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Profiles of Parent-Child Attachment and Peer Attachment among Adolescents and Associations with Internalizing Problems
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作者 Chao Qu Xiaoshan Jia Haidong Zhu 《International Journal of Mental Health Promotion》 2025年第3期401-420,共20页
Objectives:Attachment is a profound and enduring connection to the emotion children progressively form with their parents as they mature.It significantly impacts the social and psychological development of kids and te... Objectives:Attachment is a profound and enduring connection to the emotion children progressively form with their parents as they mature.It significantly impacts the social and psychological development of kids and teenagers.This study aimed to explore the latent profiles and longitudinal transition patterns of parent-child and peer attachments among adolescents.Methods:A cohort of 914 participants from China completed the measures with a twelve-month interval.There were 46.8%boys and 53.2%girls in this survey.Latent profile analysis(LPA)was adopted to explore the distinct profiles reflecting different parent-child and peer attachment response patterns at each time point.Latent transition analysis(LTA)was used to examine the membership of distinct latent profiles and how individuals move between profiles over time.Results:Three latent profiles were found:the poor parent-child communication profile,the moderate attachment profile,and the good attachment profile.It was shown that the transition probability from the poor parent-child communication and good attachment profiles to the moderate attachment profile was higher than the transition probability between the poor parent-child communication and good attachment profiles.Patterns of parent-child and peer attachments were associated with depression and anxiety.Conclusion:This study demonstrates differences in adolescents’attachment to fathers,mothers,and peers and the need for targeted interventions for groups of adolescents with moderate levels of parent-child and peer attachment. 展开更多
关键词 Parent-child attachment peer attachment ADOLESCENCE latent profile analysis latent transition analysis
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Determining Dynamic Influence of Human and Machine System on Live-Streaming Addiction:Critical Mediating Mechanisms of Emotional and Functional Attachment
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作者 Hua Pang Xiaoyi Jin 《International Journal of Mental Health Promotion》 2025年第11期1709-1728,共20页
Background:Live streaming has become a globally prevalent form of digital entertainment,particularly among young audiences,fostering new modes of online engagement through real-time interaction.However,excessive use m... Background:Live streaming has become a globally prevalent form of digital entertainment,particularly among young audiences,fostering new modes of online engagement through real-time interaction.However,excessive use may lead to addictive behaviors in certain users.Current research on live-streaming addiction remains limited,with prior studies focusing primarily on socio-psychological drivers rather than the role of technological affordances.To address this gap,this study develops a conceptual model based on socio-technical systems and attachment theory to investigate how emotional and functional attachment mediate the relationship between platform features and addictive behavior.Methods:A total of 533 valid responses were collected in a cross-sectional survey(mean age=26.4 years,standard deviation[SD]=4.7;53.8%female).Data were analyzed using structural equation modeling(SEM)to test the hypothesized relationships.Additionally,the potential mediating effects of emotional and functional attachment between the platform features and live-streaming addiction were examined using the Bootstrap method.Results:Social factors(perceived interactivity,β=0.204,p<0.001;perceived confirmation,β=0.379,p<0.001)and technical factors(perceived customization,β=0.227,p<0.001;perceived amusement,β=0.252,p<0.001;vicarious expression,β=0.352,p<0.001)significantly strengthen both emotional and functional attachment,which in turn positively predict live-streaming addiction(emotional attachment:β=0.468,p<0.001;functional attachment:β=0.393,p<0.001).Furthermore,emotional attachment exerted a stronger influence on addiction than functional attachment.Conclusions:These findings deepen the understanding of live-streaming addiction by integrating socio-technical perspectives and offer practical implications for stakeholders to mitigate negative outcomes through effective strategies. 展开更多
关键词 Perceived interactivity perceived confirmation emotional attachment functional attachment live-streaming addiction
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Self-Esteem as a Mediator:Analyzing Its Impact on Parental Attachment and Adolescent Delinquency
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作者 Mahshid Manouchehri Musheer A.Aljaberi +3 位作者 Yi-Ching Lin Aiche Sabah Amira Mohammed Ali Chung-Ying Lin 《International Journal of Mental Health Promotion》 2025年第7期1013-1028,共16页
