BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gast...BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gastrointestinal disorders are related to spleen and stomach weakness.This study hypothesizes that the combination of acupoint application at the Ziwu Liuzhu acupoint and percutaneous acupoint electrical stimulation can promote postoperative gastrointestinal function recovery and alleviate stress reactions.AIM To investigate the effects of acupoint application of Ziwu Liuzhu combined with percutaneous acupoint electrical stimulation on postoperative gastrointestinal function recovery and stress response in patients undergoing gastrointestinal endoscopy surgery.METHODS A total of 120 patients who underwent gastroscopy surgery were selected and treated between October 2024 and January 2025.This study used a stratified block randomization method,and then allocated groups using computer-generated random number sequences(SAS 9.4 software).The groups were divided into two groups:A control group of 60 patients who received routine postoperative intervention measures,and an observation group of 60 patients who received acupuncture point application combined with transcutaneous acupoint electrical CONCLUSION The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective.The benefits of this approach include the promotion of postoperative gastrointestinal function,the reduction of stress response,the attainment of optimal results,and the enhancement of patient satisfaction.展开更多
This study summarized traditional Chinese medicine(TCM)master in the capital,HE Sisheng’s experience in acupuncture on single acupoint application.He emphasizes the properties and therapeutic effects of acupuncture p...This study summarized traditional Chinese medicine(TCM)master in the capital,HE Sisheng’s experience in acupuncture on single acupoint application.He emphasizes the properties and therapeutic effects of acupuncture points in clinical practice,adhering to the principles of balancing Yin and Yang and selecting points along meridians.Acupuncture at Neiguan(PC6)acupoint can clear the heart fire and unclog meridians,harmonize the triple energizer,and treat cardiovascular diseases and gastrointestinal disorders.Acupuncture at Renzhong(GV26)acupoint can awaken the mind,open the orifices,and unblock the governor vessel to treat mental diseases,treating mental disorders and acute lumbar sprain.Acupuncture at Cuanzhu(BL2)acupoint can dispel wind and relieve pain,soothe the spleen and stomach and regulate Qi for headache,eye diseases and hiccup.Acupuncture at Yifeng(SJ17)can nourish Qi,tonify Yang,dispel wind,and unblock meridians,and is effective for diseases of the head and facial features.Acupuncture at Yongquan(KI1)acupoint can invigorate Qi and reinforcing Yang,disperses the wind,passes through the channels and collaterals for diseases of facial features.Acupuncture at Dadun(LR1)acupoint can clear away dampness and heat,regulate Qi and harmonize liver to treat diseases of urogenital system and vertigo and epilepsy.展开更多
Gastric ulcer(GU)is a common digestive system disease.Acupuncture,as one of the external treatments of traditional Chinese medicine(TCM),has the characteristics of multi-target,multi-pathway and multi-level action in ...Gastric ulcer(GU)is a common digestive system disease.Acupuncture,as one of the external treatments of traditional Chinese medicine(TCM),has the characteristics of multi-target,multi-pathway and multi-level action in the treatment of GU.The relationship between meridian points and Zang-fu is an important part of the theory of TCM,which is crucial for the diagnosis and treatment of diseases.There is an external and internal link between acupoints and Zang-fu.The pathological reaction of Zang-fu can manifest as acupoint sensitization,while stimulation of acupoints can play a therapeutic role in the internal Zang-fu.Therefore,the acupoint has the functions of reflecting and treating diseases.This review explores the tender points on the body surface of patients with GU and the rules of acupoint selection.In addition,Zusanli(ST36),as one of the most used acupoints of the stomach meridian,was selected to show the mechanisms behind acupoint stimulation in the treatment of GU in greater detail,specifically in the well-studied model of the stress GU(SGU).Hence,the mechanisms of acupuncture at ST36 and points commonly used in combination with ST36 to treat SGU are discussed further.Treatment effects can be achieved through anti-inflammatory and antioxidant activities,gastric mucosal injury repair,and interaction with the brain-gut axis.In summary,this review provides evidence for a comprehensive understanding of the phenomena and mechanism of acupoint functions for GU.展开更多
Transcutaneous electrical acupoint stimulation(TEAS)is a kind of physical therapy that use electric cur-rent through the electrodes placed on the surface of acupoints to produce clinical effects in the human body,whic...Transcutaneous electrical acupoint stimulation(TEAS)is a kind of physical therapy that use electric cur-rent through the electrodes placed on the surface of acupoints to produce clinical effects in the human body,which is characterized by less adverse reaction and convenient operation.It has been widely used in the treatment of various diseases.This review introduces six major clinical applications of TEAS,named analgesia,regulation of gastrointestinal function,improvement of reproductive function,enhancement of cognitive function,promotion of limb function recovery and relief of fatigue.Besides,TEAS has been ap-plied to the treatment of other chronic diseases such as hypertension and diabetes,achieving satisfactory clinical effects.However,two crucial challenges are encountered in the development of TEAS.One is the lack of standardization in the selection of parameters such as waveform,frequency,intensity and stimula-tion duration.The other is the limitation on the flexibility in the acupoint selection.This review analyzes key issues that need to be addressed in the current clinical application of TEAS,such as the selection of parameters and acupoints,and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.展开更多
[Objectives]To investigate the clinical efficacy of acupoint injection of nerve growth factors combined with task-oriented training for patients with post-stroke hemiplegic gait,and quantitatively evaluate the outcome...[Objectives]To investigate the clinical efficacy of acupoint injection of nerve growth factors combined with task-oriented training for patients with post-stroke hemiplegic gait,and quantitatively evaluate the outcomes using the Gait Watch analysis system.[Methods]A total of 90 patients with post-stroke hemiplegia,who were hospitalized at the Rehabilitation Center of Taihe Hospital between January 2023 and December 2023,were selected for this study.The participants were randomly assigned to three groups:the task-oriented rehabilitation training group(control group I,n=30),the ordinary acupuncture combined with task-oriented training group(control group II,n=30),and the acupoint injection combined with task-oriented training group(observation group,n=30).Each group underwent treatment for 4 weeks.The Gait Watch analysis system was employed to assess the spatiotemporal gait parameters of the patients prior to treatment,as well as 2 weeks post treatment and 4 weeks post treatment.The efficacy of the treatment was subsequently analyzed.[Results]After 4 weeks of treatment,the spatiotemporal gait parameters,specifically step length,step speed,step frequency,percentage of the standing phase,and percentage of the swinging phase,exhibited significant improvement in the observation group compared to those before treatment(P<0.05).Furthermore,the degree of improvement in the observation group was superior to that observed in both control group I and control group II,with the differences reaching statistical significance(P<0.05).[Conclusions]Acupoint injection combined with task-oriented training has been shown to significantly enhance gait function in patients with post-stroke hemiplegia.The Gait Watch analysis system offers an accurate and objective quantitative assessment,making it a valuable tool for clinical application and promotion.展开更多
