In the last decade,the study of pressure in active matter has attracted growing attention due to its fundamental relevance to nonequilibrium statistical physics.Active matter systems are composed of particles that con...In the last decade,the study of pressure in active matter has attracted growing attention due to its fundamental relevance to nonequilibrium statistical physics.Active matter systems are composed of particles that consume energy to sustain persistent motion,which are inherently far from equilibrium.These particles can exhibit complex behaviors,including motility-induced phase separation,clustering,and anomalous stress distributions,motivating the introduction of active swim stress and swim pressure.Unlike in passive fluids,pressure in active systems emerges from momentum flux originating from swim force rather than equilibrium conservative interactions,offering a distinct perspective for understanding their mechanical response.Simple models of active Brownian particles(ABPs)have been employed in theoretical and simulation studies across both dilute and dense regimes,revealing that pressure is a state function and exhibits a nontrivial dependence on density.Together with nonequilibrium statistical concepts such as effective temperature and effective adhesion,pressure offers important insight for understanding behaviors in active matter such as sedimentation equilibrium and motility induced phase separation.Extensions of ABP models beyond their simplest form have underscored the fragility of the pressure-based equation of state,which can break down under factors such as density-dependent velocity,torque,complex boundary geometries and interactions.Building on these developments,this review provides a comprehensive survey of theoretical and experimental advances,with particular emphasis on the microscopic origins of active pressure and the mechanisms underlying the breakdown of the equation of state.展开更多
Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power o...Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem.展开更多
Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to th...Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to the long-term use of chemical acaricides in agriculture.In contrast,bioactive substances of biological origin offer advantages such as wide availability,environmental friendliness,and low tendency to induce resistance,making them a research hotspot for spider mite control.This review summarizes recent advances in the use of plant-derived active compounds(exemplified by extracts from Veratrum rhizomes),RNA interference(RNAi)technology,and microorganism-derived active substances for controlling spider mites.These bioactive agents exert acaricidal effects by disrupting the nervous system,interfering with metabolic processes,or silencing key genes in mites,demonstrating favorable efficacy and considerable potential for development.However,challenges remain,including poor environmental stability,slow action,high production costs,and insufficient understanding of their effects on non-target organisms.Therefore,future research should focus on the screening and development of novel bioactive substances of biological origin,elucidation of their mechanisms of action,optimization of formulation technologies,and assessment of their ecological safety.These efforts will provide valuable insights for promoting the advancement of bioactive substances and supporting sustainable agricultural development.展开更多
Electrocatalytic nitrate reduction reaction(NitRR)utilizing water as a hydrogen source under ambient conditions represents a highly promising avenue for sustainable ammonia synthesis and environmental remediation.Howe...Electrocatalytic nitrate reduction reaction(NitRR)utilizing water as a hydrogen source under ambient conditions represents a highly promising avenue for sustainable ammonia synthesis and environmental remediation.However,achieving high efficiency and selectivity in NitRR is fundamentally challenged by the complex lifecycle management of active hydrogen derived from water splitting.This review provides a timely and comprehensive analysis centered on the pivotal role and meticulous regulation of active hydrogen throughout the NitRR process.We first elucidate the distinct functions and characteristics of various hydrogen species,followed by a survey of advanced characterization techniques crucial for monitoring the dynamics of active hydrogen.Critically,three core strategies were systematically dissected to modulate the active hydrogen lifecycle:accelerating water activation and dissociation,enhancing the directional transport of hydrogen species,and precisely tuning active hydrogen coupling pathways while suppressing parasitic hydrogen evolution.By consolidating current understanding from both catalyst design and reaction mechanism perspectives,this review offers a hydrogen-centric roadmap and highlights emerging opportunities for rationally engineering advanced NitRR systems.展开更多
Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active...Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active sites inside the cavity of macrocyclic arenes to better mimic molecular recognition of bioreceptors and enzymes.The editorial aims to enlighten scientists in this field when they develop novel macrocycles for molecular recognition, supramolecular assembly, and applications.展开更多
Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibra...Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibration.An active damping device(ADD)is used to the vibration of the pump valve pipeline system to apply the control force,to achieve the active control of the pipeline vibration.A pump-valve pipeline vibration test bench was built to compare the control effect of active damping device on pipeline vibration under different pump valve working conditions,and the results show that applying ADD control could effectively suppress the vibration of the pump valve pipeline and enhance the stability of the equipment during operation.At different pump operating rotation frequencies,the vibration amplitude of the pump valve pipeline in working frequency and its multiple frequencies are also effectively suppressed,with the maximum amplitude reduction of more than 60%.For the valve vibration caused by different operating openings,the vibration of the highest reduction of 68%,and the centrifugal pump drive shaft vi-bration reduced by up to 73%,which provides a new idea for vibration control of pump valve pipeline system.展开更多