Background:While various factors contributing to delinquency have been explored,the role of selfesteem in this specific context has received little attention.Hence,this study aims to investigate the complex issue of a... Background:While various factors contributing to delinquency have been explored,the role of selfesteem in this specific context has received little attention.Hence,this study aims to investigate the complex issue of adolescent delinquency in Iran by focusing on the mediating role of self-esteem in the relationship between parental attachment and delinquent behavior.Methods:Using the multistage cluster random sampling method,the research involved 528 high school students in Tehran.Each student completed validated scales assessing their parental attachment,self-esteem,and delinquency at school.Multiple regression analyses with the Sobel test and bootstrappingmethod were used to examine mediated effects.Results:Thefindings reveal that self-esteem significantly mediates the relationship betweenmaternal attachment and delinquency(standardized coefficient=−0.0292;p=0.04).Adolescents with secure maternal attachments tend to exhibit higher self-esteem,which reduces the likelihood of delinquent behavior.In contrast,paternal attachment did not show a significant mediating effect in this study.These results underscore the importance of cultivating secure maternal relationships and fostering positive self-esteem to address adolescent delinquency.Conclusion:The study suggests that targeted interventions that strengthen maternal attachment and boost self-esteem could effectively mitigate delinquent behaviors among Iranian adolescents.These interventions should prioritize the emotional support and value of secure maternal bonds as key factors in promoting healthy adolescent development. 展开更多
关键词 ADOLESCENT DELINQUENCY maternal attachments parental influence paternal attachments SELF-ESTEEM
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Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures:An in vitro study
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作者 Radha Chauhan Narendra Padiyar +2 位作者 Pragati Kaurani Ajay Gupta Sachin Chauhan 《World Journal of Methodology》 2025年第3期114-123,共10页
BACKGROUND The primary issue in managing edentulous patients is the severely resorbed mandibular ridge,particularly in older individuals with diminished adaptive capacities.This compromised situation leads to the fabr... BACKGROUND The primary issue in managing edentulous patients is the severely resorbed mandibular ridge,particularly in older individuals with diminished adaptive capacities.This compromised situation leads to the fabrication of inadequate dentures that lack retention and stability,potentially causing psychosocial issues.AIM To determine the difference in retentive capacity between three attachment systems in implant-retained overdentures.METHODS Three edentulous mandibular models were fabricated using heat-cured polymethacrylate resin,with two implant replicas placed in the intra-foraminal region of each model.30 acrylic resin mandibular overdentures were fabricated with provisions for three different overdenture attachment systems:A prefabricated ball/O-ring attachment,a locator attachment system,and an equator attachment system.Each model was subjected to 15000 pulls using a universal testing machine to remove the overdenture from the acrylic model and the force data were recorded.RESULTS The ball/O-ring attachment system demonstrated superior retentive capacity for 15 years,while the locator and equator attachment systems maintained excellent retentive capacity for 5 years.CONCLUSION The ball/O-ring attachment system outperformed better than the other two attachment systems regarding retentive capacity.The locator and equator attachment systems presented sufficient retentive abilities until 15000 cycles.After 7500 cycles,significant differences in retentive force between the systems evolved. 展开更多
关键词 DENTURES Overdenture attachment systems EQUATOR Dislodging cycles Retentive capacity
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Childhood Environmental Unpredictability and Psychopathy:Mediating Roles of Insecure Attachment and Life History Strategy
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作者 Fengbo Guo Leru Zhong +2 位作者 Xingru Huang Zewei Chen Xiaoyuan Sun 《International Journal of Mental Health Promotion》 2025年第2期111-124,共14页
Background:Childhood environmental unpredictability(CEU)is crucial to personal development,profoundly influence physical and psychological growth particularly,and psychopathy is recognized as a dark personality trait.... Background:Childhood environmental unpredictability(CEU)is crucial to personal development,profoundly influence physical and psychological growth particularly,and psychopathy is recognized as a dark personality trait.The aim of this study is to investigate the effects of insecure attachment and life history strategy(LHS)on the relationship between CEU and psychopathy by establishing a sequential mediation model based on evolutionary life history theory and cognitive-affective personality system.Methods:A group of 532 undergraduates completed the measurements for CEU,insecure attachment,LHS,and psychopathy,and Bootstrap mediation test through SPSS 25.0 and PROCESS macro tool was used to examine the relationship among these variables.Results:The results revealed positive relations between CEU and insecure attachment(β=0.87,p<0.001),CEU and LHS(β=0.11,p<0.001),and CEU and psychopathy(β=0.14,p<0.001).Insecure attachment was also positively associated with LHS(β=0.62,p<0.001)and psychopathy(β=0.04,p<0.001).In addition,LHS was significantly associated with psychopathy(β=0.08,p<0.001).The relationship between CEU and psychopathy is mediated independently and sequentially by insecure attachment and LHS.Conclusion:The current research shows the relationship between CEU and psychopathy,as well as the mechanism of insecure attachment and life history strategy as mediators. 展开更多
