BACKGROUND Data regarding complex Crohn’s perianal fistulas(CPF)epidemiology are limited,and optimal treatment strategies are elusive.An improved understanding of how CPF treatment options are used in the real-world ...BACKGROUND Data regarding complex Crohn’s perianal fistulas(CPF)epidemiology are limited,and optimal treatment strategies are elusive.An improved understanding of how CPF treatment options are used in the real-world setting and factors associated with CPF development,treatment failure,and reasons for undergoing multiple surgeries may help to inform optimal patient management strategies,reduce treatment burden,and improve outcomes in patients with CPF.AIM To describe the epidemiology,treatments,outcomes,and associated risk/protective factors for complex CPF.METHODS Electronic databases(MEDLINE,EMBASE,EBM Reviews,EconLit)were searched.Two reviewers independently used populations,interventions,comparators,outcomes,study designs,and time criteria to identify relevant studies.Observational studies published in English from January 1,2015 to February 17,2022 with>50 patients were included,even if complex CPF was not defined.Items of interest included complex CPF definitions,epidemiology,treatment patterns,morbidity,mortality,and risk factors associated with complex CPF development,treatment failure,and undergoing multiple surgeries.Data were reported using descriptive statistics.RESULTS Overall,140 studies were included.Complex CPF definitions were heterogeneous and rarely reported(24 studies).Hence,data mostly related to CPF in general.CPF prevalence was variable(range:1.5%-81.0%).Incidence was wide-ranging and mostly reported cumulatively at 1-year post-Crohn’s disease diagnosis(range:3.5%-50.1%).Overall healing and failure rates after treatment were in the range of 10.5%-80.2%and 3.6%-83.0%,respectively.Abscesses were the most frequently reported morbidity(n=18).No CPF-related deaths were reported.No consistent risk or protective factors were identified.CONCLUSION Epidemiology,treatment patterns,and risk factors for CPF vary,likely due to inconsistent CPF and clinical outcome definitions.Standardization would facilitate comparability,which may inform optimal complex CPF treatment strategies.展开更多
The Mohorovicic discontinuity(Moho)boundary separating the Earth’s crust and mantle reflects the evolutionary trajectory of the Earth’s crust,yielding crucial insights into crustal formation,tectonic evolution,and p...The Mohorovicic discontinuity(Moho)boundary separating the Earth’s crust and mantle reflects the evolutionary trajectory of the Earth’s crust,yielding crucial insights into crustal formation,tectonic evolution,and profound dynamic processes.However,the prevailing Moho models for China and its adjacent areas suffer from limited accuracy,owing to the irregular and sparse distribution of seismic data collection.In this study,we employ gravimetric data to derive Moho depth,and employ Bott’s regularization method,integrating gravity and seismic data to reconstruct the Moho structure with high precision in a three-dimensional framework across China and its adjacent areas.By optimizing gravity potential field separation and interface inversion techniques,we present a detailed and accurate zoning scheme for classifying China and its adjacent areas into 35 gradient belts,6 primary tectonic units,and 35 secondary tectonic units,based on the spatial distribution characteristics of the Moho discontinuity.Notably,our tectonic pattern division results surpass previous studies in terms of resolution,providing a wealth of tectonic information.Leveraging the Moho depth model of China and its adjacent areas,we discuss orogenic belts,sedimentary basins,fault systems,plate boundaries,and land-sea coupled tectonic patterns.We meticulously summarize the Moho depth distribution characteristics of each tectonic unit,while exploring the macrostructural framework and geological significance of the study area.Our findings highlight the close relationship between China and its adjacent areas Moho depth model and deep geodynamics,elucidating the tectonic evolution both between and within tectonic plates,as well as the tectonic effects induced by mantle dynamics.These insights have crucial implications for the study of deep geodynamics in China and its adjacent areas.展开更多
