To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,an...To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,and pulmonary artery(PA)and vein(PV)stenosis.Moreover,long-term obstruction of PAs and PVs may lead to pulmonary hypertension(PH),right heart failure(RHF),and death.[1]Although it is generally held that FM is an aberrant immunoproliferative response of the mediastinum to a triggering factor,such as infection of Mycobacterium tuberculosis and Histoplasma capsulatum,the exact etiology and pathogenesis of FM remain unclear;in particular,the genetic susceptibility of this fatal disease is unknown.展开更多
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted ...Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted gut homeostasis,primarily due to an aberrant innate immune response to intestinal microbiota and an underlying genetic background.1 Recently,complete healing of mucosal inflammation has been suggested as a new therapeutic goal in UC treatment.2 However,this goal remains challenging,as approximately 20%of individuals in clinical remission still exhibit active mucosal inflammation.3 Understanding the molecular alterations underlying this persistent mucosal inflammation is crucial for advancing UC pathogenesis insights and treatment strategies.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.82070052 and U25A2001)the Tianjin high-level talent selection and training project in the health industry(No.TJSJMYXYC-D2-042)+1 种基金the Natural Science Foundation of Gansu Province of China(No.24JRRA1049)the Lanzhou Science and Technology Program of Gansu Province of China(No.LX-62000001-2022-090).
文摘To the Editor:Fibrous mediastinitis(FM)is a rare group of diseases characterized by excessive proliferation of fibrous tissue in the mediastinum,which can cause bronchial stenosis,superior vena cava(SVC)obstruction,and pulmonary artery(PA)and vein(PV)stenosis.Moreover,long-term obstruction of PAs and PVs may lead to pulmonary hypertension(PH),right heart failure(RHF),and death.[1]Although it is generally held that FM is an aberrant immunoproliferative response of the mediastinum to a triggering factor,such as infection of Mycobacterium tuberculosis and Histoplasma capsulatum,the exact etiology and pathogenesis of FM remain unclear;in particular,the genetic susceptibility of this fatal disease is unknown.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education of the Republic of Korea(No.2020R1I1A1A01073545 to E.M.S.,2020R1A2C1010786 to C.M.M.,2021R1A6A1A10044154 to J.K).
文摘Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted gut homeostasis,primarily due to an aberrant innate immune response to intestinal microbiota and an underlying genetic background.1 Recently,complete healing of mucosal inflammation has been suggested as a new therapeutic goal in UC treatment.2 However,this goal remains challenging,as approximately 20%of individuals in clinical remission still exhibit active mucosal inflammation.3 Understanding the molecular alterations underlying this persistent mucosal inflammation is crucial for advancing UC pathogenesis insights and treatment strategies.