Objective:Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis(OA).Skin temperature,a guiding factor for acupoint selection,may help...Objective:Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis(OA).Skin temperature,a guiding factor for acupoint selection,may help to address this issue.This study explored thermal sensitization of acupoints used for the treatment of knee OA.Methods:This cross-sectional case-control study enrolled cases aged 45–75 years with symptomatic knee OA and age-and gender-matched non-knee OA controls in a 1:1 ratio.All participants underwent infrared thermographic imaging.The primary outcome was the relative skin temperature of acupoint(STA),and the secondary outcome was the absolute STA of 11 acupoints.The Z test was used to compare the relative and absolute STAs between the groups.Principal component analysis was used to extract the common factors(CFs,acupoint cluster)in the STAs.A general linear model was used to identify factors affecting the STA in the knee OA cases.For the group comparisons of relative STA,P<0.0045(adjusted for 11 acupoints through Bonferroni correction)was considered to indicate statistical significance.For other analyses,P<0.05 was used as the threshold for statistical significance.Results:The analysis included 308 participants,consisting of 151 cases(mean age:[64.58±6.67]years;male:25.83%;mean body mass index:[25.70±3.16]kg/m~2)and 157 controls(mean age:[63.37±5.96]years;male:26.11%;mean body mass index:[24.47±2.84]kg/m~2).The relative STAs of ST34(P=0.0001),EX-LE2(P<0.0001),EX-LE5(P=0.0006),SP10(P<0.0001),BL40(P=0.0012)and GB39(P=0.0037)were higher in the knee OA group.No difference was found in the STAs of ST35,ST36,SP9,GB33 and GB34.Four CFs were identified for relative STA in both groups.The acupoints within each CF were consistent between the groups.The mean values of the relative STAs across each CF were higher in the knee OA group.In the knee OA cases,no factors were observed to affect the relative STA,while age and gender were found to affect the absolute STA.Conclusion:Among patients with knee OA,thermal sensitization occurs in the acupoints of the lower extremity,exhibiting localized and regional thermal consistencies.The thermally sensitized acupoints that we identified in this study,ST34,SP10,EX-LE2,EX-LE5,GB39 and BL40,may be good choices for the acupuncture treatment of knee OA.展开更多
Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint de...Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint delivery of nanovaccines(ADN)to elicit dual-niche immunological priming.ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes.We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α^(+)dendritic cells,but also induces the accumulation of nanovaccines in B-cell zones,amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes.ADN also generates systemic immune responses by causing immune memory and preventing T-cell anergy in the spleen.Further supported by evoking effective antitumor responses and high-level antiviral antibodies in mice,ADN provides a simple yet versatile platform for advanced nanovaccination.展开更多
BACKGROUND This study seeks to systematically assess the effects of warm acupuncture combined with acupoint massage on the recovery of gastrointestinal function following gastric cancer surgery.AIM To evaluate the imp...BACKGROUND This study seeks to systematically assess the effects of warm acupuncture combined with acupoint massage on the recovery of gastrointestinal function following gastric cancer surgery.AIM To evaluate the impact of warm acupuncture combined with acupoint massage on postoperative gastrointestinal function recovery after gastric cancer surgery,based on a systematic review and meta-analysis.METHODS A comprehensive search was conducted across multiple databases,including PubMed,Cochrane Library,EMBASE,Web of Science,CNKI,Wanfang,and VIP,for relevant studies published up to January 2025.Meta-analyses were carried out using RevMan 5.4,with results presented as standardized mean difference(SMD)or odds ratio with 95%confidence interval(CI).Study heterogeneity was evaluated using the I2 statistic,and sensitivity analyses were performed to assess the stability of the findings.RESULTS A total of 8 randomized controlled trials involving 694 patients were included.The meta-analysis showed that warm acupuncture combined with acupoint massage significantly improved postoperative gastrointestinal function by reducing the time to first flatus(SMD=-2.14,95%CI:-3.14 to-1.14,P<0.0001),time to first bowel movement(SMD=-2.43,95%CI:-3.52 to-1.34,P<0.0001),time to bowel sounds recovery(SMD=-3.15,95%CI:-4.50 to-1.80,P<0.00001),and time to initiate nasogastric or jejunal feeding(SMD=-1.31,95%CI:-2.44 to-0.18,P=0.02).CONCLUSION The combination of warm acupuncture and acupoint massage markedly enhances gastrointestinal recovery following surgery.展开更多
Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and...Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and safety of acupuncture on corticospinal excitability(CSE),and the credibility of the evidence has yet to be quantified.Objective:This study was designed to assess the efficacy and safety of electroacupuncture(EA)and manual acupuncture(MA)in enhancing brain excitability,specifically focusing on CSE as measured by transcranial magnetic stimulation(TMS).Search strategy:This study followed a systematic approach,searching 9 databases up to August 2024 and examining grey literature,in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Inclusion criteria:Studies were included if they compared the clinical efficacy of EA or MA with sham acupuncture,no treatment or usual training.Data extraction and analysis:Three investigators independently conducted literature screening,data extraction,and risk of bias assessment.The primary outcome focused on motor-evoked potentials as measured by TMS,with treatment effects quantified using mean differences or standardized mean differences between pre-and post-treatment.Subgroup analyses were conducted using mixed-effects models,while random-effects or fixed-effects models were used to estimate average treatment differences across studies.Results:Based on 34 studies involving 1031 adults,acupuncture techniques significantly enhanced CSE.EA had a greater impact than MA,with effect sizes of 0.53 mV vs 0.43 mV(95%confidence interval[CI]:[0.30,0.76],P<0.00001 vs 95%CI:[0.28,0.59],P<0.00001).The 5 most frequently used acupoints were LI4(Hegu,32 times),ST36(Zusanli,10 times),LI11(Quchi,7 times),TE5(Waiguan,6 times),and GB34(Yanglingquan,5 times).Conclusion:This systematic review indicates that both EA and MA could effectively and safely enhance CSE,bringing the corticospinal pathway closer to the threshold for firing,which may ultimately improve motor function.LI4,ST36,LI11,TE5 and GB34 are the most commonly used acupoints.展开更多
Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this ...Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this approach from the perspective of gut microbiota.Methods:This multicenter,randomized,double-blind(patients and assessors),placebo-controlled trial will enroll 80 patients with PSD,and include a 1-week run-in period,a 4-week treatment phase,and a 12-week follow-up.Eligible participants will randomly be assigned in a 1:1 ratio to either the acupoint application or placebo(non-acupoint)groups.Treatments will be administered thrice weekly for 4 weeks.The primary outcome is change in the Hamilton Rating Scale for Depression(HAMD)score.Secondary outcomes include the Beck Depression Inventory(BDI),36-Item Short-Form Health Survey(SF-36),Barthel Index of Activities of Daily Living,Social Adaptation Self-Evaluation Scale(SASS),and gut microbiota profiling.All outcomes will be assessed at baseline(prior to treatment),during treatment(weeks 2 and 4),and during follow-up(weeks 8,12,and 16).The Treatment Emergent Symptom Scale(TESS)will be used for evaluation throughout the 4-week treatment phase.Discussion:The results of this study will provide important evidence supporting a novel treatment strategy for PSD that targets gastrointestinal regulation,potentially informing future clinical practice.展开更多
