Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.Th...Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.The published version showed“Hongzhen Chen”,whereas the correct spelling should be“Hongzheng Chen”.The correct author name has been provided in this Correction,and the original article[1]has been corrected.展开更多
Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from cli...Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from clinical studies,particularly with the widespread use of next-generation sequencing.Validating these candidate genes is emerging as a valuable yet challenging task.Drosophila serves as an ideal animal model for validating candidate genes associated with neurogenetic disorders such as epilepsy,due to its rapid reproduction rate,powerful genetic tools,and efficient use of ethological and electrophysiological assays.Here,we systematically summarize the advantageous techniques of the Drosophila model used to investigate epilepsy genes,including genetic tools for manipulating target gene expression,ethological assays for seizure-like behaviors,electrophysiological techniques,and functional imaging for recording neural activity.We then introduce several typical strategies for identifying epilepsy genes and provide new insights into gene-gene interactions in epilepsy with polygenic causes.We summarize well-established precision medicine strategies for epilepsy and discuss prospective treatment options,including drug therapy and gene therapy for genetic epilepsy based on the Drosophila model.Finally,we also address genetic counseling and assisted reproductive technology as potential approaches for the prevention of genetic epilepsy.展开更多
In the competitive retail industry of the digital era,data-driven insights into gender-specific customer behavior are essential.They support the optimization of store performance,layout design,product placement,and ta...In the competitive retail industry of the digital era,data-driven insights into gender-specific customer behavior are essential.They support the optimization of store performance,layout design,product placement,and targeted marketing.However,existing computer vision solutions often rely on facial recognition to gather such insights,raising significant privacy and ethical concerns.To address these issues,this paper presents a privacypreserving customer analytics system through two key strategies.First,we deploy a deep learning framework using YOLOv9s,trained on the RCA-TVGender dataset.Cameras are positioned perpendicular to observation areas to reduce facial visibility while maintaining accurate gender classification.Second,we apply AES-128 encryption to customer position data,ensuring secure access and regulatory compliance.Our system achieved overall performance,with 81.5%mAP@50,77.7%precision,and 75.7%recall.Moreover,a 90-min observational study confirmed the system’s ability to generate privacy-protected heatmaps revealing distinct behavioral patterns between male and female customers.For instance,women spent more time in certain areas and showed interest in different products.These results confirm the system’s effectiveness in enabling personalized layout and marketing strategies without compromising privacy.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly f...The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.展开更多
Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery ...Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.展开更多
Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O soluti...Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O solution.The assembly and fluorescence behavior of PDI-COOH/Ca^(2+)were studied in detail by changing hydration state with different concentrations.Based on the differences in assembly morphology and stoichiometric ratios of PDICOOH/Ca^(2+),we proposed the fluorescence emission mechanism of PDI-COOH/Ca^(2+)in THF/H_(2)O and THF,respectively.This work reveals a novel strategy of aggregated state fluorescence enhancement and reminds us of the important role of water in molecular fluorescence emission and assembly.展开更多
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigati...A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.展开更多
文章使用CiteSpace软件对1990~2022年《Journal of Environmental Psychology》和《Environment and Behavior》所刊发的2851篇论文进行文献计量学分析。结果表明:(1)代表人物国籍分布正从美国转向荷兰、德国、澳大利亚等国家,从美国中...文章使用CiteSpace软件对1990~2022年《Journal of Environmental Psychology》和《Environment and Behavior》所刊发的2851篇论文进行文献计量学分析。结果表明:(1)代表人物国籍分布正从美国转向荷兰、德国、澳大利亚等国家,从美国中心走向全球关注;(2)环境心理学围绕环境感知、环境偏好、地点依恋等九个主题展开,亲环境行为、亲环境态度、环保主义已成为当前热点,未来热点将聚焦于气候变化、亲环境行为和绿色消费等主题;(3)研究呈现出“人类中心”向“生态中心”的转变;(4)环境心理学研究主题表现出较强的分散性。未来,我国环境心理学应聚焦“人-环境关系”核心命题,明晰“环境”范畴,厘清基础理论和范式,从空间、时间和关系核心三个维度构建内容框架,形成具有中国特色的环境心理学知识体系。展开更多
