Aggression,an evolutionarily conserved social behavior,is essential for animals to compete for valuable resources like food,territory,and mates,and to protect kin.Although aggression is required for the survival of bo...Aggression,an evolutionarily conserved social behavior,is essential for animals to compete for valuable resources like food,territory,and mates,and to protect kin.Although aggression is required for the survival of both sexes,it is often displayed in a sexually dimorphic manner,with males typically exhibiting higher levels of aggression than females.展开更多
BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for r...BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.AIM To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.METHODS Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were identified.Network pharmacology was used to establish protein-protein interaction networks of the core targets of olanzapine.Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently performed.RESULTS Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.After treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with schizophrenia.Olanzapine effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.Ten core targets of olanzapine were involved in several key pathways.CONCLUSION The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.展开更多
This letter critically reviews a recent longitudinal network study by Bai et al examining the dynamic,symptom-level interplay among peer bullying victimization,depression,anxiety,and aggression in Chinese adolescents....This letter critically reviews a recent longitudinal network study by Bai et al examining the dynamic,symptom-level interplay among peer bullying victimization,depression,anxiety,and aggression in Chinese adolescents.The study highlights that key symptoms,such as persistent sad mood,sleep disturbances,and cyberbullying victimization play a pivotal role in reinforcing the vicious cycle between mental health issues and bullying experiences.While the application of cross-lagged panel network analysis offers a nuanced understanding of these bidirectional relationships,several limitations remain,including the use of selfreported measures and a region-specific sample.Nevertheless,the findings underscore the urgent need for early screening and targeted interventions in school settings,particularly those addressing both emotional symptoms and digital forms of bullying.Moving forward,integrated and culturally sensitive approaches are essential to prevent escalation and break the link between peer victimization and adolescent psychopathology.Future research should incorporate multi-informant data and broaden the cultural context to strengthen generalizability and intervention design.展开更多
When the War of Resistance Against Japanese Aggression broke out,a large number of Tibetan Buddhist monks who loved the country also participated in this all-out war.
BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ us...BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.展开更多
It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression, as it holds ...It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression, as it holds historical and contemporary relevance. The research findings indicate that the Comintern played a crucial role as the key intermediary in facilitating the establishment of connections between the CPC and the JCP and in driving the deepening of their relationship. During their exchanges, both parties adhered to a flexible and multi-layered friendship based on the unified values of patriotism and internationalism. Their efforts played a significant role in the establishment of an international anti-fascist front in the East.展开更多
It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspectiv...It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspective of personalitysolidification theory, this study sample of 1951 primary and secondary school students was used toexplore the relationship between child maltreatment, Big Five personality and internalized and externalizedaggression, as well as the different mechanisms of differentiation of personality components in child maltreatmenton two different natures of aggression, using four scales: The Childhood Trauma Questionnaire (CTQ), RevisedNEO Personality Inventory (NEO-PI-R), None-suicidal Self-Injury Scale and Aggression Questionnaire. The findingssuggest that (1) neuroticism plays the same mediating mechanism in the effect of child maltreatment on thepersistence of internalized and externalized aggression;and (2) conscientiousness plays a different mechanism ineffect of child maltreatment on both internalized and externalized aggression. Therefore, child maltreatmentshould be discouraged and the development of a sound personality should be guided, thus reducing future aggressivebehavior and promoting child development and social harmony.展开更多
BACKGROUND Displaced aggression occurs when a person encounters a provoking situation,is unable or unwilling to retaliate against the original provocateur,and subsequently aggresses against a target that is not the so...BACKGROUND Displaced aggression occurs when a person encounters a provoking situation,is unable or unwilling to retaliate against the original provocateur,and subsequently aggresses against a target that is not the source of the initial provocation.The displaced aggression questionnaire(DAQ)was developed to measure individual differences in the tendency to displace aggression.AIM To develop a Dutch version of the DAQ and examine relationships between the DAQ and novel individual differences.METHODS The Dutch version of the DAQ was created using a back-translation procedure.Undergraduate students(n=413)participated in the current study.The questionnaires were administered online.RESULTS The results confirmed the original three-factor structure and showed good reliability and validity.We also found differential relationships between trait displaced aggression,social anxiety and cognitive distortions.CONCLUSION The results may indicate that distinct patterns exist in the development of the different dimensions of trait displaced aggression.This study adds to the growing cross-cultural literature showing the robustness of trait displaced aggression in several different cultures.展开更多
Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause...Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.展开更多
Aggression is a common behavioral trait shared in many animals, including both vertebrates and invertebrates. However, the type and intensity of agonistic encounters and displays can vary widely both across and within...Aggression is a common behavioral trait shared in many animals, including both vertebrates and invertebrates. However, the type and intensity of agonistic encounters and displays can vary widely both across and within species, resulting in complicated or subjective interpretations that create difficulties in developing theoretical models that can be widely applied. The need to easily and objectively identify quantifiable behaviors and their associated morphologies becomes especially important when attempting to decipher the neurological mechanisms underlying this complex behavior. Monoamines, neuropeptides, and pheromones have been implicated as important neuromodulators for agonistic displays in both invertebrates and vertebrates. Ad- ditionally, recent breakthroughs in insect research have revealed exciting proximate mechanisms important in aggression that may be broadly relevant, due to the relatively high conservation of these neurochemical systems across animal taxa. In this review, we present the latest research demonstrating the importance of monoamines, neuropeptides, and pheromones as neuromodulators for aggression across a variety of insect species. Additionally, we describe the stalk-eyed fly as a model system for studying aggres- sion, which integrates physiological, morphological, and neurochemical approaches in exploring detailed mechanisms responsible for this common yet complex behavior. We conclude with our perspective on the most promising lines of future research aimed at understanding the proximate and ultimate mechanisms underlying aggressive behaviors .展开更多
Traits that aid in the invasion process should exhibit a gradient across the expansion range in response to changing selection pressures. Aggression has been repeatedly associated with invasion success in many taxa, a...Traits that aid in the invasion process should exhibit a gradient across the expansion range in response to changing selection pressures. Aggression has been repeatedly associated with invasion success in many taxa, as it may help invaders to wrestle the resources from other species which enhances their success in a novel environment. However, aggression primarily al lows individuals to overcome conspecific rivals, providing advantages in competition over resources. Agonistic prowess could therefore increase fitness at both ends of the expansion gradient. Here we review the role of aggression in range expansion of in vasive species, and its potential role as a driver of range expansion. We analyze how these different mechanisms could affect trait variation in expanding and invasive populations. Specifically, we look at how aggression could help dilate the edges of a popula tion through niche competition, as well as lead to exclusion from the center （Le. areas of high population density） by the conspe cities. Both of these processes will result in a characteristic spatial distribution of phenotypes related to aggression that could provide insights into the ecological pressures and dynamics of expanding populations, potentially providing clues to their success as niche competitors and invasive species展开更多
Females increase aggression for mating opportunities and for acquiring reproductive resources.Although the close relationship between female aggression and mating status is widely appreciated,whether and how female ag...Females increase aggression for mating opportunities and for acquiring reproductive resources.Although the close relationship between female aggression and mating status is widely appreciated,whether and how female aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observation that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vaccenyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggressive behavior in Drosophila females.展开更多
Despite growing interest in female ornament evolution, we still have a rudimentary understanding of female display traits relative to similar traits in males. Under one popular adaptive scenario, female ornaments are ...Despite growing interest in female ornament evolution, we still have a rudimentary understanding of female display traits relative to similar traits in males. Under one popular adaptive scenario, female ornaments are hypothesized to function in female-female competition and serve as badges of status, such that their expression is linked with elevated aggression in some cases. In this study, we investigated the relationship between 2 female ornaments--male-like red throat color and red spine coloration--and female aggression in 2 independently derived stream-resident populations of three-spined stickleback Gasterosteus aculeatus. Using simulated intrusions, we tested whether females with redder ornaments were generally more aggressive, and for variation in aggressive and social behaviors between the 2 populations. We found that the red intensity of the throat and spine did not predict aggression levels in either population, suggesting a limited role for both female ornaments during female-female interaction. The 2 populations exhibited different levels of aggressive behaviors, unrelated to the color patches. Our results suggest that variation in selective pressures between populations may promote interpopulation variance in aggressive behavior but not the correlation between female ornamentation and aggression, and raise the possibility that red coloration may have evolved through different mechanisms or processes in the 2 populations.展开更多
