A novel hydrangea-like boron and nitrogen co-doped carbon material synthesised by the cross-linking reaction of spiny spherical polymers and co-doped with boron and nitrogen(B/N)via high-temperature calcination was us...A novel hydrangea-like boron and nitrogen co-doped carbon material synthesised by the cross-linking reaction of spiny spherical polymers and co-doped with boron and nitrogen(B/N)via high-temperature calcination was used to construct an electrochemical sensor for the detection of aristolochic acid.Under optimal conditions,the sensor showed good electrochemical response to aristolochic acid,with a theoretical detection limit of 47.3 nmol/L and the sensitivity reaching 0.31μA Lμmol^(-1)cm^(-2).Moreover,the sensor was successfully applied to the detection of aristolochic acid in the extracts of Chinese herbal medicine samples,and the detection results were consistent with those of high-performance liquid chromatography.With a strong selectivity for substances to be measured in complex environments,this study provides a new and efficient method by which to detect aristolochic acid in Chinese herbal medicine,which greatly expands the application field of B/N heteroatom-doped carbon materials.展开更多
2022年中央一号文件《中共中央国务院关于做好2022年全面推进乡村振兴重点工作的意见》明确要求大力推进数字农业建设,推进智慧农业发展;2022年12月23日至24日中央农村工作会议上习近平总书记指出“产业振兴是乡村振兴的重中之重,要落...2022年中央一号文件《中共中央国务院关于做好2022年全面推进乡村振兴重点工作的意见》明确要求大力推进数字农业建设,推进智慧农业发展;2022年12月23日至24日中央农村工作会议上习近平总书记指出“产业振兴是乡村振兴的重中之重,要落实产业帮扶政策,做好‘土特产’文章,依托农业农村特色资源,向开发农业多种功能、挖掘乡村多元价值要效益,向一二三产业融合发展要效益,强龙头、补链条、兴业态、树品牌,推动乡村产业全链条升级,增强市场竞争力和可持续发展能力”。本文深刻领会习近平总书记、中央一号文件、中共浙江省委十五届二次全会精神,通过深入总结嘉兴与丽水近二十年开展“山海协作”的成功经验,并针对嘉兴与丽水联动发展特色农业产业链目前遇到的种养技术、销售模式、专家团队、高技能人才等瓶颈,提出构建“嘉兴农产品专业市场与丽水种养基地联动发展特色农业产业链的‘W2F+B2M’(Wholesale to Farmer+Business to Member,即嘉兴农产品专业市场与丽水种养基地+嘉兴专业市场商户与商户的会员联动)模式”,进一步完善嘉兴与丽水特色农业产业链的联动发展机制,助推嘉兴与丽水共同富裕。展开更多
Small-sized,low-cost,and high-sensitivity sensors are required for pressure-sensing applications because of their critical role in consumer electronics,automotive applications,and industrial environments.Thus,micro/na...Small-sized,low-cost,and high-sensitivity sensors are required for pressure-sensing applications because of their critical role in consumer electronics,automotive applications,and industrial environments.Thus,micro/nanoscale pressure sensors based on micro/nanofabrication and micro/nanoelectromechanical system technologies have emerged as a promising class of pressure sensors on account of their remarkable miniaturization and performance.These sensors have recently been developed to feature multifunctionality and applicability to novel scenarios,such as smart wearable devices and health monitoring systems.In this review,we summarize the major sensing principles used in micro/nanoscale pressure sensors and discuss recent progress in the development of four major categories of these sensors,namely,novel material-based,flexible,implantable,and selfpowered pressure sensors.展开更多
A novel, rapid and simple CdTe quantum dots （QDs） based technology platform was established for selective and sensitive determination of vitamin B6 in aqueous solution. It can perform accurate and reproducible quant...A novel, rapid and simple CdTe quantum dots （QDs） based technology platform was established for selective and sensitive determination of vitamin B6 in aqueous solution. It can perform accurate and reproducible quantification of vitamin B6 in pharmaceutical with satisfactory results.展开更多