The objective of this study is to analyze the relevant literature on acupoint massage applied to patients with poststroke constipation,to explore the research status,research hotspots,and research frontiers of poststr...The objective of this study is to analyze the relevant literature on acupoint massage applied to patients with poststroke constipation,to explore the research status,research hotspots,and research frontiers of poststroke constipation,and to provide reference for clinical practice and scientific research.With the help of CiteSpace software,the related literatures published in the China National Knowledge Infrastructure database on the application of acupoint massage to constipation after stroke were analyzed,and scientific atlas for visual analysis was drawn.The hot keywords in the field of acupoint massage for post-stroke constipation are constipation,nursing intervention,and traditional Chinese medicine(TCM)nursing,indicating the great importance of TCM nursing for such patients.In mutation word detection,words such as constipation,nursing,stroke,and defecation reflex have earlier mutation times.Massage is the keyword with the longest mutation time,suggesting it is an effective intervention for post-stroke patients and is widely recognized.The commonly used acupoints for poststroke constipation are Tianshu(ST 25),Zhongwan(CV 12),and Qihai(CV 6).These acupoints can regulate qi and blood and enhance gastrointestinal peristalsis,providing guiding significance for formulating relevant clinical practice guidelines.The research of acupoint massage in the nursing of poststroke constipation is still in the stage of practice and exploration,and the specific definition of operation process,technique,acupoint,time,and intensity is still not clear.Multicenter,large-sample,in-depth intervention research,and cohort studies hold immense significance for the future development of this discipline.展开更多
[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese m...[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.展开更多
Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clini...Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clinical practice.Methods Clinical studies on acupuncture for gallbladder colic,renal colic,and primary dysmenorrhea published between 2006 and 2025 were retrieved from the Chinese National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Wanfang,and PubMed.Bibliometric analysis was performed using IBM SPSS Modeler 18.0,and the Apriori algorithm was applied to evaluate acupoint-use patterns.Results The analysis demonstrated that commonly selected acupoints for these conditions have remained relatively consistent over the past two decades.Frequently used acupoints for gallbladder colic included Yanglingquan(GB 34),Dannang(EX-LE 6),Qiuxu(GB 40),Taichong(LR 3),Danshu(BL 19),Zusanli(ST 36),Qimen(LR 14),Riyue(GB 24),and Ganshu(BL 18).For renal colic,the most frequently reported points were Shenshu(BL 23),Sanyinjiao(SP 6),Zusanli(ST 36),Yinlingquan(SP 9),Jingmen(GB 25),Guanyuan(CV 4),Ashi points,Zhongji(CV 3),and Pangguangshu(BL 28).The main acupoints for primary dysmenorrhea were Sanyinjiao(SP 6),Guanyuan(CV 4),Ciliao(BL 32),Diji(SP 8),Shiqizhui(EX-B 8),Zhongji(CV 3),Zusanli(ST 36),Zigong(EX-CA 1),and Qihai(CV 6).On average,treatment protocols employed 3-4 acupoints per session.Conclusions The most frequently selected acupoints for visceral smooth muscle spasmodic pain were located within the ganglion segment innervation areas,showing close association with the target organs.Furthermore,treatment protocols typically involved a small number of acupoints.These findings highlight the need for further systematic research,particularly randomized controlled trials,to validate and strengthen the evidence base.展开更多
Objective To analyze the electrostimulation parameters and acupoint prescriptions for treatment of functional dyspepsia(FD)based on bibliometric methods.Methods The relevant papers were searched from PubMed,Web of Sci...Objective To analyze the electrostimulation parameters and acupoint prescriptions for treatment of functional dyspepsia(FD)based on bibliometric methods.Methods The relevant papers were searched from PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP)and China Biology Medicine disc(Sinomed),dated from January 1st,2010 to May 31st,2023.Inclusion criteria of studies:①“functional dyspepsia”and electric stimulation involved in the title or abstract;and②related to the assessment of electrostimulation therapy in clinical trials and experimental research for FD.Exclusion criteria of studies:①duplication or failure to obtain full text;②published in newspaper,presenting as research achievement,and review;③nothing related to the acupoint selection;and④nothing related to the parameters of electrostimulation.Using Excel 2019 and VOSviewer software,acupoint association and the parameters of electrostimulation were analyzed and graphed.Results A total of 181 eligible articles were screened.Statistical analysis revealed that the most frequently targeted acupoints for electrostimulation in functional dyspepsia(FD)were Zusanli(ST36),Taichong(LR3),and Neiguan(PC6),while the most commonly utilized auricular point was Erjia(CO,concha zone).The acupoint group demonstrating the strongest association consisted of ST36,LR3,Zhongwan(CV12),and PC6,which constituted the primary prescription for electrostimulation in FD.The optimal parameters for electrostimulation were identified as a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.The acupoints ST36,LR3,and PC6 are the most prevalent for electrostimulation in FD,with CO being the most common auricular point.The optimal electrostimulation parameters are a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.Conclusion The acupoints ST36,LR3,and PC6 are the most prevalent for electrostimulation in FD,with CO being the most common auricular point.The optimal electrostimulation parameters are a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.展开更多
Objective To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.Methods ...Objective To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.Methods Clinical studies of abdominal obesity treated with acupuncture and moxibustion,collected in the past 10 years,were searched from China Biology Medicine disc(CBMdisc),China National knowledge infrastructure(CNKI),Wanfang,China Science and Technology Journal Database(VIP),Pubmed,Embase,Google Scholar,Web of Science,(The Cumulative Index to Nursing and Allied Health Literature)CINAHL,Psyclnfo and Scopus,dated from March 1,2013 to March 31,2023.Using IBM SPSS Modeler 18.0 and other software,the frequency analysis,association-rules analysis and cluster analysis were conducted on interventions,traditional Chinese medicine(TCM)patterns,use frequency of acupoint,meridian attribution of acupoint,acupoint location,etc.Results A total of 55 articles were included,with 102 prescriptions and 71 acupoints involved.The top 3 interventions were acupoint embedding method,simple electroacupuncture and simple filiform needling.Seventeen patterns/syndromes of TCM differentiation were collected,dominated by spleen deficiency and damp blockage,spleen and kidney yang deficiency and heat accumulation in stomach and intestines.The acupoints in clinical practice were mostly at the foot-yangming stomach meridian,the conception vessel and the foot-taiyin spleen meridian,and located at the abdominal region.The top 5 acupoints of high frequency were Tianshu(ST25),Zhongwan(CV12),Daheng(SP15),Zusanli(ST36),Huaroumen(ST24)and Daimai(GB26).The specific points of the high frequency were the crossing points and front-mu points,of which,ST25 and CV12 were the most prominent.After association-rules analysis on the high-frequency acupoints,20 groups of associated acupoints were obtained,in which,the core acupoints included ST25,CV12,SP15 and ST36.Conclusion In recent 10 years,abdominal obesity is treated by the acupoints of foot-yangming stomach meridian,the conception vessel and the foot-taiyin spleen meridian.Compared with the regimen for simple obesity,the acupoints at the abdominal region are specially selected in treatment of abdominal obesity,such as ST25,CV12,SP15 and ST36.Supplementary acupoints are selected based on syndrome differentiation to simultaneously address both the disease manifestations and root causes.展开更多
Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to ...Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to four groups:normal,sham operation,model,and TMTP Tuina.Successful model induction was confirmed by observable hind limb lameness.After 20 sessions,hind limb grip strength and motor nerve conduction velocity(MNCV)were measured at baseline and following the 10th and 20th intervention.CD31 and a-SMA in the ventral horn of SNI model rats were detected using immunofluorescence.Motor neurons in the ventral horn were detected by Nissl staining.PTEN levels in the ventral horn were measured by ELISA,and PI3K,Akt,BDNF,VEGF,and HIF-1a expression was determined by RT-PCR.Spinal cord microcirculation was evaluated by western blotting analysis of the levels of Akt,p-Akt,BDNF,and VEGF.Results:Hind limb grip strength and MNCV significantly improved in the TMTP Tuina group compared to the model group(both P<.001).Morphology of ventral horn motor neurons in the TMTP Tuina group improved compared to the model group,with increased expressions of a-SMA(P=.002)and CD31(P=.006).Western blot analysis indicated increased expression of VEGF(P=.005),p-Akt(P<.001),and BDNF(P=.008)in the ventral horn following Tuina treatment.RT-PCR analysis revealed increased expression of PI3K,Akt,BDNF,VEGF and HIF-1a(all P<.05).In contrast,expression of PTEN decreased compared to the model group(P<.001).Conclusion:TMTP Tuina therapy may restore motor function in rats,enhance ventral horn motor neuron morphology,and promote angiogenesis and vascular smooth muscle proliferation.The mechanism may involve the activation of the PI3K/Akt signaling pathway.展开更多
Objective:To explore the core acupuncture acupoints and pattern-adapted acupoint combination rules for autism spectrum disorder(ASD)complicated with sleep disorder using clinical data mining technology.Methods:A retro...Objective:To explore the core acupuncture acupoints and pattern-adapted acupoint combination rules for autism spectrum disorder(ASD)complicated with sleep disorder using clinical data mining technology.Methods:A retrospective analysis was conducted on the diagnosis and treatment data of 104 children with ASD complicated with sleep disorder admitted to Xi’an Traditional Chinese Medicine(TCM)Encephalopathy Hospital from January 2022 to December 2024.Cross-pattern main acupoints were screened via frequency statistics,chi-square test,and factor analysis;pattern-specific auxiliary acupoints were extracted by combining multiple correspondence analysis,cluster analysis,and association rule mining.Results:Ten cross-pattern main acupoints(Baihui,Sishenzhen,Language Area 1,Language Area 2,Neiguan,Shenmen,Yongquan,Xuanzhong)were identified,and acupoint combination schemes for four major TCM patterns(Hyperactivity of Liver and Heart Fire,Deficiency of Kidney Essence,Deficiency of Both Heart and Spleen,Hyperactivity of Liver with Spleen Deficiency)were established.Conclusion:Acupuncture treatment should follow the principle of“regulating spirit and calming the brain as the root,and dredging collaterals based on pattern differentiation as the branch”.The synergy between main and auxiliary acupoints can accurately regulate the disease,providing a basis for precise clinical treatment.展开更多
Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiff...Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiffness and atrophy of facial muscles on one side,which affect activities of daily living.Acupoint Injection is a treatment for facial paralysis,combining the meridian theory of traditional Chinese medicine,with the injection of specific drugs into acupuncture points of the face.In recent years,the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects.We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.展开更多
Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This ...Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This was a two-arm randomized controlled trial wherein 80 patients were recruited and divided into control(n=40)and intervention(n=40)groups.The control group received conventional orthopedic treatment,whereas the intervention group received TEAS and conventional treatment.The intervention group received TEAS 3 times a week for 30 min each time for 8 weeks.The primary out-comes were muscle thickness(MT)and cross-sectional area(CSA)of the rectus femoris and gastroc-nemius muscles,whereas the secondary outcome measure was echo intensity(EI).Data were collected before the fixation operations(baseline assessment)and 4 and 8 weeks after intervention.Results:Compared with baseline,the MT and CSA were reduced in both groups by the end of treatment,whereas EI increased in both groups.At week 4,the reduction in the rectus femoris CSA in the inter-vention group was significantly lower than that in the control group(P=0.02);however,the between-group differences in the MT and EI(all P>0.05)were not significant.No serious adverse events were observed in either group.Conclusion:Our study showed that TEAS can improve muscle atrophy by attenuating the decline in the muscle CSA.Because this was only a pilot trial,subsequent studies will need longer follow-ups and larger sample sizes.展开更多
Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NAS...Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NASH)of liver depression and spleen deficiency type.Methods:Sixty patients with NASH of liver depression and spleen deficiency type admitted to our hospital from January 2021 to December 2023 were selected and divided into an acupoint catgut embedding group(n=30)and a combined group(n=30)using the envelope lottery method.The acupoint catgut embedding group received acupoint catgut embedding intervention,while the combined group received auricular point pressing with beans on the basis of the acupoint catgut embedding group.The two groups were compared in terms of TCM syndrome scores,symptom management self-efficacy[Chronic Disease Self-Efficacy Scale(CDSES)],and quality of life[Chronic Liver Disease Questionnaire(CLDQ)].Results:After intervention,the combined group had lower TCM syndrome scores for both primary and secondary symptoms compared to the acupoint catgut embedding group(P<0.05).The combined group also had higher scores in all dimensions and total score of the CDSES compared to the acupoint catgut embedding group(P<0.05).Similarly,the combined group had higher scores in all dimensions and total score of the CLDQ compared to the acupoint catgut embedding group(P<0.05).Conclusion:Acupoint catgut embedding combined with auricular point pressing with beans can effectively improve TCM symptoms,enhance symptom management self-efficacy,and improve quality of life in patients with NASH of liver depression and spleen deficiency type.展开更多
基金Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2023ZL230。
文摘BACKGROUND Although gastroscopy is a commonly used diagnostic and therapeutic technique,postoperative gastrointestinal dysfunction is prone to occur.Traditional Chinese medicine theory suggests that postoperative gastrointestinal disorders are related to spleen and stomach weakness.This study hypothesizes that the combination of acupoint application at the Ziwu Liuzhu acupoint and percutaneous acupoint electrical stimulation can promote postoperative gastrointestinal function recovery and alleviate stress reactions.AIM To investigate the effects of acupoint application of Ziwu Liuzhu combined with percutaneous acupoint electrical stimulation on postoperative gastrointestinal function recovery and stress response in patients undergoing gastrointestinal endoscopy surgery.METHODS A total of 120 patients who underwent gastroscopy surgery were selected and treated between October 2024 and January 2025.This study used a stratified block randomization method,and then allocated groups using computer-generated random number sequences(SAS 9.4 software).The groups were divided into two groups:A control group of 60 patients who received routine postoperative intervention measures,and an observation group of 60 patients who received acupuncture point application combined with transcutaneous acupoint electrical CONCLUSION The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective.The benefits of this approach include the promotion of postoperative gastrointestinal function,the reduction of stress response,the attainment of optimal results,and the enhancement of patient satisfaction.
基金supported by“New 3+3 Project”Demonstration Research on Inheritance of“HE’s Tube Acupuncture”Technique“Seven Skills and Five Methods”Project of Beijing Administration of Traditional Chinese Medicine(No.2023-ZYSF-09).
