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Fully coupled fluid-structure interaction of diaphragm rupture in high-pressure-ratio shock tunnels
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作者 Zhe XU Hong CHEN +1 位作者 Conglin LIU Junmou SHEN 《Chinese Journal of Aeronautics》 2026年第2期341-355,共15页
Shock tunnels are indispensable facilities for hypersonic aerodynamic experimentation.Within these systems,the diaphragm plays a pivotal role,as its rupture process critically influences shock wave generation quality,... Shock tunnels are indispensable facilities for hypersonic aerodynamic experimentation.Within these systems,the diaphragm plays a pivotal role,as its rupture process critically influences shock wave generation quality,experimental repeatability,and facility reliability.A thorough understanding of diaphragm rupture dynamics is therefore essential for optimizing shock tunnel design,improving experimental accuracy,and ensuring operational safety.To address the complex challenge of fully coupled multiphysics analysis in high-pressure-ratio shock tunnels,this study introduces a high-fidelity,three-dimensional,fully coupled Fluid-Structure Interaction(FSI)simulation framework.This framework seamlessly integrates the Dual Conservation Element and Solution Element(Dual-CESE)method,the Immersed Boundary Method(IBM),and the JohnsonCook(J-C)material constitutive and failure model.The combined approach enables synchronized simulation and analysis of the entire diaphragm rupture sequence—including pre-deformation,crack initiation and propagation,and fully developed petaling deformation—alongside the formation and evolution of the associated supersonic flow field.The simulation results show strong agreement with experimental observations,with the post-rupture geometric morphology accurately replicated and a shock wave velocity deviation of only 2.55%from experimental measurements.The study uncovers the dynamic failure mechanisms,revealing that nonlinear pressure loading initiates cracking within the diaphragm.It further elucidates how the nonlinearly coupled interactions between petaling dynamics and fracture morphology directly impact shock wave formation and evolution.This computational framework provides a novel and robust methodology for advancing shock tunnel design and conducting comprehensive reliability assessments. 展开更多
关键词 DIAPHRAGM Diaphragm rupture Fully coupled fluid-structure interaction Nonlinear coupling Shock tunnel
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Interannual modulation of summer precipitation over North China by the coupled tropical Pacific-Atlantic SST Dipole Mode
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作者 Yanjin Mao Xiaorui Niu +3 位作者 Ping Li Xianchun Chen Libin Huang Xin Tan 《Atmospheric and Oceanic Science Letters》 2026年第1期1-6,共6页
Using multi-source reanalysis data,this study examines the relationship between the tropical Pacific-Atlantic SST Dipole Mode(TPA-DM)and summer precipitation in North China(NCSP)on the interannual timescale during the... Using multi-source reanalysis data,this study examines the relationship between the tropical Pacific-Atlantic SST Dipole Mode(TPA-DM)and summer precipitation in North China(NCSP)on the interannual timescale during the period of 1979-2022.The results show that the TPA-DM,the dominant pattern of interannual variability in the tropical Pacific and Atlantic regions,exhibits a significant negative correlation with NCSP.The positive phase of TPA-DM induces subsidence over the Maritime Continent through a zonal circulation pattern,which initiates a Pacific-Japan-like wave train along the East Asian coast.The circulation anomalies lead to moisture deficits and convergence subsidence over North China,leading to below-normal rainfall.Further analysis reveals that cooler SST in the Southern Tropical Atlantic facilitates the persistence of the TPA-DM by stimulating the anomalous Walker circulation associated with wind-evaporation-SST-convection feedback. 展开更多
关键词 coupled tropical Pacific-Atlantic SST mode Precipitation ENSO Atmospheric teleconnection
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Coupled numerical modelling of high-voltage electric pulse(HVEP)rock fracturing using COMSOL and 4D-LSM
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作者 Chenghui Liu Qin Li +3 位作者 Fuxin Rui Tubing Yin Yang Zou Gaofeng Zhao 《International Journal of Mining Science and Technology》 2026年第3期517-533,共17页
