Arylamine N-acetyltransferases （NATs, EC 2.3.1.5） catalyze the N-acetylation of primary arylamines, and play a key role in the biotransformation and metabolism of drugs, carcinogens, etc. In this paper, three possib...Arylamine N-acetyltransferases （NATs, EC 2.3.1.5） catalyze the N-acetylation of primary arylamines, and play a key role in the biotransformation and metabolism of drugs, carcinogens, etc. In this paper, three possible reaction mechanisms are investigated and the results indicate that if the acetyl group directly transfers from the donor to the acceptor, the high activation energies will make it hard to obtain the target products. When using histidine to mediate the acetylation process, these energies will drop in the 15-45 kJ/mol range. If the histidine residue is protonated, the corresponding energies will be decreased by about 35-87 kJ/mol. The calculations predict an enzymatic acetylation mechanism that undergoes a thiolate-imidazolium pair, which agrees with the experimental results very well.展开更多
In this work,a fast and efficient microwave-assisted extraction(MAE) method was developed to extract main bioactive alkaloids from lotus plumue.To optimize MAE conditions,three main factors were selected using univari...In this work,a fast and efficient microwave-assisted extraction(MAE) method was developed to extract main bioactive alkaloids from lotus plumue.To optimize MAE conditions,three main factors were selected using univariate approach experiments,and then central composite design(CCD).The optimal extraction conditions were as follows:methanol concentration of 65%,microwave power of 200 W,and extraction time of 260 s.A high performance liquid chromatography–diode array detector(HPLC–DAD) method was established to quantitatively analyze these phytochemicals in different lotus plumule samples and in different part of lotus.Chromatographic separation was carried out on an Agilent Zorbax Extend-C_(18) column(4.6 mm×150 mm,3.5 μm).Gradient elution was applied with the mobile phase constituted with 0.1% triethylamine in water(A)and acetonitrile(B):40%-70% B at 0-8 min,70%-100% B at 8–9 min,100% B for 2 min,and then equilibrated with 40% B for 2 min.展开更多
The ring opening of β-sultam v/a an H2O-assisted ammonolysis process was studied by using Density Functional Theory（DFT） method at the B3LYP/6-31G level as a further step in the theoretical investigation of the amm...The ring opening of β-sultam v/a an H2O-assisted ammonolysis process was studied by using Density Functional Theory（DFT） method at the B3LYP/6-31G level as a further step in the theoretical investigation of the ammonolysis reaction of β-sultams. The calculated pathways are analogous to those previously described for the non-assisted ammonolysis reaction. Solvent effects were assessed by using the polarized continuum model（PCM） method. The results show that mode 1 and pathway a in channel Ⅱ are the most favorable ones in both the cases. The energy barrier of the cleavage of C-S bonds producing P1 is the highest among all the energy barriers. The presence of a solvent in the continuum model disfavors the reaction, whereas the participation of water in the ammonolysis reaction plays a positive role and reduces the active energy greatly. The relative energies of all the transition states in the assisted ammonolysis are 20-80 kJ/mol lower than those for the non-assisted reaction.展开更多
Background: Ventricular assist devices are now used as a bridge to recovery/decision/transplant or as destination therapy in end-stage heart failure. Continued improvements in technology and pump design have made impl...Background: Ventricular assist devices are now used as a bridge to recovery/decision/transplant or as destination therapy in end-stage heart failure. Continued improvements in technology and pump design have made implantation an easier process with reduced operative risks and pump-related adverse events. Considering the beneficial effects of these devices in the clinical setting, it seemed logical to address the long-term effect of the continuous flow pumps on diastolic dysfunction. Methods: This study addresses the effect of HeartMate IITM(HMII) support for 284+/-97 days on echocardiographic parameters of diastolic function. Data from fifteen patients was retrospectively studied status post left ventricular assist device (LVAD) implantation. The data at approximately 1-year post implantation was compared with that obtained prior to implantation. Statistical analyses were performed using the Microsoft Excel Program/MSExcel