文摘This study summarized traditional Chinese medicine(TCM)master in the capital,HE Sisheng’s experience in acupuncture on single acupoint application.He emphasizes the properties and therapeutic effects of acupuncture points in clinical practice,adhering to the principles of balancing Yin and Yang and selecting points along meridians.Acupuncture at Neiguan(PC6)acupoint can clear the heart fire and unclog meridians,harmonize the triple energizer,and treat cardiovascular diseases and gastrointestinal disorders.Acupuncture at Renzhong(GV26)acupoint can awaken the mind,open the orifices,and unblock the governor vessel to treat mental diseases,treating mental disorders and acute lumbar sprain.Acupuncture at Cuanzhu(BL2)acupoint can dispel wind and relieve pain,soothe the spleen and stomach and regulate Qi for headache,eye diseases and hiccup.Acupuncture at Yifeng(SJ17)can nourish Qi,tonify Yang,dispel wind,and unblock meridians,and is effective for diseases of the head and facial features.Acupuncture at Yongquan(KI1)acupoint can invigorate Qi and reinforcing Yang,disperses the wind,passes through the channels and collaterals for diseases of facial features.Acupuncture at Dadun(LR1)acupoint can clear away dampness and heat,regulate Qi and harmonize liver to treat diseases of urogenital system and vertigo and epilepsy.
基金funded by National Key Research and Development Program of China(No.2022YFC3501705)National Natural Science Foundation of China general projects(No.82274066)Shanghai Science and Technology Innovation Project(No.22S21901200).
文摘Gastric ulcer(GU)is a common digestive system disease.Acupuncture,as one of the external treatments of traditional Chinese medicine(TCM),has the characteristics of multi-target,multi-pathway and multi-level action in the treatment of GU.The relationship between meridian points and Zang-fu is an important part of the theory of TCM,which is crucial for the diagnosis and treatment of diseases.There is an external and internal link between acupoints and Zang-fu.The pathological reaction of Zang-fu can manifest as acupoint sensitization,while stimulation of acupoints can play a therapeutic role in the internal Zang-fu.Therefore,the acupoint has the functions of reflecting and treating diseases.This review explores the tender points on the body surface of patients with GU and the rules of acupoint selection.In addition,Zusanli(ST36),as one of the most used acupoints of the stomach meridian,was selected to show the mechanisms behind acupoint stimulation in the treatment of GU in greater detail,specifically in the well-studied model of the stress GU(SGU).Hence,the mechanisms of acupuncture at ST36 and points commonly used in combination with ST36 to treat SGU are discussed further.Treatment effects can be achieved through anti-inflammatory and antioxidant activities,gastric mucosal injury repair,and interaction with the brain-gut axis.In summary,this review provides evidence for a comprehensive understanding of the phenomena and mechanism of acupoint functions for GU.
基金Supported by Shanghai 2020“Science and Technology Innovation Action Plan”Medical Innovation Research Special Program:20Y21902800Shanghai Municipal Health Commission Shanghai Three-Year Action Plan to Further Accelerate the Development of Traditional Chinese Medicine Inheritance and Innovation:ZY(2021-2023)−0302)+1 种基金Shanghai Key Specialty(Acupuncture)Construction Project:shslczdzk04701Shanghai 2024"Science and Technology Innovation Action Plan"star cultivation(Sail special):24YF2740600.
文摘Transcutaneous electrical acupoint stimulation(TEAS)is a kind of physical therapy that use electric cur-rent through the electrodes placed on the surface of acupoints to produce clinical effects in the human body,which is characterized by less adverse reaction and convenient operation.It has been widely used in the treatment of various diseases.This review introduces six major clinical applications of TEAS,named analgesia,regulation of gastrointestinal function,improvement of reproductive function,enhancement of cognitive function,promotion of limb function recovery and relief of fatigue.Besides,TEAS has been ap-plied to the treatment of other chronic diseases such as hypertension and diabetes,achieving satisfactory clinical effects.However,two crucial challenges are encountered in the development of TEAS.One is the lack of standardization in the selection of parameters such as waveform,frequency,intensity and stimula-tion duration.The other is the limitation on the flexibility in the acupoint selection.This review analyzes key issues that need to be addressed in the current clinical application of TEAS,such as the selection of parameters and acupoints,and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.
基金Supported by Hospital-level Project of Shiyan Taihe Hospital(2019JJXM117).
文摘[Objectives]To investigate the clinical efficacy of acupoint injection of nerve growth factors combined with task-oriented training for patients with post-stroke hemiplegic gait,and quantitatively evaluate the outcomes using the Gait Watch analysis system.[Methods]A total of 90 patients with post-stroke hemiplegia,who were hospitalized at the Rehabilitation Center of Taihe Hospital between January 2023 and December 2023,were selected for this study.The participants were randomly assigned to three groups:the task-oriented rehabilitation training group(control group I,n=30),the ordinary acupuncture combined with task-oriented training group(control group II,n=30),and the acupoint injection combined with task-oriented training group(observation group,n=30).Each group underwent treatment for 4 weeks.The Gait Watch analysis system was employed to assess the spatiotemporal gait parameters of the patients prior to treatment,as well as 2 weeks post treatment and 4 weeks post treatment.The efficacy of the treatment was subsequently analyzed.[Results]After 4 weeks of treatment,the spatiotemporal gait parameters,specifically step length,step speed,step frequency,percentage of the standing phase,and percentage of the swinging phase,exhibited significant improvement in the observation group compared to those before treatment(P<0.05).Furthermore,the degree of improvement in the observation group was superior to that observed in both control group I and control group II,with the differences reaching statistical significance(P<0.05).[Conclusions]Acupoint injection combined with task-oriented training has been shown to significantly enhance gait function in patients with post-stroke hemiplegia.The Gait Watch analysis system offers an accurate and objective quantitative assessment,making it a valuable tool for clinical application and promotion.
基金funded by the National Natural Science Foundation of China(No.82104693 and 81825024)。
文摘Objective:Varied acupoint selections represent a potential cause of the uncertainty surrounding the efficacy of acupuncture for knee osteoarthritis(OA).Skin temperature,a guiding factor for acupoint selection,may help to address this issue.This study explored thermal sensitization of acupoints used for the treatment of knee OA.Methods:This cross-sectional case-control study enrolled cases aged 45–75 years with symptomatic knee OA and age-and gender-matched non-knee OA controls in a 1:1 ratio.All participants underwent infrared thermographic imaging.The primary outcome was the relative skin temperature of acupoint(STA),and the secondary outcome was the absolute STA of 11 acupoints.The Z test was used to compare the relative and absolute STAs between the groups.Principal component analysis was used to extract the common factors(CFs,acupoint cluster)in the STAs.A general linear model was used to identify factors affecting the STA in the knee OA cases.For the group comparisons of relative STA,P<0.0045(adjusted for 11 acupoints through Bonferroni correction)was considered to indicate statistical significance.For other analyses,P<0.05 was used as the threshold for statistical significance.Results:The analysis included 308 participants,consisting of 151 cases(mean age:[64.58±6.67]years;male:25.83%;mean body mass index:[25.70±3.16]kg/m~2)and 157 controls(mean age:[63.37±5.96]years;male:26.11%;mean body mass index:[24.47±2.84]kg/m~2).The relative STAs of ST34(P=0.0001),EX-LE2(P<0.0001),EX-LE5(P=0.0006),SP10(P<0.0001),BL40(P=0.0012)and GB39(P=0.0037)were higher in the knee OA group.No difference was found in the STAs of ST35,ST36,SP9,GB33 and GB34.Four CFs were identified for relative STA in both groups.The acupoints within each CF were consistent between the groups.The mean values of the relative STAs across each CF were higher in the knee OA group.In the knee OA cases,no factors were observed to affect the relative STA,while age and gender were found to affect the absolute STA.Conclusion:Among patients with knee OA,thermal sensitization occurs in the acupoints of the lower extremity,exhibiting localized and regional thermal consistencies.The thermally sensitized acupoints that we identified in this study,ST34,SP10,EX-LE2,EX-LE5,GB39 and BL40,may be good choices for the acupuncture treatment of knee OA.