A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity a...A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity and aggression were measured by the Barratt Impulsivity Scale（BIS）and the Aggression Inventory（AI）.展开更多
Childhood Onset Conduct Disorder [CD] is a condition characterized by at least one symptom of conduct disorder (based on Diagnostic and Statistical Manual of Mental Disorders criteria—Fifth Edition) prior to 10 years...Childhood Onset Conduct Disorder [CD] is a condition characterized by at least one symptom of conduct disorder (based on Diagnostic and Statistical Manual of Mental Disorders criteria—Fifth Edition) prior to 10 years of age. Children affected exhibit disruptive behaviors, usually negative, hostile, and defiant behavior similar to Oppositional Defiant Disorder [ODD]. As the child gets older they begin to display more characteristic of Conduct Disorder (lying, fighting, and stealing, vindictive behavior). These children are also likely to have comorbidities including Attention Deficit Hyperactivity Disorder (ADHD), learning disabilities, poor academic achievement, and substance abuse. Distinguishing early between symptoms of Conduct Disorder versus other differential diagnoses is essential in effective treatment. Early intervention with these children leads to a better prognosis and likelihood of functioning in society. This case illustrates the difficulty of diagnosing a young child with Childhood Onset Conduct Disorder.展开更多
The year 2005 marks the 60th anniversary of the victory of the Chinese People’s War of Resistance Against Japanese Aggression and the world’s anti-fascist war. China and many other countries have held all kinds of a...The year 2005 marks the 60th anniversary of the victory of the Chinese People’s War of Resistance Against Japanese Aggression and the world’s anti-fascist war. China and many other countries have held all kinds of activities to commemorate this event that has most deeply impacted human history. The Second World War, the crudest war展开更多
Emotional and motivational disorders in adults are often considered to be the result of altered neurodevelopment. Clinical and experimental data provide evidence that serine protease dipeptidyl peptidase-IV (DPP-IV, E...Emotional and motivational disorders in adults are often considered to be the result of altered neurodevelopment. Clinical and experimental data provide evidence that serine protease dipeptidyl peptidase-IV (DPP-IV, EC 3.4.14.5) is involved in the pathophysiology of psycho-emotional disorders. Recently, we have shown that adolescent and adult rats exhibit an increase in anxiety and depression-related behaviors after neonatal administration of a synthetic non-competitive inhibitor of DPP-IV, methionyl-2(S)-cyano-pyrrolidine. In the present study, we tested the effects of two competitive, selective DPP-IV inhibitors, sitagliptin (4 mg/kg) and diprotin A (2 mg/kg), administered at postnatal days 5 - 18 on the emotional and motivational behavior of adolescent and adult rats. We observed increased anxiety in one-month-old diprotin A- or sitagliptin-treated rats in the elevated plus maze;diprotin A also enhanced the animals’ anxiety score using a ranked scale for evaluating anxiety and phobias. In the sucrose consumption and preference test, depressive-like behavior was pronounced in both the diprotin A- and sitagliptin-treated one-month-old animals, while only the diprotin A-treated rats exhibited a decrease in sucrose consumption at the age of 2 months. The diprotin A-treated rats also demonstrated behavioral despair and decreased activity in the forced swimming test within 1 - 3 months of age. Increased aggression was observed in 1 - 3-month-old diprotin A-treated rats and in two-month-old sitagliptin-treated rats. These findings support the hypothesis that DPP-IV is involved in the genesis of emotional and motivational disorders. Additionally, the results show that diprotin А impairs the adolescent and adult rats’ behavior more significantly than sitagliptin when the animals were treated with the DPP-IV inhibitors in the early postnatal period.展开更多
How to quickly predict an individual’s behavioral choices is an important issue in the field of human behavior research.Using noninvasive electroencephalography,we aimed to identify neural markers in the prior outcom...How to quickly predict an individual’s behavioral choices is an important issue in the field of human behavior research.Using noninvasive electroencephalography,we aimed to identify neural markers in the prior outcome-evaluation stage and the current option-assessment stage of the chicken game that predict an individual’s behavioral choices in the subsequent decision-output stage.Hierarchical linear modeling-based brain-behavior association analyses revealed that midfrontal theta oscillation in the prior outcome-evaluation stage positively predicted subsequent aggressive choices;also,beta oscillation in the current option-assessment stage positively predicted subsequent cooperative choices.These findings provide electrophysiological evidence for the three-stage theory of decision-making and strengthen the feasibility of predicting an individual’s behavioral choices using neural oscillations.展开更多
Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other places.Colleg...Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other places.College students with left-behind experience showed higher aggression levels.To further explore the relationship between left-behind experience and aggression,the current study categorized left-behind experience using latent class analysis and explored its relationship with aggression.One thousand twenty-eight Chinese college students with left-behind experience were recruited,and their aggression levels were assessed.The results showed that there were four categories of left-behind experience:“starting from preschool,frequent contact”(35.5%),“less than 10 years in duration,limited contact”(27.0%),“starting from preschool,over 10 years in duration,limited contact”(10.9%),and“starting from school age,frequent contact”(26.6%).Overall,college students who reported frequent contact with their parents during the left-behind period showed lower levels of aggression than others did.Females were less aggressive than males in the“starting from preschool,frequent contact”left-behind situation,while males were less aggressive than females in the“starting from school age,frequent contact”situation.Thesefindings indicate that frequent contact with leaving parents contributes to decreasing aggression of college students with left-behind experience.Meanwhile,gender is an important factor in this relationship.展开更多
The objective of this cross-sectional study was to investigate if Traumatic Brain Injury (TBI) is related to decision-making deficits as well as to heightened levels of (reactive) aggression and criminal behavior in a...The objective of this cross-sectional study was to investigate if Traumatic Brain Injury (TBI) is related to decision-making deficits as well as to heightened levels of (reactive) aggression and criminal behavior in a group of Dutch male prisoners. Characteristics of aggression were assessed using three self-report questionnaires as well as systematic staff observations, complemented with data from criminal records. A semi-structured interview was conducted to rate lifetime prevalence of TBI and the Iowa Gambling Task (IGT) was completed to assess risky decision-making. Out of the total of 133 participants, 74 (55.6%) reported having sustained one or more incidents with potential TBI. Statistical comparisons between offenders with and without TBI indicated that the offenders with TBI reported significantly higher levels of (reactive) aggression on two out of three questionnaires than offenders without TBI (p-values ranging from 0.003 to 0.008), but no significant differences were found on staff observations of aggression and on the IGT. The higher conviction rates in offenders with TBI compared to the non-TBI group showed a trend. The confirmed relationship between TBI and higher aggressive tendencies is especially relevant for forensic populations due to the high prevalence rates of TBI in offenders. How this relates to specific cognitive processes remains unclear. The lack of a statistical difference between offenders with and without TBI on the IGT is in contrast with literature in non-offender samples, but seems to be in line with other studies in forensic populations.展开更多
基金supported by the New Cornerstone Science Foundation and the Key R&D Program of Zhejiang(2024SSYS0016).
文摘Aggression,an evolutionarily conserved social behavior,is essential for animals to compete for valuable resources like food,territory,and mates,and to protect kin.Although aggression is required for the survival of both sexes,it is often displayed in a sexually dimorphic manner,with males typically exhibiting higher levels of aggression than females.
基金Supported by Henan Provincial Science and Technology Research Project,No.242102310203.
文摘BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.AIM To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.METHODS Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were identified.Network pharmacology was used to establish protein-protein interaction networks of the core targets of olanzapine.Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently performed.RESULTS Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.After treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with schizophrenia.Olanzapine effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis pathways.Ten core targets of olanzapine were involved in several key pathways.CONCLUSION The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287。
文摘This letter critically reviews a recent longitudinal network study by Bai et al examining the dynamic,symptom-level interplay among peer bullying victimization,depression,anxiety,and aggression in Chinese adolescents.The study highlights that key symptoms,such as persistent sad mood,sleep disturbances,and cyberbullying victimization play a pivotal role in reinforcing the vicious cycle between mental health issues and bullying experiences.While the application of cross-lagged panel network analysis offers a nuanced understanding of these bidirectional relationships,several limitations remain,including the use of selfreported measures and a region-specific sample.Nevertheless,the findings underscore the urgent need for early screening and targeted interventions in school settings,particularly those addressing both emotional symptoms and digital forms of bullying.Moving forward,integrated and culturally sensitive approaches are essential to prevent escalation and break the link between peer victimization and adolescent psychopathology.Future research should incorporate multi-informant data and broaden the cultural context to strengthen generalizability and intervention design.
文摘When the War of Resistance Against Japanese Aggression broke out,a large number of Tibetan Buddhist monks who loved the country also participated in this all-out war.
基金Supported by Wuxi Municipal Health Commission Major Project,No.Z202107Wuxi Taihu Talent Project,No.WXTTP 2021.
文摘BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.
