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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury 被引量:1
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作者 Xiangzi Wang Xiaofei Niu +4 位作者 Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi 《Neural Regeneration Research》 SCIE CAS 2025年第8期2231-2244,共14页
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand... Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury. 展开更多
关键词 apoptosis c-c motif chemokine ligand 2/c-c motif chemokine receptor 2 pathway c-c motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method
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血清趋化因子C-C配体19与21水平在住院心力衰竭患者中的预后价值
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作者 曾文飞 李玲 +3 位作者 林凯玲 黄道昕 李力 余惠珍 《中华高血压杂志(中英文)》 北大核心 2025年第7期669-679,共11页
目的观察血清趋化因子C-C配体19(CCL19)和CCL21水平在住院心力衰竭(心衰)患者中的预后价值。方法入选2018年12月至2021年10月于福建省立医院南院心内科住院的心衰患者共221例(心衰组),同期健康体检的55名体检者作为对照组,出院后定期随... 目的观察血清趋化因子C-C配体19(CCL19)和CCL21水平在住院心力衰竭(心衰)患者中的预后价值。方法入选2018年12月至2021年10月于福建省立医院南院心内科住院的心衰患者共221例(心衰组),同期健康体检的55名体检者作为对照组,出院后定期随访。采用酶联免疫吸附试验法检测血清CCL19和CCL21水平,收集两组患者临床基线资料信息。采用时间依赖性受试者操作特征(ROC)曲线、Kaplan-Meier生存曲线和Cox回归分析评估CCL19和CCL21对心衰的预后价值。结果最终纳入心衰患者170例,中位随访时间为722.5(396.5,898.0)d,全因死亡30例,78例发生复合终点事件(包括全因死亡、急性心肌梗死、恶性心律失常、猝死和心衰再入院)。心衰患者血清CCL19和CCL21浓度较对照组高。多因素Cox回归分析显示,校正心血管危险因素后,CCL19、CCL21升高以及CCL19与CCL21均升高与心衰患者全因死亡风险相关[HR(95%CI)分别为3.904(1.561~9.760)、3.946(1.561~9.978)、6.048(2.646~13.824)];CCL21以及CCL19与CCL21均升高与复合终点事件发生率升高相关[HR(95%CI)分别为2.204(1.350~3.599)、1.883(1.157~3.066)]。时间依赖性ROC曲线分析提示,CCL19、CCL21以及CCL19联合CCL21均升高可以预测各时间点心衰患者的全因死亡和远期复合终点事件的发生。Kaplan-Meier曲线显示,血清CCL19、CCL21以及CCL19联合CCL21均升高的心衰患者全因死亡率及复合终点事件发生率高(P<0.05)。结论心衰患者血清CCL19和CCL21水平明显升高,与心衰患者全因死亡相关,CCL21升高与心衰患者复合终点事件发生相关。 展开更多
关键词 趋化因子c-c配体19 趋化因子c-c配体21 心力衰竭 预后
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二甲双胍调节C-C基序趋化因子配体2/C-C基序趋化因子受体2轴对糖尿病大鼠17型辅助T细胞/调节性T细胞平衡影响的研究
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作者 刘前华 周俊洪 +2 位作者 李朝敏 吴宇 谭薇 《中国糖尿病杂志》 北大核心 2025年第8期623-630,共8页
目的探讨二甲双胍(Met)调节C-C基序趋化因子配体2(CCL2)/C-C基序趋化因子受体2(CCR2)轴对DM大鼠17型辅助T细胞(Th17)/调节性T细胞(Treg)平衡的影响。方法取SD大鼠50只随机分为正常对照(NC)组、模型(Mod)组、Met(100 mg/kg)组、Met+空载(... 目的探讨二甲双胍(Met)调节C-C基序趋化因子配体2(CCL2)/C-C基序趋化因子受体2(CCR2)轴对DM大鼠17型辅助T细胞(Th17)/调节性T细胞(Treg)平衡的影响。方法取SD大鼠50只随机分为正常对照(NC)组、模型(Mod)组、Met(100 mg/kg)组、Met+空载(Met+oe-NC)组、Met+CCL2过表达(Met+oe-CCL2)组,每组10只。观察各组FBG变化,HE染色检测各组胰腺中胰岛组织变化并进行病理评分,流式细胞术检测各组外周血Th17/Treg比值,ELISA检测各组血清IL-17、TNF-α、TGF-β、IL-10水平,免疫荧光检测各组胰腺组织Th17、Treg浸润比例,RT-PCR和Western blot检测各组胰腺组织视黄酸受体相关孤儿受体γt(ROR-γt)、叉头框蛋白P3(FOXP3)、CCL2、CCR2 mRNA及蛋白表达。结果NC组胰岛组织中胰岛结构完好且边界清晰,无病理损伤,Mod组胰岛组织呈现明显病理损伤,可见胰岛结构受损明显且体积缩小,与周围组织间分界不清,胰岛内细胞分布杂乱且缺失明显,与Mod组比较,Met、Met+oe-NC组胰岛组织病理损伤均减轻,与Met组比较,Met+oe-CCL2组病理损伤加重。Mod组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达高于NC组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达低于NC组(P<0.05)。Met、Met+oe-NC组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达低于Mod组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达高于Mod组(P<0.05)。Met+oe-CCL2组FBG、Th17/Treg比值、IL-17、TNF-α、Th17浸润比例、ROR-γt、CCL2、CCR2 mRNA及蛋白表达高于Met组(P<0.05),TGF-β、IL-10、Treg浸润比例、FOXP3 mRNA及蛋白表达高于Met组(P<0.05)。结论Met可通过抑制CCL2/CCR2轴激活促使Th17/Treg细胞平衡向Treg方向漂移,抑制炎症反应发生发展,减轻DM大鼠胰岛损伤,改善其糖代谢。 展开更多
关键词 二甲双胍 c-c基序趋化因子配体2/c-c基序趋化因子受体2轴 糖尿病 17型辅助T细胞/调节性T细胞比值
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Study of the Transport Behavior of Multispherical Proppant in Intersecting Fracture Based on Discrete Element Method 被引量:1
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作者 Chengyong Peng JianshuWu +2 位作者 Mao Jiang Biao Yin Yishan Lou 《Energy Engineering》 EI 2025年第1期185-201,共17页