The conventional feedforward hybrid active noise control(FFHANC)system combines the advantages of the feedforward narrowband active noise control(FFNANC)system and the feedforward broadband active noise control(FFBANC...The conventional feedforward hybrid active noise control(FFHANC)system combines the advantages of the feedforward narrowband active noise control(FFNANC)system and the feedforward broadband active noise control(FFBANC)system.To enhance its adaptive adjustment capability under frequency mismatch(FM)conditions,this paper introduces a narrowband frequency adaptive estimation module into the conventional FFHANC system.This module integrates an autoregressive(AR)model and a linear cascaded adaptive notch filter(LCANF),enabling accurate reference signal frequency estimation even under significant FM.Furthermore,in order to improve the coherence between narrowband and broadband components in the system’s error signal and its corresponding control filter for the conventional FFHANC system,this paper proposes an algorithm based on autoregressive bandpass filter bank(AR-BPFB)for error separation.Simulation results demonstrate that the proposed FFHANC system maintains robust performance under high FM conditions and effectively suppresses hybrid-band noise.The AR-BPFB algorithm significantly elevates the convergence speed of the FFHANC system.展开更多
Corrosion activities and related accidents are significant issues for marine facilities,leading to considerable economic losses.Waterborne epoxy(EP)coating has been seen as one of the optimal options for corrosion pro...Corrosion activities and related accidents are significant issues for marine facilities,leading to considerable economic losses.Waterborne epoxy(EP)coating has been seen as one of the optimal options for corrosion protection due to its stable properties and eco-friendliness(0 g/L volatile organic compounds).Nevertheless,several intrinsic deficiencies require improvement,such as fragile mechanical properties and defects(macro and micro),resulting in the continuous deterioration of comprehensive coating performances.In this work,a novel nanocomposite coating with mechanical enhancement,intelligent self-reporting,and active protection is fabricated by integrating the functionalized and compatible graphene oxide/cerium based metal-organic framework multiscale structure(GO-CeMOF-P/M).Notably,the homogenous dispersion of GO-CeMOF-P/M and its chemical interaction with the polymer matrix effectively reduces the defects resulting from solution volatilizing and enhances the compactness,which boosts the tensile strength(32.1 MPa/8.5%)and dry adhesion force(5.8 MPa)of the coating.Additionally,the controllable responsiveness and release of multiscale nanocomposite within external environments endow intelligent active protection and self-reporting characteristics for the GO-CeMOF-P/M-EP coating,making it especially suitable for a variety of practical marine applications.Furthermore,following immersion of 80 d in the aggressive environment,Zf=0.01 Hz value of GO-CeMOF-P/M-EP coating is 1.2×10^(10)Ωcm^(2),which is 164.4 times larger than that of EP coating(7.3×10^(7)Ωcm^(2)),demonstrating remarkably strengthened anti-corrosion ability.Consequently,by offering an intriguing design strategy,the current work anticipates addressing the inherent deficiencies of EP coating and facilitating its practicality and feasibility in real sea environments.展开更多
In clinical practice,antibiotics have historically been utilized for the treatment of pathogenic bacteria.However,the gradual emergence of antibiotic resistance among bacterial strains has posed a significant challeng...In clinical practice,antibiotics have historically been utilized for the treatment of pathogenic bacteria.However,the gradual emergence of antibiotic resistance among bacterial strains has posed a significant challenge to this approach.In 2022,Escherichia coli,a Gram-negative bacterium renowned for its widespread pathogenicity and high virulence,emerged as the predominant pathogenic bacterium in China.The rapid emergence of antibiotic-resistant E.coli strains has rendered antibiotics insufficient to fight E.coli infections.Traditional Chinese medicine(TCM)has made remarkable contributions to the health of Chinese people for thousands of years,and its significant therapeutic effects have been proven in clinical practice.In this paper,we provide a comprehensive review of the advances and mechanisms of TCM and its active ingredients against antibiotic-resistant E.coli infections.First of all,this review introduces the classification,antibiotic resistance characteristics and mechanisms of E.coli.Then,the TCM formulas and extracts are listed along with their active ingredients against E.coli,including extraction solution,minimum inhibitory concentration(MIC),and the antibacterial mechanisms.In addition,there is growing evidence supporting the synergistic therapeutic strategy of combining TCM with antibiotics for the treatment of antibiotic-resistant E.coli infections,and we provide a summary of this evidence and its underlying mechanisms.In conclusion,we present a comprehensive review of TCM and highlight its potential and advantages in the prevention and treatment of E.coli infections.We hold the opinion that TCM will play an important role in global health,pharmaceutical development,and livestock farming in the future.展开更多
The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses ...The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.展开更多
Gallium nitride(GaN)single crystal with prominent electron mobility and heat resistance have great potential in the high temperature integrate electric power systems.However,the sluggish charge storage kinetics and in...Gallium nitride(GaN)single crystal with prominent electron mobility and heat resistance have great potential in the high temperature integrate electric power systems.However,the sluggish charge storage kinetics and inadequate energy densities are bottlenecks to its practical application.Herein,the self-supported GaN/Mn_(3)O_(4) integrated electrode is developed for both energy harvesting and storage under the high temperature environment.The experimental and theoretical calculations results reveal that such integrated structures with Mn-N heterointerface bring abundant active sites and reconstruct low-energy barrier channels for efficient charge transferring,reasonably optimizing the ions adsorption ability and strengthening the structural stability.Consequently,the assembled GaN based supercapacitors deliver the power density of 34.0 mW cm^(-2) with capacitance retention of 81.3%after 10000 cycles at 130℃.This work innovatively correlates the centimeter scale GaN single crystal with ideal theoretical capacity Mn_(3)O_(4) and provides an effective avenue for the follow-up energy storage applications of the wide bandgap semiconductor.展开更多
Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical...Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.展开更多
In recent years,numer-ous single-atom catalysts(SACs)have been synthesized to activate persulfate(PS)by a non-radical pathway because of its high se-lectivity,and activity for the cata-lyst.Metal-nitrogen-carbon(M-N_(...In recent years,numer-ous single-atom catalysts(SACs)have been synthesized to activate persulfate(PS)by a non-radical pathway because of its high se-lectivity,and activity for the cata-lyst.Metal-nitrogen-carbon(M-N_(x)-C)has been identified as the key active site in SACs.Although methods for preparing SACs have been extensively reported,a systematic summary of the direct construction of M-N_(x)-C,espe-cially unconventional metal-nitrogen-carbon(UM-N_(x)-C,x≠4),on SACs for PS non-radical activation has still not been reported.The role of the M-N_(x)-C active sites on PS non-radical activation is discussed and methods for the formation of M-N_(x)-C and UM-N_(x)-C active sites in SACs and the effect of catalyst carriers such as carbon nitride(g-C_(3)N_(4)),MOFs,COFs,and other car-bon materials are reviewed.Direct and indirect methods,especially for UM-N_(x)-C active site formation,are also elaborated.Factors affecting the formation of a M-N_(x)-C active site on SACs are also discussed.Prospects for the use of M-N_(x)-C active sites for the non-radical activation of PS by SACs to remove organic contaminants from wastewater are evaluated.展开更多
Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active...Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active centers influencing the rate of both methanol and CO formation.The particle size and the interaction between Cu and the support materials are influenced by the coprecipitation conditions,let alone that the mechanistic divergence remains unclear.In this work,a series of Cu/ZnO/ZrO_(2) catalysts were prepared via co-precipitation at different pH value and systematically characterized.The structure has been correlated with kinetic results to establish the structure-performance relationship.Kinetic analysis demonstrates that methanol synthesis follows a single-site Langmuir-Hinshelwood(L-H)mechanism,i.e.,Cu serves as the active site where CO_(2) and H_(2) competitively adsorb and react to form methanol.In contrast,CO formation proceeds via a dual-site L-H mechanism,where CO_(2) adsorbs onto ZnO and H_(2) onto Cu,with the reaction occurring at the Cu/ZnO interface.Therefore,for the direct formation of methanol,solely reducing the particle size of Cu would not be beneficial.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
The conformational and dynamical properties of a long semi-flexible active polymer chain confined in a circular cavity are studied by using Langevin dynamics simulation method.Results show that the steady radius of gy...The conformational and dynamical properties of a long semi-flexible active polymer chain confined in a circular cavity are studied by using Langevin dynamics simulation method.Results show that the steady radius of gyration of the polymer decreases monotonically with increasing the active force.Interestingly,the polymer forms stable compact spiral with directional rotation at the steady state when the active force is large.Both the radius of gyration and the angular velocity of the spiral are nearly independent of the cavity size,but show scaling relations with the active force and the polymer length.It is further found that the formation of the stable compact spiral in most cases is a two-step relaxation process,where the polymer first forms a metastable swelling quasi spiral and then transforms into the stable compacted spiral near the wall of the cavity.The relaxation time is mainly determined by the transformation of the swelling quasi spiral,and shows remarkable dependence on the size of the cavity.Specially,when the circumference of the circular is nearly equivalent to the polymer length,it is difficult for the polymer to form the compacted spiral,leading to a large relaxation time.The underlying mechanism of the formation of the compacted spiral is revealed.展开更多
The thought of living near an active volcano probably sounds like an unimaginable experience-and rightly so.An active volcano can turn a forested hillside into a lifeless wasteland in seconds.From molten avalanches of...The thought of living near an active volcano probably sounds like an unimaginable experience-and rightly so.An active volcano can turn a forested hillside into a lifeless wasteland in seconds.From molten avalanches of rock to razor-sharp lung-shredding ash,volcanoes threaten people's lives and property.展开更多
A comprehensive understanding of the structure and dynamic evolution of catalytic active sites is vital for advancing the study of liquid-phase acetylene hydrochlorination.Here,we successfully developed a Ru-DIPEA/TMS...A comprehensive understanding of the structure and dynamic evolution of catalytic active sites is vital for advancing the study of liquid-phase acetylene hydrochlorination.Here,we successfully developed a Ru-DIPEA/TMS catalyst optimised through systematic composition and condition tuning,demonstrating exceptional performance with 95.5%C_(2)H_(2)conversion and sustaining over 91.1%activity along with nearly 100%selectivity for VCM during a continuous 900-h test.Using a combination of characterisation techniques,including UV–vis spectroscopy,FT-IR spectroscopy,X-ray photoelectron spectroscopy,singlecrystal X-ray diffraction,and X-ray absorption spectroscopy,along with density functional theory(DFT)calculations,the structure and dynamic behaviour of the active sites were thoroughly investigated under the synergistic influence of ligands and HCl.The results revealed that HCl activation induces a significant structural transformation of the active sites,leading to the formation of a hexacoordinate complex,Ru(CO)_(2)C_(12)(C_(6)H_(15)N·HCl)_(2).DFT calculations further elucidated the mechanism underlying active site formation,revealing that an increased electron density around the Ru centre and corresponding changes in its coordination environment play critical roles in enhancing catalyst stability and activity.This study contributes to a deeper understanding of the structural basis of active site evolution during acetylene hydrochlorination,offering both practical insights into industrial applications and foundational knowledge for advancing liquid-phase catalysis.展开更多
