The development of digital construction management is an important initiative to promote the digital transformation of the construction industry. But the attention to the regional differences in the development level ...The development of digital construction management is an important initiative to promote the digital transformation of the construction industry. But the attention to the regional differences in the development level of digital construction management in China from the industrial level is still relatively scarce. In this paper, the combination assignment method, Dagum’s Gini coefficient and Kernel density estimation method, are used to explore the regional differences and their dynamic evolution trends of China’s digital construction management development level. The study finds that the overall development level in China’s construction industry is on the rise, but it is still at a relatively low level. The overall Gini coefficient has increased, which is mainly due to uneven development between regions. There are large development differences between the eastern region and the other three regions. The interregional Gini coefficients for the Central-Northeastern and Central-Western regions are all growing at a higher rate.展开更多
The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the...The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.展开更多
As an emerging media format with immense growth potential,micro-dramas(MDs)carry the critical mission of inheriting and innovating China’s fine traditional culture in the new era.From the three dimensions of time,spa...As an emerging media format with immense growth potential,micro-dramas(MDs)carry the critical mission of inheriting and innovating China’s fine traditional culture in the new era.From the three dimensions of time,space,and landscape in media geography,the pathways for cultural inheritance and innovation through MDs can be summarized as follows:Temporally,cultural MDs construct cultural narratives from the“past”to the“future;”spatially,they build immersive cultural spaces blending reality and imagination,enhancing viewers’audiovisual experiences;through the interplay of time and space,they create diversified cultural landscapes on new media platforms,revitalize enduring cultural memories and foster a sense of community for the Chinese nation through media innovation.展开更多
In this work,history of education is expressed and evaluated generally/specifically by considering the related concepts.Definition and types of education explained with specific approaches in the literature.Early chil...In this work,history of education is expressed and evaluated generally/specifically by considering the related concepts.Definition and types of education explained with specific approaches in the literature.Early childhood development briefly defined and the correlation with education systems outlined.Five education evolution phases expressed with its basic concepts.The meaning and importance of philosophy of education are then defined according to the general approaches.Some of the important philosophers of education and their philosophical/scientific interests are compared and expressed with a table.New perspective of the philosophy generally defined by considering new era philosophy,eight basic philosophies,and hybrid philosophies.R-Philosophy,R-Science,R-Information,R-Education,and R-System new disciplines are shortly expressed.New perspective for the philosophy of education defined as sub-branch of philosophy of information and explained regarding the basic information on the related theories.17 education components are defined for continuable/sustainable education,and efficiency,effective use,and improvement/development of each of the components expressed specifically.Performance of the education components for a country-X is given with a figure as an example.Relation between education,values,and basic senses is interpreted.Evaluation of the education due to 17 specific perspectives is generally mentioned.Then,evaluation of the education from philosophical,academic,and administration perspectives is specifically explained.Continuable/sustainable education administration system for a world country is defined with figures.Education system administration is defined with bloc diagrams accordingly.Ideal political/nonpolitical education construction for a progressive world country is outlined with 5x5 table,and related explanations done.Then importance of education due to 39 subjects of services is expressed with a table.Categories of education programs outlined.Digital education&digital tools and engineering education and related five industry evolution phases are defined as special education programs.New proposal is given for Education 5.0 and Engineering Education 5.0.展开更多
The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle...The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle remains a challenging task.To tackle this challenge,the present study proposes a novel approach for identifying the gradient-distributed plastic parameters for the S38C axle by integrating nano-indentation techniques with the machine learning method.Firstly,nano-indentation tests are conducted along the radial direction of the S38C axle to obtain the gradient-distributed load-displacement curves,nano-hardness,and elastic modulus.Subsequently,the dimensionless analysis is performed to obtain the representative stress,strain,and yield stress from load-displacement curves.These parameters are then incorporated into the machine learning method as physical information to identify the gradient-distributed plastic parameters of the S38C axle.The results indicate that the proposed method based on the physics-informed neural network and multi-fidelity neural network successfully identifies the gradient-distributed plastic parameters of the S38C axles and demonstrates superior prediction accuracy and generalization compared with the purely data-driven machine learning method.展开更多