The capability of embedded piezoelectric wafer active sensors(PWAS)to perform in-situ nondestructive evaluation(NDE)for structural health monitoring(SHM)of reinforced concrete(RC)structures strengthened with fiber rei...The capability of embedded piezoelectric wafer active sensors(PWAS)to perform in-situ nondestructive evaluation(NDE)for structural health monitoring(SHM)of reinforced concrete(RC)structures strengthened with fiber reinforced polymer(FRP)composite overlays is explored.First,the disbond detection method were developed on coupon specimens consisting of concrete blocks covered with an FRP composite layer.It was found that the presence of a disbond crack drastically changes the electromecfianical(E/M)impedance spectrum lneasurcd at the PWAS terlninals.The spectral changes depend on the distance between the PWAS and the crack tip.Second,large scale experiments were conducted on a RC beam strengthened with carbon fiber reinforced polymer(CFRP)composite overlay.The beam was subject to an accelerated fatigue load regime in a three-point bending configuration up to a total of 807,415 cycles.During these fatigue tests,the CFRP overlay experienced disbonding beginning at about 500,000 cycles.The PWAS were able to detect the disbonding before it could be reliably seen by visual inspection.Good correlation between the PWAS readings and the position and extent of disbond damage was observed.These preliminary results demonstrate the potential of PWAS technology for SHM of RC structures strengthened with FRP composite overlays.展开更多
NORHA,a long non-coding RNA(lncRNA),serves as a key inducer of follicular atresia in sows by triggering granulosa cells(GCs)apoptosis.However,its regulation by N6-methyladenosine(m6A)-the most abundant RNA modificatio...NORHA,a long non-coding RNA(lncRNA),serves as a key inducer of follicular atresia in sows by triggering granulosa cells(GCs)apoptosis.However,its regulation by N6-methyladenosine(m6A)-the most abundant RNA modification-remains unresolved.This study identified NORHA as a functional target of the m6A reader HNRNPA2B1 in sow GCs(sGCs).Transcriptome-wide mapping of RNA modification sites revealed extensive m6A enrichment on NORHA,with HNRNPA2B1 binding directly to the transcript and enhancing its stability via modification of multiple m6A sites,including A261,A441,and A919.HNRNPA2B1 suppressed 17β-estradiol(E2)biosynthesis and promoted sGC apoptosis by activating the NORHA-FoxO1 axis.FoxO1 subsequently repressed expression of cytochrome P450 family 19 subfamily A member 1(CYP19A1),which encodes the enzyme essential for E2 biosynthesis.Additionally,HNRNPA2B1 functioned as a critical mediator of METTL3-dependent m6A modification,modulating NORHA expression and activity in sGCs.This study highlights an important m6Adependent regulatory mechanism governing NORHA expression in sGCs.展开更多
M-health, which is known as the practice of medical and public health supported by mobile devices such as mobile phones and PDAs for delivering medical and healthcare services, is currently being heavily developed to ...M-health, which is known as the practice of medical and public health supported by mobile devices such as mobile phones and PDAs for delivering medical and healthcare services, is currently being heavily developed to keep pace with the continuously rising demand for personalized healthcare. To this end, the MobiHealthcare system, which provides a personalized healthcare based on body sensor network, is developed. The system includes various body sensors to collect physiological signals specifically for different requirements, a cell phone to facilitate the joint processing of spatially and temporally collected medical data from different parts of the body for resource optimization and systematic health monitoring, a server cluster with great data storage capacity, powerful analysis capabilities to provide data storage, data mining and visualization. Compared with existing M-Health system, the MobiHealthcare system is characteristics of low coupling and powerful parallel computing capabilities. Various healthcare applications have been implemented in the proposed system to demonstrate its effectiveness in providing a powerful platform.展开更多