To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fract... To analyze the differences in the transport and distribution of different types of proppants and to address issues such as the short effective support of proppant and poor placement in hydraulically intersecting fractures,this study considered the combined impact of geological-engineering factors on conductivity.Using reservoir production parameters and the discrete elementmethod,multispherical proppants were constructed.Additionally,a 3D fracture model,based on the specified conditions of the L block,employed coupled(Computational Fluid Dynamics)CFD-DEM(Discrete ElementMethod)for joint simulations to quantitatively analyze the transport and placement patterns of multispherical proppants in intersecting fractures.Results indicate that turbulent kinetic energy is an intrinsic factor affecting proppant transport.Moreover,the efficiency of placement and migration distance of low-sphericity quartz sand constructed by the DEM in the main fracture are significantly reduced compared to spherical ceramic proppants,with a 27.7%decrease in the volume fraction of the fracture surface,subsequently affecting the placement concentration and damaging fracture conductivity.Compared to small-angle fractures,controlling artificial and natural fractures to expand at angles of 45°to 60°increases the effective support length by approximately 20.6%.During hydraulic fracturing of gas wells,ensuring the fracture support area and post-closure conductivity can be achieved by controlling the sphericity of proppants and adjusting the perforation direction to control the direction of artificial fractures. 展开更多
关键词 Hydraulic fracturing discrete element method PROPPANT SPHERICITY CFD-DEM
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高强钢筋增强UHPC-CFST组合桥墩抗震性能研究 被引量:1
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作者 郑仁亮 庄一舟 +1 位作者 张仁巍 曾武华 《浙江工业大学学报》 北大核心 2025年第1期40-51,共12页
采用有限元软件ABAQUS,开展了高强钢筋增强UHPC-CFST组合桥墩的抗震数值建模分析,通过与已有试验结果的对比,验证了建模方法的准确性。在此基础上,分析了轴压比、UHPC强度、UHPC厚度和钢管屈服强度等参数对组合桥墩受力性能的影响规律,... 采用有限元软件ABAQUS,开展了高强钢筋增强UHPC-CFST组合桥墩的抗震数值建模分析,通过与已有试验结果的对比,验证了建模方法的准确性。在此基础上,分析了轴压比、UHPC强度、UHPC厚度和钢管屈服强度等参数对组合桥墩受力性能的影响规律,并给出了各参数的建议取值范围。研究结果表明:增大轴压比和纵筋配筋率可提升组合桥墩的水平承载力和耗能能力,然而会限制试件的变形;提高UHPC强度和UHPC厚度,组合桥墩的水平承载力和位移延性系数均呈现出先增大后减小的趋势;提升钢管屈服强度可稳步增强组合桥墩的水平承载力;增加钢管厚度可明显提升组合桥墩的抗震性能,而体积配箍率和混凝土强度对组合桥墩的抗震性能影响较小。基于分析数据样本,采用多元非线性回归分析得到水平峰值荷载和位移延性系数的计算方法,公式计算值与有限元分析值吻合良好。 展开更多
关键词 高强钢筋 超高性能混凝土 钢管混凝土柱 有限元 计算方法
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Combing the Entropy Weight Method with Fuzzy Mathematics for Assessing the Quality and Post-Ripening Mechanism of High-Temperature Daqu during Storage 被引量:1
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作者 YANG Junlin YANG Shaojuan +8 位作者 WU Cheng YIN Yanshun YOU Xiaolong ZHAO Wenyu ZHU Anran WANG Jia HU Feng HU Jianfeng WANG Diqiang 《食品科学》 北大核心 2025年第9期48-62,共15页
This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standar... This study investigated the physicochemical properties,enzyme activities,volatile flavor components,microbial communities,and sensory evaluation of high-temperature Daqu(HTD)during the maturation process,and a standard system was established for comprehensive quality evaluation of HTD.There were obvious changes in the physicochemical properties,enzyme activities,and volatile flavor components at different storage periods,which affected the sensory evaluation of HTD to a certain extent.The results of high-throughput sequencing revealed significant microbial diversity,and showed that the bacterial community changed significantly more than did the fungal community.During the storage process,the dominant bacterial genera were Kroppenstedtia and Thermoascus.The correlation between dominant microorganisms and quality indicators highlighted their role in HTD quality.Lactococcus,Candida,Pichia,Paecilomyces,and protease activity played a crucial role in the formation of isovaleraldehyde.Acidic protease activity had the greatest impact on the microbial community.Moisture promoted isobutyric acid generation.Furthermore,the comprehensive quality evaluation standard system was established by the entropy weight method combined with multi-factor fuzzy mathematics.Consequently,this study provides innovative insights for comprehensive quality evaluation of HTD during storage and establishes a groundwork for scientific and rational storage of HTD and quality control of sauce-flavor Baijiu. 展开更多
关键词 microbial community high-temperature Daqu comprehensive quality evaluation entropy weight method maturation process
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In situ stress inversion using nonlinear stress boundaries achieved by the bubbling method 被引量:1