Mango is a plant with high economic value in the agricultural industry;thus,it is necessary to maximize the productivity performance of the mango plant,which can be done by implementing artificial intelligence.In this...Mango is a plant with high economic value in the agricultural industry;thus,it is necessary to maximize the productivity performance of the mango plant,which can be done by implementing artificial intelligence.In this study,a lightweight object detection model will be developed that can detect mango plant conditions based on disease potential,so that it becomes an early detection warning system that has an impact on increasing agricultural productivity.The proposed lightweight model integrates YOLOv7-Tiny and the proposed modules,namely the C2S module.The C2S module consists of three sub-modules such as the convolutional block attention module(CBAM),the coordinate attention(CA)module,and the squeeze-and-excitation(SE)module.The dataset is constructed by eight classes,including seven classes of disease conditions and one class of health conditions.The experimental result shows that the proposed lightweight model has the optimal results,which increase by 13.15% of mAP50 compared to the original model YOLOv7-Tiny.While the mAP50:95 also achieved the highest results compared to other models,including YOLOv3-Tiny,YOLOv4-Tiny,YOLOv5,and YOLOv7-Tiny.The advantage of the proposed lightweightmodel is the adaptability that supports it in constrained environments,such as edge computing systems.This proposedmodel can support a robust,precise,and convenient precision agriculture system for the user.展开更多
Alzheimer’s disease is initially thought to be caused by age-associated accumulation of plaques,in recent years,research has increasingly associated Alzheimer’s disease with lysosomal storage and metabolic disorders...Alzheimer’s disease is initially thought to be caused by age-associated accumulation of plaques,in recent years,research has increasingly associated Alzheimer’s disease with lysosomal storage and metabolic disorders,and the explanation of its pathogenesis has shifted from amyloid and tau accumulation to oxidative stress and impaired lipid and glucose metabolism aggravated by hypoxic conditions.However,the underlying mechanisms linking those cellular processes and conditions to disease progression have yet to be defined.Here,we applied a disease similarity approach to identify unknown molecular targets of Alzheimer’s disease by using transcriptomic data from congenital diseases known to increase Alzheimer’s disease risk,namely Down syndrome,Niemann-Pick type C disease,and mucopolysaccharidoses I.We uncovered common pathways,hub genes,and miRNAs across in vitro and in vivo models of these diseases as potential molecular targets for neuroprotection and amelioration of Alzheimer’s disease pathology,many of which have never been associated with Alzheimer’s disease.We then investigated common molecular alterations in brain samples from a Niemann-Pick type C disease mouse model by juxtaposing them with brain samples of both human and mouse models of Alzheimer’s disease.Detailed phenotypic,molecular,chronological,and biological aging analyses revealed that the Npc1tm(I1061T)Dso mouse model can serve as a potential short-lived in vivo model for brain aging and Alzheimer’s disease research.This research represents the first comprehensive approach to congenital disease association with neurodegeneration and a new perspective on Alzheimer’s disease research while highlighting shortcomings and lack of correlation in diverse in vitro models.Considering the lack of an Alzheimer’s disease mouse model that recapitulates the physiological hallmarks of brain aging,the short-lived Npc1^(tm(I1061T)Dso) mouse model can further accelerate the research in these fields and offer a unique model for understanding the molecular mechanisms of Alzheimer’s disease from a perspective of accelerated brain aging.展开更多
Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular st...Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.展开更多
文摘The development of digital construction management is an important initiative to promote the digital transformation of the construction industry. But the attention to the regional differences in the development level of digital construction management in China from the industrial level is still relatively scarce. In this paper, the combination assignment method, Dagum’s Gini coefficient and Kernel density estimation method, are used to explore the regional differences and their dynamic evolution trends of China’s digital construction management development level. The study finds that the overall development level in China’s construction industry is on the rise, but it is still at a relatively low level. The overall Gini coefficient has increased, which is mainly due to uneven development between regions. There are large development differences between the eastern region and the other three regions. The interregional Gini coefficients for the Central-Northeastern and Central-Western regions are all growing at a higher rate.
