Programmable and precise regulation of genetic information is crucial in bioengineering and biomedicine;however, it remains challenging to implement this objective. Here we deployed DNA-functionalized MXenes as a smar...Programmable and precise regulation of genetic information is crucial in bioengineering and biomedicine;however, it remains challenging to implement this objective. Here we deployed DNA-functionalized MXenes as a smart delivery system for spatiotemporally controllable genome editing. The MXene nanovehicles rationally integrated photothermal effect with nucleic acid strand displacement reaction, thereby allowing for the binary logic gate-controlled release of Cas ribonucleoprotein complexes in response to different input patterns of NIR light and nucleic acids. This system was highly programmable and could be harnessed to construct 2-input(AND, OR, and N-IMPLY) and 3-input(AND/OR and N-IMPLY/OR) logic gates for precise gene editing in mammalian cells. Moreover, an AND logic gate-controlled delivery system achieved selective induction of tumor cell death in a xenograft mice model using tissue-penetrating NIR light and cancer-relevant microRNA as the inputting cues.Therefore, the MXene nanovehicles adopted both the external and endogenous signals as the stimuli to precisely control gene editing under logic computation, presenting a helpful strategy for therapeutic genome editing.展开更多
By means of Logic symmetric relation,the single neighboring Logic path for Ndimensions Boolean ordered set is solved.A new method of determining any logic neighboringsubset in limited dimension is proposed.Its results...By means of Logic symmetric relation,the single neighboring Logic path for Ndimensions Boolean ordered set is solved.A new method of determining any logic neighboringsubset in limited dimension is proposed.Its results are intuitional and realizable for computer.展开更多
The paper consists in the use of some logical functions decomposition algorithms with application in the implementation of classical circuits like SSI, MSI and PLD. The decomposition methods use the Boolean matrix cal...The paper consists in the use of some logical functions decomposition algorithms with application in the implementation of classical circuits like SSI, MSI and PLD. The decomposition methods use the Boolean matrix calculation. It is calculated the implementation costs emphasizing the most economical solutions. One important aspect of serial decomposition is the task of selecting “best candidate” variables for the G function. Decomposition is essentially a process of substituting two or more input variables with a lesser number of new variables. This substitutes results in the reduction of the number of rows in the truth table. Hence, we look for variables which are most likely to reduce the number of rows in the truth table as a result of decomposition. Let us consider an input variable purposely avoiding all inter-relationships among the input variables. The only available parameter to evaluate its activity is the number of “l”s or “O”s that it has in the truth table. If the variable has only “1” s or “0” s, it is the “best candidate” for decomposition, as it is practically redundant.展开更多
This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The ...This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The main point is to show that a so-called “superposition” of two (or more) quantum events (usually with mutually inconsistent initial conditions) can be represented in this algebra of conditional events and assigned a consistent conditional probability. There is no need to imagine that a quantum particle can simultaneously straddle two inconsistent possibilities.展开更多
In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS...In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS), static hazard “0”. In the first method, it used the consensus theorem to determine the cover term that is equal with the product of the two residual implicants, and in the second method it resolved a Boolean equation system. The authors observed that in the second method the digital hazard can be earlier detected. If the Boolean equation system is incompatible (doesn’t have solutions), the considered logical function doesn’t have the static 1 hazard regarding the coupled variable. Using the logical computations, this method permits to determine the needed transitions to eliminate the digital hazard.展开更多
Organic field-effect transistors (OFETs), with their potential for low-cost manufacturing and compatibility with flexible substrates,have emerged as an indispensable element in next-generation electronics. However, th...Organic field-effect transistors (OFETs), with their potential for low-cost manufacturing and compatibility with flexible substrates,have emerged as an indispensable element in next-generation electronics. However, the existing OFETs are significantlyhindered by their lack of reconfigurability and multifunctionality for application in complex electronic systems. To addressthese limitations, we propose a novel design strategy to develop a dual-gate organic field-effect transistor (DG-OFET), primarilyfeaturing a synergistic combination of interface charge trapping and the nonvolatile nature of ferroelectric polarization, whichrealizes the multifunctional integration within a single platform. Specifically, the DG-OFET can