In order to explore the fertilizing ways and dynamic changes of soil carbon and nitrogen in the main producing areas of tobacco in Guizhou,research was conducted to study the variations of dissolved organic carbon and...In order to explore the fertilizing ways and dynamic changes of soil carbon and nitrogen in the main producing areas of tobacco in Guizhou,research was conducted to study the variations of dissolved organic carbon and nitrogen,total organic carbon and nitrogen and their ratio of tobacco-topsoil in organic fertilization pattern and conventional cultivation pattern （No fertilizer as control） by pot experiment.The results were as follows：（1） The effects of different fertilization patterns on soil dissolved organic carbon and nitrogen and total organic carbon and nitrogen were significantly different.The content of DOC,DON,TOC and TON in tobaccotopsoil was decreased with the advancing of growth period in conventional fertilization pattern.In the conventional fertilization pattern,the accumulation of DOC and TOC was increased first and then decreased,and the accumulation of DON and TON was decreased first and then increased.（2） The TOC content at the different growing stage and DOC content at the middle and later stage of tobacco were significantly improved in organic fertilization patterns.The accumulation of DON and TON in the conventional fertilization pattern was significantly higher than those in the organic fertilizer pattern and control at the rosette stage and vigorous stage.In the harvest period,the content of DOC,DON,TOC and TON of tobacco-topsoil in the conventional fertilization and organic fertilization pattern was significantly higher than those in the control.（3）The DOC/DON ratio and the TOC/TiON ratio was increased gradually with the advancing of growth period in conventional fertilization pattern,but they were increased first and then decreased in the organic fertilization pattern and CK.The DOC/DON and TOC/TON ratio of tobacco-topsoil in different fertilization patterns was showed as Y J＞ CK＞ CG at the different growing stage.The experiment results revealed that：The organic fertilization pattern may improve significantly the accumulation of DOC,DON,TOC and TON of tobacco-topsoil at the middle and later stage and the DOC/DON and TOC/TON ratio at the different growth stage.It contributed to the continuous and balanced supply of nutrients at the middle and later stage of tobacco and the soil fertility.展开更多
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.展开更多
In this paper, we analyzed the spatial patterns of cultivated land change between 1982 and 2011 using global vector-based land use/land cover data. （1） Our analysis showed that the total global cultivated land area ...In this paper, we analyzed the spatial patterns of cultivated land change between 1982 and 2011 using global vector-based land use/land cover data. （1） Our analysis showed that the total global cultivated land area increased by 528.768×10^4 km^2 with a rate of 7.920×10^4 km^2/a, although this increasing trend was not significant. The global cultivated land increased fastest in the 1980s. Since the 1980s, the cultivated land area in North America, South America and Oceania increased by 170.854×10^4 km^2, 107.890×10^4 km^2, and 186.492×10^4 km^2, respectively. In contrast, that in Asia, Europe and Africa decreased by 23.769×10^4 km^2, 4.035×10^4 km^2 and 86.76×10^4 km^2, respectively. Furthermore, the cultivated land area in North America, South America and Oceania exhibited significant increasing trends of 7.236× 10^4 km^2/a, 2.780×10^4 km^2/a and 3.758×10^4 km^2/a, respectively. On the other hand, that of Asia, Europe and Africa exhibited decreasing trend rates of–5.641×10^4 km^2/a,–0.831×10^4 km^2/a and–0.595×10^4 km^2/a, respectively. Moreover, the decreasing trend in Asia was significant. （2） Since the 1980s, the increase in global cultivated lands was mainly due to converted grasslands and woodlands, which accounted for 53.536% and 26.148% of the total increase, respectively. The increase was found in southern and central Africa, eastern and northern Australia, southeastern South America, central US and Alaska, central Canada, western Russia, northern Finland and northern Mongolia. Among them, Botswana in southern Africa experienced an 80%–90% increase, making it the country with the highest increase worldwide. （3） Since the 1980s, the total area of cultivated lands converted to other types of land was 1071.946×10^4 km^2. The reduction was mainly converted to grasslands and woodlands, which accounted for 57.482% and 36.000%, respectively. The reduction occurred mainly in southern Sudan in central Africa, southern and central US, southern Russia, and southern European countries including Bulgaria, Romania, Serbia and Hungary. The greatest reduction occurred in southern Africa with a 60% reduction. （4） The cultivated lands in all the continents analyzed exhibited a trend of expansion to high latitudes. Additionally, most countries displayed an expansion of newly increased cultivated lands and the reduction of the original cultivated lands.展开更多
基金Supported by Takeda Pharmaceuticals USA,Inc.Medical writing support was provided by Luke Humphreys,PhD,of Oxford PharmaGenesis,Oxford,UK and was funded by Takeda Development Center Americas,Inc.