基金supported by the National Key Research and Development Program of China(2021YFA0909400)the National Natural Science Foundation of China(22425505,32301099,and 21834007)+2 种基金the Shanghai Sailing Program(22YF1424200)the Interdisciplinary Program of Shanghai Jiao Tong University(YG2022QN032)the Xiangfu Lab Research Project(XF012022E0100).
文摘Immunization has long played essential roles in preventing diseases.However,the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet.Here,we describe the use of acupoint delivery of nanovaccines(ADN)to elicit dual-niche immunological priming.ADN can simultaneously stimulate mast cell-assisted maturation of dendritic cells at the acupoint and enable direct delivery of nanovaccines into the draining lymph nodes.We demonstrate that ADN not only provokes antigen presentation by lymph node-resident CD8α^(+)dendritic cells,but also induces the accumulation of nanovaccines in B-cell zones,amplifying antigen-specific cytotoxic T lymphocyte responses and immunoglobulin G antibody expression in draining lymph nodes.ADN also generates systemic immune responses by causing immune memory and preventing T-cell anergy in the spleen.Further supported by evoking effective antitumor responses and high-level antiviral antibodies in mice,ADN provides a simple yet versatile platform for advanced nanovaccination.
文摘BACKGROUND This study seeks to systematically assess the effects of warm acupuncture combined with acupoint massage on the recovery of gastrointestinal function following gastric cancer surgery.AIM To evaluate the impact of warm acupuncture combined with acupoint massage on postoperative gastrointestinal function recovery after gastric cancer surgery,based on a systematic review and meta-analysis.METHODS A comprehensive search was conducted across multiple databases,including PubMed,Cochrane Library,EMBASE,Web of Science,CNKI,Wanfang,and VIP,for relevant studies published up to January 2025.Meta-analyses were carried out using RevMan 5.4,with results presented as standardized mean difference(SMD)or odds ratio with 95%confidence interval(CI).Study heterogeneity was evaluated using the I2 statistic,and sensitivity analyses were performed to assess the stability of the findings.RESULTS A total of 8 randomized controlled trials involving 694 patients were included.The meta-analysis showed that warm acupuncture combined with acupoint massage significantly improved postoperative gastrointestinal function by reducing the time to first flatus(SMD=-2.14,95%CI:-3.14 to-1.14,P<0.0001),time to first bowel movement(SMD=-2.43,95%CI:-3.52 to-1.34,P<0.0001),time to bowel sounds recovery(SMD=-3.15,95%CI:-4.50 to-1.80,P<0.00001),and time to initiate nasogastric or jejunal feeding(SMD=-1.31,95%CI:-2.44 to-0.18,P=0.02).CONCLUSION The combination of warm acupuncture and acupoint massage markedly enhances gastrointestinal recovery following surgery.
文摘Background:Acupuncture is widely used in modulating brain excitability and motor function,as a form of complementary and alternative medicine.However,there is no existing meta-analysis evaluating the effectiveness and safety of acupuncture on corticospinal excitability(CSE),and the credibility of the evidence has yet to be quantified.Objective:This study was designed to assess the efficacy and safety of electroacupuncture(EA)and manual acupuncture(MA)in enhancing brain excitability,specifically focusing on CSE as measured by transcranial magnetic stimulation(TMS).Search strategy:This study followed a systematic approach,searching 9 databases up to August 2024 and examining grey literature,in compliance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Inclusion criteria:Studies were included if they compared the clinical efficacy of EA or MA with sham acupuncture,no treatment or usual training.Data extraction and analysis:Three investigators independently conducted literature screening,data extraction,and risk of bias assessment.The primary outcome focused on motor-evoked potentials as measured by TMS,with treatment effects quantified using mean differences or standardized mean differences between pre-and post-treatment.Subgroup analyses were conducted using mixed-effects models,while random-effects or fixed-effects models were used to estimate average treatment differences across studies.Results:Based on 34 studies involving 1031 adults,acupuncture techniques significantly enhanced CSE.EA had a greater impact than MA,with effect sizes of 0.53 mV vs 0.43 mV(95%confidence interval[CI]:[0.30,0.76],P<0.00001 vs 95%CI:[0.28,0.59],P<0.00001).The 5 most frequently used acupoints were LI4(Hegu,32 times),ST36(Zusanli,10 times),LI11(Quchi,7 times),TE5(Waiguan,6 times),and GB34(Yanglingquan,5 times).Conclusion:This systematic review indicates that both EA and MA could effectively and safely enhance CSE,bringing the corticospinal pathway closer to the threshold for firing,which may ultimately improve motor function.LI4,ST36,LI11,TE5 and GB34 are the most commonly used acupoints.
基金supported by the Chinese Medicine Development Fund,Hong Kong SAR,China(23B2/027A_R1)the National Natural Science Foundation of China(81704198).
文摘Objective:To evaluate the efficacy and safety of acupoint application for post-stroke depression(PSD)by regulating gastrointestinal function.A secondary objective is to explore the potential mechanism underlying this approach from the perspective of gut microbiota.Methods:This multicenter,randomized,double-blind(patients and assessors),placebo-controlled trial will enroll 80 patients with PSD,and include a 1-week run-in period,a 4-week treatment phase,and a 12-week follow-up.Eligible participants will randomly be assigned in a 1:1 ratio to either the acupoint application or placebo(non-acupoint)groups.Treatments will be administered thrice weekly for 4 weeks.The primary outcome is change in the Hamilton Rating Scale for Depression(HAMD)score.Secondary outcomes include the Beck Depression Inventory(BDI),36-Item Short-Form Health Survey(SF-36),Barthel Index of Activities of Daily Living,Social Adaptation Self-Evaluation Scale(SASS),and gut microbiota profiling.All outcomes will be assessed at baseline(prior to treatment),during treatment(weeks 2 and 4),and during follow-up(weeks 8,12,and 16).The Treatment Emergent Symptom Scale(TESS)will be used for evaluation throughout the 4-week treatment phase.Discussion:The results of this study will provide important evidence supporting a novel treatment strategy for PSD that targets gastrointestinal regulation,potentially informing future clinical practice.