A rhodamine-benzimidazole conjugate （RB） as a probe was investigated. UV-Vis analysis showed that a strong absorption band at 552 nm was formed with the addition of Cu^2＋, while other transition metal ions induced ...A rhodamine-benzimidazole conjugate （RB） as a probe was investigated. UV-Vis analysis showed that a strong absorption band at 552 nm was formed with the addition of Cu^2＋, while other transition metal ions induced a little more absorption. The absorption value of RB solution at 552 nm has a linear correlation with Cu^2＋ concentration between 35-70 μmol/L; the detection limit reached 6.82x 10-2 gmol/L, which is lower than the settled limitation for copper in the drinking water （-30 μmol/L） standardized by World Health Organization （WHO）. Moreover, FL analysis showed that only Fe^3＋ could induce large fluorescence intensity enhance- ment at 582 nm; other common metal ions including Cu^2＋ cannot induce the enhancement. There was a good linear correlation be Fe^3＋ tween relatwe fluorescence ntenslty and Fe concentration ranging from 2 μmol/L to 20 μmol/L, and the detection limit reached 1.70×10^-2 μmol/L. The results showed that RB could detect Cu^2＋ and Fe^3＋ simultaneously, with the UV-Vis and fluorescence spectroscopy, respectively.展开更多
This paper presents the studying results of the sodium ion sensor device based on the SnO_2/ITO glass structure in the detection of rinsing solution for contact lenses.The selective membrane contains poly (vinyl chlor...This paper presents the studying results of the sodium ion sensor device based on the SnO_2/ITO glass structure in the detection of rinsing solution for contact lenses.The selective membrane contains poly (vinyl chloride) (PVC),bis (2-ethylhexyl) sebacate (DOS),(12-crown-4) methylmalonate (B12C4),and sodium tetrakis (4-fluoropbenyl) borate dehydrate (NaTFBD). The final weight ratios are PVC:DOS:B12C4:NaTFBD=33:66:2:2.In this condition,the sensor has performances with linear sensitivity,short response time,good repeatability and selectivity.The sensor was used to measure the rinsing solution for the contact lenses.Because the experimental results show close to the accurate value for four commercial products,this sensor can preliminary be used in detecting the rinsing solution for the contact lenses.Using this structure and sodium-sensing membrane to construct the sodium sensor is proven successfully in this application.展开更多
基金funded by the National Natural Science Foundation of China(No.22476170)Science and Technology Talent and Platform Program of Yunnan Provincial Science and Technology Department(No.202505AW340011)。
文摘A novel hydrangea-like boron and nitrogen co-doped carbon material synthesised by the cross-linking reaction of spiny spherical polymers and co-doped with boron and nitrogen(B/N)via high-temperature calcination was used to construct an electrochemical sensor for the detection of aristolochic acid.Under optimal conditions,the sensor showed good electrochemical response to aristolochic acid,with a theoretical detection limit of 47.3 nmol/L and the sensitivity reaching 0.31μA Lμmol^(-1)cm^(-2).Moreover,the sensor was successfully applied to the detection of aristolochic acid in the extracts of Chinese herbal medicine samples,and the detection results were consistent with those of high-performance liquid chromatography.With a strong selectivity for substances to be measured in complex environments,this study provides a new and efficient method by which to detect aristolochic acid in Chinese herbal medicine,which greatly expands the application field of B/N heteroatom-doped carbon materials.