关键词 Childhood environmental unpredictability PSYCHOPATHY insecure attachment life history strategy mediating effect
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Antigenic and structural insights into Langya henipavirus attachment glycoprotein
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作者 Yaohui Li Xiaoyan Huang +7 位作者 Xiaodong Zai Chenfeng Mao Ruihua Li Yamei Feng Yue Zhang Zhang Zhang Jun Zhang Junjie Xu 《Virologica Sinica》 2025年第5期769-777,共9页
The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment(G)and fusion(F)glycoproteins with receptors on the cell surface.Langya henipavirus(LayV)was newly identifie... The invasion of host cells by the henipavirus is facilitated through the interaction between viral attachment(G)and fusion(F)glycoproteins with receptors on the cell surface.Langya henipavirus(LayV)was newly identified in China in 2022.The G proteins of LayV and Mojiang virus(MojV)exhibit high amino acid homology(86%),while they are located in a unique evolutionary clade within the Henipavirus genus.In this study,the crystal structure of the LayV G protein was resolved at a 3.37Åresolution,revealing a head domain with sixβ-propeller-like domains distinct from other henipavirus G proteins,such as those of Nipah virus(NiV)and Hendra virus(HeV).Furthermore,the prominent loop in the center cavity of the LayV G protein showed unique structural features.In the ELISA and SPR assays,the LayV G protein was unable to bind to the existing henipavirus-neutralizing antibodies or the ephrin-B2 receptor.Immunogenicity studies in mice demonstrated robust antibody responses elicited by the LayV G protein.These antibodies exhibited strong reactivity against both LayV and MojV G proteins.However,only weak cross-reactivity was observed with other henipaviruses.Moreover,eight monoclonal antibodies targeting the LayV G protein were generated,two of which exhibited broad binding activity across different henipavirus G proteins.These findings underscore the need for tailored vaccines and therapeutics for LayV and related novel henipaviruses. 展开更多
关键词 Langya henipavirus(LayV) attachment glycoprotein Crystal structure GLYCOSYLATION IMMUNOGENICITY Monoclonal antibodies
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Perceived value,awe,and place attachment:Influencing tourists'environmentally responsible behavior in desert tourism
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作者 Shan Huang LiJuan Shi +3 位作者 DanHua Sheng TianTian He Xing Guo JianHua Xiao 《Research in Cold and Arid Regions》 2025年第4期261-268,共8页
This study explores the impact of perceived value,awe,and place attachment on tourists'environmentally responsible behavior(ERB)in desert tourism contexts,using the Singing Sands Mountain and Crescent Spring sceni... This study explores the impact of perceived value,awe,and place attachment on tourists'environmentally responsible behavior(ERB)in desert tourism contexts,using the Singing Sands Mountain and Crescent Spring scenic area in Dunhuang,China as a case study.Data were collected from 315 tourists using a structured questionnaire and analyzed through a structural equation model.Results show that perceived value and awe significantly influence ERB both directly and indirectly via place attachment.Specifically,perceived value has a stronger direct effect on ERB compared to awe,highlighting the importance of tourists'overall evaluation of the destination in promoting sustainable behaviors.The mediating role of place attachment underscores the significance of emotional connections to the environment in fostering ERB.These findings provide valuable insights for sustainable tourism management in fragile desert ecosystems.The study also highlights the importance of enhancing perceived value through high-quality services and leveraging awe-inspiring experiences to promote sustainable behaviors. 展开更多
关键词 Perceived value AWE Place attachment Tourists'environmentally responsible behavior Desert tourism
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Numerical Modeling of Bubble-Particle Attachment in a Volume-of-Fluid Framework
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作者 Hojun Moon Donghyun You 《Computer Modeling in Engineering & Sciences》 2025年第10期367-390,共24页