Stats. Echocardiographic measurements were carried out in accordance with the American Society of Echocardiography guidelines. Results: Of all the echocardiographic parameters assessed only E/Ea and calculated left atrial pressure (LAP) showed a statistically significant decrease. Two parameters that showed a trend towards significance are Ea (septal) and global functional index (p = 0.05). Conclusions: Continuous Flow LVAD support appears to improve diastolic dysfunction. This study has limitations in that we used a single type of continuous flow device (HeartMate IITM) and was conducted as a retrospective analysis. Further studies with larger populations and longer support are required to validate this finding.展开更多
The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteri...The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different bacteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of biological effects in bacterial growth, the more rigid control of bacterial culture conditions seems to be a critical factor for improving the rate of correctness for bacterial classification.展开更多
We investigate the time-modulated electronic and spin transport properties through two T-shaped three-quantum-dot molecules embedded in an Aharonov-Bohm（A-B） interferometer. By using the Keldysh non-equilibrium Gree...We investigate the time-modulated electronic and spin transport properties through two T-shaped three-quantum-dot molecules embedded in an Aharonov-Bohm（A-B） interferometer. By using the Keldysh non-equilibrium Green＇s function technique, the photon-assisted spin-dependent average current is analyzed. The T-shaped three-quantum-dot molecule A-B interferometer exhibits excellent controllability in the average current resonance spectra by adjusting the interdot coupling strength, Rashba spin-orbit coupling strength, magnetic flux, and amplitude of the time-dependent external field.Efficient spin filtering and multiple electron-photon pump functions are exploited in the multi-quantum-dot molecule A-B interferometer by a time-modulated external field.展开更多
This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entai...This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entailed semi-structured, in-depth interviews with women utilizing lower limb prostheses and prosthetic specialists. This approach was selected to unearth pivotal design prerequisites and comprehend the specific challenges these women encounter within the realm of clothing. The utilization of selective sampling facilitated the collection of intricate and valuable insights. A Functional, Expressive, and Aesthetic (FEA) User Needs model was utilized to scrutinize participant feedback. Functional requisites encompass ease of dressing and undressing, accessibility to the prosthetic limb, comfort, mobility with the prosthesis, and appropriate fit. Additionally, participants highlighted various expressive needs, including privacy preservation, modesty, camouflaging disability appearances, maintaining alignment with non-disabled women’s fashion, and considerations about the aesthetic aspects of garments.展开更多
Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commerci...Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commercial temperature controlled microwave chemistry ovens (TCMC), digesters, and axial field helical antennae. For each of these microwave applicators the process energy budget where estimated (Watts multiplied by process time = kJ) and energy density (applied energy divided by suspension volume = kJ·ml<sup>-1</sup>) range between 180 ± 176.8 kJ, and 79.5 ± 79 kJ·ml<sup>-1</sup>, respectively. The axial field helical field an-tenna applicator is found to be the most energy efficient (0.253 kJ·m<sup>-1</sup> per kJ, at 36 W). Followed by microwave ovens (4.47 ± 3.9 kJ·ml<sup>-1</sup> per 76.83 ± 39 kJ), and TCMC ovens (2.86 ± 2.3 kJ·m<sup>-1</sup> per 343 ± 321.5 kJ). The digester applicators have the least energy efficiency (36.2 ± 50.7 kJ·m<sup>-1</sup> per 1010 ± 620 kJ). A comparison with reconstructed ‘non-thermal’ microwave oven inactivation microorganism experiments yields a power-law signature of n = 0.846 (R<sup>2</sup> = 0.7923) four orders of magnitude. The paper provides a discussion on the Au and Ag nanoparticle chemistry and bio-chemistry synthesis aspects of the microwave applicator energy datasets and variation within each dataset. The visual and analytical approach within the energy phase-space projection enables a nanoparticle synthesis route to be systematically characterized, and where changes to the synthesis are to be mapped and compared directly with historical datasets. In order to help identify lower cost nanoparticle synthesis, in addition to potentially reduce synthesis energy to routes informed changes to potentially reduce synthesis energy budget, along with nanoparticle morphology and yield.展开更多
