A novel photocatalytic energy transfer-driven radical relay strategy has been introduced for the chemoand regioselective 1,4-difunctionalization of carbon-sulfur double bonds.This represents the first instance of radi...A novel photocatalytic energy transfer-driven radical relay strategy has been introduced for the chemoand regioselective 1,4-difunctionalization of carbon-sulfur double bonds.This represents the first instance of radical-mediated dual-functionalization of X-Y type unsaturated bonds,enabling the synthesis of complex linear molecules with C–O,C–N,and C-S bonds in a single operation.The method surpasses traditional approaches by avoiding the need for thiourea intermediates and the harsh conditions typically associated with them.The developed strategy exemplifies versatility,being applicable to 1,4-oxyamination,1,4-diamination,and 1,4-sulfonamination reactions,and has demonstrated compatibility with over 60 different substrates.The research also elucidates the role of electronic complementarity between radicals and receptors in achieving high selectivity in 1,4-difunctionalization reactions.This study significantly advances the field of bifunctionalization and remote difunctionalization reactions,with profound implications for the development of pharmaceuticals and materials science.展开更多
Parkinson’s disease is a neurodegenerative disorder that inflicts irreversible damage on humans.Some experimental data regarding Parkinson’s patients are redundant and irrelevant,posing significant challenges for di...Parkinson’s disease is a neurodegenerative disorder that inflicts irreversible damage on humans.Some experimental data regarding Parkinson’s patients are redundant and irrelevant,posing significant challenges for disease detection.Therefore,there is a need to devise an effective method for the selective extraction of disease-specific information,ensuring both accuracy and the utilization of fewer features.In this paper,a Binary Hybrid Artificial Hummingbird and Flower Pollination Algorithm(FPA),called BFAHA,is proposed to solve the problem of Parkinson’s disease diagnosis based on speech signals.First,combining FPA with Artificial Hummingbird Algorithm(AHA)can take advantage of the strong global exploration ability possessed by FPA to improve the disadvantages of AHA,such as premature convergence and easy falling into local optimum.Second,the Hemming distance is used to determine the difference between the other individuals in the population and the optimal individual after each iteration,if the difference is too significant,the cross-mutation strategy in the genetic algorithm(GA)is used to induce the population individuals to keep approaching the optimal individual in the random search process to speed up finding the optimal solution.Finally,an S-shaped function converts the improved algorithm into a binary version to suit the characteristics of the feature selection(FS)tasks.In this paper,10 high-dimensional datasets from UCI and the ASU are used to test the performance of BFAHA and apply it to Parkinson’s disease diagnosis.Compared with other state-of-the-art algorithms,BFAHA shows excellent competitiveness in both the test datasets and the classification problem,indicating that the algorithm proposed in this study has apparent advantages in the field of feature selection.展开更多
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.展开更多
基金the National Natural Science Foundation of China(No.22101059)the financial support from Guangxi Science and Technology Program of China(No.2023GXNSFBA026275)Guangxi Normal University。
文摘A novel photocatalytic energy transfer-driven radical relay strategy has been introduced for the chemoand regioselective 1,4-difunctionalization of carbon-sulfur double bonds.This represents the first instance of radical-mediated dual-functionalization of X-Y type unsaturated bonds,enabling the synthesis of complex linear molecules with C–O,C–N,and C-S bonds in a single operation.The method surpasses traditional approaches by avoiding the need for thiourea intermediates and the harsh conditions typically associated with them.The developed strategy exemplifies versatility,being applicable to 1,4-oxyamination,1,4-diamination,and 1,4-sulfonamination reactions,and has demonstrated compatibility with over 60 different substrates.The research also elucidates the role of electronic complementarity between radicals and receptors in achieving high selectivity in 1,4-difunctionalization reactions.This study significantly advances the field of bifunctionalization and remote difunctionalization reactions,with profound implications for the development of pharmaceuticals and materials science.
基金supported by the National Natural Science Foundation of China under Grant Nos.U21A20464,62066005the Innovation Project of Guangxi Graduate Education under Grant No.YCSW2023259.
文摘Parkinson’s disease is a neurodegenerative disorder that inflicts irreversible damage on humans.Some experimental data regarding Parkinson’s patients are redundant and irrelevant,posing significant challenges for disease detection.Therefore,there is a need to devise an effective method for the selective extraction of disease-specific information,ensuring both accuracy and the utilization of fewer features.In this paper,a Binary Hybrid Artificial Hummingbird and Flower Pollination Algorithm(FPA),called BFAHA,is proposed to solve the problem of Parkinson’s disease diagnosis based on speech signals.First,combining FPA with Artificial Hummingbird Algorithm(AHA)can take advantage of the strong global exploration ability possessed by FPA to improve the disadvantages of AHA,such as premature convergence and easy falling into local optimum.Second,the Hemming distance is used to determine the difference between the other individuals in the population and the optimal individual after each iteration,if the difference is too significant,the cross-mutation strategy in the genetic algorithm(GA)is used to induce the population individuals to keep approaching the optimal individual in the random search process to speed up finding the optimal solution.Finally,an S-shaped function converts the improved algorithm into a binary version to suit the characteristics of the feature selection(FS)tasks.In this paper,10 high-dimensional datasets from UCI and the ASU are used to test the performance of BFAHA and apply it to Parkinson’s disease diagnosis.Compared with other state-of-the-art algorithms,BFAHA shows excellent competitiveness in both the test datasets and the classification problem,indicating that the algorithm proposed in this study has apparent advantages in the field of feature selection.
基金supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC)the National Key Research and Development Program of China,No.2021YFC2502100(to GC)the National Natural Science Foundation of China,No.82071183(to ZZ).
文摘Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.