A numerical method is presented to simulate bubble–particle interaction phenomena in particle-laden flows.The bubble surface is represented in an Eulerian framework by a volume-of-fluid(VOF)method,while particle moti... A numerical method is presented to simulate bubble–particle interaction phenomena in particle-laden flows.The bubble surface is represented in an Eulerian framework by a volume-of-fluid(VOF)method,while particle motions are predicted in a Lagrangian framework.Different frameworks for describing bubble surfaces and particles make it difficult to predict the exact locations of collisions between bubbles and particles.An effective bubble,defined as having a larger diameter than the actual bubble represented by the VOFmethod,is introduced to predict the collision locations.Once the collision locations are determined,the attachment of particles to the bubble surface is determined using a novel numerical algorithm based on collision/induction times.The proposed numerical method is validated through simulations of a rising bubble moving through a layer of particles.The validity of the collision detection algorithm is examined by comparing the collision probability predicted by the present numerical method with that predicted from a theoretical relationship based on bubble/particle diameters.The attachment probability predicted by the present algorithm is found to agree well with that of an experiment. 展开更多
关键词 Bubble-particle interaction VOLUME-OF-FLUID gas-liquid-solid flows attachment probability
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Single amino acid substitution in Hendra virus attachment glycoprotein induces cross-neutralizing antibodies against Nipah virus
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作者 Yaohui Li Xiaoyan Huang +7 位作者 Ruihua Li Xiaodong Zai Yilong Yang Yue Zhang Zhang Zhang Jun Zhang Junjie Xu Wei Chen 《Signal Transduction and Targeted Therapy》 2025年第9期5314-5324,共11页
Nipah virus(NiV)and Hendra virus(HeV)are highly pathogenic henipaviruses within the Paramyxoviridae family,causing severe respiratory and neurological diseases in humans and animals with fatality rates up to 75%,and n... Nipah virus(NiV)and Hendra virus(HeV)are highly pathogenic henipaviruses within the Paramyxoviridae family,causing severe respiratory and neurological diseases in humans and animals with fatality rates up to 75%,and no licensed human vaccines or therapeutics.In this study,we identified a unique vulnerable epitope on the NiV attachment glycoprotein(G)recognized by the potent neutralizing antibody 14F8,which targets a receptor-binding site and neutralizes NiV effectively.Using the 2.8Åcrystal structure of the 14F8 Fab–NiV-G complex as a guide,we reconstructed this epitope on HeV-G via a single amino acid substitution(S586N),creating the HeV-G_(S586N) mutant.Immunization with HeV-G_(S586N) in BALB/c mice and cynomolgus monkeys elicited robust,broadly neutralizing antibody responses against both NiV and HeV,achieving higher NiV-neutralizing titers post-prime compared to wild-type HeV-G,as confirmed by pseudovirus and live-virus assays.Crystal structures of HeV-G_(S586N)(3.3Å)and its 14F8 complex(3.2Å)showed the S586N substitution induced a 9Åconformational rearrangement inβ-propeller blade 6,reshaping the molecular skeleton and solvent-accessible surface without direct N586–14F8 interaction,thus mimicking the NiV epitope.These findings position HeV-G_(S586N) as a promising broad-spectrum antigen for henipavirus prevention and demonstrate the value of structure-guided epitope reconstruction in universal vaccine design for emerging viral threats. 展开更多
关键词 severe respiratory neurological diseases neutralizing antibody f which neutralizes niv hendra virus hev nipah virus niv attachment Glycoprotein Hendra Virus Nipah Virus
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Role of attachment style in the association between childhood adversities and non-suicidal self-injury among young adults:a multigroup structural equation study
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作者 Rodolfo Rossi Tommaso B Jannini +3 位作者 Valentina Socci Francesca Pacitti Alessandro Rossi Giorgio Di Lorenzo 《General Psychiatry》 2025年第2期103-112,共10页
Background Non-suicidal self-injury(NSSI)is a significant health concern among adolescents and young adults,often resulting from adverse childhood experiences(ACEs).Dissociation,post-traumatic symptoms and attachment ... Background Non-suicidal self-injury(NSSI)is a significant health concern among adolescents and young adults,often resulting from adverse childhood experiences(ACEs).Dissociation,post-traumatic symptoms and attachment style may have a role in shaping such associations.Aims This study aims to provide a unified model of the impact of ACEs on NSSI,exploring complex post-traumatic stress disorder(cPTSD)symptoms and dissociation as potential mediators and the role of the predominant attachment style in affecting such associations.Methods 1010 young individuals attending the last year of high school participated in this cross-sectional study.ACEs,cPTSD,dissociation and NSSI were evaluated using self-report questionnaires.We fitted a path model of NSSI,with ACEs as exogenous variables and cPTSD and dissociation as sequential mediators.Secure,fearful and preoccupied attachment styles were modelled as grouping variables.Results Our findings showed that dissociation mediated the impact of ACEs on NSSI in subjects with a fearful attachment style,as opposed to those with a preoccupied attachment for whom cPTSD symptoms mediated the ACEs-NSSI association.Conclusions Attachment styles moderate the relationship between ACEs and NSSI,with either dissociation or post-traumatic symptomatology mediating the impact of ACEs on NSSI,depending on the predominant attachment style.Our results highlight the importance of attachment as a pathway modifier in the relationships between different psychopathology dimensions,providing a useful framework to better conceptualise the ACEs-NSSI association. 展开更多