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作者 Xige Liu Chenchun Huang +3 位作者 Wancheng Zhu Joung Oh Chengguo Zhang Guangyao Si 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第3期1510-1527,共18页
Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this cha... Due to the heterogeneity of rock masses and the variability of in situ stress,the traditional linear inversion method is insufficiently accurate to achieve high accuracy of the in situ stress field.To address this challenge,nonlinear stress boundaries for a numerical model are determined through regression analysis of a series of nonlinear coefficient matrices,which are derived from the bubbling method.Considering the randomness and flexibility of the bubbling method,a parametric study is conducted to determine recommended ranges for these parameters,including the standard deviation(σb)of bubble radii,the non-uniform coefficient matrix number(λ)for nonlinear stress boundaries,and the number(m)and positions of in situ stress measurement points.A model case study provides a reference for the selection of these parameters.Additionally,when the nonlinear in situ stress inversion method is employed,stress distortion inevitably occurs near model boundaries,aligning with the Saint Venant's principle.Two strategies are proposed accordingly:employing a systematic reduction of nonlinear coefficients to achieve high inversion accuracy while minimizing significant stress distortion,and excluding regions with severe stress distortion near the model edges while utilizing the central part of the model for subsequent simulations.These two strategies have been successfully implemented in the nonlinear in situ stress inversion of the Xincheng Gold Mine and have achieved higher inversion accuracy than the linear method.Specifically,the linear and nonlinear inversion methods yield root mean square errors(RMSE)of 4.15 and 3.2,and inversion relative errors(δAve)of 22.08%and 17.55%,respectively.Therefore,the nonlinear inversion method outperforms the traditional multiple linear regression method,even in the presence of a systematic reduction in the nonlinear stress boundaries. 展开更多
关键词 In situ stress field Inversion method The bubbling method Nonlinear stress boundary Multiple linear regression method
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Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates
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作者 Yufeng Xing Ye Yuan Gen Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期329-355,共27页
The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytica... The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical shells.By taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue equations.Besides,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are investigated.It is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well. 展开更多
关键词 Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method
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Improved methods,properties,applications and prospects of microbial induced carbonate precipitation(MICP)treated soil:A review 被引量:2
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作者 Xuanshuo Zhang Hongyu Wang +3 位作者 Ya Wang Jinghui Wang Jing Cao Gang Zhang 《Biogeotechnics》 2025年第1期34-54,共21页
Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vi... Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications. 展开更多
关键词 Soil improvement Bio-cement MICP Improved methods Field application cases
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一种基于Least Square Method算法的城轨车辆车门动作时间精准判断的研究
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作者 李宏菱 宋华杰 +3 位作者 马仲智 周辉 李晴 陈龙 《时代汽车》 2025年第3期190-192,共3页
为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波... 为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波形矫正模型,利用数学方法校准波形,让MCU找出最佳计时点并处理(误差不超过10ms),采用最小二乘法模型,通过最小化误差的平方和找到一组数据的最佳函数匹配,求得未知的数据,并使得这些求得的数据与实际数据之间误差的平方和为最小,可精准地得到门动作时间。模拟测试结果表明,门动作时间测算误差所示其误差为7.42ms,小于10ms。 展开更多
关键词 城轨车辆 客室车门 电机码盘 Least Square method算法 门动作时间精准