文摘BACKGROUND Data regarding complex Crohn’s perianal fistulas(CPF)epidemiology are limited,and optimal treatment strategies are elusive.An improved understanding of how CPF treatment options are used in the real-world setting and factors associated with CPF development,treatment failure,and reasons for undergoing multiple surgeries may help to inform optimal patient management strategies,reduce treatment burden,and improve outcomes in patients with CPF.AIM To describe the epidemiology,treatments,outcomes,and associated risk/protective factors for complex CPF.METHODS Electronic databases(MEDLINE,EMBASE,EBM Reviews,EconLit)were searched.Two reviewers independently used populations,interventions,comparators,outcomes,study designs,and time criteria to identify relevant studies.Observational studies published in English from January 1,2015 to February 17,2022 with>50 patients were included,even if complex CPF was not defined.Items of interest included complex CPF definitions,epidemiology,treatment patterns,morbidity,mortality,and risk factors associated with complex CPF development,treatment failure,and undergoing multiple surgeries.Data were reported using descriptive statistics.RESULTS Overall,140 studies were included.Complex CPF definitions were heterogeneous and rarely reported(24 studies).Hence,data mostly related to CPF in general.CPF prevalence was variable(range:1.5%-81.0%).Incidence was wide-ranging and mostly reported cumulatively at 1-year post-Crohn’s disease diagnosis(range:3.5%-50.1%).Overall healing and failure rates after treatment were in the range of 10.5%-80.2%and 3.6%-83.0%,respectively.Abscesses were the most frequently reported morbidity(n=18).No CPF-related deaths were reported.No consistent risk or protective factors were identified.CONCLUSION Epidemiology,treatment patterns,and risk factors for CPF vary,likely due to inconsistent CPF and clinical outcome definitions.Standardization would facilitate comparability,which may inform optimal complex CPF treatment strategies.
基金supported by the National Natural Science Foundation of China(Grant Nos.42474121 and 42192535)the Basic Frontier Science Research Program of the Chinese Academy of Sciences(Grant No.ZDBS-LY-DQC028).
文摘The Mohorovicic discontinuity(Moho)boundary separating the Earth’s crust and mantle reflects the evolutionary trajectory of the Earth’s crust,yielding crucial insights into crustal formation,tectonic evolution,and profound dynamic processes.However,the prevailing Moho models for China and its adjacent areas suffer from limited accuracy,owing to the irregular and sparse distribution of seismic data collection.In this study,we employ gravimetric data to derive Moho depth,and employ Bott’s regularization method,integrating gravity and seismic data to reconstruct the Moho structure with high precision in a three-dimensional framework across China and its adjacent areas.By optimizing gravity potential field separation and interface inversion techniques,we present a detailed and accurate zoning scheme for classifying China and its adjacent areas into 35 gradient belts,6 primary tectonic units,and 35 secondary tectonic units,based on the spatial distribution characteristics of the Moho discontinuity.Notably,our tectonic pattern division results surpass previous studies in terms of resolution,providing a wealth of tectonic information.Leveraging the Moho depth model of China and its adjacent areas,we discuss orogenic belts,sedimentary basins,fault systems,plate boundaries,and land-sea coupled tectonic patterns.We meticulously summarize the Moho depth distribution characteristics of each tectonic unit,while exploring the macrostructural framework and geological significance of the study area.Our findings highlight the close relationship between China and its adjacent areas Moho depth model and deep geodynamics,elucidating the tectonic evolution both between and within tectonic plates,as well as the tectonic effects induced by mantle dynamics.These insights have crucial implications for the study of deep geodynamics in China and its adjacent areas.