关键词 adverse childhood experiences aces dissociationpost traumatic non suicidal self injury childhood adversities complex post traumatic stress disorder attachment style DISSOCIATION unified model impact MEDIATION
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Screening and identification of functional bacterial attachment genes in aerobic granular sludge
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作者 Kai Qiao Tingting Zhao +5 位作者 LeiWang Wei Zhang WeiMeng Fan Liu Xu Gao Jianrong Zhu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第7期205-214,共10页
The screening and identification of attachment genes is important to exploring the formation mechanism of biofilms at the gene level.It is helpful to the development of key culture technologies for aerobic granular sl... The screening and identification of attachment genes is important to exploring the formation mechanism of biofilms at the gene level.It is helpful to the development of key culture technologies for aerobic granular sludge(AGS).In this study,genome-wide sequencing and gene editing were employed for the first time to investigate the effects and functions of attachment genes in AGS.With the help of whole-genome analysis,ten attachment genes were screened from thirteen genes,and the efficiency of gene screening was greatly improved.Then,two attachment genes were selected as examples to further confirm the gene functions by constructing gene-knockout recombinant mutants of Stenotrophomonas maltophilia;when the two attachment genes were knocked out,the attachment potential was reduced by 50.67%and 43.93%,respectively.The results provide a new theoretical principle and efficient method for the development of AGS from the perspective of attachment genes. 展开更多
关键词 attachment gene Genome-wide sequence Gene-knockout attachment potential Aerobic granular sludge biofilm
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Mirror,Mirror on the Wall:The Role of Self-Esteem and Attachments in Early Adolescent Body-Esteem
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作者 Young Mi Kim 《International Journal of Mental Health Promotion》 2024年第12期1017-1024,共8页
Background:Early adolescents become increasingly conscious of their body image,which can profoundly impact their mental health and well-being.In South Korea,societal pressures and expectations regarding physical appea... Background:Early adolescents become increasingly conscious of their body image,which can profoundly impact their mental health and well-being.In South Korea,societal pressures and expectations regarding physical appearance are particularly intense,making the study of body-esteem in Korean adolescents especially pertinent.This study explores the roles of self-esteem,peer attachment,and maternal attachments in shaping body-esteem among early adolescents.Methods:Structural equation modeling(SEM)was employed using data from 1326 Korean middle school students(Mean_(age)=13.32,SD=1.73).Results:The results revealed that self-esteem had a significantly positive effect on both peer attachment and maternal attachment.However,while peer attachment positively influenced body-esteem,maternal attachment did not have a significant direnct effect on body-esteem.Conclusions:These findings suggest that during early adolescence,peer relationships,rather than maternal bonds,play a more critical role in shaping body image.In a culture that emphasizes peer validation and societal beauty standards,peer relationships have a stronger impact on body-esteem.Interventions should focus on fostering supportive peer environments and enhancing self-esteem to promote positive body-esteem and mental health among adolescents. 展开更多
关键词 SELF-ESTEEM peer attachment maternal attachment body-esteem early adolescence
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Wheel-legged In-pipe Robot with a Bioinspired Hook and Dry Adhesive Attachment Device 被引量:1
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作者 Yahong Liu Yi Sun +9 位作者 Kai Cao Shutao Wu Xiaofeng Xu Qingfei Han Shikun Wen Huan Shen Guangming Chen Jiajun Xu Zhiwei Yu Aihong Ji 《Journal of Bionic Engineering》 SCIE EI CSCD 2024年第3期1208-1222,共15页
In-pipe robots have been widely used in pipes-with smooth inner walls.However,current in-pipe robots face challenges in terms of moving past obstacles and climbing in marine-vessel pipeline systems,which are affected ... In-pipe robots have been widely used in pipes-with smooth inner walls.However,current in-pipe robots face challenges in terms of moving past obstacles and climbing in marine-vessel pipeline systems,which are affected by marine biofouling and electrochemical corrosion.This paper takes inspiration from the dual-hook structure of Trypoxylus dichotomus’s feet and gecko‑like dry adhesives,proposing an in-pipe robot that is capable of climbing on rough and smooth pipe inwalls.The combination of the bioinspired hook and dry adhesives allows the robot to stably attach to rough or smooth pipe inwalls,while the wheel-leg hybrid mechanism provides better conditions for obstacle traversal.The paper explores the attachment and obstacle-surmounting mechanisms of the robot.Moreover,motion strategies for the robot are devised based on different pipe structural features.The experiments showed that this robot can adapt to both smooth and rough pipe environments simultaneously,and its motion performance is superior to conventional driving mechanisms.The robot’s active turning actuators also enable it to navigate through horizontally or vertically oriented 90°bends. 展开更多