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Research on Bearing Fault Diagnosis Method Based on Deep Learning 被引量:1
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作者 Ting Zheng 《Journal of Electronic Research and Application》 2025年第1期1-6,共6页
Bearing is an indispensable key component in mechanical equipment,and its working state is directly related to the stability and safety of the whole equipment.In recent years,with the rapid development of artificial i... Bearing is an indispensable key component in mechanical equipment,and its working state is directly related to the stability and safety of the whole equipment.In recent years,with the rapid development of artificial intelligence technology,especially the breakthrough of deep learning technology,it provides a new idea for bearing fault diagnosis.Deep learning can automatically learn features from a large amount of data,has a strong nonlinear modeling ability,and can effectively solve the problems existing in traditional methods.Aiming at the key problems in bearing fault diagnosis,this paper studies the fault diagnosis method based on deep learning,which not only provides a new solution for bearing fault diagnosis but also provides a reference for the application of deep learning in other mechanical fault diagnosis fields. 展开更多
关键词 Deep learning Bearing failure Diagnostic methods
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Design and Optimization of Anode Catalysts for Direct Ethanol Fuel Cells:Advances and Challenges in C-C bond Activation and Selective Modulation of the C1 Pathway
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作者 Kai-Chi Qin Meng-Tian Huo +3 位作者 Yu Liang Si-Yuan Zhu Zi-Hao Xing Jin-Fa Chang 《电化学(中英文)》 北大核心 2025年第8期1-22,共22页
Direct ethanol fuel cells(DEFCs)are a promising alternative to conventional energy sources,offering high energy density,environmental sustainability,and operational safety.Compared to methanol fuel cells,DEFCs exhibit... Direct ethanol fuel cells(DEFCs)are a promising alternative to conventional energy sources,offering high energy density,environmental sustainability,and operational safety.Compared to methanol fuel cells,DEFCs exhibit lower toxicity and a more mature preparation process.Unlike hydrogen fuel cells,DEFCs provide superior storage and transport feasibility,as well as cost-effectiveness,significantly enhancing their commercial viability.However,the stable C-C bond in ethanol creates a high activation energy barrier,often resulting in incomplete electrooxidation.Current commercial platinum(Pt)-and palladium(Pd)-based catalysts demonstrate low C-C bond cleavage efficiency(<7.5%),severely limiting DEFC energy output and power density.Furthermore,high catalyst costs and insufficient activity impede large-scale commercialization.Recent advances in DEFC anode catalyst design have focused on optimizing material composition and elucidating catalytic mechanisms.This review systematically examines developments in ethanol electrooxidation catalysts over the past five years,highlighting strategies to improve C1 pathway selectivity and C-C bond activation.Key approaches,such as alloying,nanostructure engineering,and interfacial synergy effects,are discussed alongside their mechanistic implications.Finally,we outline current challenges and future prospects for DEFC commercialization. 展开更多
关键词 Direct ethanol fuel cells Ethanol electrooxidation c-c bond cleavage ELECTROCATALYSIS Anode catalyst
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A dual⁃parameter method for seismic resilience assessment of buildings 被引量:1
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作者 LI Shuang HU Binbin +1 位作者 LIU Wen ZHAI Changhai 《Journal of Southeast University(English Edition)》 2025年第1期1-11,共11页