基金Youth Fund for Humanities and Social Sciences Research of the Ministry of Education “Research on the Translation, Sharing, and Evolution of Marxist Terminology in the Early Translation of the Communist Manifesto between China and Japan”
文摘It is important to clarify the historical facts and summarize the characteristics of the communication and cooperation between the CPC and the JCP during the War of Resistance against Japanese Aggression, as it holds historical and contemporary relevance. The research findings indicate that the Comintern played a crucial role as the key intermediary in facilitating the establishment of connections between the CPC and the JCP and in driving the deepening of their relationship. During their exchanges, both parties adhered to a flexible and multi-layered friendship based on the unified values of patriotism and internationalism. Their efforts played a significant role in the establishment of an international anti-fascist front in the East.
基金Program of Philosophy and Social Science Foundation of Hunan Province(18YBA324).
文摘It has been shown that early experiences of maltreatment can stably influence an individual’s internal and externalaggressive behavior in adulthood. And on what mechanisms do this stability arise? From the perspective of personalitysolidification theory, this study sample of 1951 primary and secondary school students was used toexplore the relationship between child maltreatment, Big Five personality and internalized and externalizedaggression, as well as the different mechanisms of differentiation of personality components in child maltreatmenton two different natures of aggression, using four scales: The Childhood Trauma Questionnaire (CTQ), RevisedNEO Personality Inventory (NEO-PI-R), None-suicidal Self-Injury Scale and Aggression Questionnaire. The findingssuggest that (1) neuroticism plays the same mediating mechanism in the effect of child maltreatment on thepersistence of internalized and externalized aggression;and (2) conscientiousness plays a different mechanism ineffect of child maltreatment on both internalized and externalized aggression. Therefore, child maltreatmentshould be discouraged and the development of a sound personality should be guided, thus reducing future aggressivebehavior and promoting child development and social harmony.
文摘BACKGROUND Displaced aggression occurs when a person encounters a provoking situation,is unable or unwilling to retaliate against the original provocateur,and subsequently aggresses against a target that is not the source of the initial provocation.The displaced aggression questionnaire(DAQ)was developed to measure individual differences in the tendency to displace aggression.AIM To develop a Dutch version of the DAQ and examine relationships between the DAQ and novel individual differences.METHODS The Dutch version of the DAQ was created using a back-translation procedure.Undergraduate students(n=413)participated in the current study.The questionnaires were administered online.RESULTS The results confirmed the original three-factor structure and showed good reliability and validity.We also found differential relationships between trait displaced aggression,social anxiety and cognitive distortions.CONCLUSION The results may indicate that distinct patterns exist in the development of the different dimensions of trait displaced aggression.This study adds to the growing cross-cultural literature showing the robustness of trait displaced aggression in several different cultures.
基金supported by the National Natural Science Foundation of China (81425009, 31630028, 91632305, 30950030, 31170988, and 81671044)the National Basic Research Development Program (973 Program) of China (2009CB522002)
文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions.
文摘Aggression is a common behavioral trait shared in many animals, including both vertebrates and invertebrates. However, the type and intensity of agonistic encounters and displays can vary widely both across and within species, resulting in complicated or subjective interpretations that create difficulties in developing theoretical models that can be widely applied. The need to easily and objectively identify quantifiable behaviors and their associated morphologies becomes especially important when attempting to decipher the neurological mechanisms underlying this complex behavior. Monoamines, neuropeptides, and pheromones have been implicated as important neuromodulators for agonistic displays in both invertebrates and vertebrates. Ad- ditionally, recent breakthroughs in insect research have revealed exciting proximate mechanisms important in aggression that may be broadly relevant, due to the relatively high conservation of these neurochemical systems across animal taxa. In this review, we present the latest research demonstrating the importance of monoamines, neuropeptides, and pheromones as neuromodulators for aggression across a variety of insect species. Additionally, we describe the stalk-eyed fly as a model system for studying aggres- sion, which integrates physiological, morphological, and neurochemical approaches in exploring detailed mechanisms responsible for this common yet complex behavior. We conclude with our perspective on the most promising lines of future research aimed at understanding the proximate and ultimate mechanisms underlying aggressive behaviors .