文摘2022年中央一号文件《中共中央国务院关于做好2022年全面推进乡村振兴重点工作的意见》明确要求大力推进数字农业建设,推进智慧农业发展;2022年12月23日至24日中央农村工作会议上习近平总书记指出“产业振兴是乡村振兴的重中之重,要落实产业帮扶政策,做好‘土特产’文章,依托农业农村特色资源,向开发农业多种功能、挖掘乡村多元价值要效益,向一二三产业融合发展要效益,强龙头、补链条、兴业态、树品牌,推动乡村产业全链条升级,增强市场竞争力和可持续发展能力”。本文深刻领会习近平总书记、中央一号文件、中共浙江省委十五届二次全会精神,通过深入总结嘉兴与丽水近二十年开展“山海协作”的成功经验,并针对嘉兴与丽水联动发展特色农业产业链目前遇到的种养技术、销售模式、专家团队、高技能人才等瓶颈,提出构建“嘉兴农产品专业市场与丽水种养基地联动发展特色农业产业链的‘W2F+B2M’(Wholesale to Farmer+Business to Member,即嘉兴农产品专业市场与丽水种养基地+嘉兴专业市场商户与商户的会员联动)模式”,进一步完善嘉兴与丽水特色农业产业链的联动发展机制,助推嘉兴与丽水共同富裕。
基金the National Natural Science Foundation of China(NSFC Nos.61674114,91743110,21861132001)National Key Research and Development Program of China(No.2017YFF0204604)+2 种基金Tianjin Applied Basic Research and Advanced Technology(No.17JCJQJC43600)the Foundation for Talent Scientists of Nanchang Institute for Microtechnology of Tianjin Universitythe 111 Project(No.B07014).
文摘Small-sized,low-cost,and high-sensitivity sensors are required for pressure-sensing applications because of their critical role in consumer electronics,automotive applications,and industrial environments.Thus,micro/nanoscale pressure sensors based on micro/nanofabrication and micro/nanoelectromechanical system technologies have emerged as a promising class of pressure sensors on account of their remarkable miniaturization and performance.These sensors have recently been developed to feature multifunctionality and applicability to novel scenarios,such as smart wearable devices and health monitoring systems.In this review,we summarize the major sensing principles used in micro/nanoscale pressure sensors and discuss recent progress in the development of four major categories of these sensors,namely,novel material-based,flexible,implantable,and selfpowered pressure sensors.
基金the National Natural Science Foundation of China (No.20275014)for financially supporting this work.
文摘A novel, rapid and simple CdTe quantum dots （QDs） based technology platform was established for selective and sensitive determination of vitamin B6 in aqueous solution. It can perform accurate and reproducible quantification of vitamin B6 in pharmaceutical with satisfactory results.
基金the National Seienee Foundation through grants NSF#CMS-9908293 and NSF INT-9904493the Federal Highway Administration and the South Carolina Department of TransPortation(projeet Number 614)
文摘The capability of embedded piezoelectric wafer active sensors(PWAS)to perform in-situ nondestructive evaluation(NDE)for structural health monitoring(SHM)of reinforced concrete(RC)structures strengthened with fiber reinforced polymer(FRP)composite overlays is explored.First,the disbond detection method were developed on coupon specimens consisting of concrete blocks covered with an FRP composite layer.It was found that the presence of a disbond crack drastically changes the electromecfianical(E/M)impedance spectrum lneasurcd at the PWAS terlninals.The spectral changes depend on the distance between the PWAS and the crack tip.Second,large scale experiments were conducted on a RC beam strengthened with carbon fiber reinforced polymer(CFRP)composite overlay.The beam was subject to an accelerated fatigue load regime in a three-point bending configuration up to a total of 807,415 cycles.During these fatigue tests,the CFRP overlay experienced disbonding beginning at about 500,000 cycles.The PWAS were able to detect the disbonding before it could be reliably seen by visual inspection.Good correlation between the PWAS readings and the position and extent of disbond damage was observed.These preliminary results demonstrate the potential of PWAS technology for SHM of RC structures strengthened with FRP composite overlays.