High-voltage electric pulse(HVEP)rock fragmentation has demonstrated substantial potential for sustainable fracturing of hard rocks owing to its energy efficiency.The transient nature and highly disruptive characteris... High-voltage electric pulse(HVEP)rock fragmentation has demonstrated substantial potential for sustainable fracturing of hard rocks owing to its energy efficiency.The transient nature and highly disruptive characteristics of its physical fracturing process render experimental investigation of the underlying rock-breaking mechanisms challenging.However,existing numerical studies lack comprehensive models that precisely link electrical breakdown phenomena with mechanical disintegration processes.This study combines COMSOL electrical breakdown simulations with four-dimension lattice spring model(4D-LSM)mechanical analysis to establish a coupled HVEP rock fragmentation model.The core concept of the model construction is to import the temperature field of the plasma channel obtained from the electrical breakdown into the mechanical solver to realize the precise connection between the two stages.The validated numerical model elucidates the full process of HVEP-induced fragmentation under varying electrical parameters.Furthermore,the effects of confining pressure and mineral grain size on fragmentation behavior have been investigated.Finally,parametric simulations across 25 electrical parameter combinations demonstrate the critical role of electrode spacing optimization in achieving energy-efficient rock fragmentation.These findings provide a predictive tool for designing efficient HVEP systems in deep resource extraction and mineral processing engineering. 展开更多
关键词 Rock fracturing High-voltage electric pulse Thermal-mechanical coupling Lattice spring model
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Coupled thermo-hydro-mechanical-damage modeling of cold-water injection in deep geothermal reservoirs
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作者 Liyuan Liu Yaohui Li +3 位作者 Wenzhuo Cao Tao Wang Le Zhang Xianhui Feng 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期39-54,共16页
Rock damage significantly affects coupled thermo-hydro-mechanical(THM)behavior in deep geothermal exploitation through changing thermal and hydrological properties of rocks.For this,a thermo-hydro-mechanical-damage(TH... Rock damage significantly affects coupled thermo-hydro-mechanical(THM)behavior in deep geothermal exploitation through changing thermal and hydrological properties of rocks.For this,a thermo-hydro-mechanical-damage(THMD)coupled model was developed to describe the coupling between rock damage and mechanical,fluid flow and heat transfer fields.The model considers rock heterogeneity,and incorporates the Mohr-Coulomb failure criterion and the maximum tensile stress criterion to evaluate shear and tensile damage.This numerical modeling methodology was first verified against analytical solutions and experimental results,and was then used to simulate the THMD coupling behavior in deep geothermal exploitation.A coupled numerical model was set up to simulate the geothermal fluids extraction and re-injection process in a reservoir at 1 km depth over a 7-year period.Rock damage was found to accelerate the propagation of cold fronts away from the injection well,and have a distinct effect on the performance of geothermal exploitation.When the rock damage was considered,the field injectivity increases by 8.4 times,the range of cooled regions increases by 18.6 times,and the vertical deformation changes by 1.2 times after 7 years of geothermal operations,compared to the scenario where it was not considered.Parametric studies have suggested that thermal contraction dominates the rock damage evolution,and that thermal-induced rock damage only occurs at a sufficiently large temperature difference between fluids injected and the reservoir.This work underscores the importance of accurately accounting for the damage effect on reservoir response during fluid injection activities that cause significant cooling of reservoir rocks. 展开更多
关键词 Thermo-hydro-mechanical-damage (THMD)coupling Rock heterogeneity Geothermal reservoir Rock damage
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Coupled Effects of Single-Vacancy Defect Positions on the Mechanical Properties and Electronic Structure of Aluminum Crystals
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作者 Binchang Ma Xinhai Yu Gang Huang 《Computers, Materials & Continua》 2026年第1期332-352,共21页
Vacancy defects,as fundamental disruptions in metallic lattices,play an important role in shaping the mechanical and electronic properties of aluminum crystals.However,the influence of vacancy position under coupled t... Vacancy defects,as fundamental disruptions in metallic lattices,play an important role in shaping the mechanical and electronic properties of aluminum crystals.However,the influence of vacancy position under coupled thermomechanical fields remains insufficiently understood.In this study,transmission and scanning electron microscopy were employed to observe dislocation structures and grain boundary heterogeneities in processed aluminum alloys,suggesting stress concentrations and microstructural inhomogeneities associated with vacancy accumulation.To complement these observations,first-principles calculations and molecular dynamics simulations were conducted for seven single-vacancy configurations in face-centered cubic aluminum.The stress response,total energy,density of states(DOS),and differential charge density were examined under varying compressive strain(ε=0–0.1)and temperature(0–600 K).The results indicate that face-centered vacancies tend to reduce mechanical strength and perturb electronic states near the Fermi level,whereas corner and edge vacancies appear to have weaker effects.Elevated temperatures may partially restore electronic uniformity through thermal excitation.Overall,these findings suggest that vacancy position exerts a critical but position-dependent influence on coupled structure-property relationships,offering theoretical insights and preliminary experimental support for defect-engineered aluminum alloy design. 展开更多
