An actively mode-locked Ho： YAG laser pumped by a diode-pumped Tin-doped fiber laser is reported. For the cw operation, we obtain the maximum output power of 3.43 W with a central wavelength 2022.2nm at the maximum i...An actively mode-locked Ho： YAG laser pumped by a diode-pumped Tin-doped fiber laser is reported. For the cw operation, we obtain the maximum output power of 3.43 W with a central wavelength 2022.2nm at the maximum incident pump power of 11.4 W, corresponding to a slope efficiency of 34.5%. The beam quality factor M2 is 1.16, and the output beam is close to fundamental TEMoo. In the case of the CWML operation, a stable pulse train is generated with an average output power up to 3.41 W with a slope efficiency of 34.3% at the incident pump power of 11.4 W and a pulse duration of 294ps at a repetition rate of 81.92MHz. In addition, the maximum single pulse energy is 41.6nJ.展开更多
We demonstrate a mid-IR ZnGeP2 （ZGP） optical parametric oscillator （OPO） pumped by a dual-end-pumped actively aeoasto-optie Q-switched Ho：YAG ceramic laser. The maximum average output power of 35 W is obtained at...We demonstrate a mid-IR ZnGeP2 （ZGP） optical parametric oscillator （OPO） pumped by a dual-end-pumped actively aeoasto-optie Q-switched Ho：YAG ceramic laser. The maximum average output power of 35 W is obtained at a pulse repetition frequency of 20 kHz from the Ho：YAG ceramic laser. Under the maximum incident pump power of Ho：YAG ceramic laser, the maximum output power of 14 W is obtained from the ZGP OPO, corresponding to the slope efficiency of 49.6% with respect to the incident pump power. The wavelength can be tuned from 3.5 μm to 4.2μm （signal）, corresponding to 5.24.1 μm （idler）. The beam quality M2 is less than 2.3 from the ZGP OPO.展开更多
A theoretical model concerning active Q-switching of an Fe:ZnSe laser pumped by a continuous-wave(CW)2.8μm fiber laser is developed.Calculations are compared with the recently reported experiment results,and good agr...A theoretical model concerning active Q-switching of an Fe:ZnSe laser pumped by a continuous-wave(CW)2.8μm fiber laser is developed.Calculations are compared with the recently reported experiment results,and good agreement is achieved.Effects of principal parameters,including pump power,output reflectivity,ion concentration and temperature of crystal,on the laser output performance are investigated and analyzed.Numerical results demonstrate that similar to highly efficient CWFe:ZnSe laser,low temperature of the crystal is significant to obtain high peak power Q-switched pulses.The numerical simulation results are useful for optimizing the design of actively Q-switched Fe:ZnSe laser.展开更多
Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton ...Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton pumping activity of H+-ATPases in tonoplast vesicles were studied by acridine orange fluorescent quenching measured at 22 degreesC. The proton pumping activity of ATPase was ATP-dependent with apparent Michaelis-Menten Constant (K-m) for ATP about 0.65 mmol/L. The optimal pH for H+-ATPases activity was 7.5. The proton pumping activity of H+-ATPase could be initiated by some divalent cations, Mg2+ being highly efficient, much more than Fe2+; and Ca2+, Cu2+ and Zn2+ were inefficient under the experimental condition. The proton translocation could be stimulated by halide anions, with potencies decreasing in the order Cl- > Br- > I- > F-. The proton pumping activity was greatly inhibited by N-ethylmaleimide (NEM), N, N'-dicyclohexylcarbodiimide (DCCD), NO3- and Bafilomycin A(1), but not by orthovanadate and azide. These results demonstrated that the H+-ATPase in the tonoplast of Populus euphratica belonged to vacuolar type ATPase. This work was the first time that tonoplast-enriched vesicles were isolated from Populus euphratica cells.展开更多