In materials science,a significant correlation often exists between material input parameters and their corresponding performance attributes.Nevertheless,the inherent challenges associated with small data obscure thes...In materials science,a significant correlation often exists between material input parameters and their corresponding performance attributes.Nevertheless,the inherent challenges associated with small data obscure these statistical correlations,impeding machine learning models from effectively capturing the underlying patterns,thereby hampering efficient optimization of material properties.This work presents a novel active learning framework that integrates generative adversarial networks(GAN)with a directionally constrained expected absolute improvement(EAI)acquisition function to accelerate the discovery of ultra-high temperature ceramics(UHTCs)using small data.The framework employs GAN for data augmentation,symbolic regression for feature weight derivation,and a self-developed EAI function that incorporates input feature importance weighting to quantify bidirectional deviations from zero ablation rate.Through only two iterations,this framework successfully identified the optimal composition of HfB_(2)-3.52SiC-5.23TaSi_(2),which exhibits robust near-zero ablation rates under plasma ablation at 2500℃ for 200 s,demonstrating superior sampling efficiency compared to conventional active learning approaches.Microstructural analysis reveals that the exceptional performance stems from the formation of a highly viscous HfO_(2)-SiO_(2)-Ta_(2)O_(5)-HfSiO_(4)-Hf_(3)(BO_(3))_(4) oxide layer,which provides effective oxygen barrier protection.This work demonstrates an efficient and universal approach for rapid materials discovery using small data.展开更多
Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-relate...Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-related diseases like Alzheimer’s disease,osteoporosis,low immunity,glucose and lipid metabolism disorders,and cardiovascular diseases.With the continuous increase of the elderly population,the pressure on the medical industry is increasing.To lower the burden on the medical industry and increase the average age of the elderly,it is vital to explore effective anti-aging materials.Ginseng Radix et Rhizoma(Renshen),as a traditional and precious Chinese medicinal herb,is known as the“king of all herbs”.It is famous for its effects of“tonifying Qi,restoring pulse”(helping with the generation of Qi(the fundamental,vital energy that continuously flows within the body)and the circulation of blood)and strengthening the body,nourishing the spleen and lungs,generating fluids and nourishing blood,calming the mind and improving intelligence.Recently,its anti-aging effect has received increasing attention from modern scientific research.This study summarizes the pharmacological effects of the main active ingredients of Renshen(ginsenosides,polysaccharides,etc.)on resisting aging,including preventing neuroaging,suppressing skin aging,mitigating ovarian aging,inhibiting osteoporosis and arthritis,enhancing the immune system of the elderly,protecting the cardiovascular system,resisting aging-induced fatigue and exerting the anti-tumor effects.Through network pharmacology and molecular docking,the anti-aging active ingredients of Renshen were screened,and the key targets and pathways of anti-aging active ingredients in Renshen were determined.Using network pharmacology,totally 106 drug targets and 3,479 disease targets were screened,and 79 common targets between aging and Renshen were identified.Three core targets were identified in the PPI network,including TNF,AKT1,and IL-1β.Molecular docking was used to obtain further verification.This study emphasizes the potential of Renshen as a source of anti-aging activity,which can be developed into a novel drug for the treatment of age-related diseases.展开更多
基金financial support from the General Program of the National Natural Science Foundation of China(Grant No.12474195)the Key Project of Guangdong Provincial Department of Education(Grant No.2023ZDZX3021)the Natural Science Foundation of Guangdong Province(Grant No.2024A1515011343)。
文摘In the last decade,the study of pressure in active matter has attracted growing attention due to its fundamental relevance to nonequilibrium statistical physics.Active matter systems are composed of particles that consume energy to sustain persistent motion,which are inherently far from equilibrium.These particles can exhibit complex behaviors,including motility-induced phase separation,clustering,and anomalous stress distributions,motivating the introduction of active swim stress and swim pressure.Unlike in passive fluids,pressure in active systems emerges from momentum flux originating from swim force rather than equilibrium conservative interactions,offering a distinct perspective for understanding their mechanical response.Simple models of active Brownian particles(ABPs)have been employed in theoretical and simulation studies across both dilute and dense regimes,revealing that pressure is a state function and exhibits a nontrivial dependence on density.Together with nonequilibrium statistical concepts such as effective temperature and effective adhesion,pressure offers important insight for understanding behaviors in active matter such as sedimentation equilibrium and motility induced phase separation.Extensions of ABP models beyond their simplest form have underscored the fragility of the pressure-based equation of state,which can break down under factors such as density-dependent velocity,torque,complex boundary geometries and interactions.Building on these developments,this review provides a comprehensive survey of theoretical and experimental advances,with particular emphasis on the microscopic origins of active pressure and the mechanisms underlying the breakdown of the equation of state.