关键词 Aluminum crystal vacancy defect microstructural characterization stress response electronic structure thermomechanical coupling
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Effects of coil structure and electromagnetic shielding on plasma distribution and uniformity in large-area radio-frequency inductively coupled plasmas
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作者 Cheng Xin Xiang-Yun Lyu +5 位作者 Si-Yu Xing Yu-Ru Zhang Tao Liu Wei-Ping Le Fei Gao You-Nian Wang 《Chinese Physics B》 2026年第2期233-246,共14页
Improving plasma uniformity is a critical issue in the development of large-area radio-frequency(RF)inductively coupled plasma(ICP)sources.In this work,the effects of coil structure and electromagnetic shielding on th... Improving plasma uniformity is a critical issue in the development of large-area radio-frequency(RF)inductively coupled plasma(ICP)sources.In this work,the effects of coil structure and electromagnetic shielding on the spatial distribution and uniformity of the plasma are systematically investigated using a three-dimensional fluid model.The model integrates plasma and electromagnetic field modules to simulate the discharge characteristics of a large-area RF ICP source with dimensions of 100 cm×50 cm.The results reveal that the electron density distribution varies significantly with the coil structure.For the rotating and translating coil structures,the electron density is high at off-axis positions and low at the center.In contrast,the mirror coil structure exhibits a significantly higher electron density at the chamber center,resulting in a high-center and low-edge density distribution.Among the three configurations,the rotating coil structure provides the best plasma uniformity.The incorporation of electromagnetic shielding further improves plasma uniformity,particularly for the mirror coil structure.For the rotating and translating coil structures,the electron density exhibits a saddle-shaped distribution regardless of electromagnetic shielding.However,introducing electromagnetic shielding into the mirror coil structure reduces the electron density at the chamber center and decreases the non-uniformity degree by 18.4%.Overall,the mirror coil structure with electromagnetic shielding achieves the highest uniformity,with an exceptional plasma uniformity of 94%.This work offers valuable insights for the design of large-area ICP sources in advanced plasma processing systems. 展开更多
关键词 large-area radio-frequency inductively coupled plasma three-dimensional fluid model plasma uniformity
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Quantum coherence and thermodynamic performance of an Otto heat engine using a pair of dipole-coupled two-level atoms
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作者 Hao Wang 《Communications in Theoretical Physics》 2026年第1期166-180,共15页
We developed a model of a quantum Otto engine using two coupled two-level atoms.Based on the platform,we show that frequency detuning and the coupling strength induced by dipoledipole interactions can lead to decohere... We developed a model of a quantum Otto engine using two coupled two-level atoms.Based on the platform,we show that frequency detuning and the coupling strength induced by dipoledipole interactions can lead to decoherence by disrupting coherent energy exchange.We focus on fundamental thermodynamic quantities,including heat absorption,release to heat baths,work done and efficiency.It is noteworthy that the interatomic coupling strength and frequency detuning do not merely affect the shape of the work and the efficiency but ultimately govern its quantitative magnitude.In the field of quantum thermodynamics,we have established an upper bound efficiency that is stricter than the Carnot limit.Moreover,our analysis confirms that quantum coherence enables the system to exceed the efficiency threshold of a classical Otto heat engine.The second law of thermodynamics holds all the while.Our results constitute a step forward in the design of conceptually new quantum thermodynamic devices which take advantage of uniquely quantum resources of quantum coherence. 展开更多
关键词 two-level atoms dipole coupled quantum coherence Otto engine local and global efficiency
