This project studies marine terraces in western Messenia, southwestern Peloponnese, Greece, to propose a model of neotectonic configuration and paleogeographic evolution of western Messenia during the Quaternary. GIS ...This project studies marine terraces in western Messenia, southwestern Peloponnese, Greece, to propose a model of neotectonic configuration and paleogeographic evolution of western Messenia during the Quaternary. GIS analysis of topographic data and geological mapping revealed flanks of raised terraces created on Quaternary marine deposits. Luminescence ages of sediments from the three westernmost marine terraces tend to be consistent OIS-5, OIS-7 and OIS-9, respectively, thus agreeing with the three latest warm stages of the Pleistocene. Moreover, the type and the extent of deformation of the dated marine terraces allowed us to reflect on the neotectonic configuration of western Messenia as well as to conclude that progressive differential uplift over the last 300 ka has induced a dome-like structure to the upper crust of western Messenia.展开更多
背景与目的骨代谢标志物是一类源于骨基质或骨细胞的代谢指标,可反映骨代谢情况。本研究旨在探讨血清骨代谢生化指标I型胶原交联羧基端肽(cross-linked telopeptide of type I collage,ICTP)和骨特异性碱性磷酸酶(bone-specific alkalin...背景与目的骨代谢标志物是一类源于骨基质或骨细胞的代谢指标,可反映骨代谢情况。本研究旨在探讨血清骨代谢生化指标I型胶原交联羧基端肽(cross-linked telopeptide of type I collage,ICTP)和骨特异性碱性磷酸酶(bone-specific alkaline phosphatase,BAP)在肺癌骨转移诊断中的意义及其临床应用价值。方法采用前瞻性对照方法,共入组110例,分为3组。初治肺癌患者共90例,临床分期为IV期,分为骨转移组50例和非骨转移组40例,健康对照组20例,采用酶联免疫法和电化学发光免疫测定法检测所有入组者治疗前的血清骨代谢生化指标ICTP和BAP水平,对骨转移的各因素与血清ICTP和BAP的相关性进行统计学分析。结果骨转移组的血清ICTP和BAP水平显著高于非骨转移组和健康对照组(P<0.05)。多发性骨转移组(骨转移数≥3)的血清BAP水平显著高于少发性骨转移组(骨转移数<3)(P<0.05)。混合性骨转移组的血清BAP水平显著高于溶骨性骨转移组(P<0.05)。ICTP和BAP在肺癌骨转移诊断中的敏感性分别为18%和40%,特异性分别为98.3%和95%,准确度分别为61.8%和70%。联合检测血清ICTP和BAP可提高其敏感性和准确度(分别为52%和74.5%)。结论由于检测方便、无创性、成本较低,血清骨代谢生化指标ICTP和BAP在肺癌骨转移的临床诊断中有一定的实用价值。展开更多
基金supported by the State Scholarships Foundation of Greece(No.1500521537.008.040)
文摘This project studies marine terraces in western Messenia, southwestern Peloponnese, Greece, to propose a model of neotectonic configuration and paleogeographic evolution of western Messenia during the Quaternary. GIS analysis of topographic data and geological mapping revealed flanks of raised terraces created on Quaternary marine deposits. Luminescence ages of sediments from the three westernmost marine terraces tend to be consistent OIS-5, OIS-7 and OIS-9, respectively, thus agreeing with the three latest warm stages of the Pleistocene. Moreover, the type and the extent of deformation of the dated marine terraces allowed us to reflect on the neotectonic configuration of western Messenia as well as to conclude that progressive differential uplift over the last 300 ka has induced a dome-like structure to the upper crust of western Messenia.
文摘背景与目的骨代谢标志物是一类源于骨基质或骨细胞的代谢指标,可反映骨代谢情况。本研究旨在探讨血清骨代谢生化指标I型胶原交联羧基端肽(cross-linked telopeptide of type I collage,ICTP)和骨特异性碱性磷酸酶(bone-specific alkaline phosphatase,BAP)在肺癌骨转移诊断中的意义及其临床应用价值。方法采用前瞻性对照方法,共入组110例,分为3组。初治肺癌患者共90例,临床分期为IV期,分为骨转移组50例和非骨转移组40例,健康对照组20例,采用酶联免疫法和电化学发光免疫测定法检测所有入组者治疗前的血清骨代谢生化指标ICTP和BAP水平,对骨转移的各因素与血清ICTP和BAP的相关性进行统计学分析。结果骨转移组的血清ICTP和BAP水平显著高于非骨转移组和健康对照组(P<0.05)。多发性骨转移组(骨转移数≥3)的血清BAP水平显著高于少发性骨转移组(骨转移数<3)(P<0.05)。混合性骨转移组的血清BAP水平显著高于溶骨性骨转移组(P<0.05)。ICTP和BAP在肺癌骨转移诊断中的敏感性分别为18%和40%,特异性分别为98.3%和95%,准确度分别为61.8%和70%。联合检测血清ICTP和BAP可提高其敏感性和准确度(分别为52%和74.5%)。结论由于检测方便、无创性、成本较低,血清骨代谢生化指标ICTP和BAP在肺癌骨转移的临床诊断中有一定的实用价值。
