An effective vaccine for human immunodeficiency virus(HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome(AIDS). As glycosylation of viral proteins becomes better un...An effective vaccine for human immunodeficiency virus(HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome(AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.展开更多
Oil and gas production systems have the characteristics of high operation and maintenance risk and great accident influence.With the deep integration of informationization and industrialization,the development directio...Oil and gas production systems have the characteristics of high operation and maintenance risk and great accident influence.With the deep integration of informationization and industrialization,the development direction and necessary choice of the oil and gas industry is to develop the oil and gas production system into the interconnected,multi-domain interactive cyber-physical intelligent system.In order to avoid or reduce the complex,diverse and potentially unknown safety risks in the process of oil and gas production,improve the safety and reliability of oil and gas production system and increase the production efficiency,this paper analyzes the safety problems occurring in the intelligentization process of oil and gas production system and constructs a system from the perspective of operation and maintenance based on key elements of intelligent safe operation and maintenance technology,combined with the typical production scenarios in the oil and gas production industry.And the following research results are obtained.First,the connotation of intelligent safe operation and maintenance technology is clarified,the key elements and existing problems and challenges of intelligent safe operation and maintenance technology are analyzed,and the“1-2-3-4-5-6”intelligent safe operation and maintenance technology system of oil and gas production system is constructed,which empowers six key technologies with key elements of oil and gas production to realize the essential safety of oil and gas production system.Second,the intelligent safe operation and maintenance technology actively promotes the application and implementation of condition monitoring,health management,risk assessment,intelligent early warning technologies in typical production scenarios such as drilling and extraction,storage and transportation,refining and chemical industry in up,middle and down streams of oil and gas production.Third,in view of the characteristics of oil and gas production system under digital transformation,it is proposed to develop the intelligent safe operation and maintenance technology with the functions of intelligent decision-making,active prevention and comprehensive safety in the future to help the safe construction in thefield of oil and gas production and promote the safe and healthy development of the oil and gas industry.In conclusion,the research on intelligent safe operation and maintenance technology system of oil and gas production system is conducive to the safe construction in thefield of oil and gas production,which will not only provide technical support for the realization of trouble-free oil and gas production system,but also provide reference for the intelligent development of the world oil and gas industry.展开更多
基金the National Science Foundation for Young Scientists of China(No.21302068)the Natural Science Foundation of Jiangsu Province,China(No.BK20130127,BK20140154,and BK20150140)+1 种基金the Public Health Research Center at Jiangnan University(No.JUPH201502)Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education,Jiangnan University(KLCCB-KF201504)
文摘An effective vaccine for human immunodeficiency virus(HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome(AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.
基金supported by the Key Program of National Natural Science Foundation of China“Research on risk formation mechanism and control method of oil&gas storage and transportation system from the perspective of cyber-physics”(No:52234007).
文摘Oil and gas production systems have the characteristics of high operation and maintenance risk and great accident influence.With the deep integration of informationization and industrialization,the development direction and necessary choice of the oil and gas industry is to develop the oil and gas production system into the interconnected,multi-domain interactive cyber-physical intelligent system.In order to avoid or reduce the complex,diverse and potentially unknown safety risks in the process of oil and gas production,improve the safety and reliability of oil and gas production system and increase the production efficiency,this paper analyzes the safety problems occurring in the intelligentization process of oil and gas production system and constructs a system from the perspective of operation and maintenance based on key elements of intelligent safe operation and maintenance technology,combined with the typical production scenarios in the oil and gas production industry.And the following research results are obtained.First,the connotation of intelligent safe operation and maintenance technology is clarified,the key elements and existing problems and challenges of intelligent safe operation and maintenance technology are analyzed,and the“1-2-3-4-5-6”intelligent safe operation and maintenance technology system of oil and gas production system is constructed,which empowers six key technologies with key elements of oil and gas production to realize the essential safety of oil and gas production system.Second,the intelligent safe operation and maintenance technology actively promotes the application and implementation of condition monitoring,health management,risk assessment,intelligent early warning technologies in typical production scenarios such as drilling and extraction,storage and transportation,refining and chemical industry in up,middle and down streams of oil and gas production.Third,in view of the characteristics of oil and gas production system under digital transformation,it is proposed to develop the intelligent safe operation and maintenance technology with the functions of intelligent decision-making,active prevention and comprehensive safety in the future to help the safe construction in thefield of oil and gas production and promote the safe and healthy development of the oil and gas industry.In conclusion,the research on intelligent safe operation and maintenance technology system of oil and gas production system is conducive to the safe construction in thefield of oil and gas production,which will not only provide technical support for the realization of trouble-free oil and gas production system,but also provide reference for the intelligent development of the world oil and gas industry.