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Damage evolution and constitutive model of limestone with horizontal fissure under the coupled effects of dry-wet cycling and precompression stress
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作者 Shunbo Zhang Zhongping Yang +2 位作者 Yang Gao Miao Liu Shanmeng Hou 《International Journal of Mining Science and Technology》 2026年第1期205-228,共24页
To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests ... To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97. 展开更多
关键词 Dry-wet cycling Precompression stress coupled effect Fractured limestone Damage evolution Damage constitutive model
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Study on Temperature Field Distribution of Hydraulic Motor Pump and Heat Dissipation Simulation of Flow-Solid-Heat Coupled with Spoiler Cooling Device
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作者 Geqiang Li Kai Wang +3 位作者 Juntao Liu Zhengyang Han Shuai Wang Donglin Li 《Frontiers in Heat and Mass Transfer》 2026年第1期120-139,共20页
To explore the distribution law of the temperature field in the motor pump and the influence of the fanshaped DC channel with spoiler in the pump housing on its heat dissipation performance.This study takes the arc-ge... To explore the distribution law of the temperature field in the motor pump and the influence of the fanshaped DC channel with spoiler in the pump housing on its heat dissipation performance.This study takes the arc-gear type hydraulicmotor pump as the research object.In COMSOL,a coupled heat transfer simulationmodel of themotor pump’s fluid-solid coupling is established,and the internal temperature field characteristics are analyzed.To improve the heat dissipation effect of the motor pump,it is proposed to arrange spoiler in the fan-shaped DC channel of the pump housing to enhance heat dissipation.Three types of spoilers,namely,wing-shaped,inclined rectangle-shaped,and wave-shaped,are designed.The simulation results show that when the motor pump operates under rated conditions,due to the poor heat dissipation environment inside the motor pump,the high-temperature areas of the motor pump are concentrated in the rotor and permanent magnet parts.After arranging the spoiler,the turbulent kinetic energy and vorticity in the fan-shaped DC channel of the pump housing are significantly enhanced.All three spoiler structures can reduce the maximum temperature of each component of the motor.According to the comprehensive performance evaluation criterion(PEC),the inclined rectangle-shaped structure has the best comprehensive heat transfer performance(PEC=1.114),while the wave-shaped structure has higher heat transfer efficiency but greater pressure loss.The wing-shaped structure has relatively limited enhancement effect on heat dissipation.This study systematically quantifies the influence of different spoiler structures on heat dissipation performance and flowresistance characteristics,providing a solution for enhancing the heat dissipation of the motor pump. 展开更多
关键词 Motor pump fluid-solid coupling heat dissipation performance SPOILER enhancing the heat dissipation
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Design and experimental verification of a large-scale coupled morphing-wing mechanism for hypersonic vehicles
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作者 Yanbing Wang Honghao Yue +5 位作者 Xueting Pan Jun Wu Fei Yang Yong Zhao Xue Bai Jicheng Liu 《Defence Technology(防务技术)》 2026年第2期125-141,共17页
Hypersonic morphing vehicle(HMV)can reconfigure aerodynamic geometries in real time,adapting to diverse needs like multi-mission profiles and wide-speed-range flight,spanwise morphing and sweep angle variation are rep... Hypersonic morphing vehicle(HMV)can reconfigure aerodynamic geometries in real time,adapting to diverse needs like multi-mission profiles and wide-speed-range flight,spanwise morphing and sweep angle variation are representative large-scale wing reconfiguration modes.To meet the HMV's need for an increased lift and a lift to drag ratio during hypersonic maneuverability and cruise or reentry equilibrium glide,this paper proposes an innovative single-DOF coupled morphing-wing system.We then systematically analyze its open-loop kinematics and closed-loop connectivity constraints,and the proposed system integrates three functional modules:the preset locking/release mechanism,the coupled morphing-wing mechanism,and the integrated wing locking with active stiffness control mechanism.Experimental validation confirms stable,continuous morphing under simulated aerodynamic loads.The experimental results indicate:(i)SMA actuators exhibit response times ranging from 18 s to 160 s,providing sufficient force output for wing unlocking;(ii)The integrated wing locking with active stiffness control mechanism effectively secures wing positions while eliminating airframe clearance via SMA actuation,improving the first-order natural frequency by more than 17%;(iii)The distributed aerodynamic loading system enables precise multi-stage follow-up loading during morphing,with the coupled morphing wing maintaining stable,continuous operation under 0-3500 N normal loads and 110-140 N axial force.The proposed single-DOF coupled morphing mechanism not only simplifies and improves structural efficiency but also demonstrates superior performance in locking control,stiffness enhancement,and aerodynamic responsiveness.This establishes a foundational framework for the design of future intelligent morphing configurations and the implementation of flight control systems. 展开更多