High-entropy materials possess high hardness and strong wear resistance,yet the key bottleneck for their practical applications is the poor corrosion resistance in harsh environments.In this work,the high-entropy nitr...High-entropy materials possess high hardness and strong wear resistance,yet the key bottleneck for their practical applications is the poor corrosion resistance in harsh environments.In this work,the high-entropy nitride(HEN)coatings of(MoNbTaTiZr)1-x Nx(x=0-0.47)were fabricated using a hybrid di-rect current magnetron sputtering technique.The research focus was dedicated to the effect of nitrogen content on the microstructure,mechanical and electrochemical properties.The results showed that the as-deposited coatings exhibited a typical body-centered cubic(BCC)structure without nitrogen,while the amorphous matrix with face-centered cubic(FCC)nanocrystalline grain was observed at x=0.17.Further increasing x in the range of 0.35-0.47 caused the appearance of polycrystalline FCC phase in structure.Compared with the MoNbTaTiZr metallic coating,the coating containing nitrogen favored the high hard-ness around 13.7-32.4 GPa,accompanied by excellent tolerance both against elastic and plastic deforma-tion.Furthermore,such N-containing coatings yielded a low corrosion current density of about 10−8-10−7 A/cm^(2) and high electrochemical impedance of 10^(6)Ωcm^(2) in 3.5 wt.%NaCl solution,indicating the supe-rior corrosion resistance.The reason for the enhanced electrochemical behavior could be ascribed to the spontaneous formation of protective passive layers over the coating surface,which consisted of the domi-nated multi-elemental oxides in chemical stability.Particularly,noted that the(MoNbTaTiZr)_(0.83) N0.17 coat-ing displayed the highest hardness of 32.4±2.6 GPa and H/E ratio at 0.09,together with remarkable cor-rosion resistance,proposing the strongest capability for harsh-environmental applications required both good anti-wear and anti-corrosion performance.展开更多
Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typical...Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typically applied to weld joints for engineering purposes via heat treatment,in order to avoid prema-ture failure and performance degradation.In the present work,we found that proper welding residual stresses in laser-welded Ti-6Al-4 V sheets can maintain better ductility during uniaxial tension,as op-posed to the stress-relieved counterparts.A detailed experimental investigation has been performed on the deformation behaviours of Ti-6Al-4 V butt welds,including residual stress distribution characteriza-tions by focused ion beam ring-coring coupled with digital image correlation(FIB-DIC),X-ray comput-erized tomography(CT)for internal voids,and in-situ DIC analysis of the subregional strain evolutions.It was found that the pores preferentially distributed near the fusion zone(FZ)boundary,where the compressive residual stress was up to-330 MPa.The removal of residual stress resulted in a changed failure initiation site from the base material to the FZ boundary,the former with ductile and the latter with brittle fracture characteristics under tensile deformation.The combined effects of residual stresses,microstructures,and internal pores on the mechanical responses are discussed in detail.This work high-lights the importance of inevitable residual stress and pores in laser weld pieces,leading to key insights for post-welding treatment and service performance evaluations.展开更多
A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anod...A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm^(2),reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm^(2).This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture.展开更多
Pyrrolizidine alkaloids(PAs)and their N-oxides(PANOs)are phytotoxins produced by various plant species and have been emerged as environmental pollutants.The sorption/desorption behaviors of PAs/PANOs in soil are cruci...Pyrrolizidine alkaloids(PAs)and their N-oxides(PANOs)are phytotoxins produced by various plant species and have been emerged as environmental pollutants.The sorption/desorption behaviors of PAs/PANOs in soil are crucial due to the horizontal transfer of these natural products from PA-producing plants to soil and subsequently absorbed by plant roots.This study firstly investigated the sorption/desorption behaviors of PAs/PANOs in tea plantation soils with distinct characteristics.Sorption amounts for seneciphylline(Sp)and seneciphylline-N-oxide(SpNO)in three acidic soils ranged from 2.9 to 5.9μg/g and 1.7 to 2.8μg/g,respectively.Desorption percentages for Sp and SpNO were from 22.2%to 30.5%and 36.1%to 43.9%.In the mixed PAs/PANOs systems,stronger sorption of PAs over PANOs was occurred in tested soils.Additionally,the Freundlich models more precisely described the sorption/desorption isotherms.Cation exchange capacity,sand content and total nitrogen were identified as major influencing factors by linear regression models.Overall,the soils exhibiting higher sorption capacities for compounds with greater hydrophobicity.PANOs were more likely to migrate within soils and be absorbed by tea plants.It contributes to the understanding of environmental fate of PAs/PANOs in tea plantations and provides basic data and clues for the development of PAs/PANOs reduction technology.展开更多
Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates...Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates the preparation of ZnO-containing micro-arc oxidation coatings with dual functionality by incorporating nano-ZnO into MAO electrolyte.The influence of varying ZnO concentrations on the microstructure,corrosion resistance,and antibacterial properties of the coating was examined through microstructure analysis,immersion tests,electrochemical experiments,and antibacterial assays.The findings revealed that the addition of nano-ZnO significantly enhanced the corrosion resistance of the MAO-coated alloy.Specifically,when the ZnO concentration in the electrolyte was 5 g/L,the corrosion rate was more than ten times lower compared to the MAO coatings without ZnO.Moreover,the antibacterial efficacy of ZnO+MAO coating,prepared with a ZnO concentration of 5 g/L,surpassed 95%after 24 h of co-culturing with Staphylococcus aureus(S.aureus).The nano-ZnO+MAO-coated alloy exhibited exceptional degradation resistance,corrosion resistance,and antibacterial effectiveness.展开更多
The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activit...The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.展开更多
Objective:This study aimed to examine the reliability and validity of the Chinese version of the Behavioral Inhibition System/Behavioral Activation System(BIS/BAS)scales among stroke survivors.Methods:The cross-sectio...Objective:This study aimed to examine the reliability and validity of the Chinese version of the Behavioral Inhibition System/Behavioral Activation System(BIS/BAS)scales among stroke survivors.Methods:The cross-sectional study was conducted at four comprehensive hospitals in Taizhou,Jiangsu,China.A sample of 232 first-ever stroke survivors were recruited from June to August 2023.Validity was examined using face validity and construct validity,which used confirmatory factor analysis(CFA)and known-group analysis.Reliability was evaluated by internal consistency and test-retest reliability.Results:The BIS/BAS scales demonstrated satisfactory face validity.The findings of CFAs supported the original four-factor structure of BAS-reward,BAS-drive,BAS-fun seeking,and BIS with acceptable model fit indices.Discriminative validity,assessed via known-group analysis,indicated that stroke survivors with probable depression had significantly lower mean BAS-reward,BAS-drive,and BAS-fun seeking scores(P<0.001)and a higher mean BIS score(P=0.028)compared to those without probable depression.The internal consistency,measured by Cronbach’s a coefficients for the subscales,ranged from 0.669 to 0.964.Test-retest reliability,assessed using intra-class correlation coefficients,ranged from 0.61 to 0.93.Conclusions:The Chinese version of the BIS/BAS scales could be a reliable and valid instrument for measuring behavioral activation among stroke survivors.展开更多
The swelling behavior and stability in solid electrolyte interphase(SEI)have been proved to determine the battery cycle life.A high swollen,unstable SEI shows a high permeability to electrolyte,which results in the ra...The swelling behavior and stability in solid electrolyte interphase(SEI)have been proved to determine the battery cycle life.A high swollen,unstable SEI shows a high permeability to electrolyte,which results in the rapid battery performance degradation.Here,we customize two SEIs with different spatial structures(bilayer and mosaic)by simply regulating the proportion of additive fluoroethylene carbonate.Surprisingly,due to the uniform distribution of dense inorganic nano-crystals in the inner,the bilayer SEI exhibits low-swelling and excellent mechanical properties,so the undesirable side reactions of the electrolyte are effectively suppressed.In addition,we put forward the growth rate of swelling ratio(GSR)as a key indicator to reveal the swelling change in SEI.The GSR of bilayer SEI merely increases from1.73 to 3.16 after the 300th cycle,which enables the corresponding graphite‖Li battery to achieve longer cycle stability.The capacity retention is improved by 47.5% after 300 cycles at 0.5 C.The correlation among SEI spatial structure,swelling behavior,and battery performance provides a new direction for electrolyte optimization and interphase structure design of high energy density batteries.展开更多