关键词 In-pipe robot Bioinspired attachment device Wheel-legged robot Mechanical design
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Self-Preloading Flexible Attachment Actuator with Multi-Mechanism Hierarchical Structure
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作者 Zhouyi Wang Qingsong Yuan +6 位作者 Zhiyuan Weng Junsheng Yao Xuan Wu Lei Li Weipeng Li Yiping Feng Zhendong Dai 《Journal of Bionic Engineering》 SCIE EI CSCD 2024年第4期1830-1846,共17页
Flexible attachment actuators are popular in a wide range of applications,owing to their flexibility and highly reliable attachment.However,their reversible adhesion performance depends on the actual effective contact... Flexible attachment actuators are popular in a wide range of applications,owing to their flexibility and highly reliable attachment.However,their reversible adhesion performance depends on the actual effective contact area and peel angle during operation.Therefore,a good actuator must ensure a uniform and reliable pre-pressure load on an adhesive surface,to increase the effective contact area of the attached surface,thereby maximizing adhesion.This study was inspired by fusion bionics for designing a hierarchical attachment structure with vacuum-adsorption and dry-adhesion mechanisms.The designed structure used the normal force under the negative pressure of a suction cup as a stable source of a pre-pressure load.By optimizing the rigid and flexible structural layers of the attachment structure,a load was applied uniformly to the adhesion area;thus,reliable attachment was achieved by self-preloading.The structure achieved detachment by exploiting the large deformation of a pneumatic structure under a positive pressure.The hierarchical attachment structure achieved up to 85%of the optimal performance of the adhesive surface.Owing to its self-preloading and reliable attachment characteristics,the designed structure can be used as an attachment unit in various complex scenarios,such as small,lightweight climbing platforms and the transport of objects in long,narrow pipelines. 展开更多
关键词 Multi-mechanism attachment Self-preloading Hierarchical structure ADHESION Vacuum adsorption
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C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus
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作者 Lei Yu Xinjin Liu +4 位作者 Xiaoqin Wei Junrui Ren Xueyun Wang Shuwen Wu Ke Lan 《Virologica Sinica》 SCIE CAS CSCD 2024年第2期277-289,共13页
Influenza A virus(IAV)binds sialic acid receptors on the cell surface to enter the host cells,which is the key step in initiating infection,transmission and pathogenesis.Understanding the factors that contribute to th... Influenza A virus(IAV)binds sialic acid receptors on the cell surface to enter the host cells,which is the key step in initiating infection,transmission and pathogenesis.Understanding the factors that contribute to the highly efficient entry of IAV into human cells will help elucidate the mechanism of viral entry and pathogenicity,and provide new targets for intervention.In the present study,we reported a novel membrane protein,C1QTNF5,which binds to the hemagglutinin protein of IAV and promotes IAV infection in vitro and in vivo.We found that the HA1 region of IAV hemagglutinin is critical for the interaction with C1QTNF5 protein,and C1QTNF5 interacts with hemagglutinin mainly through its N-terminus(1–103 aa).In addition,we further demonstrated that overexpression of C1QTNF5 promotes IAV entry,while blocking the interaction between C1QTNF5 and IAV hemagglutinin greatly inhibits viral entry.However,C1QTNF5 does not function as a receptor to mediate IAV infection in sialic acid-deficient CHO-Lec2 cells,but promotes IAV to attach to these cells,suggesting that C1QTNF5 is an important attachment factor for IAV.This work reveals C1QTNF5 as a novel IAV attachment factor and provides a new perspective for antiviral strategies. 展开更多
关键词 C1QTNF5 Influenza A virus Viral entry HEMAGGLUTININ attachment factor
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Safety and efficacy of posterior approach for resection of spinal meningioma:Impact of dural attachment location
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作者 Hong Chen Ya-Ni Fu Chu-Di Fu 《World Journal of Clinical Cases》 SCIE 2024年第36期6905-6915,共11页