目的探究卵巢储备功能低下(decline in ovarian reserbe,DOR)患者的中医体质、中医证型分布特点及吴克明教授临床治疗的用药规律。方法遵循流行病学调查方法,采用《中医体质分类与判定表》对DOR患者进行打分和体质分类,参考《中医妇科...目的探究卵巢储备功能低下(decline in ovarian reserbe,DOR)患者的中医体质、中医证型分布特点及吴克明教授临床治疗的用药规律。方法遵循流行病学调查方法,采用《中医体质分类与判定表》对DOR患者进行打分和体质分类,参考《中医妇科常见病诊疗指南》及《中医妇科学》中“不孕症”“月经病”等证候分类,进行辨证分型,并收集吴克明教授门诊治疗DOR的中药处方信息。采用中医传承辅助平台(V2.5)进行挖掘分析相关用药规律。结果在所收集124例DOR患者的体质信息中,阳虚质36例,占29.03%;血瘀质19例,占15.32%;平和质16例,占12.9%;而气郁质、阴虚质、气虚质等占较少比例。中医证型分类中肾虚血瘀证共48例、脾肾阳虚证27例、肝郁肾虚证22例、气血两虚证14例、肝肾阴虚证13例。使用中医传承辅助平台对124例门诊处方进行数据挖掘,得出核心组方为:肉苁蓉、菟丝子、淫羊藿、枸杞子、覆盆子、黄精、当归、山萸肉、熟地黄、牡丹皮、香附。结论通过中医辅助平台对临床收集124例DOR患者的体质类型及其中药处方进行分析,阳虚质、血瘀质和肾虚血瘀证、脾肾阳虚证患者占比最多,而核心组方药物主要为肉苁蓉、菟丝子、淫羊藿、当归等,其中肉苁蓉、菟丝子、淫羊藿补肾精温肾阳,当归养血活血调经,初步揭示了吴克明教授在补肾养血活血法指导下临床治疗DOR的用药规律,并为不同体质类型、中医证型分类下DOR的临床治疗提供一定参考依据。展开更多
This research work is focused on simulation of laser assisted turning as a new solution for machining of hard steels. A transient, three-dimensional model was developed to predict the temperature distribution of a rot...This research work is focused on simulation of laser assisted turning as a new solution for machining of hard steels. A transient, three-dimensional model was developed to predict the temperature distribution of a rotated cylindrical steel workpiece subjected to a localized heating using a moving Gaussian laser beam. In this regard, a User-Defined Function was created to overcome the problem of a moving Gaussian heat source’ definition. This User-Defined Function was compiled into a finite volume software package (Fluent), where three-dimensional single precision solver was used for analysis. Based on this model, simulation of the surface temperature of 32 mm diameter workpiece of AISI51 50H steel was performed as a function of time at a specific distance behind the laser beam spot, which is corresponding to 30° angle from the laser beam. The simulation results were compared with other published data of the same steel type where a close agreement was obtained. The verified model was used for simulation of laser assisted turning of 20 mm diameter workpiece of AISI D2 tool steel. The cutting depth, behind the laser beam, was set at a distance corresponding to 60° angle from the laser beam for having sufficient access for handling both laser head and cutting tool. This cutting depth was studied as a function of different lasers and machining parameters. The results indicated that the optimum parameters for successful laser-assisted turning process of the concerned steels are 800 W laser power, 5 mm laser beam spot diameter, 20 sec preheating time, 0.8 mm/sec laser scanning speed, 300 rpm rotational speed and 0.8 mm/sec feed rate. These parameters ensure easy/successful cutting of 1 mm depth in one pass without deteriorating the properties of the remaining bulk material. It can be deduced that the developed model might provide a useful tool for online process control of different steel types regardless of their physical properties and geometries.展开更多
The interposition sural nerve graft has been attempted occasionally during radical prostatectomy for the recovery of continence and erectile function;however, nerve autograft may result in adverse events for the patie...The interposition sural nerve graft has been attempted occasionally during radical prostatectomy for the recovery of continence and erectile function;however, nerve autograft may result in adverse events for the patient. Here, we present our initial experiences using NerbridgeTM, a novel conduit for peripheral nerve regeneration, rather than utilizing sural nerve grafting, in robot-assisted laparoscopic radical prostatectomy to overcome autograft problems such as prolongation of operation time and postoperative abnormal sensation. This novel artificial conduit interposition can be technically feasible when combined with robotic surgery, and prospective randomized controlled trials with high patients-numbers and long follow-up periods are warranted.展开更多
基金the National Natural Scientific Foundation of China(No.20603030)the Youth Natural Science Foundation of Ludong University(No.042902)+1 种基金the Post-doctor Research Foundation of Shandong Province(No.200601007)the Youth Natural Science Foundation of Shandong Provincial Education Department(No.200139)