文摘The objective of this study is to analyze the relevant literature on acupoint massage applied to patients with poststroke constipation,to explore the research status,research hotspots,and research frontiers of poststroke constipation,and to provide reference for clinical practice and scientific research.With the help of CiteSpace software,the related literatures published in the China National Knowledge Infrastructure database on the application of acupoint massage to constipation after stroke were analyzed,and scientific atlas for visual analysis was drawn.The hot keywords in the field of acupoint massage for post-stroke constipation are constipation,nursing intervention,and traditional Chinese medicine(TCM)nursing,indicating the great importance of TCM nursing for such patients.In mutation word detection,words such as constipation,nursing,stroke,and defecation reflex have earlier mutation times.Massage is the keyword with the longest mutation time,suggesting it is an effective intervention for post-stroke patients and is widely recognized.The commonly used acupoints for poststroke constipation are Tianshu(ST 25),Zhongwan(CV 12),and Qihai(CV 6).These acupoints can regulate qi and blood and enhance gastrointestinal peristalsis,providing guiding significance for formulating relevant clinical practice guidelines.The research of acupoint massage in the nursing of poststroke constipation is still in the stage of practice and exploration,and the specific definition of operation process,technique,acupoint,time,and intensity is still not clear.Multicenter,large-sample,in-depth intervention research,and cohort studies hold immense significance for the future development of this discipline.
基金Supported by Hospital-level Project of Shiyan Taihe Hospital(2018JJXM093).
文摘[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.
基金supported by the Research and Innovation Fund of Shandong University of Traditional Chinese Medicine(2018-220315).
文摘Objective To investigate three representative conditions,gallbladder colic,renal colic,and primary dysmenorrhea,to identify trends and regularities in acupoint selection and provide evidence-based references for clinical practice.Methods Clinical studies on acupuncture for gallbladder colic,renal colic,and primary dysmenorrhea published between 2006 and 2025 were retrieved from the Chinese National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Wanfang,and PubMed.Bibliometric analysis was performed using IBM SPSS Modeler 18.0,and the Apriori algorithm was applied to evaluate acupoint-use patterns.Results The analysis demonstrated that commonly selected acupoints for these conditions have remained relatively consistent over the past two decades.Frequently used acupoints for gallbladder colic included Yanglingquan(GB 34),Dannang(EX-LE 6),Qiuxu(GB 40),Taichong(LR 3),Danshu(BL 19),Zusanli(ST 36),Qimen(LR 14),Riyue(GB 24),and Ganshu(BL 18).For renal colic,the most frequently reported points were Shenshu(BL 23),Sanyinjiao(SP 6),Zusanli(ST 36),Yinlingquan(SP 9),Jingmen(GB 25),Guanyuan(CV 4),Ashi points,Zhongji(CV 3),and Pangguangshu(BL 28).The main acupoints for primary dysmenorrhea were Sanyinjiao(SP 6),Guanyuan(CV 4),Ciliao(BL 32),Diji(SP 8),Shiqizhui(EX-B 8),Zhongji(CV 3),Zusanli(ST 36),Zigong(EX-CA 1),and Qihai(CV 6).On average,treatment protocols employed 3-4 acupoints per session.Conclusions The most frequently selected acupoints for visceral smooth muscle spasmodic pain were located within the ganglion segment innervation areas,showing close association with the target organs.Furthermore,treatment protocols typically involved a small number of acupoints.These findings highlight the need for further systematic research,particularly randomized controlled trials,to validate and strengthen the evidence base.
基金Supported by National Natural Science Foundation:82405564General project of Natural Science Foundation of Chongqing Municipality:CSTB2022NSCQMSX1559+1 种基金Scientific Research Project of Chongqing Municipal Education Commission:KJQN202315124General Program of Natural Science Foundation of Sichuan Province:2024NSFSC0560。
文摘Objective To analyze the electrostimulation parameters and acupoint prescriptions for treatment of functional dyspepsia(FD)based on bibliometric methods.Methods The relevant papers were searched from PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP)and China Biology Medicine disc(Sinomed),dated from January 1st,2010 to May 31st,2023.Inclusion criteria of studies:①“functional dyspepsia”and electric stimulation involved in the title or abstract;and②related to the assessment of electrostimulation therapy in clinical trials and experimental research for FD.Exclusion criteria of studies:①duplication or failure to obtain full text;②published in newspaper,presenting as research achievement,and review;③nothing related to the acupoint selection;and④nothing related to the parameters of electrostimulation.Using Excel 2019 and VOSviewer software,acupoint association and the parameters of electrostimulation were analyzed and graphed.Results A total of 181 eligible articles were screened.Statistical analysis revealed that the most frequently targeted acupoints for electrostimulation in functional dyspepsia(FD)were Zusanli(ST36),Taichong(LR3),and Neiguan(PC6),while the most commonly utilized auricular point was Erjia(CO,concha zone).The acupoint group demonstrating the strongest association consisted of ST36,LR3,Zhongwan(CV12),and PC6,which constituted the primary prescription for electrostimulation in FD.The optimal parameters for electrostimulation were identified as a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.The acupoints ST36,LR3,and PC6 are the most prevalent for electrostimulation in FD,with CO being the most common auricular point.The optimal electrostimulation parameters are a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.Conclusion The acupoints ST36,LR3,and PC6 are the most prevalent for electrostimulation in FD,with CO being the most common auricular point.The optimal electrostimulation parameters are a disperse-dense wave,a frequency of 2/100 Hz,and an intensity of 1 mA.
基金Supported by Shanghai College Students Innovation and Entrepreneurship Training Program Project:202310268066The 16th Batch of Science And Technology Innovation Projects of Shanghai University of Traditional Chinese Medicine:SHUTCM2023010+1 种基金2024 Shanghai Oriental Talent Program Youth Project2021 High-level Local University Innovation Team Project of Shanghai University of Traditional Chinese Medicine:No.3 Shanghai Education Commission Personnel [2022]。
文摘Objective To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.Methods Clinical studies of abdominal obesity treated with acupuncture and moxibustion,collected in the past 10 years,were searched from China Biology Medicine disc(CBMdisc),China National knowledge infrastructure(CNKI),Wanfang,China Science and Technology Journal Database(VIP),Pubmed,Embase,Google Scholar,Web of Science,(The Cumulative Index to Nursing and Allied Health Literature)CINAHL,Psyclnfo and Scopus,dated from March 1,2013 to March 31,2023.Using IBM SPSS Modeler 18.0 and other software,the frequency analysis,association-rules analysis and cluster analysis were conducted on interventions,traditional Chinese medicine(TCM)patterns,use frequency of acupoint,meridian attribution of acupoint,acupoint location,etc.Results A total of 55 articles were included,with 102 prescriptions and 71 acupoints involved.The top 3 interventions were acupoint embedding method,simple electroacupuncture and simple filiform needling.Seventeen patterns/syndromes of TCM differentiation were collected,dominated by spleen deficiency and damp blockage,spleen and kidney yang deficiency and heat accumulation in stomach and intestines.The acupoints in clinical practice were mostly at the foot-yangming stomach meridian,the conception vessel and the foot-taiyin spleen meridian,and located at the abdominal region.The top 5 acupoints of high frequency were Tianshu(ST25),Zhongwan(CV12),Daheng(SP15),Zusanli(ST36),Huaroumen(ST24)and Daimai(GB26).The specific points of the high frequency were the crossing points and front-mu points,of which,ST25 and CV12 were the most prominent.After association-rules analysis on the high-frequency acupoints,20 groups of associated acupoints were obtained,in which,the core acupoints included ST25,CV12,SP15 and ST36.Conclusion In recent 10 years,abdominal obesity is treated by the acupoints of foot-yangming stomach meridian,the conception vessel and the foot-taiyin spleen meridian.Compared with the regimen for simple obesity,the acupoints at the abdominal region are specially selected in treatment of abdominal obesity,such as ST25,CV12,SP15 and ST36.Supplementary acupoints are selected based on syndrome differentiation to simultaneously address both the disease manifestations and root causes.