BACKGROUND Spinal meningiomas(SMs)are common benign tumors that are typically treated with surgical resection.The choice of surgical approach may vary depending on the location of dural attachment of the SM,with a pos... BACKGROUND Spinal meningiomas(SMs)are common benign tumors that are typically treated with surgical resection.The choice of surgical approach may vary depending on the location of dural attachment of the SM,with a posterior approach being the traditional preference.However,there is limited research available on the impact of dural attachment location on outcomes following posterior approach for SM resection.The average age of the included 34 patients’(10 males and 24 females)age was 62.09 years.Mean follow-up duration was 22.65 months.The location of SM was the thoracic spine in 32 cases,with only 2 in the cervical spine.On average,intraoperative blood loss was 520.59 mL,and operating time was 176.76 minutes.Thirty three cases had successful outcomes while only 1 experienced an unexpe-cted outcome.The tumor recurrence rate was 2.9%.After surgery,there were 3 cases of cerebral spinal fluid leakage,1 case of pneumonia,and 1 case of urinary tract infection.Dural attachments were predominantly found dorsal or dorso-lateral(13 cases),followed by ventral or ventrolateral(14 cases),and lateral(7 cases).The outcomes among these subgroups were similar.CONCLUSION The posterior approach for SM resection is safe and effective,yielding comparable surgical and neurological outcomes regardless of the dural attachment location. 展开更多
关键词 Spinal meningioma Posterior approach Dural attachment OUTCOMES COMPLICATIONS RECURRENCE
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Research on the Association between Fear of Cancer Recurrence in Young Breast Cancer Patients and Adult Attachment and Self-Disclosure
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作者 Huimin Zheng Minghui Wang Miao Ye 《Psycho-Oncologie》 SCIE 2024年第3期169-179,共11页
Background:Although fear of cancer recurrence(FCR)is the most important factor affecting the life quality of young breast cancer patients,and it may be affected by the patient’s personality,marital relationship and c... Background:Although fear of cancer recurrence(FCR)is the most important factor affecting the life quality of young breast cancer patients,and it may be affected by the patient’s personality,marital relationship and communication,there is a lack of research on the relationship between adult attachment,self-disclosure and FCR in patients.This study investigated the current situation of FCR in young breast cancer patients,its correlation with adult attachment and self-disclosure and its influencing factors,in order to predict the impact of adult attachment and self-disclosure of patients to spouse on FCR.Methods:A survey was conducted on 126 breast cancer patients at our hospital using the General Information Questionnaire(GIQ),Fear of Progression Questionnaire-Short Form(FoP-Q-SF),Experiences in Close Relationships inventory(ECR),and Distress Disclosure Index(DDI).The study analyzed the status of FCR among young breast cancer patients and its correlation with adult attachment and self-disclosure,along with its influencing factors.Results:Among the 126 young breast cancer patients,50 had a FoP-Q-SF score<34(normal group),while 76 had a FoP-Q-SF score≥34(FCR positive group),with an FCR incidence rate of 60.32%.Univariate analysis showed statistically significant differences between the two groups in terms of FoP-Q-SF score,ECR score,attachment anxiety score,attachment avoidance score,DDI score,age,educational level,employment status,per capita monthly income,and treatment method(p<0.05).Correlation analysis revealed that FoP-Q-SF scores were positively correlated with attachment anxiety score,attachment avoidance score,ECR scores and negatively correlated with DDI scores(p<0.05).Linear regression analysis indicated that age,per capita monthly income,treatment method,attachment anxiety,attachment avoidance and self-disclosure level were negative predictors of FoP-Q-SF scores in young breast cancer patients(p<0.05).Conclusion:The incidence rate of FCR among young breast cancer patients is high.There is a positive correlation between adult attachment and the level of FCR,and a negative correlation between the level of self-disclosure and FCR.Patients with lower per capita monthly income,more complex treatment methods,higher level of attachment anxiety,higher level of attachment avoidance and lower DDI scores had higher FoP-Q-SF scores. 展开更多
关键词 Breast cancer fear of recurrence adult attachment SELF-DISCLOSURE
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Mechanism of Tourists’Happiness in Traditional Village Tourism: A Perspective Grounded in Nostalgia and Cultural Attachment
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作者 JIANG Juan LIU Yu 《Journal of Landscape Research》 2024年第4期73-79,共7页
In recent years,traditional villages have emerged as popular tourist destinations due to their distinctive resource value.Typically situated in remote and less developed areas,traditional villages boast primitive natu... In recent years,traditional villages have emerged as popular tourist destinations due to their distinctive resource value.Typically situated in remote and less developed areas,traditional villages boast primitive natural surroundings and rich historical and cultural heritage.These characteristics offer urban dwellers a temporary escape from the complexities of modern life,allowing them to experience physical and mental rejuvenation,mental relaxation,and overall happiness during their visit.By conducting a review of the existing literature concerning tourists’happiness in traditional villages,this study establishes a framework to understand tourists’happiness in traditional village tourism.Using the Qiangang ancient village in Conghua District,Guangzhou as a case study,the research examines the current state of rural characteristics,the establishment of cultural brands,and the promotion of the active utilization of ancient villages within the context of integrating culture,sports,tourism,and agriculture.Based on this analysis,the author proposes strategies to enhance tourists’happiness,including the preservation and development of rural characteristics,the promotion and preservation of local cultural attributes,and the collaborative advancement of culture,sports,tourism,and agriculture to engage key stakeholders actively. 展开更多