文摘Arylamine N-acetyltransferases （NATs, EC 2.3.1.5） catalyze the N-acetylation of primary arylamines, and play a key role in the biotransformation and metabolism of drugs, carcinogens, etc. In this paper, three possible reaction mechanisms are investigated and the results indicate that if the acetyl group directly transfers from the donor to the acceptor, the high activation energies will make it hard to obtain the target products. When using histidine to mediate the acetylation process, these energies will drop in the 15-45 kJ/mol range. If the histidine residue is protonated, the corresponding energies will be decreased by about 35-87 kJ/mol. The calculations predict an enzymatic acetylation mechanism that undergoes a thiolate-imidazolium pair, which agrees with the experimental results very well.
基金partially supported by grants from the Science and Technology Development Fund of Macao(FDCT059/2011/A3)the University of Macao(MYRG085 to Jing Zhao and MYRG201400041 to LSP,respectively)
文摘In this work,a fast and efficient microwave-assisted extraction(MAE) method was developed to extract main bioactive alkaloids from lotus plumue.To optimize MAE conditions,three main factors were selected using univariate approach experiments,and then central composite design(CCD).The optimal extraction conditions were as follows:methanol concentration of 65%,microwave power of 200 W,and extraction time of 260 s.A high performance liquid chromatography–diode array detector(HPLC–DAD) method was established to quantitatively analyze these phytochemicals in different lotus plumule samples and in different part of lotus.Chromatographic separation was carried out on an Agilent Zorbax Extend-C_(18) column(4.6 mm×150 mm,3.5 μm).Gradient elution was applied with the mobile phase constituted with 0.1% triethylamine in water(A)and acetonitrile(B):40%-70% B at 0-8 min,70%-100% B at 8–9 min,100% B for 2 min,and then equilibrated with 40% B for 2 min.
文摘The ring opening of β-sultam v/a an H2O-assisted ammonolysis process was studied by using Density Functional Theory（DFT） method at the B3LYP/6-31G level as a further step in the theoretical investigation of the ammonolysis reaction of β-sultams. The calculated pathways are analogous to those previously described for the non-assisted ammonolysis reaction. Solvent effects were assessed by using the polarized continuum model（PCM） method. The results show that mode 1 and pathway a in channel Ⅱ are the most favorable ones in both the cases. The energy barrier of the cleavage of C-S bonds producing P1 is the highest among all the energy barriers. The presence of a solvent in the continuum model disfavors the reaction, whereas the participation of water in the ammonolysis reaction plays a positive role and reduces the active energy greatly. The relative energies of all the transition states in the assisted ammonolysis are 20-80 kJ/mol lower than those for the non-assisted reaction.
文摘Background: Ventricular assist devices are now used as a bridge to recovery/decision/transplant or as destination therapy in end-stage heart failure. Continued improvements in technology and pump design have made implantation an easier process with reduced operative risks and pump-related adverse events. Considering the beneficial effects of these devices in the clinical setting, it seemed logical to address the long-term effect of the continuous flow pumps on diastolic dysfunction. Methods: This study addresses the effect of HeartMate IITM(HMII) support for 284+/-97 days on echocardiographic parameters of diastolic function. Data from fifteen patients was retrospectively studied status post left ventricular assist device (LVAD) implantation. The data at approximately 1-year post implantation was compared with that obtained prior to implantation. Statistical analyses were performed using the Microsoft Excel Program/MSExcel Stats. Echocardiographic measurements were carried out in accordance with the American Society of Echocardiography guidelines. Results: Of all the echocardiographic parameters assessed only E/Ea and calculated left atrial pressure (LAP) showed a statistically significant decrease. Two parameters that showed a trend towards significance are Ea (septal) and global functional index (p = 0.05). Conclusions: Continuous Flow LVAD support appears to improve diastolic dysfunction. This study has limitations in that we used a single type of continuous flow device (HeartMate IITM) and was conducted as a retrospective analysis. Further studies with larger populations and longer support are required to validate this finding.