Nearly 1100 fissures have formed on the Hebei Plain in China.Within the Yellow RiverQinghe River-Zhanghe River shallow buried paleochannel band on the plain,93 ground fissures controlled by paleochannels have develope...Nearly 1100 fissures have formed on the Hebei Plain in China.Within the Yellow RiverQinghe River-Zhanghe River shallow buried paleochannel band on the plain,93 ground fissures controlled by paleochannels have developed,of which the Wuyi-Fuping ground fissure is a typical paleochannel-controlled fissure located in Hengshui,Hebei Province,with a total length of 3 km,a dominant strike of NE78°,and nearly upright in the shallow layer.The surface damage observed in this fissure primarily manifests as beaded pits,and its activity shows distinct segmentation characteristics.On the trench profiles,the offset distance of shallow layers remains consistently around 20 cm within the depth range of 0 to-3 m.An evident flexure is observed in the strata at depths ranging from-4.5 to-7 m.The drilling profile reveals that there is an absence of dislocations in the deeper strata.Nonetheless,the shallow seismic physical profiles unveil the presence of underlying faults beneath the study area,underscoring the intricate formation process and genesis mechanism of the Wuyi-Fuping ground fissure.Firstly,the formation and evolution of the Qingling River's paleochannel were shaped by the actions of fault blocks and underlying faults.The interplay of the regional stress field,fault block movement,and fault activity played pivotal roles in driving the development of this paleochannel.Secondly,the paleochannel exerts a controlling influence on the development location and severity of the fissure.During pumping,the confined aquifer within the paleochannel undergoes water loss and compression,resulting in the formation of a surface subsidence funnel.When the tensile stress surpasses the soil's tensile strength at the funnel's edge,the soil fractures give rise to a ground fissure.Finally,large amounts of surface water generated by heavy rainfall and irrigation can cause existing hidden ground fissures to rupture,emerge,and expand.This paper provides a heretofore generally unknown example,promotes research on the mechanisms of paleochannel-controlled fissures,and has guiding significance for disaster prevention and reduction in this area.展开更多
External counterpulsation therapy(ECP)is a non-invasive method to assist the circulatory system.The main principle of ECP is to initiate a diastolic pulse wave in the arterial system by squeezing the inner leg vessels...External counterpulsation therapy(ECP)is a non-invasive method to assist the circulatory system.The main principle of ECP is to initiate a diastolic pulse wave in the arterial system by squeezing the inner leg vessels.Superficial and low veins are compressed due to muscle contractions,which are triggered by functional electrical stimulation(FES).In this work,a new trigger method for the stimulation is proposed.Blood flow is determined by measuring the pulsatile change of conductivity in the observed segment by impedance plethysmography.The proposed“adaptive stimulation”allows the automatic adjustment of the start and duration of the stimulation to improve transport of venous blood.For this purpose,a mathematical circulation model was developed for optimization of the adaptive functional electrical stimulation.The model takes into account the effects of gravity,muscle pump with or without FES,and venous regurgitation.The model was shown to have a behavior similar to that of clinical measurements.The simulation showed a flow enhancement of up to 14%and,furthermore,that the start of the stimulation is less important than the duration of each stimulation phase.Therefore,an adaptation of the heart rate seems necessary,as the expulsion and refill times must remain relatively constant for an optimal pumping result.For a practical approach,it is reasonable to adapt the duration of stimulation to 56%of the cardiac cycle in order to reach a maximum flow.展开更多
Objective: To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of Replenishing Qi and Nourishing Yin (RQNY) with a small dosage of Tapazole for treatment of Graves’ dis...Objective: To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of Replenishing Qi and Nourishing Yin (RQNY) with a small dosage of Tapazole for treatment of Graves’ disease (GD).Methods: The changes of thyroid function and the activity of sodium pump of human erythrocyte in the patients with Graves’ disease were observed and compared before and after treatment between the treated group (42 cases) by combining treatment mainly using TCM of RQNY and a small amount of Tapazole and a control group (42 cases) by Tapazole alone.Results: After treatment for half a year, one and two years, the serum levels of T3, T4 in above two groups were markedly decreased than those of before treatment, the therapeutic effect of treated group was superior to that of the control group. The activity of sodium pump in human erythrocyte in the GD patients was obviously higher than that of normal group and that of before treatment. After treatment for one and two years mainly by TCM or western medicine, the erythrocyte sodium pump activity was obviously lower than that of normal group and that of before treatment. The decrease of erythrocyte sodium pump activity in the treated group was markedly lower than that in the control group.