基金funded by the“Research and Application Project of Collaborative Optimization Control Technology for Distribution Station Area for High Proportion Distributed PV Consumption(4000-202318079A-1-1-ZN)”of the Headquarters of the State Grid Corporation.
文摘Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem.
文摘Spider mites are significant pests in agricultural production.The increasing resistance of spider mites,along with environmental pollution and ecological imbalance caused by their control,is primarily attributed to the long-term use of chemical acaricides in agriculture.In contrast,bioactive substances of biological origin offer advantages such as wide availability,environmental friendliness,and low tendency to induce resistance,making them a research hotspot for spider mite control.This review summarizes recent advances in the use of plant-derived active compounds(exemplified by extracts from Veratrum rhizomes),RNA interference(RNAi)technology,and microorganism-derived active substances for controlling spider mites.These bioactive agents exert acaricidal effects by disrupting the nervous system,interfering with metabolic processes,or silencing key genes in mites,demonstrating favorable efficacy and considerable potential for development.However,challenges remain,including poor environmental stability,slow action,high production costs,and insufficient understanding of their effects on non-target organisms.Therefore,future research should focus on the screening and development of novel bioactive substances of biological origin,elucidation of their mechanisms of action,optimization of formulation technologies,and assessment of their ecological safety.These efforts will provide valuable insights for promoting the advancement of bioactive substances and supporting sustainable agricultural development.
基金financially supported by the National Natural Science Foundation of China(22179035)the Science Fund for Distinguished Young Scholars of Heilongjiang Province(JQ2022B001)the Fundamental Research Funds for the Universities of Heilongjiang Province of China(2023-KYYWF1440)。
文摘Electrocatalytic nitrate reduction reaction(NitRR)utilizing water as a hydrogen source under ambient conditions represents a highly promising avenue for sustainable ammonia synthesis and environmental remediation.However,achieving high efficiency and selectivity in NitRR is fundamentally challenged by the complex lifecycle management of active hydrogen derived from water splitting.This review provides a timely and comprehensive analysis centered on the pivotal role and meticulous regulation of active hydrogen throughout the NitRR process.We first elucidate the distinct functions and characteristics of various hydrogen species,followed by a survey of advanced characterization techniques crucial for monitoring the dynamics of active hydrogen.Critically,three core strategies were systematically dissected to modulate the active hydrogen lifecycle:accelerating water activation and dissociation,enhancing the directional transport of hydrogen species,and precisely tuning active hydrogen coupling pathways while suppressing parasitic hydrogen evolution.By consolidating current understanding from both catalyst design and reaction mechanism perspectives,this review offers a hydrogen-centric roadmap and highlights emerging opportunities for rationally engineering advanced NitRR systems.
文摘Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active sites inside the cavity of macrocyclic arenes to better mimic molecular recognition of bioreceptors and enzymes.The editorial aims to enlighten scientists in this field when they develop novel macrocycles for molecular recognition, supramolecular assembly, and applications.
基金The Fundamental Research Funds for the Central Universities(JD2423)。
文摘Pump valve pipeline vibration brings serious safety hazards to the operation of the equipment,for the pump valve system in the process of variable flow,variable speed,variable openings lead to excessive pipeline vibration.An active damping device(ADD)is used to the vibration of the pump valve pipeline system to apply the control force,to achieve the active control of the pipeline vibration.A pump-valve pipeline vibration test bench was built to compare the control effect of active damping device on pipeline vibration under different pump valve working conditions,and the results show that applying ADD control could effectively suppress the vibration of the pump valve pipeline and enhance the stability of the equipment during operation.At different pump operating rotation frequencies,the vibration amplitude of the pump valve pipeline in working frequency and its multiple frequencies are also effectively suppressed,with the maximum amplitude reduction of more than 60%.For the valve vibration caused by different operating openings,the vibration of the highest reduction of 68%,and the centrifugal pump drive shaft vi-bration reduced by up to 73%,which provides a new idea for vibration control of pump valve pipeline system.
基金supported in part by the Postgraduate Research&Practice Innovation Program of Nanjing University of Aeronautics and Astronautics(No.xcxjh20240326).