关键词 Hypersonic vehicle coupled morphing wing Locking/release Active stiffness control Distributed loading
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Study on the influence of internal bearing parameters on the critical speed and vibration behavior of the rotor-bearing coupled system
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作者 Fanyu ZHANG Yulai ZHAO +3 位作者 Qingyu ZHU Xiangyu MENG Junzhe LIN Qingkai HAN 《Applied Mathematics and Mechanics(English Edition)》 2026年第3期653-674,I0016-I0022,共29页
The dual challenges of critical speed prediction inaccuracies and ambiguous vibration behaviors are present in high-speed flexible rotors,particularly in free turbine rotors in turboshaft engine systems.The study begi... The dual challenges of critical speed prediction inaccuracies and ambiguous vibration behaviors are present in high-speed flexible rotors,particularly in free turbine rotors in turboshaft engine systems.The study begins with an examination of the rotor-bearing bidirectional coupling mechanism,with a primary focus on the nonlinear characteristics of the bearing.An investigation is carried out on the mechanical modeling methodologies for four-point contact ball bearings(FPCBBs)and cylindrical roller bearings(CRBs).To address the issue of excessive computational time in traditional bearing calculation methods,the sled dog optimization(SDO)algorithm is substituted for the conventional Newton-Raphson method.A rotor-bearing coupling dynamics model is developed by the finite element and lumped mass methods,with experimental validation achieved through a simulator test rig.The effects of three internal bearing parameters in FPCBBs(arching width and raceway groove curvature coefficient)and CRBs(initial radial clearance)on the critical speed characteristics and vibrational behavior of rotorbearing coupled systems are examined.The numerical simulation results show some interesting conclusions. 展开更多
关键词 critical speed vibration behavior sled dog optimization(SDO)algorithm rotor-bearing coupled system
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Seismic design and performance of building structures with self-centering steel-concrete hybrid single-pier coupled walls
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作者 Mojtaba Farahi Fabio Freddi Massimo Latour 《Resilient Cities and Structures》 2026年第1期85-101,共17页
In response to the demand for seismic-resilient structures,various innovative solutions have emerged to reduce local damage and residual deformations,facilitating repair operations in the aftermath of high-intensity e... In response to the demand for seismic-resilient structures,various innovative solutions have emerged to reduce local damage and residual deformations,facilitating repair operations in the aftermath of high-intensity earth-quakes.This paper examines the seismic performance of a steel-concrete hybrid wall system equipped with a selfcentering solution to mitigate earthquake-induced residual deformations.The considered hybrid system includes a Reinforced Concrete(RC)shear wall with two steel side columns connected by coupling steel beams.In this study,a novel type of coupling beams featuring a friction-damped self-centering system is implemented.The system is referred to as Self-Centering Hybrid Single-Pier Coupled Wall(SC-SP-HCW)and aims to minimize damage and residual deformations after earthquakes,which in turn facilitates repairs and enhances seismic resilience.Unlike conventional self-centering coupling beams with post-tensioned tendons,the self-centering configuration in this system does not rely on a gap-opening mechanism at the wall-beam connection interface,eliminating frame expansion effects.The proposed self-centering devices can also be implemented as preassembled links,which facilitates installation and reduces uncertainties associated with the on-site posttensioning procedure.The seismic performance of SC-SP-HCWs is investigated through nonlinear static and incremental dynamic analyses on case study SC-SP-HCWs designed as the lateral load-resisting systems of an eight-story building.The seismic response of the case study SC-SP-HCWs is investigated,considering both local and global engineering demand parameters(EDPs).The results demonstrate the ability of the SC-SP-HCWs to significantly reduce earthquake-induced residual deformations without exacerbating damage to structural ele-ments typically observed in conventional coupled walls. 展开更多