be utilized as synaptic devicesthat can successfully perform both short-term and long-term synaptic plasticity by manipulating the input gate of artificial pulsevoltages, depending on the switching mechanism between bottom-gate controlled electrostatic doping and top-gate inducedferroelectric polarization. Besides, the presynaptic spike applied to a specific gate electrode can trigger the excitatory andinhibitory postsynaptic current response. The potentiation and depression of synaptic weight are mimicked by consecutivepositive and negative spikes, respectively. The dual-gate coupling strategy further expands its functionality towards simulatingthe operation of logic gates. By modulating the combination of dual-gate input signals, the channel conductivity can analogouslyperform a family of elementary Boolean logic operations, including AND, OR, NAND, NOR, XOR, and XNOR. Theseresults highlight the electronic reconfigurability of DG-OFET and tremendous potential for applications in energy-efficientneuromorphic computing networks and organic circuits, thus providing a versatile strategy for the development of advancedand efficient multifunctional integration.展开更多
In-memory computing(IMC)based on spin-logic devices is regarded as an advantageous way to optimize the Von Neumann bottleneck.However,performing complete Boolean logic with spintronic devices typi-cally requires an in...In-memory computing(IMC)based on spin-logic devices is regarded as an advantageous way to optimize the Von Neumann bottleneck.However,performing complete Boolean logic with spintronic devices typi-cally requires an initialization operation,which can reduce processing speed.In this work,we conceptu-alize and experimentally demonstrate a programmable and initialization-free spin-logic gate,leveraging spin-orbit torque(SOT)to effectuate magnetization switching,assisted by in-plane Oersted field gener-ated by an integrated bias-field Au line.This spin-logic gate,fabricated as a Hall bar,allows complete Boolean logic operations without initialization.A current flowing through the bias-field line,which is electrically isolated from the device by a dielectric,generates an in-plane magnetic field that can invert the SOT-induced switching chirality,enabling on-the-fly complete Boolean logic operations.Additionally,the device demonstrated good reliability,repeatability,and reproducibility during logic operations.Our work demonstrates programmable and scalable spin-logic functions in a single device,offering a new approach for spin-logic operations in an IMC architecture.展开更多
基金supported by the National Key Research and Development Program of China (2020YFA0907500)the National Natural Science Foundation of China (22034002, 21974038, 21725503, 22074034)+1 种基金the Natural Science Foundation of Hunan Province (2022JJ20004)。
文摘Programmable and precise regulation of genetic information is crucial in bioengineering and biomedicine;however, it remains challenging to implement this objective. Here we deployed DNA-functionalized MXenes as a smart delivery system for spatiotemporally controllable genome editing. The MXene nanovehicles rationally integrated photothermal effect with nucleic acid strand displacement reaction, thereby allowing for the binary logic gate-controlled release of Cas ribonucleoprotein complexes in response to different input patterns of NIR light and nucleic acids. This system was highly programmable and could be harnessed to construct 2-input(AND, OR, and N-IMPLY) and 3-input(AND/OR and N-IMPLY/OR) logic gates for precise gene editing in mammalian cells. Moreover, an AND logic gate-controlled delivery system achieved selective induction of tumor cell death in a xenograft mice model using tissue-penetrating NIR light and cancer-relevant microRNA as the inputting cues.Therefore, the MXene nanovehicles adopted both the external and endogenous signals as the stimuli to precisely control gene editing under logic computation, presenting a helpful strategy for therapeutic genome editing.
文摘By means of Logic symmetric relation,the single neighboring Logic path for Ndimensions Boolean ordered set is solved.A new method of determining any logic neighboringsubset in limited dimension is proposed.Its results are intuitional and realizable for computer.
文摘The paper consists in the use of some logical functions decomposition algorithms with application in the implementation of classical circuits like SSI, MSI and PLD. The decomposition methods use the Boolean matrix calculation. It is calculated the implementation costs emphasizing the most economical solutions. One important aspect of serial decomposition is the task of selecting “best candidate” variables for the G function. Decomposition is essentially a process of substituting two or more input variables with a lesser number of new variables. This substitutes results in the reduction of the number of rows in the truth table. Hence, we look for variables which are most likely to reduce the number of rows in the truth table as a result of decomposition. Let us consider an input variable purposely avoiding all inter-relationships among the input variables. The only available parameter to evaluate its activity is the number of “l”s or “O”s that it has in the truth table. If the variable has only “1” s or “0” s, it is the “best candidate” for decomposition, as it is practically redundant.