To quantify the seismic resilience of buildings,a method for evaluating functional loss from the component level to the overall building is proposed,and the dual-parameter seismic resilience assessment method based on... To quantify the seismic resilience of buildings,a method for evaluating functional loss from the component level to the overall building is proposed,and the dual-parameter seismic resilience assessment method based on postearthquake loss and recovery time is improved.A threelevel function tree model is established,which can consider the dynamic changes in weight coefficients of different category of components relative to their functional losses.Bayesian networks are utilized to quantify the impact of weather conditions,construction technology levels,and worker skill levels on component repair time.A method for determining the real-time functional recovery curve of buildings based on the component repair process is proposed.Taking a three-story teaching building as an example,the seismic resilience indices under basic earthquakes and rare earthquakes are calculated.The results show that the seismic resilience grade of the teaching building is comprehensively judged as GradeⅢ,and its resilience grade is more significantly affected by postearthquake loss.The proposed method can be used to predict the seismic resilience of buildings prior to earthquakes,identify weak components within buildings,and provide guidance for taking measures to enhance the seismic resilience of buildings. 展开更多
关键词 seismic resilience assessment dual-parameter method functional loss recovery time Bayesian networks
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A Review of the Hydrodynamic Damping Characteristics of Blade-like Structures:Focus on the Quantitative Identification Methods and Key Influencing Parameters 被引量:1
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作者 Yongshun Zeng Zhaohui Qian +1 位作者 Jiayun Zhang Zhifeng Yao 《哈尔滨工程大学学报(英文版)》 2025年第1期21-34,共14页
Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.Howev... Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.However,the widened hydraulic excitation frequency may satisfy the blade resonance due to the time variation in the velocity and angle of attack of the ocean current,even resulting in blade fatigue and destructively interfering with grid stability.A key parameter that determines the resonance amplitude of the blade is the hydrodynamic damping ratio(HDR).However,HDR is difficult to obtain due to the complex fluid-structure interaction(FSI).Therefore,a literature review was conducted on the hydrodynamic damping characteristics of blade-like structures.The experimental and simulation methods used to identify and obtain the HDR quantitatively were described,placing emphasis on the experimental processes and simulation setups.Moreover,the accuracy and efficiency of different simulation methods were compared,and the modal work approach was recommended.The effects of key typical parameters,including flow velocity,angle of attack,gap,rotational speed,and cavitation,on the HDR were then summarized,and the suggestions on operating conditions were presented from the perspective of increasing the HDR.Subsequently,considering multiple flow parameters,several theoretical derivations and semi-empirical prediction formulas for HDR were introduced,and the accuracy and application were discussed.Based on the shortcomings of the existing research,the direction of future research was finally determined.The current work offers a clear understanding of the HDR of blade-like structures,which could improve the evaluation accuracy of flow-induced vibration in the design stage. 展开更多
关键词 Blade fatigue Hydrodynamic damping ratio Identification method Affecting factors Prediction formula
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Formation mechanism of herpetrione self-assembled nanoparticles based on p H-driven method 被引量:1
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作者 Yuwen Zhu Xiang Deng +4 位作者 Yan Wu Baode Shen Lingyu Hang Yuye Xue Hailong Yuan 《Chinese Chemical Letters》 2025年第1期387-391,共5页