文摘Traits that aid in the invasion process should exhibit a gradient across the expansion range in response to changing selection pressures. Aggression has been repeatedly associated with invasion success in many taxa, as it may help invaders to wrestle the resources from other species which enhances their success in a novel environment. However, aggression primarily al lows individuals to overcome conspecific rivals, providing advantages in competition over resources. Agonistic prowess could therefore increase fitness at both ends of the expansion gradient. Here we review the role of aggression in range expansion of in vasive species, and its potential role as a driver of range expansion. We analyze how these different mechanisms could affect trait variation in expanding and invasive populations. Specifically, we look at how aggression could help dilate the edges of a popula tion through niche competition, as well as lead to exclusion from the center （Le. areas of high population density） by the conspe cities. Both of these processes will result in a characteristic spatial distribution of phenotypes related to aggression that could provide insights into the ecological pressures and dynamics of expanding populations, potentially providing clues to their success as niche competitors and invasive species
基金This work was supported by grants from the National Natural Science Foundation of China(31872280 and 31622054)the Strategic Priority Research Program of the Chinese Academy of Science(XDB11010800)the China Postdoctoral Science Foundation(E290D51135),and the Chinese Academy of Sciences(E129Q21105).
文摘Females increase aggression for mating opportunities and for acquiring reproductive resources.Although the close relationship between female aggression and mating status is widely appreciated,whether and how female aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observation that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vaccenyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggressive behavior in Drosophila females.
文摘Despite growing interest in female ornament evolution, we still have a rudimentary understanding of female display traits relative to similar traits in males. Under one popular adaptive scenario, female ornaments are hypothesized to function in female-female competition and serve as badges of status, such that their expression is linked with elevated aggression in some cases. In this study, we investigated the relationship between 2 female ornaments--male-like red throat color and red spine coloration--and female aggression in 2 independently derived stream-resident populations of three-spined stickleback Gasterosteus aculeatus. Using simulated intrusions, we tested whether females with redder ornaments were generally more aggressive, and for variation in aggressive and social behaviors between the 2 populations. We found that the red intensity of the throat and spine did not predict aggression levels in either population, suggesting a limited role for both female ornaments during female-female interaction. The 2 populations exhibited different levels of aggressive behaviors, unrelated to the color patches. Our results suggest that variation in selective pressures between populations may promote interpopulation variance in aggressive behavior but not the correlation between female ornamentation and aggression, and raise the possibility that red coloration may have evolved through different mechanisms or processes in the 2 populations.
基金partially supported by the Colorado Injury Control Research Center Grant Number 5R49CE001168 from the Centers for Disease Control and Preventionthe USA-China Agricultural Injury Research Training Project Grant Number 5DW43TW007257 from the National Institutes of Health,Fogarty International Center
文摘A case-control study was conducted to investigate associations between organophosphate pesticide（OP）exposure,aggression,impulsivity,and attempted suicide.Questionnaires were used to collect information;impulsivity and aggression were measured by the Barratt Impulsivity Scale（BIS）and the Aggression Inventory（AI）.
文摘Childhood Onset Conduct Disorder [CD] is a condition characterized by at least one symptom of conduct disorder (based on Diagnostic and Statistical Manual of Mental Disorders criteria—Fifth Edition) prior to 10 years of age. Children affected exhibit disruptive behaviors, usually negative, hostile, and defiant behavior similar to Oppositional Defiant Disorder [ODD]. As the child gets older they begin to display more characteristic of Conduct Disorder (lying, fighting, and stealing, vindictive behavior). These children are also likely to have comorbidities including Attention Deficit Hyperactivity Disorder (ADHD), learning disabilities, poor academic achievement, and substance abuse. Distinguishing early between symptoms of Conduct Disorder versus other differential diagnoses is essential in effective treatment. Early intervention with these children leads to a better prognosis and likelihood of functioning in society. This case illustrates the difficulty of diagnosing a young child with Childhood Onset Conduct Disorder.