文摘This paper begins with an overview of quantum mechanics, and then recounts a relatively recent algebraic extension of the Boolean algebra of probabilistic events to “conditional events” (order pairs of events). The main point is to show that a so-called “superposition” of two (or more) quantum events (usually with mutually inconsistent initial conditions) can be represented in this algebra of conditional events and assigned a consistent conditional probability. There is no need to imagine that a quantum particle can simultaneously straddle two inconsistent possibilities.
文摘In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS), static hazard “0”. In the first method, it used the consensus theorem to determine the cover term that is equal with the product of the two residual implicants, and in the second method it resolved a Boolean equation system. The authors observed that in the second method the digital hazard can be earlier detected. If the Boolean equation system is incompatible (doesn’t have solutions), the considered logical function doesn’t have the static 1 hazard regarding the coupled variable. Using the logical computations, this method permits to determine the needed transitions to eliminate the digital hazard.
基金supported by the Ministry of Science and Technology of the People's Republic of China(2022YFB3603804)Natural Science Foundation of Shanghai Municipality(22ZR1407800).
文摘Organic field-effect transistors (OFETs), with their potential for low-cost manufacturing and compatibility with flexible substrates,have emerged as an indispensable element in next-generation electronics. However, the existing OFETs are significantlyhindered by their lack of reconfigurability and multifunctionality for application in complex electronic systems. To addressthese limitations, we propose a novel design strategy to develop a dual-gate organic field-effect transistor (DG-OFET), primarilyfeaturing a synergistic combination of interface charge trapping and the nonvolatile nature of ferroelectric polarization, whichrealizes the multifunctional integration within a single platform. Specifically, the DG-OFET can be utilized as synaptic devicesthat can successfully perform both short-term and long-term synaptic plasticity by manipulating the input gate of artificial pulsevoltages, depending on the switching mechanism between bottom-gate controlled electrostatic doping and top-gate inducedferroelectric polarization. Besides, the presynaptic spike applied to a specific gate electrode can trigger the excitatory andinhibitory postsynaptic current response. The potentiation and depression of synaptic weight are mimicked by consecutivepositive and negative spikes, respectively. The dual-gate coupling strategy further expands its functionality towards simulatingthe operation of logic gates. By modulating the combination of dual-gate input signals, the channel conductivity can analogouslyperform a family of elementary Boolean logic operations, including AND, OR, NAND, NOR, XOR, and XNOR. Theseresults highlight the electronic reconfigurability of DG-OFET and tremendous potential for applications in energy-efficientneuromorphic computing networks and organic circuits, thus providing a versatile strategy for the development of advancedand efficient multifunctional integration.
基金supported by the National Science and Technology Major Project(2020AAA0109005)the National Natural Science Foundation of China(62374055,12327806,62304083,62074063,61821003,61904060,61904051,61674062)+4 种基金the Interdisciplinary Program of Wuhan National High Magnetic Field Center(WHMFC202119)the Shenzhen Science and Technology Program Award(JCYJ20220818103410022)the Shenzhen Virtual University Park(2021Szvup091)the Natural Science Foundation of Wuhan(2024040701010049)Shuai Zhang acknowledges support from the China Postdoctoral Science Foundation(2022M721237).
文摘In-memory computing(IMC)based on spin-logic devices is regarded as an advantageous way to optimize the Von Neumann bottleneck.However,performing complete Boolean logic with spintronic devices typi-cally requires an initialization operation,which can reduce processing speed.In this work,we conceptu-alize and experimentally demonstrate a programmable and initialization-free spin-logic gate,leveraging spin-orbit torque(SOT)to effectuate magnetization switching,assisted by in-plane Oersted field gener-ated by an integrated bias-field Au line.This spin-logic gate,fabricated as a Hall bar,allows complete Boolean logic operations without initialization.A current flowing through the bias-field line,which is electrically isolated from the device by a dielectric,generates an in-plane magnetic field that can invert the SOT-induced switching chirality,enabling on-the-fly complete Boolean logic operations.Additionally,the device demonstrated good reliability,repeatability,and reproducibility during logic operations.Our work demonstrates programmable and scalable spin-logic functions in a single device,offering a new approach for spin-logic operations in an IMC architecture.