The microstructural characterization,corrosion behavior and tensile properties of the extruded lean Mg−1Bi−0.5Sn−0.5In(wt.%)alloy were investigated through scanning electron microscopy(SEM),electron backscatter diffra...The microstructural characterization,corrosion behavior and tensile properties of the extruded lean Mg−1Bi−0.5Sn−0.5In(wt.%)alloy were investigated through scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),X-ray photoelectron spectroscopy(XPS),electrochemical measurements and tensile tests.The results reveal that a microstructure consisting of dynamically recrystallized and deformed grains is obtained.Notably,the investigated alloy exhibits excellent strength−ductility synergy,with tensile yield strength(TYS),ultimate tensile strength(UTS)and elongation(EL)of 254.8 MPa,315.4 MPa,and 25.3%,respectively.Furthermore,in 3.5 wt.%NaCl solution,with the increase of immersion time,the dominant corrosion mechanism of the studied alloy transforms from pitting corrosion to filiform corrosion.After the immersion for 24 h,a composite oxide film(SnO2−Bi2O3−In2O3)is formed,which delays the corrosion process,and the corrosion rate(PH=1.53 mm/a)is finally stabilized.展开更多
In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate p...In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate precipitation of the semi-coherent~Mg_(3)Zn phase.The aging softening of the studied alloy is mainly caused by the rapid transformation of the strengthening~Mg_(3)Zn phase to the softening MgLi(Al,Zn)phase,along with the coarsening of theα-Mg matrix and precipitates withinβ-Li matrix.Further analysis indicates that the quick precipitation and transformation of~Mg_(3)Zn is a consequence of the high diffusion rate of solute atoms,resulting from dense vacancy concentration in theβ-Li matrix.This research bridges a critical gap in the study of aging mechanism in the dual-phase Mg-Li-Al-Zn alloy,providing a theoretical basis for the development and application of high-performance and thermal-stable Mg-Li alloys.展开更多
文摘Correction to:Nano-Micro Letters(2026)18:10.https://doi.org/10.1007/s40820-025-01852-8 Following publication of the original article[1],the authors reported that the last author’s name was inadvertently misspelled.The published version showed“Hongzhen Chen”,whereas the correct spelling should be“Hongzheng Chen”.The correct author name has been provided in this Correction,and the original article[1]has been corrected.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,No.2022A1515111123(to JQ)。
文摘Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from clinical studies,particularly with the widespread use of next-generation sequencing.Validating these candidate genes is emerging as a valuable yet challenging task.Drosophila serves as an ideal animal model for validating candidate genes associated with neurogenetic disorders such as epilepsy,due to its rapid reproduction rate,powerful genetic tools,and efficient use of ethological and electrophysiological assays.Here,we systematically summarize the advantageous techniques of the Drosophila model used to investigate epilepsy genes,including genetic tools for manipulating target gene expression,ethological assays for seizure-like behaviors,electrophysiological techniques,and functional imaging for recording neural activity.We then introduce several typical strategies for identifying epilepsy genes and provide new insights into gene-gene interactions in epilepsy with polygenic causes.We summarize well-established precision medicine strategies for epilepsy and discuss prospective treatment options,including drug therapy and gene therapy for genetic epilepsy based on the Drosophila model.Finally,we also address genetic counseling and assisted reproductive technology as potential approaches for the prevention of genetic epilepsy.
文摘In the competitive retail industry of the digital era,data-driven insights into gender-specific customer behavior are essential.They support the optimization of store performance,layout design,product placement,and targeted marketing.However,existing computer vision solutions often rely on facial recognition to gather such insights,raising significant privacy and ethical concerns.To address these issues,this paper presents a privacypreserving customer analytics system through two key strategies.First,we deploy a deep learning framework using YOLOv9s,trained on the RCA-TVGender dataset.Cameras are positioned perpendicular to observation areas to reduce facial visibility while maintaining accurate gender classification.Second,we apply AES-128 encryption to customer position data,ensuring secure access and regulatory compliance.Our system achieved overall performance,with 81.5%mAP@50,77.7%precision,and 75.7%recall.Moreover,a 90-min observational study confirmed the system’s ability to generate privacy-protected heatmaps revealing distinct behavioral patterns between male and female customers.For instance,women spent more time in certain areas and showed interest in different products.These results confirm the system’s effectiveness in enabling personalized layout and marketing strategies without compromising privacy.