文摘The year 2005 marks the 60th anniversary of the victory of the Chinese People’s War of Resistance Against Japanese Aggression and the world’s anti-fascist war. China and many other countries have held all kinds of activities to commemorate this event that has most deeply impacted human history. The Second World War, the crudest war
文摘Emotional and motivational disorders in adults are often considered to be the result of altered neurodevelopment. Clinical and experimental data provide evidence that serine protease dipeptidyl peptidase-IV (DPP-IV, EC 3.4.14.5) is involved in the pathophysiology of psycho-emotional disorders. Recently, we have shown that adolescent and adult rats exhibit an increase in anxiety and depression-related behaviors after neonatal administration of a synthetic non-competitive inhibitor of DPP-IV, methionyl-2(S)-cyano-pyrrolidine. In the present study, we tested the effects of two competitive, selective DPP-IV inhibitors, sitagliptin (4 mg/kg) and diprotin A (2 mg/kg), administered at postnatal days 5 - 18 on the emotional and motivational behavior of adolescent and adult rats. We observed increased anxiety in one-month-old diprotin A- or sitagliptin-treated rats in the elevated plus maze;diprotin A also enhanced the animals’ anxiety score using a ranked scale for evaluating anxiety and phobias. In the sucrose consumption and preference test, depressive-like behavior was pronounced in both the diprotin A- and sitagliptin-treated one-month-old animals, while only the diprotin A-treated rats exhibited a decrease in sucrose consumption at the age of 2 months. The diprotin A-treated rats also demonstrated behavioral despair and decreased activity in the forced swimming test within 1 - 3 months of age. Increased aggression was observed in 1 - 3-month-old diprotin A-treated rats and in two-month-old sitagliptin-treated rats. These findings support the hypothesis that DPP-IV is involved in the genesis of emotional and motivational disorders. Additionally, the results show that diprotin А impairs the adolescent and adult rats’ behavior more significantly than sitagliptin when the animals were treated with the DPP-IV inhibitors in the early postnatal period.
基金the National Social Science Foundation of China(19ZDA361)。
文摘How to quickly predict an individual’s behavioral choices is an important issue in the field of human behavior research.Using noninvasive electroencephalography,we aimed to identify neural markers in the prior outcome-evaluation stage and the current option-assessment stage of the chicken game that predict an individual’s behavioral choices in the subsequent decision-output stage.Hierarchical linear modeling-based brain-behavior association analyses revealed that midfrontal theta oscillation in the prior outcome-evaluation stage positively predicted subsequent aggressive choices;also,beta oscillation in the current option-assessment stage positively predicted subsequent cooperative choices.These findings provide electrophysiological evidence for the three-stage theory of decision-making and strengthen the feasibility of predicting an individual’s behavioral choices using neural oscillations.
基金supported by the National Natural Science Foundation of China(Grant No.31800929)Fundamental Research Funds for the Central Universities(Grant No.2020NTSS42).
文摘Left-behind experience refers to the experience of children staying behind in their hometown under the care of only one parent or their relatives while one or both of their parents leave to work in other places.College students with left-behind experience showed higher aggression levels.To further explore the relationship between left-behind experience and aggression,the current study categorized left-behind experience using latent class analysis and explored its relationship with aggression.One thousand twenty-eight Chinese college students with left-behind experience were recruited,and their aggression levels were assessed.The results showed that there were four categories of left-behind experience:“starting from preschool,frequent contact”(35.5%),“less than 10 years in duration,limited contact”(27.0%),“starting from preschool,over 10 years in duration,limited contact”(10.9%),and“starting from school age,frequent contact”(26.6%).Overall,college students who reported frequent contact with their parents during the left-behind period showed lower levels of aggression than others did.Females were less aggressive than males in the“starting from preschool,frequent contact”left-behind situation,while males were less aggressive than females in the“starting from school age,frequent contact”situation.Thesefindings indicate that frequent contact with leaving parents contributes to decreasing aggression of college students with left-behind experience.Meanwhile,gender is an important factor in this relationship.
文摘The objective of this cross-sectional study was to investigate if Traumatic Brain Injury (TBI) is related to decision-making deficits as well as to heightened levels of (reactive) aggression and criminal behavior in a group of Dutch male prisoners. Characteristics of aggression were assessed using three self-report questionnaires as well as systematic staff observations, complemented with data from criminal records. A semi-structured interview was conducted to rate lifetime prevalence of TBI and the Iowa Gambling Task (IGT) was completed to assess risky decision-making. Out of the total of 133 participants, 74 (55.6%) reported having sustained one or more incidents with potential TBI. Statistical comparisons between offenders with and without TBI indicated that the offenders with TBI reported significantly higher levels of (reactive) aggression on two out of three questionnaires than offenders without TBI (p-values ranging from 0.003 to 0.008), but no significant differences were found on staff observations of aggression and on the IGT. The higher conviction rates in offenders with TBI compared to the non-TBI group showed a trend. The confirmed relationship between TBI and higher aggressive tendencies is especially relevant for forensic populations due to the high prevalence rates of TBI in offenders. How this relates to specific cognitive processes remains unclear. The lack of a statistical difference between offenders with and without TBI on the IGT is in contrast with literature in non-offender samples, but seems to be in line with other studies in forensic populations.