基金“Research on Social Change and Network Society Planning in the Internet of Everything Era”(ID:21BSH005),a project under the National Social Science Fund of China
文摘The idea of a network society was introduced by Western sociologists at the end of the 20th century after in-depth research was conducted from perspectives such as informationalism.Influenced by these developments,the concept of constructing a network society also emerged in China.Over the past 30 years,China has made significant progress and achievements in constructing a network society,both in terms of its fundamental construction and social development.It is important that these advancements be summarized and reviewed.China’s network society construction can be divided into two relatively independent yet interconnected components,based on their focal points:its foundational infrastructure and its social development.These two components of China’s network society are managed by different departments.China has integrated the fundamental construction of its network society with the social development of its network society,thereby achieving unified planning,collaborative advancement,and coordinated development.This approach aims to harmonize two aspects:building China’s cyberspace strength and contributing to Chinese informatization,thereby advancing Chinese modernization.
基金supported by“Reliable,Admirable,Respectable:The Inheritance and Innovation of Li Bai’s Image in ACG Media”(Project No.LB24-A05)funded by the Research Center of Libai,a Key Research Base for Philosophy and Social Sciences in Sichuan Province,“Mechanisms for Enhancing the Modern Dissemination of Three Kingdoms Figures Through Short-Form Dramas”(Project No.24ZGL05).
文摘As an emerging media format with immense growth potential,micro-dramas(MDs)carry the critical mission of inheriting and innovating China’s fine traditional culture in the new era.From the three dimensions of time,space,and landscape in media geography,the pathways for cultural inheritance and innovation through MDs can be summarized as follows:Temporally,cultural MDs construct cultural narratives from the“past”to the“future;”spatially,they build immersive cultural spaces blending reality and imagination,enhancing viewers’audiovisual experiences;through the interplay of time and space,they create diversified cultural landscapes on new media platforms,revitalize enduring cultural memories and foster a sense of community for the Chinese nation through media innovation.
文摘In this work,history of education is expressed and evaluated generally/specifically by considering the related concepts.Definition and types of education explained with specific approaches in the literature.Early childhood development briefly defined and the correlation with education systems outlined.Five education evolution phases expressed with its basic concepts.The meaning and importance of philosophy of education are then defined according to the general approaches.Some of the important philosophers of education and their philosophical/scientific interests are compared and expressed with a table.New perspective of the philosophy generally defined by considering new era philosophy,eight basic philosophies,and hybrid philosophies.R-Philosophy,R-Science,R-Information,R-Education,and R-System new disciplines are shortly expressed.New perspective for the philosophy of education defined as sub-branch of philosophy of information and explained regarding the basic information on the related theories.17 education components are defined for continuable/sustainable education,and efficiency,effective use,and improvement/development of each of the components expressed specifically.Performance of the education components for a country-X is given with a figure as an example.Relation between education,values,and basic senses is interpreted.Evaluation of the education due to 17 specific perspectives is generally mentioned.Then,evaluation of the education from philosophical,academic,and administration perspectives is specifically explained.Continuable/sustainable education administration system for a world country is defined with figures.Education system administration is defined with bloc diagrams accordingly.Ideal political/nonpolitical education construction for a progressive world country is outlined with 5x5 table,and related explanations done.Then importance of education due to 39 subjects of services is expressed with a table.Categories of education programs outlined.Digital education&digital tools and engineering education and related five industry evolution phases are defined as special education programs.New proposal is given for Education 5.0 and Engineering Education 5.0.
基金supported by the National Key Research and Development Plan(Grant No.2022YFB3401901)the National Natural Science Foundation of China(Grant Nos.12192210,12192214,12072295,and 12222209)+1 种基金Independent Project of State Key Laboratory of Rail Transit Vehicle System(Grant No.2023TPL-T03)Fundamental Research Funds for the Central Universities(Grant No.2682023CG004).