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金supported by European Union Funding Programme,PNRR,No. 760058(to DMH)the UEFISCDI Project,No. PN-III-P4-IDPCE-2020-059(to APW)
文摘The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia.One option is to stimulate endogenous neurogenesis in the subventricular zone and direct the newly formed neurons to the damaged area.However,only a small percentage of these neurons survive,and many do not reach the damaged area,possibly because the corpus callosum impedes the migration of subventricular zone-derived stem cells into the lesioned cortex.A second major obstacle to stem cell therapy is the strong inflammatory reaction induced by cerebral ischemia,whereby the associated phagocytic activity of brain macrophages removes both therapeutic cells and/or cell-based drug carriers.To address these issues,neurogenesis was electrically stimulated in the subventricular zone,followed by isolation of proliferating cells,including newly formed neurons,which were subsequently mixed with a nutritional hydrogel.This mixture was then transferred to the stroke cavity of day 14 post-stroke mice.We found that the performance of the treated animals improved in behavioral tests,including novel object,open field,hole board,grooming,and“time-to-feel”adhesive tape tests.Furthermore,immunostaining revealed that the stem cell marker nestin,the neuroepithelial marker Mash1,and the immature neuronal marker doublecortin-positive cells survived in the transplanted area for 2 weeks,possibly due to reduced phagocytic activity and supportive angiogenesis.These results clearly indicate that the transplantation of committed subventricular zone stem cells combined with a protective nutritional gel directly into the infarct cavity after the peak of stroke-induced neuroinflammation represents a feasible approach to improve neurorestoration after cerebral ischemia.
基金supported by the NIH (R01NS103481, R01NS111776, and R01NS131489)Indiana Department of Health (ISDH58180)(all to WW)。
文摘Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.
文摘Bay-site carboxyl functionalized perylene diimide derivative 1,7-COOH-PDI-C_(12)(PDI-COOH)was synthesized and distinct enhanced fluorescence was observed through combining with calcium ion(Ca^(2+))in THF/H_(2)O solution.The assembly and fluorescence behavior of PDI-COOH/Ca^(2+)were studied in detail by changing hydration state with different concentrations.Based on the differences in assembly morphology and stoichiometric ratios of PDICOOH/Ca^(2+),we proposed the fluorescence emission mechanism of PDI-COOH/Ca^(2+)in THF/H_(2)O and THF,respectively.This work reveals a novel strategy of aggregated state fluorescence enhancement and reminds us of the important role of water in molecular fluorescence emission and assembly.
基金supported by the National Natural Science Foundation of China,No.82001155(to LL)the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL)+5 种基金the Natural Science Foundation of Ningbo,No.2023J068(to LL)the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL)the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC)the Student ResearchInnovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ)the K.C.Wong Magna Fund in Ningbo University。
文摘A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and progression.Nonetheless,nonpharmacological interventions aimed at inducing adult neurogenesis are currently limited.Although individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully explored.In this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 months.Amyloid deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease progressed.However,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus decreased.These findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 mice.Furthermore,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice following multifactor stimulation,as evidenced by Morris water maze,novel object recognition,forced swimming test,and tail suspension test results.Notably,the efficacy of multifactor stimulation in consolidating immature neurons persisted for at least 2weeks after treatment cessation.At the molecular level,multifactor stimulation upregulated the expression of neuron-related proteins(NeuN,doublecortin,postsynaptic density protein-95,and synaptophysin),anti-apoptosis-related proteins(Bcl-2 and PARP),and an autophagyassociated protein(LC3B),while decreasing the expression of apoptosis-related proteins(BAX and caspase-9),in the hippocampus of amyloid precursor protein/presenilin 1 mice.These observations might be attributable to both the brain-derived neurotrophic factor-mediated signaling pathway and antioxidant pathways.Furthermore,serum metabolomics analysis indicated that multifactor stimulation regulated differentially expressed metabolites associated with cell apoptosis,oxidative damage,and cognition.Collectively,these findings suggest that multifactor stimulation is a novel non-invasive approach for the prevention and treatment of Alzheimer's disease.
