The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcriptio...The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcription,protein phosphorylation,cell proliferation,survival,differentiation and motility,and Ca 2+ homeostasis,by interacting with a wide array of proteins(i.e.,enzymes,enzyme substrates,cytoskeletal subunits,scaffold/adaptor proteins,transcription factors,ubiquitin E3 ligases,ion channels) in a restricted number of cell types.As an extracellular signal,S100B engages the pattern recognition receptor,receptor for advanced glycation end-products(RAGE),on immune cells as well as on neuronal,astrocytic and microglial cells,vascular smooth muscle cells,skeletal myoblasts and cardiomyocytes.However,RAGE may not be the sole receptor activated by S100B,the protein being able to enhance bFGF-FGFR1 signaling by interacting with FGFR1-bound bFGF in particular cell types.Moreover,extracellular effects of S100B vary depending on its local concentration.Increasing evidence suggests that at the concentration found in extracellular fluids in normal physiological conditions and locally upon acute tissue injury,which is up to a few nM levels,S100B exerts trophic effects in the central and peripheral nervous system and in skeletal muscle tissue thus participating in tissue homeostasis.The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development,repair and regeneration.展开更多
China shipbuilding industry has shown its strong development trend at the beginning of the new century. It has entered a new stage of rapid developmentChina shipbuilding industry has achieved continuous development in...China shipbuilding industry has shown its strong development trend at the beginning of the new century. It has entered a new stage of rapid developmentChina shipbuilding industry has achieved continuous development in the past 20 years since the beginning of opening up and reforming. China展开更多
This paper introduces the system structure and work principle of the upgraded real time information system in Wangting Power Plant, and then expounds the realization way and function features of this system on B/S co...This paper introduces the system structure and work principle of the upgraded real time information system in Wangting Power Plant, and then expounds the realization way and function features of this system on B/S computing mode. The results of field application show the new system has good capability, reliability and expandability.展开更多
Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market...Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market economic system emerges,China is basically qualified to link up withcustomary international trade rules.In the Ninth Five-Year Plan period,China’s reform of its foreigntrade system aims at setting up a trade system that conforms with international trade practice.Forthe purpose,the author of this article suggests that a neutral trade policy should be adopted inaccordance with the international practice since it does not hinder exports,nor restrict imports toan excessive degree.展开更多
Vice-Minister Ye Rutang,ofConstruction,has said that inthe Ninth Five-Year Plan(NFYP)period,China’s constructionundertakings will promote thetransformation of economic systemand growth mode and conscientiouslyimpleme...Vice-Minister Ye Rutang,ofConstruction,has said that inthe Ninth Five-Year Plan(NFYP)period,China’s constructionundertakings will promote thetransformation of economic systemand growth mode and conscientiouslyimplement the strategy of initiatingscience and education,with thepromotion of the development of thebuilding industry as the mainstream,with the acceleration of theconstruction of houses in urban andrural areas,public facilities and keyprojects construction as focal points,with the cultivation andstandardization of the constructionmarket as a base,and with theintensification of the control andmanagement as a means,to whichend we should constantly deepenthe reform,expand the opening tothe outside world,persist in stressingboth civil construction,fulfill eachtask of construction at a high leveland on a safe and highly efficientbasis and make a due contributionto promoting the sustained,rapidand healthy development of thenational economy andcomprehensive socia progress.展开更多
Since the launch of the economic reform and opening to the outside world, China has seen rapid growth in its export of mechanical and electrical products, with its export
基金Supported by Ministero dell'Università e della Ricerca,No. PRIN 2007LNKSYS,No.2007AWZTHH_004 and No.2009WBFZYM_002Association Fran aise contre les Myopathies,No. Project 12992+1 种基金Associazione Italiana per la Ricerca sul Cancro,No. Project 6021Fondazione Cassa di Risparmio di Perugia,No. 2007.0218.020,No.2009.020.0021 and No.2012.0241.021
文摘The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcription,protein phosphorylation,cell proliferation,survival,differentiation and motility,and Ca 2+ homeostasis,by interacting with a wide array of proteins(i.e.,enzymes,enzyme substrates,cytoskeletal subunits,scaffold/adaptor proteins,transcription factors,ubiquitin E3 ligases,ion channels) in a restricted number of cell types.As an extracellular signal,S100B engages the pattern recognition receptor,receptor for advanced glycation end-products(RAGE),on immune cells as well as on neuronal,astrocytic and microglial cells,vascular smooth muscle cells,skeletal myoblasts and cardiomyocytes.However,RAGE may not be the sole receptor activated by S100B,the protein being able to enhance bFGF-FGFR1 signaling by interacting with FGFR1-bound bFGF in particular cell types.Moreover,extracellular effects of S100B vary depending on its local concentration.Increasing evidence suggests that at the concentration found in extracellular fluids in normal physiological conditions and locally upon acute tissue injury,which is up to a few nM levels,S100B exerts trophic effects in the central and peripheral nervous system and in skeletal muscle tissue thus participating in tissue homeostasis.The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development,repair and regeneration.
文摘China shipbuilding industry has shown its strong development trend at the beginning of the new century. It has entered a new stage of rapid developmentChina shipbuilding industry has achieved continuous development in the past 20 years since the beginning of opening up and reforming. China
文摘This paper introduces the system structure and work principle of the upgraded real time information system in Wangting Power Plant, and then expounds the realization way and function features of this system on B/S computing mode. The results of field application show the new system has good capability, reliability and expandability.
文摘Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market economic system emerges,China is basically qualified to link up withcustomary international trade rules.In the Ninth Five-Year Plan period,China’s reform of its foreigntrade system aims at setting up a trade system that conforms with international trade practice.Forthe purpose,the author of this article suggests that a neutral trade policy should be adopted inaccordance with the international practice since it does not hinder exports,nor restrict imports toan excessive degree.
文摘Vice-Minister Ye Rutang,ofConstruction,has said that inthe Ninth Five-Year Plan(NFYP)period,China’s constructionundertakings will promote thetransformation of economic systemand growth mode and conscientiouslyimplement the strategy of initiatingscience and education,with thepromotion of the development of thebuilding industry as the mainstream,with the acceleration of theconstruction of houses in urban andrural areas,public facilities and keyprojects construction as focal points,with the cultivation andstandardization of the constructionmarket as a base,and with theintensification of the control andmanagement as a means,to whichend we should constantly deepenthe reform,expand the opening tothe outside world,persist in stressingboth civil construction,fulfill eachtask of construction at a high leveland on a safe and highly efficientbasis and make a due contributionto promoting the sustained,rapidand healthy development of thenational economy andcomprehensive socia progress.
文摘Since the launch of the economic reform and opening to the outside world, China has seen rapid growth in its export of mechanical and electrical products, with its export