关键词 Hybrid coupled walls Damage-free self-centering links Friction devices Seismic performance Reinforced concrete walls
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Dynamic fracture behavior and coupled impact effect of as-cast W-Zr-Ti energetic structural material
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作者 Yuxuan Qi Liang Mao +3 位作者 Chunlan Jiang Guitao Liu Kongxun Zhao Mengchen Zhang 《Defence Technology(防务技术)》 2026年第1期422-435,共14页
This paper prepared a novel as-cast W-Zr-Ti metallic ESM using high-frequency vacuum induction melting technique.The above ESM performs a typical elastic-brittle material feature and strain rate strengthening behavior... This paper prepared a novel as-cast W-Zr-Ti metallic ESM using high-frequency vacuum induction melting technique.The above ESM performs a typical elastic-brittle material feature and strain rate strengthening behavior.The specimens exhibit violent chemical reaction during the fracture process under the impact loading,and the size distribution of their residual debris follows Rosin-Rammler model.The dynamic fracture toughness is obtained by the fitting of debris length scale,approximately 1.87 MPa·m~(1/2).Microstructure observation on residual debris indicates that the failure process is determined by primary crack propagation under quasi-static compression,while it is affected by multiple cracks propagation in both particle and matrix in the case of dynamic impact.Impact test demonstrates that the novel energetic fragment performs brilliant penetration and combustion effect behind the front target,leading to the effective ignition of fuel tank.For the brittleness of as-cast W-ZrTi ESM,further study conducted bond-based peridynamic(BB-PD)C++computational code to simulate its fracture behavior during penetration.The BB-PD method successfully captured the fracture process and debris cloud formation of the energetic fragment.This paper explores a novel as-cast metallic ESM,and provides an available numerical avenue to the simulation of brittle energetic fragment. 展开更多
关键词 Energetic structural material Dynamic fracture behavior coupled impact effect Mechanical property Peridynamics As-cast W-Zr-Ti alloy
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Synthesis and Design of Generalized Strongly Coupled Resonator Quartet Combline Filters with Redundant Resonance
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作者 Xiong Zhi’ang Fan Jiyuan +3 位作者 Zhao Ping Zhou Jinzhu Shen Nan Wu Qingqiang 《ZTE Communications》 2026年第1期88-96,共9页
This article proposes a generalized strongly coupled resonator quartet(GSCRQ)filter along with its synthesis approach.By introducing out-of-band reflection zeros(RZs),the proposed GSCRQ can generate a transmission zer... This article proposes a generalized strongly coupled resonator quartet(GSCRQ)filter along with its synthesis approach.By introducing out-of-band reflection zeros(RZs),the proposed GSCRQ can generate a transmission zero on each side of the passband without negative couplings.The coupling coefficients in this coupling structure change with the positions of the out-of-band RZs.Thus,the GSCRQ configuration admits flexible design solutions.For GSCRQ coaxial combline filters,all couplings can be implemented as inductive couplings,simplifying the design and manufacturing process.In this article,a 6-2 filter in the GSCRQ configuration is synthesized and designed.The simulated results of the designed filter agree very well with the theoretical characteristics. 展开更多
关键词 filter synthesis generalized strongly coupled resonator quartets(GSCRQ) out-of-band reflection zero transmission zero
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Comparison of analytical procedure validation criteria for inductively coupled plasma-mass spectrometry across different pharmacopoeias
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作者 Dongsheng Yang Chenfei Zhai +2 位作者 Nian Liu Ningyi Wei Jianzhao Niu 《Journal of Chinese Pharmaceutical Sciences》 2026年第1期80-87,共8页
Elemental impurities(EIs)in drug products are a specific class of inorganic contaminants that may originate from various sources.These residual impurities provide no therapeutic benefit to patients and,in some cases,m... Elemental impurities(EIs)in drug products are a specific class of inorganic contaminants that may originate from various sources.These residual impurities provide no therapeutic benefit to patients and,in some cases,may even catalyze the degradation of drug substances.Therefore,their levels in drug products must be controlled within acceptable limits.The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use(ICH)approved the harmonised Guideline for Elemental Impurities(ICH Q3D)on November 12,2014.On January 10,2020,the National Medical Products Administration(NMPA)announced the adoption of the ICH Q3D principles in China.Inductively coupled plasma mass spectrometry(ICP-MS)offers distinct advantages in detecting trace levels of EIs in drug products.Various validation criteria for the analytical procedure of ICP-MS are specified in the pharmacopoeias.This study compared differences in the validation criteria for ICP-MS,highlighting that the criteria adopted in the United States Pharmacopeia(USP)and European Pharmacopoeia(EP)were particularly specific and detailed,thereby facilitating analytical method development for drug quality control.The aim was to provide a useful reference for analysts conducting EI determination using ICP-MS. 展开更多