The self-assembled nanoparticles(SAN)formed during the decoction process of traditional Chinese medicine(TCM)exhibit non-uniform particle sizes and a tendency for aggregation.Our group found that the p H-driven method... The self-assembled nanoparticles(SAN)formed during the decoction process of traditional Chinese medicine(TCM)exhibit non-uniform particle sizes and a tendency for aggregation.Our group found that the p H-driven method can improve the self-assembly phenomenon of Herpetospermum caudigerum Wall.,and the SAN exhibited uniform particle size and demonstrated good stability.In this paper,we analyzed the interactions between the main active compound,herpetrione(Her),and its main carrier,Herpetospermum caudigerum Wall.polysaccharide(HCWP),along with their self-assembly mechanisms under different p H values.The binding constants of Her and HCWP increase with rising p H,leading to the formation of Her-HCWP SAN with a smaller particle size,higher zeta potential,and improved thermal stability.While the contributions of hydrogen bonding and electrostatic attraction to the formation of Her-HCWP SAN increase with rising p H,the hydrophobic force consistently plays a dominant role.This study enhances our scientific understanding of the self-assembly phenomenon of TCM improved by p H driven method. 展开更多
关键词 Traditional Chinese medicine NANOPARTICLES Herpetrione Interaction pH-driven method Self-assembly Isothermal titration calorimetry
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Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method
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作者 WANG Xin SHEN Dejian +2 位作者 TAO Sijie LIU Ruixin WU Shengxing 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2025年第1期49-64,共16页
This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydra... This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S paste.The results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age. 展开更多
关键词 tricalcium silicate simulation method chloride diffusion coefficient pore solution
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Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method
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作者 Suliang Ma Zeqing Meng +1 位作者 Mingxuan Chen Yuan Jiang 《Energy Engineering》 EI 2025年第1期63-84,共22页
In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is crucial.Still,it presents a challenge due to the significant deviations in values ofmultiple optimizatio... In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is crucial.Still,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical dimensions.These deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s values.The optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization methods.The proposed method better balances all optimization objective functions and reduces the impact of their dimensionality.When the cost of BESS decreases by approximately 30%,its participation deepens by about 1 time.Moreover,if the price of the electrolyzer is less than 15¥/kWh or if the cost of the fuel cell drops below 4¥/kWh,their participation will increase substantially.This study aims to provide a more reasonable approach to solving multi-objective optimization problems. 展开更多
关键词 Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system
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Effects of plasma screening on the^(1)P^(o)(n=3,n=4)resonance states of H-and He using the stabilization method
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作者 仲子鑫 吕柄宽 +2 位作者 姜子实 KAR Sabyasachi HO Yew Kam 《黑龙江大学自然科学学报》 2025年第4期469-487,共19页
The effects of plasma screening on the ^(1)P^(o) resonance states of H-and He below the n=3 and n=4 thresholds of the respective subsystemsare investigated using the stabilization method and correlated exponential wav... The effects of plasma screening on the ^(1)P^(o) resonance states of H-and He below the n=3 and n=4 thresholds of the respective subsystemsare investigated using the stabilization method and correlated exponential wave functions.Two plasma mediums,namely,the Debye plasma and quantum plasma environments are considered.The screened Coulomb potential(SCP)obtained from Debye-Hückel model is used to represent Debye plasma environments and the exponential cosine screened Coulomb potential(ECSCP)obtained from a modified Debye-Hückel model is used to represent quantum plasma environments.The resonance parameters(resonance positions and widths)are presented in terms of the screening parameters. 展开更多
