institute of Aging of the National Institute of Health(P01AG031719).
文摘The 2018 Chinese Longitudinal Healthy Longevity Survey(CLHLS)presents infor-mation on both individual characteristics and family characteristics of China’s elderly population.It shows that only 1%of elderly men and 0.1%of elderly women never married.Older elderly people had more children than younger elderly people on average.Younger elderly had more years of schooling on average than did the older elderly population.Elderly women were more likely than elderly men to rely on their children as the main source of their income.Eighty-four point six percent of elderly people lived with household members,13.5%lived alone and 1.9%lived in institutions.Younger elderly people preferred to live alone(or with spouse only)more than did older elderly people.Family members offered the elderly the most in the way of emotional support and comfort,while people other than friends or neigh-bors play a very limited role.