关键词 International Council for Harmonisation Permitted daily exposures Inductively coupled plasma-mass spectrometry European Pharmacopoeia Japanese Pharmacopoeia United States Pharmacopeia-National Formulary
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Reconstruction of bridge‑sensor data and detection of structural damage based on gradient‑coupled autoencoder and fully connected network
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作者 DUAN Yuanfeng DING Pengyao +1 位作者 DUAN Zhengteng CHENG J.J.Roger 《Journal of Southeast University(English Edition)》 2026年第1期1-11,共11页
A dual‑task parallel machine learning framework was developed by integrating a convolutional autoencoder(CAE)and a fully connected neural network(FCNN)via the gradient‑coupled mechanism,enabling simultaneous data comp... A dual‑task parallel machine learning framework was developed by integrating a convolutional autoencoder(CAE)and a fully connected neural network(FCNN)via the gradient‑coupled mechanism,enabling simultaneous data compression‑reconstruction and structural damage identification.Under the condition where 40% of the sensor nodes are missing,the model successfully reconstructs the full sensor network with an R^(2) of 0.916 and normalized root mean square error(NRMSE)of 0.0288.Even under significant noise contamination with an SNR of 12 dB,the model maintains strong reconstruction performance,achieving a R^(2) of 0.910 and NRMSE of 0.0253.Forty‑six structural damage scenarios were simulated using the scaled bridge model.The accuracy of spatial localization and quantification of the damage severity using the framework exceeds 99.3%.The proposed framework reduces the training time by 54.4%and iteration counts by 45.5% compared to conventional two‑stage machine learning approaches,demonstrating the efficiency of gradient‑coupled optimization. 展开更多
关键词 structural health monitoring machine learning data compression damage identification convolutional neural network fully connected neural network gradient‑coupled mechanism
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G protein-coupled receptor 37 biomarker potential in Parkinson’s disease:Inflammation might be the hidden trigger
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作者 Josep Argerich Marc López-Cano Francisco Ciruela 《Neural Regeneration Research》 2026年第7期2938-2939,共2页
G protein-coupled receptor 37(GPR37)is an orphan receptor predominantly expressed in the brain,particularly in oligodendrocytes and certain types of neurons.Notably,it has been shown that the N-terminal domain of GPR3... G protein-coupled receptor 37(GPR37)is an orphan receptor predominantly expressed in the brain,particularly in oligodendrocytes and certain types of neurons.Notably,it has been shown that the N-terminal domain of GPR37 undergoes proteolysis under normal physiological conditions,resulting in the formation of cleaved receptor forms and the release of its ectodomain(ecto-GPR37)into the extracellular milieu(Mattila et al.,2021).Importantly,ecto-GPR37 density is increased in cerebrospinal fluid(CSF)of patients suffering from sporadic Parkinson’s disease(PD),together with an abnormal GPR37 processing in post-mortem PD substantia nigra(Moratóet al.,2021;Figure 1A). 展开更多
关键词 g protein coupled receptor neurons INFLAMMATION cleaved receptor forms extracellular milieu mattila cerebrospinal fluid csf Parkinson s disease orphan receptor
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Coupled Urban Risks:A Complex Systems Perspective with a People-Centric Focus 被引量:2
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作者 Min Ouyang Zekai Cheng +2 位作者 Jiaxin Ma Hongwei Wang Stergios Aristoteles Mitoulis 《Engineering》 2025年第1期44-50,共7页
The complexity of coupled risks,which refer to the compounded effects of interacting uncertainties across multiple interdependent objectives,is inherent to cities functioning as dynamic,interdependent systems.A disrup... The complexity of coupled risks,which refer to the compounded effects of interacting uncertainties across multiple interdependent objectives,is inherent to cities functioning as dynamic,interdependent systems.A disruption in one domain ripples across various urban systems,often with unforeseen consequences.Central to this complexity are people,whose behaviors,needs,and vulnerabilities shape risk evolution and response effectiveness.Realizing cities as complex systems centered on human needs and behaviors is essential to understanding