文摘文章使用CiteSpace软件对1990~2022年《Journal of Environmental Psychology》和《Environment and Behavior》所刊发的2851篇论文进行文献计量学分析。结果表明:(1)代表人物国籍分布正从美国转向荷兰、德国、澳大利亚等国家,从美国中心走向全球关注;(2)环境心理学围绕环境感知、环境偏好、地点依恋等九个主题展开,亲环境行为、亲环境态度、环保主义已成为当前热点,未来热点将聚焦于气候变化、亲环境行为和绿色消费等主题;(3)研究呈现出“人类中心”向“生态中心”的转变;(4)环境心理学研究主题表现出较强的分散性。未来,我国环境心理学应聚焦“人-环境关系”核心命题,明晰“环境”范畴,厘清基础理论和范式,从空间、时间和关系核心三个维度构建内容框架,形成具有中国特色的环境心理学知识体系。
基金supported by the National Science Fund for Distinguished Young Scholars of China(No.52025014)Zhejiang Provincial Natural Science Foundation of China(Nos.LZJWY23E090001 and LD24E010003)the Natural Science Foundation of Ningbo(No.2022J305).
文摘High-entropy materials possess high hardness and strong wear resistance,yet the key bottleneck for their practical applications is the poor corrosion resistance in harsh environments.In this work,the high-entropy nitride(HEN)coatings of(MoNbTaTiZr)1-x Nx(x=0-0.47)were fabricated using a hybrid di-rect current magnetron sputtering technique.The research focus was dedicated to the effect of nitrogen content on the microstructure,mechanical and electrochemical properties.The results showed that the as-deposited coatings exhibited a typical body-centered cubic(BCC)structure without nitrogen,while the amorphous matrix with face-centered cubic(FCC)nanocrystalline grain was observed at x=0.17.Further increasing x in the range of 0.35-0.47 caused the appearance of polycrystalline FCC phase in structure.Compared with the MoNbTaTiZr metallic coating,the coating containing nitrogen favored the high hard-ness around 13.7-32.4 GPa,accompanied by excellent tolerance both against elastic and plastic deforma-tion.Furthermore,such N-containing coatings yielded a low corrosion current density of about 10−8-10−7 A/cm^(2) and high electrochemical impedance of 10^(6)Ωcm^(2) in 3.5 wt.%NaCl solution,indicating the supe-rior corrosion resistance.The reason for the enhanced electrochemical behavior could be ascribed to the spontaneous formation of protective passive layers over the coating surface,which consisted of the domi-nated multi-elemental oxides in chemical stability.Particularly,noted that the(MoNbTaTiZr)_(0.83) N0.17 coat-ing displayed the highest hardness of 32.4±2.6 GPa and H/E ratio at 0.09,together with remarkable cor-rosion resistance,proposing the strongest capability for harsh-environmental applications required both good anti-wear and anti-corrosion performance.
基金supported by the National Key Re-search&Development Plan of China(No.2020YFA0405900)the Major Research Plan of the National Natural Science Founda-tion of China(No.92263201)Y.P.Xia would like to thank the support by the Jiangsu Funding Program for Excellent Postdoctoral Talent.All authors thank the Advanced Material Research Institute of Jiangsu Industrial Technology Research Institute(JITRI,Suzhou,China)for the experimental support.
文摘Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typically applied to weld joints for engineering purposes via heat treatment,in order to avoid prema-ture failure and performance degradation.In the present work,we found that proper welding residual stresses in laser-welded Ti-6Al-4 V sheets can maintain better ductility during uniaxial tension,as op-posed to the stress-relieved counterparts.A detailed experimental investigation has been performed on the deformation behaviours of Ti-6Al-4 V butt welds,including residual stress distribution characteriza-tions by focused ion beam ring-coring coupled with digital image correlation(FIB-DIC),X-ray comput-erized tomography(CT)for internal voids,and in-situ DIC analysis of the subregional strain evolutions.It was found that the pores preferentially distributed near the fusion zone(FZ)boundary,where the compressive residual stress was up to-330 MPa.The removal of residual stress resulted in a changed failure initiation site from the base material to the FZ boundary,the former with ductile and the latter with brittle fracture characteristics under tensile deformation.The combined effects of residual stresses,microstructures,and internal pores on the mechanical responses are discussed in detail.This work high-lights the importance of inevitable residual stress and pores in laser weld pieces,leading to key insights for post-welding treatment and service performance evaluations.
