Objective:To evaluate the effectiveness and safety of Bushen Huoxue prescription in the treatment of recurrent spontaneous abortion(RSA)due to prethrombotic state(PTS).Methods:Databases such as CNKI,WanFang,VIP,CBM,Pu...Objective:To evaluate the effectiveness and safety of Bushen Huoxue prescription in the treatment of recurrent spontaneous abortion(RSA)due to prethrombotic state(PTS).Methods:Databases such as CNKI,WanFang,VIP,CBM,PubMed,Embase,and Cochrane Library were searched for randomized controlled trials on Bushen Huoxue prescription in treating RSA due to PTS from inception to March 2021;meta-analysis was performed by RevMan Version 5.3.0 following quality evaluation.Results:Seven trials were included,with 496 patients;the meta-analysis indicated that Bushen Huoxue prescription has advantages on the improvement of total clinical effective rate[RR=1.22,95%CI(1.10,1.35),Z=3.80(P=0.0001)],embryo survival rate at pregnancy of 12 weeks[RR=1.25,95%CI(1.10,1.41),Z=3.53(P=0.0004)],D-dimer levels[SMD=-1.59,95%CI(-2.20,-0.97),Z=5.07(P<0.00001)],and fibrinogen levels[MD=-1.00,95%CI(-1.29,-0.70),Z=6.61(P<0.00001)],but the statistical heterogeneity was significant;in terms of incidence of adverse reactions,there was no statistical difference between Bushen Huoxue prescription and western medicine.Conclusion:Compared with western medicine alone,Bushen Huoxue prescription alone or in combination with western medicine showed significant advantages in improving the overall clinical efficiency,embryonic survival rate at 12 weeks of pregnancy,and reducing D-dimer values as well as fibrinogen levels,without any significant difference in the incidence of adverse effects;however,the number of included studies is small and there are drawbacks,such as small sample size and low quality;therefore,high-quality clinical studies with large sample size and rigorous trial designs are needed in the future to provide a reliable basis for the effectiveness and safety of TCM in reducing the incidence of RSA due to prethrombotic state.展开更多
目的:探讨补肾益智活血汤治疗老年痴呆症患者的临床疗效。方法:选取老年痴呆症116例,随机分为观察组与对照组,观察组57例,对照组56例。对照组予以口服盐酸多奈哌齐治疗,观察组在对照组的基础上予自制补肾益智活血汤加减治疗。两组均治疗...目的:探讨补肾益智活血汤治疗老年痴呆症患者的临床疗效。方法:选取老年痴呆症116例,随机分为观察组与对照组,观察组57例,对照组56例。对照组予以口服盐酸多奈哌齐治疗,观察组在对照组的基础上予自制补肾益智活血汤加减治疗。两组均治疗3个疗程。治疗前、治疗3个疗程后,比较两组的相关量表评分,包括:简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)、中医临床症状积分量表,进行临床疗效比较,记录不良反应。结果:观察组与对照组有效受试者分别为57例、56例。治疗3个疗程后,两组MMSE积分、中医症候积分均降低,ADL评分均升高(t=4.86~7.37,P<0.05或P<0.01);观察组MMSE积分、中医症候积分均低于对照组,ADL评分高于对照组(t=4.10~4.76,P<0.05)。观察组显效率[52.63%vs. 28.57%]、总有效率[75.44 vs. 62.50%]均高于对照组(χ~2=5.51、4.08,P<0.05),不良反应发生率分别为5.36%、7.02%(χ~2=0.91,P>0.05)。结论:补肾益智活血法治疗老年痴呆症安全有效。展开更多
基金National Natural Science Foundation of China Project(Project Number:81603656)Shaanxi University of Traditional Chinese Medicine 2017 Annual Scientific Research Program Project(Project Number:2017PY10)Infertility Innovation Team(Project Number:132041929).
文摘Objective:To evaluate the effectiveness and safety of Bushen Huoxue prescription in the treatment of recurrent spontaneous abortion(RSA)due to prethrombotic state(PTS).Methods:Databases such as CNKI,WanFang,VIP,CBM,PubMed,Embase,and Cochrane Library were searched for randomized controlled trials on Bushen Huoxue prescription in treating RSA due to PTS from inception to March 2021;meta-analysis was performed by RevMan Version 5.3.0 following quality evaluation.Results:Seven trials were included,with 496 patients;the meta-analysis indicated that Bushen Huoxue prescription has advantages on the improvement of total clinical effective rate[RR=1.22,95%CI(1.10,1.35),Z=3.80(P=0.0001)],embryo survival rate at pregnancy of 12 weeks[RR=1.25,95%CI(1.10,1.41),Z=3.53(P=0.0004)],D-dimer levels[SMD=-1.59,95%CI(-2.20,-0.97),Z=5.07(P<0.00001)],and fibrinogen levels[MD=-1.00,95%CI(-1.29,-0.70),Z=6.61(P<0.00001)],but the statistical heterogeneity was significant;in terms of incidence of adverse reactions,there was no statistical difference between Bushen Huoxue prescription and western medicine.Conclusion:Compared with western medicine alone,Bushen Huoxue prescription alone or in combination with western medicine showed significant advantages in improving the overall clinical efficiency,embryonic survival rate at 12 weeks of pregnancy,and reducing D-dimer values as well as fibrinogen levels,without any significant difference in the incidence of adverse effects;however,the number of included studies is small and there are drawbacks,such as small sample size and low quality;therefore,high-quality clinical studies with large sample size and rigorous trial designs are needed in the future to provide a reliable basis for the effectiveness and safety of TCM in reducing the incidence of RSA due to prethrombotic state.
文摘目的:探讨补肾益智活血汤治疗老年痴呆症患者的临床疗效。方法:选取老年痴呆症116例,随机分为观察组与对照组,观察组57例,对照组56例。对照组予以口服盐酸多奈哌齐治疗,观察组在对照组的基础上予自制补肾益智活血汤加减治疗。两组均治疗3个疗程。治疗前、治疗3个疗程后,比较两组的相关量表评分,包括:简易智能精神状态检查量表(MMSE)、日常生活能力量表(ADL)、中医临床症状积分量表,进行临床疗效比较,记录不良反应。结果:观察组与对照组有效受试者分别为57例、56例。治疗3个疗程后,两组MMSE积分、中医症候积分均降低,ADL评分均升高(t=4.86~7.37,P<0.05或P<0.01);观察组MMSE积分、中医症候积分均低于对照组,ADL评分高于对照组(t=4.10~4.76,P<0.05)。观察组显效率[52.63%vs. 28.57%]、总有效率[75.44 vs. 62.50%]均高于对照组(χ~2=5.51、4.08,P<0.05),不良反应发生率分别为5.36%、7.02%(χ~2=0.91,P>0.05)。结论:补肾益智活血法治疗老年痴呆症安全有效。