the complexities of coupled urban risks.This paper adopts a complex systems perspective to examine the intricacies of coupled urban risks,emphasizing the critical role of human decisions and behavior in shaping these dynamics.We focus on two key dimensions:cascading hazards in urban environments and cascading failures across interdependent exposed systems in cities.Existing risk assessment models often fail to capture the complexity of these processes,particularly when factoring in human decision-making.To tackle these challenges,we advocate for a standardized taxonomy of cascading hazards,urban components,and their interactions.At its core is a people-centric perspective,emphasizing the bidirectional interactions between people and the systems that serve them.Building on this foundation,we argue the need for an integrated,people-centric risk assessment framework that evaluates event impacts in relation to the hierarchical needs of people and incorporates their preparedness and response capacities.By leveraging real-time data,advanced simulations,and innovative validation methods,this framework aims to enhance the accuracy of coupled urban risk modeling.To effectively manage coupled urban risks,cities can draw from proven strategies in real complex systems.However,given the escalating uncertainties and complexities associated with climate change,prioritizing people-centric strategies is crucial.This approach will empower cities to build resilience not only against known hazards but also against evolving and unforeseen challenges in an increasingly uncertain world. 展开更多
关键词 coupled urban risks People-centric Risk management
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Recent advancements of nonlinear dynamics in mode coupled microresonators:a review 被引量:2
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作者 Xuefeng WANG Zhan SHI +3 位作者 Qiqi YANG Yuzhi CHEN Xueyong WEI Ronghua HUAN 《Applied Mathematics and Mechanics(English Edition)》 2025年第2期209-232,共24页
Due to scale effects,micromechanical resonators offer an excellent platform for investigating the intrinsic mechanisms of nonlinear dynamical phenomena and their potential applications.This review focuses on mode-coup... Due to scale effects,micromechanical resonators offer an excellent platform for investigating the intrinsic mechanisms of nonlinear dynamical phenomena and their potential applications.This review focuses on mode-coupled micromechanical resonators,highlighting the latest advancements in four key areas:internal resonance,synchronization,frequency combs,and mode localization.The origin,development,and potential applications of each of these dynamic phenomena within mode-coupled micromechanical systems are investigated,with the goal of inspiring new ideas and directions for researchers in this field. 展开更多
关键词 mode coupling micro-electro-mechanical system(MEMS)resonator nonlinear dynamics
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Coupled thermo-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams 被引量:2
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作者 Jianping LIU Zhaozhong YANG +2 位作者 Liangping YI Duo YI Xiaogang LI 《Applied Mathematics and Mechanics(English Edition)》 2025年第4期663-682,共20页
A coupled thermal-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams is presented.Heat exchange between the cold fluid and the hot rock is considered,and the thermal contribution t... A coupled thermal-hydro-mechanical cohesive phase-field model for hydraulic fracturing in deep coal seams is presented.Heat exchange between the cold fluid and the hot rock is considered,and the thermal contribution terms between the cold fluid and the hot rock are derived.Heat transfer obeys Fourier's law,and porosity is used to relate the thermodynamic parameters of the fracture and matrix domains.The net pressure difference between the fracture and the matrix is neglected,and thus the fluid flow is modeled by the unified fluid-governing equations.The evolution equations of porosity and Biot's coefficient during hydraulic fracturing are derived from their definitions.The effect of coal cleats is considered and modeled by Voronoi polygons,and this approach is shown to have high accuracy.The accuracy of the proposed model is verified by two sets of fracturing experiments in multilayer coal seams.Subsequently,the differences in fracture morphology,fluid pressure response,and fluid pressure distribution between direct fracturing of coal seams and indirect fracturing of shale interlayers are explored,and the effects of the cluster number and cluster spacing on fracture morphology for multi-cluster fracturing are also examined.The numerical results show that the proposed model is expected to be a powerful tool for the fracturing design and optimization of deep coalbed methane. 展开更多
关键词 phase-field method thermo-hydro-mechanical coupling indirect fracturing cohesive zone model deep coal seam
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