基金partially supported by the National Natural Science Foundation of China(No.51901153)Shanxi Scholarship Council of China(No.2019032)+1 种基金the Natural Science Foundation of Shanxi,China(No.202103021224049)the Shanxi Zhejiang University New Materials and Chemical Research Institute Scientific Research Project,China(No.2022SX-TD025)。
文摘A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm^(2),reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm^(2).This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture.
基金supported by the earmarked fund for the Modern Agro-Industry Technology Research System (No.CARS-19)the Innovative Research Team in Chinese Academy of Agricultural Sciences (No.CAAS ASTIP-2014-TRICAAS).
文摘Pyrrolizidine alkaloids(PAs)and their N-oxides(PANOs)are phytotoxins produced by various plant species and have been emerged as environmental pollutants.The sorption/desorption behaviors of PAs/PANOs in soil are crucial due to the horizontal transfer of these natural products from PA-producing plants to soil and subsequently absorbed by plant roots.This study firstly investigated the sorption/desorption behaviors of PAs/PANOs in tea plantation soils with distinct characteristics.Sorption amounts for seneciphylline(Sp)and seneciphylline-N-oxide(SpNO)in three acidic soils ranged from 2.9 to 5.9μg/g and 1.7 to 2.8μg/g,respectively.Desorption percentages for Sp and SpNO were from 22.2%to 30.5%and 36.1%to 43.9%.In the mixed PAs/PANOs systems,stronger sorption of PAs over PANOs was occurred in tested soils.Additionally,the Freundlich models more precisely described the sorption/desorption isotherms.Cation exchange capacity,sand content and total nitrogen were identified as major influencing factors by linear regression models.Overall,the soils exhibiting higher sorption capacities for compounds with greater hydrophobicity.PANOs were more likely to migrate within soils and be absorbed by tea plants.It contributes to the understanding of environmental fate of PAs/PANOs in tea plantations and provides basic data and clues for the development of PAs/PANOs reduction technology.
基金supported by the National Natural Science Foundation of China(No.52001034)the China Postdoctoral Science Foundation(No.2023M731677)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_3032).
文摘Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates the preparation of ZnO-containing micro-arc oxidation coatings with dual functionality by incorporating nano-ZnO into MAO electrolyte.The influence of varying ZnO concentrations on the microstructure,corrosion resistance,and antibacterial properties of the coating was examined through microstructure analysis,immersion tests,electrochemical experiments,and antibacterial assays.The findings revealed that the addition of nano-ZnO significantly enhanced the corrosion resistance of the MAO-coated alloy.Specifically,when the ZnO concentration in the electrolyte was 5 g/L,the corrosion rate was more than ten times lower compared to the MAO coatings without ZnO.Moreover,the antibacterial efficacy of ZnO+MAO coating,prepared with a ZnO concentration of 5 g/L,surpassed 95%after 24 h of co-culturing with Staphylococcus aureus(S.aureus).The nano-ZnO+MAO-coated alloy exhibited exceptional degradation resistance,corrosion resistance,and antibacterial effectiveness.
基金funded in part by the German Research Foundation(Grant reference:496846758).
文摘The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.
文摘Objective:This study aimed to examine the reliability and validity of the Chinese version of the Behavioral Inhibition System/Behavioral Activation System(BIS/BAS)scales among stroke survivors.Methods:The cross-sectional study was conducted at four comprehensive hospitals in Taizhou,Jiangsu,China.A sample of 232 first-ever stroke survivors were recruited from June to August 2023.Validity was examined using face validity and construct validity,which used confirmatory factor analysis(CFA)and known-group analysis.Reliability was evaluated by internal consistency and test-retest reliability.Results:The BIS/BAS scales demonstrated satisfactory face validity.The findings of CFAs supported the original four-factor structure of BAS-reward,BAS-drive,BAS-fun seeking,and BIS with acceptable model fit indices.Discriminative validity,assessed via known-group analysis,indicated that stroke survivors with probable depression had significantly lower mean BAS-reward,BAS-drive,and BAS-fun seeking scores(P<0.001)and a higher mean BIS score(P=0.028)compared to those without probable depression.The internal consistency,measured by Cronbach’s a coefficients for the subscales,ranged from 0.669 to 0.964.Test-retest reliability,assessed using intra-class correlation coefficients,ranged from 0.61 to 0.93.Conclusions:The Chinese version of the BIS/BAS scales could be a reliable and valid instrument for measuring behavioral activation among stroke survivors.