基金Supported by Foundation for Young Mainstay TeachersEducation Ministry of China.
文摘The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different bacteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of biological effects in bacterial growth, the more rigid control of bacterial culture conditions seems to be a critical factor for improving the rate of correctness for bacterial classification.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11447132 and 11504042)the Natural Science Foundation of Heilongjiang,China(Grant No.A201405)+2 种基金111 Project to Harbin Engineering University,China(Grant No.B13015)Chongqing Science and Technology Commission Project,China(Grant Nos.cstc2014jcyj A00032 and cstc2016jcyj A1158)Scientific Research Project for Advanced Talents of Yangtze Normal University,China(Grant No.2017KYQD09)
文摘We investigate the time-modulated electronic and spin transport properties through two T-shaped three-quantum-dot molecules embedded in an Aharonov-Bohm（A-B） interferometer. By using the Keldysh non-equilibrium Green＇s function technique, the photon-assisted spin-dependent average current is analyzed. The T-shaped three-quantum-dot molecule A-B interferometer exhibits excellent controllability in the average current resonance spectra by adjusting the interdot coupling strength, Rashba spin-orbit coupling strength, magnetic flux, and amplitude of the time-dependent external field.Efficient spin filtering and multiple electron-photon pump functions are exploited in the multi-quantum-dot molecule A-B interferometer by a time-modulated external field.
文摘This study aimed to comprehensively investigate the essential considerations in designing adaptive clothing for women with lower limb prostheses in Saudi Arabia. Employing a qualitative methodology, the research entailed semi-structured, in-depth interviews with women utilizing lower limb prostheses and prosthetic specialists. This approach was selected to unearth pivotal design prerequisites and comprehend the specific challenges these women encounter within the realm of clothing. The utilization of selective sampling facilitated the collection of intricate and valuable insights. A Functional, Expressive, and Aesthetic (FEA) User Needs model was utilized to scrutinize participant feedback. Functional requisites encompass ease of dressing and undressing, accessibility to the prosthetic limb, comfort, mobility with the prosthesis, and appropriate fit. Additionally, participants highlighted various expressive needs, including privacy preservation, modesty, camouflaging disability appearances, maintaining alignment with non-disabled women’s fashion, and considerations about the aesthetic aspects of garments.
文摘Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commercial temperature controlled microwave chemistry ovens (TCMC), digesters, and axial field helical antennae. For each of these microwave applicators the process energy budget where estimated (Watts multiplied by process time = kJ) and energy density (applied energy divided by suspension volume = kJ·ml<sup>-1</sup>) range between 180 ± 176.8 kJ, and 79.5 ± 79 kJ·ml<sup>-1</sup>, respectively. The axial field helical field an-tenna applicator is found to be the most energy efficient (0.253 kJ·m<sup>-1</sup> per kJ, at 36 W). Followed by microwave ovens (4.47 ± 3.9 kJ·ml<sup>-1</sup> per 76.83 ± 39 kJ), and TCMC ovens (2.86 ± 2.3 kJ·m<sup>-1</sup> per 343 ± 321.5 kJ). The digester applicators have the least energy efficiency (36.2 ± 50.7 kJ·m<sup>-1</sup> per 1010 ± 620 kJ). A comparison with reconstructed ‘non-thermal’ microwave oven inactivation microorganism experiments yields a power-law signature of n = 0.846 (R<sup>2</sup> = 0.7923) four orders of magnitude. The paper provides a discussion on the Au and Ag nanoparticle chemistry and bio-chemistry synthesis aspects of the microwave applicator energy datasets and variation within each dataset. The visual and analytical approach within the energy phase-space projection enables a nanoparticle synthesis route to be systematically characterized, and where changes to the synthesis are to be mapped and compared directly with historical datasets. In order to help identify lower cost nanoparticle synthesis, in addition to potentially reduce synthesis energy to routes informed changes to potentially reduce synthesis energy budget, along with nanoparticle morphology and yield.