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 61308009 and 61405047the China Postdoctoral Science Foundation Funded Project under Grant Nos 2013M540288 and 2015M570290+2 种基金the Fundamental Research Funds for the Central Universities Grant under Grant Nos HIT.NSRIF.2014044 and HIT.NSRIF.2015042the Science Fund for Outstanding Youths of Heilongjiang Province under Grant No JQ201310the Heilongjiang Postdoctoral Science Foundation Funded Project under Grant No LBH-Z14085
文摘An actively mode-locked Ho： YAG laser pumped by a diode-pumped Tin-doped fiber laser is reported. For the cw operation, we obtain the maximum output power of 3.43 W with a central wavelength 2022.2nm at the maximum incident pump power of 11.4 W, corresponding to a slope efficiency of 34.5%. The beam quality factor M2 is 1.16, and the output beam is close to fundamental TEMoo. In the case of the CWML operation, a stable pulse train is generated with an average output power up to 3.41 W with a slope efficiency of 34.3% at the incident pump power of 11.4 W and a pulse duration of 294ps at a repetition rate of 81.92MHz. In addition, the maximum single pulse energy is 41.6nJ.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61308009,61405047 and 50990301the Fundamental Research Funds for the Central Universities under Grant Nos HIT.NSRIF.2014044 and HIT.NSRIF.2015042the Science Fund for Outstanding Youths of Heilongjiang Province under Grant No JQ201310
文摘We demonstrate a mid-IR ZnGeP2 （ZGP） optical parametric oscillator （OPO） pumped by a dual-end-pumped actively aeoasto-optie Q-switched Ho：YAG ceramic laser. The maximum average output power of 35 W is obtained at a pulse repetition frequency of 20 kHz from the Ho：YAG ceramic laser. Under the maximum incident pump power of Ho：YAG ceramic laser, the maximum output power of 14 W is obtained from the ZGP OPO, corresponding to the slope efficiency of 49.6% with respect to the incident pump power. The wavelength can be tuned from 3.5 μm to 4.2μm （signal）, corresponding to 5.24.1 μm （idler）. The beam quality M2 is less than 2.3 from the ZGP OPO.
基金the 2021 Annual Instructional Science and Technology Program of Yongzhou(No.2021YZKJ09)the Science Research Project of Hunan Institute of Science and Technology(No.21xky040)。
文摘A theoretical model concerning active Q-switching of an Fe:ZnSe laser pumped by a continuous-wave(CW)2.8μm fiber laser is developed.Calculations are compared with the recently reported experiment results,and good agreement is achieved.Effects of principal parameters,including pump power,output reflectivity,ion concentration and temperature of crystal,on the laser output performance are investigated and analyzed.Numerical results demonstrate that similar to highly efficient CWFe:ZnSe laser,low temperature of the crystal is significant to obtain high peak power Q-switched pulses.The numerical simulation results are useful for optimizing the design of actively Q-switched Fe:ZnSe laser.
文摘Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton pumping activity of H+-ATPases in tonoplast vesicles were studied by acridine orange fluorescent quenching measured at 22 degreesC. The proton pumping activity of ATPase was ATP-dependent with apparent Michaelis-Menten Constant (K-m) for ATP about 0.65 mmol/L. The optimal pH for H+-ATPases activity was 7.5. The proton pumping activity of H+-ATPase could be initiated by some divalent cations, Mg2+ being highly efficient, much more than Fe2+; and Ca2+, Cu2+ and Zn2+ were inefficient under the experimental condition. The proton translocation could be stimulated by halide anions, with potencies decreasing in the order Cl- > Br- > I- > F-. The proton pumping activity was greatly inhibited by N-ethylmaleimide (NEM), N, N'-dicyclohexylcarbodiimide (DCCD), NO3- and Bafilomycin A(1), but not by orthovanadate and azide. These results demonstrated that the H+-ATPase in the tonoplast of Populus euphratica belonged to vacuolar type ATPase. This work was the first time that tonoplast-enriched vesicles were isolated from Populus euphratica cells.