关键词 quantum plasma Debye plasma P-wave resonance states correlated exponential wave functions stabilization method
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Towards a blank design method for manufacturing big-tapered profiled ring disk by spinning-rolling process 被引量:1
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作者 Xuechao LI Lianggang GUO +1 位作者 Xiaoqing CHEN Heng LI 《Chinese Journal of Aeronautics》 2025年第1期70-86,共17页
The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficien... The big-tapered profiled ring disk is a key component of engines for rockets and missiles.A new forming technology,as called spinning-rolling process,has been proposed previously for the high performance,high efficiency and low-cost manufacturing of the component.Blank design is the key part of plastic forming process design.For spinning-rolling process,the shape and size of the blank play a crucial role in process stability,deformation behavior and dimensional accuracy.So this work proposes a blank design method to determine the geometry structure and sizes of the blank.The mathematical model for calculating the blank size has been deduced based on volume conservation and neutral layer length invariance principle.The FE simulation and corresponding trial production of an actual big-tapered profiled ring disk show that the proposed blank design method is applicative.In order to obtain a preferred blank,the influence rules of blank size determined by different deformation degrees(rolling ratio k)on the spinning-rolling process are revealed by comprehensive FE simulations.Overall considering the process stability,circularity of the deformed ring disk and forming forces,a reasonable range of deformation degree(rolling ratio k)is recommended for the blank design of the new spinning-rolling process. 展开更多
关键词 Blank design method Spinning-rolling process Big-tapered profiled ring disk Rolling ratio Intelligent FE simulation
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An alternative regularization approach for modeling the regional lithospheric magnetic field from satellite magnetic measurements by the spherical equivalent source method and its application in Africa 被引量:1
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作者 JiangSong Gui JinSong Du +5 位作者 Pan Zhang ChangQing Yuan YuKun Li KangAn Zhao Liang Yin HouPu Li 《Earth and Planetary Physics》 2025年第3期697-710,共14页
The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.Howeve... The equivalent source(ES)method in the spherical coordinate system has been widely applied to processing,reduction,field modeling,and geophysical and geological interpretation of satellite magnetic anomaly data.However,the inversion for the ES model suffers from nonuniqueness and instability,which remain unresolved.To mitigate these issues,we introduce both the minimum and flattest models into the model objective function as an alternative regularization approach in the spherical ES method.We first present the methods,then analyze the accuracy of forward calculation and test the proposed ES method in this study by using synthetic data.The experimental results from simulation data indicate that our proposed regularization effectively suppresses the Backus effect and mitigates inversion instability in the low-latitude region.Finally,we apply the proposed method to magnetic anomaly data from China Seismo-Electromagnetic Satellite-1(CSES-1)and Macao Science Satellite-1(MSS-1)magnetic measurements over Africa by constructing an ES model of the large-scale lithospheric magnetic field.Compared with existing global lithospheric magnetic field models,our ES model demonstrates good consistency at high altitudes and predicts more stable fields at low altitudes.Furthermore,we derive the reduction to the pole(RTP)magnetic anomaly fields and the apparent susceptibility contrast distribution based on the ES model.The latter correlates well with the regional tectonic framework in Africa and surroundings. 展开更多
关键词 regional lithospheric magnetic field model spherical equivalent source method satellite magnetism AFRICA MSS-1 CSES-1
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