基金supported by the National Natural Science Foundation of China(82274675&82074573)the Beijing Natural Science Foundation(7232278).
文摘Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to four groups:normal,sham operation,model,and TMTP Tuina.Successful model induction was confirmed by observable hind limb lameness.After 20 sessions,hind limb grip strength and motor nerve conduction velocity(MNCV)were measured at baseline and following the 10th and 20th intervention.CD31 and a-SMA in the ventral horn of SNI model rats were detected using immunofluorescence.Motor neurons in the ventral horn were detected by Nissl staining.PTEN levels in the ventral horn were measured by ELISA,and PI3K,Akt,BDNF,VEGF,and HIF-1a expression was determined by RT-PCR.Spinal cord microcirculation was evaluated by western blotting analysis of the levels of Akt,p-Akt,BDNF,and VEGF.Results:Hind limb grip strength and MNCV significantly improved in the TMTP Tuina group compared to the model group(both P<.001).Morphology of ventral horn motor neurons in the TMTP Tuina group improved compared to the model group,with increased expressions of a-SMA(P=.002)and CD31(P=.006).Western blot analysis indicated increased expression of VEGF(P=.005),p-Akt(P<.001),and BDNF(P=.008)in the ventral horn following Tuina treatment.RT-PCR analysis revealed increased expression of PI3K,Akt,BDNF,VEGF and HIF-1a(all P<.05).In contrast,expression of PTEN decreased compared to the model group(P<.001).Conclusion:TMTP Tuina therapy may restore motor function in rats,enhance ventral horn motor neuron morphology,and promote angiogenesis and vascular smooth muscle proliferation.The mechanism may involve the activation of the PI3K/Akt signaling pathway.
基金Song Hujie’s Inheritance Studio of National Renowned Traditional Chinese Medicine Experts.
文摘Objective:To explore the core acupuncture acupoints and pattern-adapted acupoint combination rules for autism spectrum disorder(ASD)complicated with sleep disorder using clinical data mining technology.Methods:A retrospective analysis was conducted on the diagnosis and treatment data of 104 children with ASD complicated with sleep disorder admitted to Xi’an Traditional Chinese Medicine(TCM)Encephalopathy Hospital from January 2022 to December 2024.Cross-pattern main acupoints were screened via frequency statistics,chi-square test,and factor analysis;pattern-specific auxiliary acupoints were extracted by combining multiple correspondence analysis,cluster analysis,and association rule mining.Results:Ten cross-pattern main acupoints(Baihui,Sishenzhen,Language Area 1,Language Area 2,Neiguan,Shenmen,Yongquan,Xuanzhong)were identified,and acupoint combination schemes for four major TCM patterns(Hyperactivity of Liver and Heart Fire,Deficiency of Kidney Essence,Deficiency of Both Heart and Spleen,Hyperactivity of Liver with Spleen Deficiency)were established.Conclusion:Acupuncture treatment should follow the principle of“regulating spirit and calming the brain as the root,and dredging collaterals based on pattern differentiation as the branch”.The synergy between main and auxiliary acupoints can accurately regulate the disease,providing a basis for precise clinical treatment.
基金funded by Beijing Municipal Key Specialty Construction Project of Traditional Chinese Medicine[(1+X+N)2017].
文摘Facial paralysis comorbidities is now understood to include two distinct forms:synkinesis and micro-entrapment syndrome of nerves innervating the face(MESNIF).These disorders manifest as oromandibular synkinesis,stiffness and atrophy of facial muscles on one side,which affect activities of daily living.Acupoint Injection is a treatment for facial paralysis,combining the meridian theory of traditional Chinese medicine,with the injection of specific drugs into acupuncture points of the face.In recent years,the use of acupoint injections has shown in remarkable clinical efficacy and few adverse effects.We report the case to introduce this integrative therapy and outline the key principles of rehabilitation therapy.
基金supported by the funded project(HYZHX M05005)in the field of space medical experiments of manned spaceflight engineering.
文摘Objective:To evaluate the efficacy and safety of transcutaneous electrical acupoint stimulation(TEAS)for muscle atrophy in patients with immobilization after surgical fixation of foot and ankle fractures.Methods:This was a two-arm randomized controlled trial wherein 80 patients were recruited and divided into control(n=40)and intervention(n=40)groups.The control group received conventional orthopedic treatment,whereas the intervention group received TEAS and conventional treatment.The intervention group received TEAS 3 times a week for 30 min each time for 8 weeks.The primary out-comes were muscle thickness(MT)and cross-sectional area(CSA)of the rectus femoris and gastroc-nemius muscles,whereas the secondary outcome measure was echo intensity(EI).Data were collected before the fixation operations(baseline assessment)and 4 and 8 weeks after intervention.Results:Compared with baseline,the MT and CSA were reduced in both groups by the end of treatment,whereas EI increased in both groups.At week 4,the reduction in the rectus femoris CSA in the inter-vention group was significantly lower than that in the control group(P=0.02);however,the between-group differences in the MT and EI(all P>0.05)were not significant.No serious adverse events were observed in either group.Conclusion:Our study showed that TEAS can improve muscle atrophy by attenuating the decline in the muscle CSA.Because this was only a pilot trial,subsequent studies will need longer follow-ups and larger sample sizes.
文摘Objective:To explore the effects of acupoint catgut embedding combined with auricular point pressing with beans on symptom management self-efficacy and quality of life in patients with nonalcoholic steatohepatitis(NASH)of liver depression and spleen deficiency type.Methods:Sixty patients with NASH of liver depression and spleen deficiency type admitted to our hospital from January 2021 to December 2023 were selected and divided into an acupoint catgut embedding group(n=30)and a combined group(n=30)using the envelope lottery method.The acupoint catgut embedding group received acupoint catgut embedding intervention,while the combined group received auricular point pressing with beans on the basis of the acupoint catgut embedding group.The two groups were compared in terms of TCM syndrome scores,symptom management self-efficacy[Chronic Disease Self-Efficacy Scale(CDSES)],and quality of life[Chronic Liver Disease Questionnaire(CLDQ)].Results:After intervention,the combined group had lower TCM syndrome scores for both primary and secondary symptoms compared to the acupoint catgut embedding group(P<0.05).The combined group also had higher scores in all dimensions and total score of the CDSES compared to the acupoint catgut embedding group(P<0.05).Similarly,the combined group had higher scores in all dimensions and total score of the CLDQ compared to the acupoint catgut embedding group(P<0.05).Conclusion:Acupoint catgut embedding combined with auricular point pressing with beans can effectively improve TCM symptoms,enhance symptom management self-efficacy,and improve quality of life in patients with NASH of liver depression and spleen deficiency type.