基金funded by the National Science Foundation of China(Nos.2022XAGG0400,42207202,42293351)the Open Fund of the Key Laboratory of Earth Fissures Geological Disaster,Ministry of Natural Resources,Geological Survey of Jiangsu Province,China(No.EFGD20240604)+2 种基金the Open Fund of the Observation and Research Station of Ground Fissure and Land Subsidence,Ministry of Natural Resources(No.GKF2024-06)the Fundamental Research Funds for the Central Universities of China University of Geosciences,Beijing(No.2-9-2021-014)the Fundamental Research Funds for the Central Universities of Chang'an University(No.300102264501-01)。
文摘Nearly 1100 fissures have formed on the Hebei Plain in China.Within the Yellow RiverQinghe River-Zhanghe River shallow buried paleochannel band on the plain,93 ground fissures controlled by paleochannels have developed,of which the Wuyi-Fuping ground fissure is a typical paleochannel-controlled fissure located in Hengshui,Hebei Province,with a total length of 3 km,a dominant strike of NE78°,and nearly upright in the shallow layer.The surface damage observed in this fissure primarily manifests as beaded pits,and its activity shows distinct segmentation characteristics.On the trench profiles,the offset distance of shallow layers remains consistently around 20 cm within the depth range of 0 to-3 m.An evident flexure is observed in the strata at depths ranging from-4.5 to-7 m.The drilling profile reveals that there is an absence of dislocations in the deeper strata.Nonetheless,the shallow seismic physical profiles unveil the presence of underlying faults beneath the study area,underscoring the intricate formation process and genesis mechanism of the Wuyi-Fuping ground fissure.Firstly,the formation and evolution of the Qingling River's paleochannel were shaped by the actions of fault blocks and underlying faults.The interplay of the regional stress field,fault block movement,and fault activity played pivotal roles in driving the development of this paleochannel.Secondly,the paleochannel exerts a controlling influence on the development location and severity of the fissure.During pumping,the confined aquifer within the paleochannel undergoes water loss and compression,resulting in the formation of a surface subsidence funnel.When the tensile stress surpasses the soil's tensile strength at the funnel's edge,the soil fractures give rise to a ground fissure.Finally,large amounts of surface water generated by heavy rainfall and irrigation can cause existing hidden ground fissures to rupture,emerge,and expand.This paper provides a heretofore generally unknown example,promotes research on the mechanisms of paleochannel-controlled fissures,and has guiding significance for disaster prevention and reduction in this area.
基金supported by the German Federal Ministry of Economics and Technology(BMWi)under the Grant ZIM(AIF FK KF2561908AK3,’RheoStim’).
文摘External counterpulsation therapy(ECP)is a non-invasive method to assist the circulatory system.The main principle of ECP is to initiate a diastolic pulse wave in the arterial system by squeezing the inner leg vessels.Superficial and low veins are compressed due to muscle contractions,which are triggered by functional electrical stimulation(FES).In this work,a new trigger method for the stimulation is proposed.Blood flow is determined by measuring the pulsatile change of conductivity in the observed segment by impedance plethysmography.The proposed“adaptive stimulation”allows the automatic adjustment of the start and duration of the stimulation to improve transport of venous blood.For this purpose,a mathematical circulation model was developed for optimization of the adaptive functional electrical stimulation.The model takes into account the effects of gravity,muscle pump with or without FES,and venous regurgitation.The model was shown to have a behavior similar to that of clinical measurements.The simulation showed a flow enhancement of up to 14%and,furthermore,that the start of the stimulation is less important than the duration of each stimulation phase.Therefore,an adaptation of the heart rate seems necessary,as the expulsion and refill times must remain relatively constant for an optimal pumping result.For a practical approach,it is reasonable to adapt the duration of stimulation to 56%of the cardiac cycle in order to reach a maximum flow.
文摘Objective: To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of Replenishing Qi and Nourishing Yin (RQNY) with a small dosage of Tapazole for treatment of Graves’ disease (GD).Methods: The changes of thyroid function and the activity of sodium pump of human erythrocyte in the patients with Graves’ disease were observed and compared before and after treatment between the treated group (42 cases) by combining treatment mainly using TCM of RQNY and a small amount of Tapazole and a control group (42 cases) by Tapazole alone.Results: After treatment for half a year, one and two years, the serum levels of T3, T4 in above two groups were markedly decreased than those of before treatment, the therapeutic effect of treated group was superior to that of the control group. The activity of sodium pump in human erythrocyte in the GD patients was obviously higher than that of normal group and that of before treatment. After treatment for one and two years mainly by TCM or western medicine, the erythrocyte sodium pump activity was obviously lower than that of normal group and that of before treatment. The decrease of erythrocyte sodium pump activity in the treated group was markedly lower than that in the control group.