文摘The conventional feedforward hybrid active noise control(FFHANC)system combines the advantages of the feedforward narrowband active noise control(FFNANC)system and the feedforward broadband active noise control(FFBANC)system.To enhance its adaptive adjustment capability under frequency mismatch(FM)conditions,this paper introduces a narrowband frequency adaptive estimation module into the conventional FFHANC system.This module integrates an autoregressive(AR)model and a linear cascaded adaptive notch filter(LCANF),enabling accurate reference signal frequency estimation even under significant FM.Furthermore,in order to improve the coherence between narrowband and broadband components in the system’s error signal and its corresponding control filter for the conventional FFHANC system,this paper proposes an algorithm based on autoregressive bandpass filter bank(AR-BPFB)for error separation.Simulation results demonstrate that the proposed FFHANC system maintains robust performance under high FM conditions and effectively suppresses hybrid-band noise.The AR-BPFB algorithm significantly elevates the convergence speed of the FFHANC system.
基金financially supported by the National Natural Science Foundation of China(Nos.52371088,52071347,and U20A20233)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515240007)Shenzhen Science and Technology Program(No.KJZD20230923114819041).
文摘Corrosion activities and related accidents are significant issues for marine facilities,leading to considerable economic losses.Waterborne epoxy(EP)coating has been seen as one of the optimal options for corrosion protection due to its stable properties and eco-friendliness(0 g/L volatile organic compounds).Nevertheless,several intrinsic deficiencies require improvement,such as fragile mechanical properties and defects(macro and micro),resulting in the continuous deterioration of comprehensive coating performances.In this work,a novel nanocomposite coating with mechanical enhancement,intelligent self-reporting,and active protection is fabricated by integrating the functionalized and compatible graphene oxide/cerium based metal-organic framework multiscale structure(GO-CeMOF-P/M).Notably,the homogenous dispersion of GO-CeMOF-P/M and its chemical interaction with the polymer matrix effectively reduces the defects resulting from solution volatilizing and enhances the compactness,which boosts the tensile strength(32.1 MPa/8.5%)and dry adhesion force(5.8 MPa)of the coating.Additionally,the controllable responsiveness and release of multiscale nanocomposite within external environments endow intelligent active protection and self-reporting characteristics for the GO-CeMOF-P/M-EP coating,making it especially suitable for a variety of practical marine applications.Furthermore,following immersion of 80 d in the aggressive environment,Zf=0.01 Hz value of GO-CeMOF-P/M-EP coating is 1.2×10^(10)Ωcm^(2),which is 164.4 times larger than that of EP coating(7.3×10^(7)Ωcm^(2)),demonstrating remarkably strengthened anti-corrosion ability.Consequently,by offering an intriguing design strategy,the current work anticipates addressing the inherent deficiencies of EP coating and facilitating its practicality and feasibility in real sea environments.
基金supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes,China(Grant Nos.:ZZ16-YQ-037,JIPY2023003,and JJPY2022022)China Academy of Chinese Medical Sciences(CACMS)Innovation Fund(Grant No.:CI2021A00601).
文摘In clinical practice,antibiotics have historically been utilized for the treatment of pathogenic bacteria.However,the gradual emergence of antibiotic resistance among bacterial strains has posed a significant challenge to this approach.In 2022,Escherichia coli,a Gram-negative bacterium renowned for its widespread pathogenicity and high virulence,emerged as the predominant pathogenic bacterium in China.The rapid emergence of antibiotic-resistant E.coli strains has rendered antibiotics insufficient to fight E.coli infections.Traditional Chinese medicine(TCM)has made remarkable contributions to the health of Chinese people for thousands of years,and its significant therapeutic effects have been proven in clinical practice.In this paper,we provide a comprehensive review of the advances and mechanisms of TCM and its active ingredients against antibiotic-resistant E.coli infections.First of all,this review introduces the classification,antibiotic resistance characteristics and mechanisms of E.coli.Then,the TCM formulas and extracts are listed along with their active ingredients against E.coli,including extraction solution,minimum inhibitory concentration(MIC),and the antibacterial mechanisms.In addition,there is growing evidence supporting the synergistic therapeutic strategy of combining TCM with antibiotics for the treatment of antibiotic-resistant E.coli infections,and we provide a summary of this evidence and its underlying mechanisms.In conclusion,we present a comprehensive review of TCM and highlight its potential and advantages in the prevention and treatment of E.coli infections.We hold the opinion that TCM will play an important role in global health,pharmaceutical development,and livestock farming in the future.
基金supported by the National Key R&D Program of China(No.2021YFB2011300)the Special Funds Project for the Transformation of Scientific and Technological Achievements of Jiangsu Province,China(No.BA2023039)+1 种基金the National Natural Science Foundation of China(No.52075262)the Fundamental Research Funds for the Central Universities,China(No.30922010706).
文摘The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.
基金supported by NSFC(Grant No.52202265,52302004,52472010,62434010)the Taishan Scholars Program of Shandong Province(tsqn202306330)+1 种基金Shenzhen Science and Technology Program(JCYJ20230807094009018)Xiaomi Young Talents Program(2023XM06).