基金Supported by The General Program of National Natural Science Foundation of China(312771673)Programs for Science and Technology Development of Tobacco Monopoly Bureau in Guizhou Province(20121126)~~
文摘In order to explore the fertilizing ways and dynamic changes of soil carbon and nitrogen in the main producing areas of tobacco in Guizhou,research was conducted to study the variations of dissolved organic carbon and nitrogen,total organic carbon and nitrogen and their ratio of tobacco-topsoil in organic fertilization pattern and conventional cultivation pattern （No fertilizer as control） by pot experiment.The results were as follows：（1） The effects of different fertilization patterns on soil dissolved organic carbon and nitrogen and total organic carbon and nitrogen were significantly different.The content of DOC,DON,TOC and TON in tobaccotopsoil was decreased with the advancing of growth period in conventional fertilization pattern.In the conventional fertilization pattern,the accumulation of DOC and TOC was increased first and then decreased,and the accumulation of DON and TON was decreased first and then increased.（2） The TOC content at the different growing stage and DOC content at the middle and later stage of tobacco were significantly improved in organic fertilization patterns.The accumulation of DON and TON in the conventional fertilization pattern was significantly higher than those in the organic fertilizer pattern and control at the rosette stage and vigorous stage.In the harvest period,the content of DOC,DON,TOC and TON of tobacco-topsoil in the conventional fertilization and organic fertilization pattern was significantly higher than those in the control.（3）The DOC/DON ratio and the TOC/TiON ratio was increased gradually with the advancing of growth period in conventional fertilization pattern,but they were increased first and then decreased in the organic fertilization pattern and CK.The DOC/DON and TOC/TON ratio of tobacco-topsoil in different fertilization patterns was showed as Y J＞ CK＞ CG at the different growing stage.The experiment results revealed that：The organic fertilization pattern may improve significantly the accumulation of DOC,DON,TOC and TON of tobacco-topsoil at the middle and later stage and the DOC/DON and TOC/TON ratio at the different growth stage.It contributed to the continuous and balanced supply of nutrients at the middle and later stage of tobacco and the soil fertility.
基金supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC)the National Key Research and Development Program of China,No.2021YFC2502100(to GC)the National Natural Science Foundation of China,No.82071183(to ZZ).
文摘Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.
基金Foundation： National Natural Science Foundation of China, No.42171217
文摘In this paper, we analyzed the spatial patterns of cultivated land change between 1982 and 2011 using global vector-based land use/land cover data. （1） Our analysis showed that the total global cultivated land area increased by 528.768×10^4 km^2 with a rate of 7.920×10^4 km^2/a, although this increasing trend was not significant. The global cultivated land increased fastest in the 1980s. Since the 1980s, the cultivated land area in North America, South America and Oceania increased by 170.854×10^4 km^2, 107.890×10^4 km^2, and 186.492×10^4 km^2, respectively. In contrast, that in Asia, Europe and Africa decreased by 23.769×10^4 km^2, 4.035×10^4 km^2 and 86.76×10^4 km^2, respectively. Furthermore, the cultivated land area in North America, South America and Oceania exhibited significant increasing trends of 7.236× 10^4 km^2/a, 2.780×10^4 km^2/a and 3.758×10^4 km^2/a, respectively. On the other hand, that of Asia, Europe and Africa exhibited decreasing trend rates of–5.641×10^4 km^2/a,–0.831×10^4 km^2/a and–0.595×10^4 km^2/a, respectively. Moreover, the decreasing trend in Asia was significant. （2） Since the 1980s, the increase in global cultivated lands was mainly due to converted grasslands and woodlands, which accounted for 53.536% and 26.148% of the total increase, respectively. The increase was found in southern and central Africa, eastern and northern Australia, southeastern South America, central US and Alaska, central Canada, western Russia, northern Finland and northern Mongolia. Among them, Botswana in southern Africa experienced an 80%–90% increase, making it the country with the highest increase worldwide. （3） Since the 1980s, the total area of cultivated lands converted to other types of land was 1071.946×10^4 km^2. The reduction was mainly converted to grasslands and woodlands, which accounted for 57.482% and 36.000%, respectively. The reduction occurred mainly in southern Sudan in central Africa, southern and central US, southern Russia, and southern European countries including Bulgaria, Romania, Serbia and Hungary. The greatest reduction occurred in southern Africa with a 60% reduction. （4） The cultivated lands in all the continents analyzed exhibited a trend of expansion to high latitudes. Additionally, most countries displayed an expansion of newly increased cultivated lands and the reduction of the original cultivated lands.
