With the rapid development of modern information technology,the Internet of Things(IoT)has been integrated into various fields such as social life,industrial production,education,and medical care.Through the connectio...With the rapid development of modern information technology,the Internet of Things(IoT)has been integrated into various fields such as social life,industrial production,education,and medical care.Through the connection of various physical devices,sensors,and machines,it realizes information intercommunication and remote control among devices,significantly enhancing the convenience and efficiency of work and life.However,the rapid development of the IoT has also brought serious security problems.IoT devices have limited resources and a complex network environment,making them one of the important targets of network intrusion attacks.Therefore,from the perspective of deep learning,this paper deeply analyzes the characteristics and key points of IoT intrusion detection,summarizes the application advantages of deep learning in IoT intrusion detection,and proposes application strategies of typical deep learning models in IoT intrusion detection so as to improve the security of the IoT architecture and guarantee people’s convenient lives.展开更多
In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so...In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so that its negative emotions accumulate,but also have a serious impact on the credibility of the media and the government,and may even further intensify social contradictions.Therefore,in the face of such a complex online public opinion space,accurately identifying the truth behind the incident and how to carry out the reversal of online public opinion governance is particularly critical.And blockchain technology,with its advantages of decentralization and immutable information,provides new technical support for the network public opinion reversal governance.Based on this,this paper gives an overview and analysis of blockchain technology and network public opinion reversal,and on this basis introduces the network public opinion reversal governance mechanism based on blockchain technology,aiming to further optimize the network public opinion reversal governance process,for reference only.展开更多
The Internet of Things technology provides a comprehensive solution for the real-time monitoring of cold chain logistics by integrating sensors,wireless communication,cloud computing,and big data analysis.Based on thi...The Internet of Things technology provides a comprehensive solution for the real-time monitoring of cold chain logistics by integrating sensors,wireless communication,cloud computing,and big data analysis.Based on this,this paper deeply explores the overview and characteristics of the Internet of Things technology,the feasibility analysis of the Internet of Things technology in the cold chain logistics monitoring,the application analysis of the Internet of Things technology in the cold chain logistics real-time monitoring to better improve the management level and operational efficiency of the cold chain logistics,to provide consumers with safer and fresh products.展开更多
Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to Augus...Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.展开更多
The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and ...The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and high-temperature(HPHT)conditions.It also continues the previous year’s6 contemporary focus on superhydrides7–11 with extremely high superconducting temperatures Tc and addresses some controversial issues.12–14 In addition,it explores unconventional pressure-induced chemistry,particularly novel chemical stoichiometry and its impact on geochemistry and cosmochemistry in the deep interiors of Earth and other planets.18–21.展开更多
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apopt...Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.展开更多
The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them w...The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.展开更多
Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ...Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.展开更多
基金the research result of the 2022 Municipal Education Commission Science and Technology Research Plan Project“Research on the Technology of Detecting Double-Surface Cracks in Concrete Lining of Highway Tunnels Based on Image Blast”(KJQN02202403)the first batch of school-level classroom teaching reform projects“Principles Applications of Embedded Systems”(23JG2166)the school-level reform research project“Continuous Results-Oriented Practice Research Based on BOPPPS Teaching Model-Taking the‘Programming Fundamentals’Course as an Example”(22JG332).
文摘With the rapid development of modern information technology,the Internet of Things(IoT)has been integrated into various fields such as social life,industrial production,education,and medical care.Through the connection of various physical devices,sensors,and machines,it realizes information intercommunication and remote control among devices,significantly enhancing the convenience and efficiency of work and life.However,the rapid development of the IoT has also brought serious security problems.IoT devices have limited resources and a complex network environment,making them one of the important targets of network intrusion attacks.Therefore,from the perspective of deep learning,this paper deeply analyzes the characteristics and key points of IoT intrusion detection,summarizes the application advantages of deep learning in IoT intrusion detection,and proposes application strategies of typical deep learning models in IoT intrusion detection so as to improve the security of the IoT architecture and guarantee people’s convenient lives.
基金Gansu Provincial Department of Education:Innovation Fund Project for College Teachers:Research on the Governance of Network Public Opinion Reversal Based on Blockchain Technology(NO.2025A-137)Teaching Reform Research at the School Level of Gansu University of Political Science and Law in 2024:Research and Implementation of CSCW Cloud Storage Collective Lesson Preparation System Based on Blockchain Technology(NO.GZJG2024-A04)+1 种基金2024 Gansu University of Political Science and Law“Three in One Education”Research:Project Research and Implementation of CSCW Network Teaching Platform Based on Web in the Direction of Network Education(NO.GZSQYR-37)2024 Lanzhou Philosophy and Social Sciences Planning Project:Research on Cloud Governance of Network Public Opinion for Major Public Events in Lanzhou City(NO.24-B45)。
文摘In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so that its negative emotions accumulate,but also have a serious impact on the credibility of the media and the government,and may even further intensify social contradictions.Therefore,in the face of such a complex online public opinion space,accurately identifying the truth behind the incident and how to carry out the reversal of online public opinion governance is particularly critical.And blockchain technology,with its advantages of decentralization and immutable information,provides new technical support for the network public opinion reversal governance.Based on this,this paper gives an overview and analysis of blockchain technology and network public opinion reversal,and on this basis introduces the network public opinion reversal governance mechanism based on blockchain technology,aiming to further optimize the network public opinion reversal governance process,for reference only.
文摘The Internet of Things technology provides a comprehensive solution for the real-time monitoring of cold chain logistics by integrating sensors,wireless communication,cloud computing,and big data analysis.Based on this,this paper deeply explores the overview and characteristics of the Internet of Things technology,the feasibility analysis of the Internet of Things technology in the cold chain logistics monitoring,the application analysis of the Internet of Things technology in the cold chain logistics real-time monitoring to better improve the management level and operational efficiency of the cold chain logistics,to provide consumers with safer and fresh products.
文摘Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.
基金financial support from the Shanghai Key Laboratory of MFree,China(Grant No.22dz2260800)the Shanghai Science and Technology Committee,China(Grant No.22JC1410300).
文摘The 2024 MRE HP Special Volume selects papers on new theoretical and experimental developments in the use of static largevolume presses(LVPs)1–3 and dynamic compression4,5 for studies under extreme high-pressure and high-temperature(HPHT)conditions.It also continues the previous year’s6 contemporary focus on superhydrides7–11 with extremely high superconducting temperatures Tc and addresses some controversial issues.12–14 In addition,it explores unconventional pressure-induced chemistry,particularly novel chemical stoichiometry and its impact on geochemistry and cosmochemistry in the deep interiors of Earth and other planets.18–21.
基金supported by the National Natural Science Foundation of China,Nos.32271043(to ZW)and 82171047(to YM)the both Science and Technology Major Project of Shanghai,No.2018SHZDZX01 and ZJLabShanghai Center for Brain Science and Brain-Inspired Technology(to ZW)。
文摘Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.
文摘The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.
基金supported by the National Key Research and Development Program(Grant No.2024YFA0917200)the Projects of the Chinese Center for Disease Control and Prevention(Grant No.BB2110240093)World Medical History under the Education Innovation Plan of the University of Science and Technology of China(Grant No.2024YCHX07).
文摘Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.