文摘Gallium nitride(GaN)single crystal with prominent electron mobility and heat resistance have great potential in the high temperature integrate electric power systems.However,the sluggish charge storage kinetics and inadequate energy densities are bottlenecks to its practical application.Herein,the self-supported GaN/Mn_(3)O_(4) integrated electrode is developed for both energy harvesting and storage under the high temperature environment.The experimental and theoretical calculations results reveal that such integrated structures with Mn-N heterointerface bring abundant active sites and reconstruct low-energy barrier channels for efficient charge transferring,reasonably optimizing the ions adsorption ability and strengthening the structural stability.Consequently,the assembled GaN based supercapacitors deliver the power density of 34.0 mW cm^(-2) with capacitance retention of 81.3%after 10000 cycles at 130℃.This work innovatively correlates the centimeter scale GaN single crystal with ideal theoretical capacity Mn_(3)O_(4) and provides an effective avenue for the follow-up energy storage applications of the wide bandgap semiconductor.
基金supported by the National Natural Science Foundation of China(Nos.52177059 and 52407064).
文摘Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.
文摘In recent years,numer-ous single-atom catalysts(SACs)have been synthesized to activate persulfate(PS)by a non-radical pathway because of its high se-lectivity,and activity for the cata-lyst.Metal-nitrogen-carbon(M-N_(x)-C)has been identified as the key active site in SACs.Although methods for preparing SACs have been extensively reported,a systematic summary of the direct construction of M-N_(x)-C,espe-cially unconventional metal-nitrogen-carbon(UM-N_(x)-C,x≠4),on SACs for PS non-radical activation has still not been reported.The role of the M-N_(x)-C active sites on PS non-radical activation is discussed and methods for the formation of M-N_(x)-C and UM-N_(x)-C active sites in SACs and the effect of catalyst carriers such as carbon nitride(g-C_(3)N_(4)),MOFs,COFs,and other car-bon materials are reviewed.Direct and indirect methods,especially for UM-N_(x)-C active site formation,are also elaborated.Factors affecting the formation of a M-N_(x)-C active site on SACs are also discussed.Prospects for the use of M-N_(x)-C active sites for the non-radical activation of PS by SACs to remove organic contaminants from wastewater are evaluated.
基金supported by Research Grant from China Petroleum and Chemical Corp。
文摘Cu/ZnO-based catalysts are widely employed for methanol synthesis via CO_(2) hydrogenation.The preparation procedure is sensitive to the particle size and interfacial structure,which are considered as potential active centers influencing the rate of both methanol and CO formation.The particle size and the interaction between Cu and the support materials are influenced by the coprecipitation conditions,let alone that the mechanistic divergence remains unclear.In this work,a series of Cu/ZnO/ZrO_(2) catalysts were prepared via co-precipitation at different pH value and systematically characterized.The structure has been correlated with kinetic results to establish the structure-performance relationship.Kinetic analysis demonstrates that methanol synthesis follows a single-site Langmuir-Hinshelwood(L-H)mechanism,i.e.,Cu serves as the active site where CO_(2) and H_(2) competitively adsorb and react to form methanol.In contrast,CO formation proceeds via a dual-site L-H mechanism,where CO_(2) adsorbs onto ZnO and H_(2) onto Cu,with the reaction occurring at the Cu/ZnO interface.Therefore,for the direct formation of methanol,solely reducing the particle size of Cu would not be beneficial.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
基金supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY20A040004)the National Natural Science Foundation of China(Nos.22203060 and 11974305).
文摘The conformational and dynamical properties of a long semi-flexible active polymer chain confined in a circular cavity are studied by using Langevin dynamics simulation method.Results show that the steady radius of gyration of the polymer decreases monotonically with increasing the active force.Interestingly,the polymer forms stable compact spiral with directional rotation at the steady state when the active force is large.Both the radius of gyration and the angular velocity of the spiral are nearly independent of the cavity size,but show scaling relations with the active force and the polymer length.It is further found that the formation of the stable compact spiral in most cases is a two-step relaxation process,where the polymer first forms a metastable swelling quasi spiral and then transforms into the stable compacted spiral near the wall of the cavity.The relaxation time is mainly determined by the transformation of the swelling quasi spiral,and shows remarkable dependence on the size of the cavity.Specially,when the circumference of the circular is nearly equivalent to the polymer length,it is difficult for the polymer to form the compacted spiral,leading to a large relaxation time.The underlying mechanism of the formation of the compacted spiral is revealed.
文摘The thought of living near an active volcano probably sounds like an unimaginable experience-and rightly so.An active volcano can turn a forested hillside into a lifeless wasteland in seconds.From molten avalanches of rock to razor-sharp lung-shredding ash,volcanoes threaten people's lives and property.