关键词 Traditional village Qiangang ancient village NOSTALGIA Cultural attachment HAPPINESS
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Attachment Styles and Traumatic Responses: Exploring the Impact of Parental Interaction on Child Development and Coping Mechanisms
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作者 Kelvin N. Christie Adalgiza Sandoval 《Open Journal of Psychiatry》 2024年第S1期467-489,共23页
This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical... This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical framework of attachment theory and incorporating contemporary research, the paper discusses how parental interactions shape the neural circuitry of infants and children, influencing their ability to form secure or insecure attachments. These attachment styles, in turn, play a critical role in determining the child’s coping mechanisms when faced with trauma. This paper focuses on trying to understand how attachment theory is connected to the reaction to trauma with a highlight on the four major styles of attachments which are secure, anxious, avoidant, and disorganized to mention but a few, and how they influence stress and adversity in children. Attachment theory holds that human beings’ ability to form affectional bonds in infancy determines their patterns of relatedness across the life cycle. The type of attachment that is secure usually supports healthy adaptation and good coping mechanisms regardless of the trauma in the childhood of the child. While secure attachment mostly facilitates favorable trauma-related outcomes, anxious or avoidant attachment can exacerbate or alter the responses. The caregiving system that is avoidant attachment has implications of autonomous self-functioning which has features of suppression of the emotional response and poor search for emotional support during stress. From the principles of developmental psychology and trauma theory, the paper also focuses on the major significance of the child’s early caregivers’ interactions that define the resilience and vulnerability factor. This knowledge is therefore critical in designing specific interventions based on the improvement of coping behaviors and emotional regulatory systems of children who have been exposed to trauma. Finally, we have the synthesis of new knowledge about the role of secure attachment relationships as its fundamental element in shaping adaptive traumatization and psychological development. The article also delves into the physiological processes involved in emotional regulation and the role of cortisol in disrupting attachment. Finally, the implications of these findings for therapeutic interventions and the challenges of addressing prolonged grief and traumatic responses in clinical settings are considered. 展开更多
关键词 attachment Styles Traumatic Response Parental Interaction Child Development Emotional Regulation CORTISOL Grief Coping NEUROBIOLOGY Therapeutic Interventions
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Collision and attachment behavior between fine cassiterite particles and H_2 bubbles 被引量:17
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作者 任浏祎 张一敏 +2 位作者 覃文庆 包申旭 王军 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第2期520-527,共8页
Particle-bubble interaction during electro-flotation of cassiterite was investigated by determining the recovery of cassiterite and the collision mechanism of cassiterite particle and H2 bubble. Flotation tests at dif... Particle-bubble interaction during electro-flotation of cassiterite was investigated by determining the recovery of cassiterite and the collision mechanism of cassiterite particle and H2 bubble. Flotation tests at different conditions were conducted in a single bubble flotation cell. The recovery of cassiterite was found to be affected by cassiterite particle and bubble size. A matching range, in which the best recovery can be obtained, was found between particle and bubble size. Collision, attachment, and detachment of the particle-bubble were observed and captured by a high-speed camera. Particle-bubble collision and attachment were analyzed with the use of particle-bubble interaction theory to obtain the experimental results. An attachment model was introduced and verified through the photos captured by the high-speed camera. A bridge role was observed between the bubbles and particles. Particle-bubble interaction was found to be affected by bubble size and particle size, which significantly influenced not only the collision and attachment behavior of the particles and bubbles but also the flotation recovery of fine cassiterite particles. 展开更多
关键词 CASSITERITE fine particle flotation particle-bubble interaction collision and attachment
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