文摘目的探究卵巢储备功能低下(decline in ovarian reserbe,DOR)患者的中医体质、中医证型分布特点及吴克明教授临床治疗的用药规律。方法遵循流行病学调查方法,采用《中医体质分类与判定表》对DOR患者进行打分和体质分类,参考《中医妇科常见病诊疗指南》及《中医妇科学》中“不孕症”“月经病”等证候分类,进行辨证分型,并收集吴克明教授门诊治疗DOR的中药处方信息。采用中医传承辅助平台(V2.5)进行挖掘分析相关用药规律。结果在所收集124例DOR患者的体质信息中,阳虚质36例,占29.03%;血瘀质19例,占15.32%;平和质16例,占12.9%;而气郁质、阴虚质、气虚质等占较少比例。中医证型分类中肾虚血瘀证共48例、脾肾阳虚证27例、肝郁肾虚证22例、气血两虚证14例、肝肾阴虚证13例。使用中医传承辅助平台对124例门诊处方进行数据挖掘,得出核心组方为:肉苁蓉、菟丝子、淫羊藿、枸杞子、覆盆子、黄精、当归、山萸肉、熟地黄、牡丹皮、香附。结论通过中医辅助平台对临床收集124例DOR患者的体质类型及其中药处方进行分析,阳虚质、血瘀质和肾虚血瘀证、脾肾阳虚证患者占比最多,而核心组方药物主要为肉苁蓉、菟丝子、淫羊藿、当归等,其中肉苁蓉、菟丝子、淫羊藿补肾精温肾阳,当归养血活血调经,初步揭示了吴克明教授在补肾养血活血法指导下临床治疗DOR的用药规律,并为不同体质类型、中医证型分类下DOR的临床治疗提供一定参考依据。
文摘This research work is focused on simulation of laser assisted turning as a new solution for machining of hard steels. A transient, three-dimensional model was developed to predict the temperature distribution of a rotated cylindrical steel workpiece subjected to a localized heating using a moving Gaussian laser beam. In this regard, a User-Defined Function was created to overcome the problem of a moving Gaussian heat source’ definition. This User-Defined Function was compiled into a finite volume software package (Fluent), where three-dimensional single precision solver was used for analysis. Based on this model, simulation of the surface temperature of 32 mm diameter workpiece of AISI51 50H steel was performed as a function of time at a specific distance behind the laser beam spot, which is corresponding to 30° angle from the laser beam. The simulation results were compared with other published data of the same steel type where a close agreement was obtained. The verified model was used for simulation of laser assisted turning of 20 mm diameter workpiece of AISI D2 tool steel. The cutting depth, behind the laser beam, was set at a distance corresponding to 60° angle from the laser beam for having sufficient access for handling both laser head and cutting tool. This cutting depth was studied as a function of different lasers and machining parameters. The results indicated that the optimum parameters for successful laser-assisted turning process of the concerned steels are 800 W laser power, 5 mm laser beam spot diameter, 20 sec preheating time, 0.8 mm/sec laser scanning speed, 300 rpm rotational speed and 0.8 mm/sec feed rate. These parameters ensure easy/successful cutting of 1 mm depth in one pass without deteriorating the properties of the remaining bulk material. It can be deduced that the developed model might provide a useful tool for online process control of different steel types regardless of their physical properties and geometries.
文摘The interposition sural nerve graft has been attempted occasionally during radical prostatectomy for the recovery of continence and erectile function;however, nerve autograft may result in adverse events for the patient. Here, we present our initial experiences using NerbridgeTM, a novel conduit for peripheral nerve regeneration, rather than utilizing sural nerve grafting, in robot-assisted laparoscopic radical prostatectomy to overcome autograft problems such as prolongation of operation time and postoperative abnormal sensation. This novel artificial conduit interposition can be technically feasible when combined with robotic surgery, and prospective randomized controlled trials with high patients-numbers and long follow-up periods are warranted.
