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细胞周期蛋白D1在听神经瘤中的表达及临床意义
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作者 陈尔东 高下 《山西医药杂志(上半月)》 CAS 2011年第8期753-755,共3页
目的评估听神经瘤中细胞周期蛋白D1(Cyclin D1)的表达及其与组织学特点、临床听力学特征的相关性。方法回顾性分析病理学上确诊听神经瘤的17例患者组织切片,进行组织病理学分型(Antoni分型)和免疫组织化学染色分析Cyclin D1的表达,结合... 目的评估听神经瘤中细胞周期蛋白D1(Cyclin D1)的表达及其与组织学特点、临床听力学特征的相关性。方法回顾性分析病理学上确诊听神经瘤的17例患者组织切片,进行组织病理学分型(Antoni分型)和免疫组织化学染色分析Cyclin D1的表达,结合临床一般资料与听力学检测数据并分析其相关性。结果 17例患者组织切片中有9例(53%)Cyclin D1阳性表达,与Cyclin D1表达阴性的患者相比,语频平均听阈(PTA)的平均值较低(P<0.05),Cyclin D1表达阳性的患者在2 000 Hz频率平均听阈较低(P<0.05)。没有发现Cyc-lin D1的表达与性别、侧别和病理分型相关(P>0.05)。结论 Cyclin D1可能在听神经瘤的细胞增殖与分化调节过程中发挥重要的作用,进一步观察Cyclin D1在听神经瘤细胞增殖与分化调节过程中的作用,对探讨听神经瘤的发生发展有着重要的意义。 展开更多
关键词 神经瘤 细胞周期蛋白D1 antoni分型
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Sinonasal Schwannoma in a Six-Year-Old: An Unusual Presentation
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作者 Oyeleye Abayomi Oyelakin Adekunle Dainel +1 位作者 Michael Chukuwugoziem Nweke Clement Abu Okolo 《Case Reports in Clinical Medicine》 2016年第2期50-56,共7页
Schwannomas commonly occur in the head and neck region and extremities, but nasal schwannoma is extremely rare. It accounts for less than 4% of benign solitary schwannomas of the head and neck region. Few cases and ve... Schwannomas commonly occur in the head and neck region and extremities, but nasal schwannoma is extremely rare. It accounts for less than 4% of benign solitary schwannomas of the head and neck region. Few cases and very few case series have been reported till date. We report the case of a six-year-old female who presented with mouth breathing of two years with persistent and progressive right nasal obstruction of three months. There was recurrent watery ipsilateral nasal discharge, but no epistaxis, no otologic or throat symptoms, no headaches, facial pain, proptosis or visual loss, no facial hypoesthesia, fever or weight loss. She also had right sided epiphora. She had used topical steroid and decongestant without improvement. Ten months prior to presentation, she had right dacrocystorhinostomy. Examination revealed mucosa mass completely filling the right nasal cavity with an ipsilateral deviation of nasal septum—it was painless with no contact bleeds. Nasal patency was clinically absent bilaterally. Computed tomogram revealed expansile isodense soft tissue mass in the right nasal cavity with heterogeneous enhancement on contrast administration which measured 2.5 cm by 3.7 cm by 5.2 cm. She had an intranasal excision of the tumour and histology revealed Antoni A and B patterns, which is diagnostic of schwannoma. She was fully relieved of symptoms after surgery. Conclusion: Solitary nasal schwannoma is rare especially in childhood. There are various causes of epiphora;definitive investigation of the cause in the index case was not established before dacrocystorhinostomy. Thorough nasal evaluation of epiphora or related ocular symptoms should be sought before definitive procedures. 展开更多
关键词 SCHWANNOMA Dacrocystorhinostomy Nasolacrimal Duct antoni A and B patterns
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