文摘The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle remains a challenging task.To tackle this challenge,the present study proposes a novel approach for identifying the gradient-distributed plastic parameters for the S38C axle by integrating nano-indentation techniques with the machine learning method.Firstly,nano-indentation tests are conducted along the radial direction of the S38C axle to obtain the gradient-distributed load-displacement curves,nano-hardness,and elastic modulus.Subsequently,the dimensionless analysis is performed to obtain the representative stress,strain,and yield stress from load-displacement curves.These parameters are then incorporated into the machine learning method as physical information to identify the gradient-distributed plastic parameters of the S38C axle.The results indicate that the proposed method based on the physics-informed neural network and multi-fidelity neural network successfully identifies the gradient-distributed plastic parameters of the S38C axles and demonstrates superior prediction accuracy and generalization compared with the purely data-driven machine learning method.
基金supported by National Science and Technology Council(NSTC)Taiwan,Grant No.NSTC 113-2221-E-167-023.
文摘Mango is a plant with high economic value in the agricultural industry;thus,it is necessary to maximize the productivity performance of the mango plant,which can be done by implementing artificial intelligence.In this study,a lightweight object detection model will be developed that can detect mango plant conditions based on disease potential,so that it becomes an early detection warning system that has an impact on increasing agricultural productivity.The proposed lightweight model integrates YOLOv7-Tiny and the proposed modules,namely the C2S module.The C2S module consists of three sub-modules such as the convolutional block attention module(CBAM),the coordinate attention(CA)module,and the squeeze-and-excitation(SE)module.The dataset is constructed by eight classes,including seven classes of disease conditions and one class of health conditions.The experimental result shows that the proposed lightweight model has the optimal results,which increase by 13.15% of mAP50 compared to the original model YOLOv7-Tiny.While the mAP50:95 also achieved the highest results compared to other models,including YOLOv3-Tiny,YOLOv4-Tiny,YOLOv5,and YOLOv7-Tiny.The advantage of the proposed lightweightmodel is the adaptability that supports it in constrained environments,such as edge computing systems.This proposedmodel can support a robust,precise,and convenient precision agriculture system for the user.
基金supported by the NIA/NIH(1K01AG060040).Studies performed by JN were funded by the NICHD/NIH(5R00HD096117)Microscopy Core Facility supported,in part,with funding from NIH-NCI Cancer Center Support Grant P30 CA016059.
文摘Alzheimer’s disease is initially thought to be caused by age-associated accumulation of plaques,in recent years,research has increasingly associated Alzheimer’s disease with lysosomal storage and metabolic disorders,and the explanation of its pathogenesis has shifted from amyloid and tau accumulation to oxidative stress and impaired lipid and glucose metabolism aggravated by hypoxic conditions.However,the underlying mechanisms linking those cellular processes and conditions to disease progression have yet to be defined.Here,we applied a disease similarity approach to identify unknown molecular targets of Alzheimer’s disease by using transcriptomic data from congenital diseases known to increase Alzheimer’s disease risk,namely Down syndrome,Niemann-Pick type C disease,and mucopolysaccharidoses I.We uncovered common pathways,hub genes,and miRNAs across in vitro and in vivo models of these diseases as potential molecular targets for neuroprotection and amelioration of Alzheimer’s disease pathology,many of which have never been associated with Alzheimer’s disease.We then investigated common molecular alterations in brain samples from a Niemann-Pick type C disease mouse model by juxtaposing them with brain samples of both human and mouse models of Alzheimer’s disease.Detailed phenotypic,molecular,chronological,and biological aging analyses revealed that the Npc1tm(I1061T)Dso mouse model can serve as a potential short-lived in vivo model for brain aging and Alzheimer’s disease research.This research represents the first comprehensive approach to congenital disease association with neurodegeneration and a new perspective on Alzheimer’s disease research while highlighting shortcomings and lack of correlation in diverse in vitro models.Considering the lack of an Alzheimer’s disease mouse model that recapitulates the physiological hallmarks of brain aging,the short-lived Npc1^(tm(I1061T)Dso) mouse model can further accelerate the research in these fields and offer a unique model for understanding the molecular mechanisms of Alzheimer’s disease from a perspective of accelerated brain aging.
基金supported by the National Italian Research Council(CNR)“Progetto DSB.AD007.305.001”to Monica Rinaldi。
文摘Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.