基金supported by the National Natural Science Foundation of China(32072693)Fundamental Research Funds for the Central Universities(KYLH2025010)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX24-0994)。
文摘NORHA,a long non-coding RNA(lncRNA),serves as a key inducer of follicular atresia in sows by triggering granulosa cells(GCs)apoptosis.However,its regulation by N6-methyladenosine(m6A)-the most abundant RNA modification-remains unresolved.This study identified NORHA as a functional target of the m6A reader HNRNPA2B1 in sow GCs(sGCs).Transcriptome-wide mapping of RNA modification sites revealed extensive m6A enrichment on NORHA,with HNRNPA2B1 binding directly to the transcript and enhancing its stability via modification of multiple m6A sites,including A261,A441,and A919.HNRNPA2B1 suppressed 17β-estradiol(E2)biosynthesis and promoted sGC apoptosis by activating the NORHA-FoxO1 axis.FoxO1 subsequently repressed expression of cytochrome P450 family 19 subfamily A member 1(CYP19A1),which encodes the enzyme essential for E2 biosynthesis.Additionally,HNRNPA2B1 functioned as a critical mediator of METTL3-dependent m6A modification,modulating NORHA expression and activity in sGCs.This study highlights an important m6Adependent regulatory mechanism governing NORHA expression in sGCs.
文摘M-health, which is known as the practice of medical and public health supported by mobile devices such as mobile phones and PDAs for delivering medical and healthcare services, is currently being heavily developed to keep pace with the continuously rising demand for personalized healthcare. To this end, the MobiHealthcare system, which provides a personalized healthcare based on body sensor network, is developed. The system includes various body sensors to collect physiological signals specifically for different requirements, a cell phone to facilitate the joint processing of spatially and temporally collected medical data from different parts of the body for resource optimization and systematic health monitoring, a server cluster with great data storage capacity, powerful analysis capabilities to provide data storage, data mining and visualization. Compared with existing M-Health system, the MobiHealthcare system is characteristics of low coupling and powerful parallel computing capabilities. Various healthcare applications have been implemented in the proposed system to demonstrate its effectiveness in providing a powerful platform.
基金Supported by National Natural Science Foundation of China(20901063,51203127)Wuhan Chenguang Scheme(Grant 201050231049)established under Wuhan Science and Technology BureauOutstanding youth project of Hubei Provincial Department of Education(20121509)
文摘A rhodamine-benzimidazole conjugate （RB） as a probe was investigated. UV-Vis analysis showed that a strong absorption band at 552 nm was formed with the addition of Cu^2＋, while other transition metal ions induced a little more absorption. The absorption value of RB solution at 552 nm has a linear correlation with Cu^2＋ concentration between 35-70 μmol/L; the detection limit reached 6.82x 10-2 gmol/L, which is lower than the settled limitation for copper in the drinking water （-30 μmol/L） standardized by World Health Organization （WHO）. Moreover, FL analysis showed that only Fe^3＋ could induce large fluorescence intensity enhance- ment at 582 nm; other common metal ions including Cu^2＋ cannot induce the enhancement. There was a good linear correlation be Fe^3＋ tween relatwe fluorescence ntenslty and Fe concentration ranging from 2 μmol/L to 20 μmol/L, and the detection limit reached 1.70×10^-2 μmol/L. The results showed that RB could detect Cu^2＋ and Fe^3＋ simultaneously, with the UV-Vis and fluorescence spectroscopy, respectively.
文摘This paper presents the studying results of the sodium ion sensor device based on the SnO_2/ITO glass structure in the detection of rinsing solution for contact lenses.The selective membrane contains poly (vinyl chloride) (PVC),bis (2-ethylhexyl) sebacate (DOS),(12-crown-4) methylmalonate (B12C4),and sodium tetrakis (4-fluoropbenyl) borate dehydrate (NaTFBD). The final weight ratios are PVC:DOS:B12C4:NaTFBD=33:66:2:2.In this condition,the sensor has performances with linear sensitivity,short response time,good repeatability and selectivity.The sensor was used to measure the rinsing solution for the contact lenses.Because the experimental results show close to the accurate value for four commercial products,this sensor can preliminary be used in detecting the rinsing solution for the contact lenses.Using this structure and sodium-sensing membrane to construct the sodium sensor is proven successfully in this application.