基金supported by the National Natural Science Foundation of China(No.22378308)Jing-Jin-Ji Regional Integrated Environmental Improvement-National Science and Technology Major Project(No.2024ZD1200301–2)the Scientific and Technological Project of Yunnan Precious Metal Laboratory(No.YPML2023050202)。
文摘A comprehensive understanding of the structure and dynamic evolution of catalytic active sites is vital for advancing the study of liquid-phase acetylene hydrochlorination.Here,we successfully developed a Ru-DIPEA/TMS catalyst optimised through systematic composition and condition tuning,demonstrating exceptional performance with 95.5%C_(2)H_(2)conversion and sustaining over 91.1%activity along with nearly 100%selectivity for VCM during a continuous 900-h test.Using a combination of characterisation techniques,including UV–vis spectroscopy,FT-IR spectroscopy,X-ray photoelectron spectroscopy,singlecrystal X-ray diffraction,and X-ray absorption spectroscopy,along with density functional theory(DFT)calculations,the structure and dynamic behaviour of the active sites were thoroughly investigated under the synergistic influence of ligands and HCl.The results revealed that HCl activation induces a significant structural transformation of the active sites,leading to the formation of a hexacoordinate complex,Ru(CO)_(2)C_(12)(C_(6)H_(15)N·HCl)_(2).DFT calculations further elucidated the mechanism underlying active site formation,revealing that an increased electron density around the Ru centre and corresponding changes in its coordination environment play critical roles in enhancing catalyst stability and activity.This study contributes to a deeper understanding of the structural basis of active site evolution during acetylene hydrochlorination,offering both practical insights into industrial applications and foundational knowledge for advancing liquid-phase catalysis.
基金supported by the Natural Science Foundation of China[grant numbers 52302093]Natural Science Foundation of Jiangxi Province[grant numbers 20224BAB204021].
文摘In materials science,a significant correlation often exists between material input parameters and their corresponding performance attributes.Nevertheless,the inherent challenges associated with small data obscure these statistical correlations,impeding machine learning models from effectively capturing the underlying patterns,thereby hampering efficient optimization of material properties.This work presents a novel active learning framework that integrates generative adversarial networks(GAN)with a directionally constrained expected absolute improvement(EAI)acquisition function to accelerate the discovery of ultra-high temperature ceramics(UHTCs)using small data.The framework employs GAN for data augmentation,symbolic regression for feature weight derivation,and a self-developed EAI function that incorporates input feature importance weighting to quantify bidirectional deviations from zero ablation rate.Through only two iterations,this framework successfully identified the optimal composition of HfB_(2)-3.52SiC-5.23TaSi_(2),which exhibits robust near-zero ablation rates under plasma ablation at 2500℃ for 200 s,demonstrating superior sampling efficiency compared to conventional active learning approaches.Microstructural analysis reveals that the exceptional performance stems from the formation of a highly viscous HfO_(2)-SiO_(2)-Ta_(2)O_(5)-HfSiO_(4)-Hf_(3)(BO_(3))_(4) oxide layer,which provides effective oxygen barrier protection.This work demonstrates an efficient and universal approach for rapid materials discovery using small data.
基金supported by the Jilin Science and Technology Development Talent Special Project,Nos.20240601086RC,23JQ08(all to ZH)YDZJ202502CXJD077+1 种基金JLARS-2025-0802-09YDZJ202501ZYTS706.
文摘Population aging is one of the common challenges in the current world.As people age,the body’s tissues including cells,and molecules inevitably degrade,and their functions gradually decline,causing various age-related diseases like Alzheimer’s disease,osteoporosis,low immunity,glucose and lipid metabolism disorders,and cardiovascular diseases.With the continuous increase of the elderly population,the pressure on the medical industry is increasing.To lower the burden on the medical industry and increase the average age of the elderly,it is vital to explore effective anti-aging materials.Ginseng Radix et Rhizoma(Renshen),as a traditional and precious Chinese medicinal herb,is known as the“king of all herbs”.It is famous for its effects of“tonifying Qi,restoring pulse”(helping with the generation of Qi(the fundamental,vital energy that continuously flows within the body)and the circulation of blood)and strengthening the body,nourishing the spleen and lungs,generating fluids and nourishing blood,calming the mind and improving intelligence.Recently,its anti-aging effect has received increasing attention from modern scientific research.This study summarizes the pharmacological effects of the main active ingredients of Renshen(ginsenosides,polysaccharides,etc.)on resisting aging,including preventing neuroaging,suppressing skin aging,mitigating ovarian aging,inhibiting osteoporosis and arthritis,enhancing the immune system of the elderly,protecting the cardiovascular system,resisting aging-induced fatigue and exerting the anti-tumor effects.Through network pharmacology and molecular docking,the anti-aging active ingredients of Renshen were screened,and the key targets and pathways of anti-aging active ingredients in Renshen were determined.Using network pharmacology,totally 106 drug targets and 3,479 disease targets were screened,and 79 common targets between aging and Renshen were identified.Three core targets were identified in the PPI network,including TNF,AKT1,and IL-1β.Molecular docking was used to obtain further verification.This study emphasizes the potential of Renshen as a source of anti-aging activity,which can be developed into a novel drug for the treatment of age-related diseases.