基金supported by the National Natural Science Foundation of China(22369011)the Gansu Key Research and Development Program(23YFGA0053 and 24YFGA025)the Hongliu Outstanding Youth Talent Support Program of Lanzhou University of Technology and Postgraduate research exploration project of Lanzhou University of Technology(256017)。
文摘The swelling behavior and stability in solid electrolyte interphase(SEI)have been proved to determine the battery cycle life.A high swollen,unstable SEI shows a high permeability to electrolyte,which results in the rapid battery performance degradation.Here,we customize two SEIs with different spatial structures(bilayer and mosaic)by simply regulating the proportion of additive fluoroethylene carbonate.Surprisingly,due to the uniform distribution of dense inorganic nano-crystals in the inner,the bilayer SEI exhibits low-swelling and excellent mechanical properties,so the undesirable side reactions of the electrolyte are effectively suppressed.In addition,we put forward the growth rate of swelling ratio(GSR)as a key indicator to reveal the swelling change in SEI.The GSR of bilayer SEI merely increases from1.73 to 3.16 after the 300th cycle,which enables the corresponding graphite‖Li battery to achieve longer cycle stability.The capacity retention is improved by 47.5% after 300 cycles at 0.5 C.The correlation among SEI spatial structure,swelling behavior,and battery performance provides a new direction for electrolyte optimization and interphase structure design of high energy density batteries.
基金supported by the National Natural Science Foundation of China(No.51901153)the Natural Science Foundation of Shanxi,China(No.202103021224049)+1 种基金the Shanxi Zhejiang University New Materials and Chemical Research Institute Scientific Research Project,China(No.2022SX-TD025)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University,China(No.2023-DXSSKF-Z02).
文摘The microstructural characterization,corrosion behavior and tensile properties of the extruded lean Mg−1Bi−0.5Sn−0.5In(wt.%)alloy were investigated through scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),X-ray photoelectron spectroscopy(XPS),electrochemical measurements and tensile tests.The results reveal that a microstructure consisting of dynamically recrystallized and deformed grains is obtained.Notably,the investigated alloy exhibits excellent strength−ductility synergy,with tensile yield strength(TYS),ultimate tensile strength(UTS)and elongation(EL)of 254.8 MPa,315.4 MPa,and 25.3%,respectively.Furthermore,in 3.5 wt.%NaCl solution,with the increase of immersion time,the dominant corrosion mechanism of the studied alloy transforms from pitting corrosion to filiform corrosion.After the immersion for 24 h,a composite oxide film(SnO2−Bi2O3−In2O3)is formed,which delays the corrosion process,and the corrosion rate(PH=1.53 mm/a)is finally stabilized.
基金supported by the Foundation Strengthening Plan Technical Field Fund(No.2021-JJ-0112)Major Scientific and Technological Innovation Project of Luoyang(No.2201029A)+1 种基金National Science and Technology Innovation Special Zone(No.02-14-01)National Natural Science Foundation of China(No.U2037601).
文摘In this work,the aging response and mechanism of dual-phase Mg-Li-Al-Zn alloy at various temperatures are investigated.The results show that the strengthening after quenching is primarily attributed to the immediate precipitation of the semi-coherent~Mg_(3)Zn phase.The aging softening of the studied alloy is mainly caused by the rapid transformation of the strengthening~Mg_(3)Zn phase to the softening MgLi(Al,Zn)phase,along with the coarsening of theα-Mg matrix and precipitates withinβ-Li matrix.Further analysis indicates that the quick precipitation and transformation of~Mg_(3)Zn is a consequence of the high diffusion rate of solute atoms,resulting from dense vacancy concentration in theβ-Li matrix.This research bridges a critical gap in the study of aging mechanism in the dual-phase Mg-Li-Al-Zn alloy,providing a theoretical basis for the development and application of high-performance and thermal-stable Mg-Li alloys.
