Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the e...Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the effects of the urbanisation on the water environment.This study aimed to design novel configurations of tidal-flow vertical subsurface flow constructed wetlands(VFCWs)for treating urban stormwater.A series of laboratory experiments were conducted with semi-synthetic influent stormwater to examine the effects of the design and operation variables on the performance of the VFCWs and to identify optimal design and operational strategies,as well as maintenance requirements.The results show that the VFCWs can significantly reduce pollutants in urban stormwater,and that pollutant removal was related to specific VFCW designs.Models based on the artificial neural network(ANN)method were built using inputs derived from data exploratory techniques,such as analysis of variance(ANOVA)and principal component analysis(PCA).It was found that PCA reduced the dimensionality of input variables obtained from different experimental design conditions.The results show a satisfactory generalisation for predicting nitrogen and phosphorus removal with fewer variable inputs,indicating that monitoring costs and time can be reduced.展开更多
In the present paper,the hydrodynamic performance of stepped planing craft is investigated by computational fluid dynamics(CFD)analysis.For this purpose,the hydrodynamic resistances of without step,one-step,and two-st...In the present paper,the hydrodynamic performance of stepped planing craft is investigated by computational fluid dynamics(CFD)analysis.For this purpose,the hydrodynamic resistances of without step,one-step,and two-step hulls of Cougar planing craft are evaluated under different distances of the second step and LCG from aft,weight loadings,and Froude numbers(Fr).Our CFD results are appropriately validated against our conducted experimental test in National Iranians Marine Laboratory(NIMALA),Tehran,Iran.Then,the hydrodynamic resistance of intended planing crafts under various geometrical and physical conditions is predicted using artificial neural networks(ANNs).CFD analysis shows two different trends in the growth rate of resistance to weight ratio.So that,using steps for planing craft increases the resistance to weight ratio at lower Fr and decreases it at higher Fr.Additionally,by the increase of the distance between two steps,the resistance to weight ratio is decreased and the porpoising phenomenon is delayed.Furthermore,we obtained the maximum mean square error of ANNs output in the prediction of resistance to weight ratio equal to 0.0027.Finally,the predictive equation is suggested for the resistance to weight ratio of stepped planing craft according to weights and bias of designed ANNs.展开更多
In agent-based automated negotiation research area,a key problem is how to make software agent more adaptable to represent user preferences or suggestions,so that agent can take further proposals that reflect user req...In agent-based automated negotiation research area,a key problem is how to make software agent more adaptable to represent user preferences or suggestions,so that agent can take further proposals that reflect user requirements to implement ecommerce activities like automated transactions.The difficulty lies in the uncertainty of user preferences that include uncertain description and contents,non-linear and dynamic variability.In this paper,fuzzy language was used to describe the uncertainty and combine with multiple classified artificial neural networks(ANNs) for self-adaptive learning of user preferences.The refinement learning results of various negotiation contracts' satisfaction degrees in the extent of fuzzy classification can be achieved.Compared to unclassified computation,the experimental results illustrate that the learning ability and effectiveness of agents have been improved.展开更多
The paper describes the application of SDSM （statistical downscaling model） and ANNs （artificial neural networks） models for prediction of the hydrological trend due to the climate-change. The SDSM has been calibr...The paper describes the application of SDSM （statistical downscaling model） and ANNs （artificial neural networks） models for prediction of the hydrological trend due to the climate-change. The SDSM has been calibrated and generated for the possible future scenarios of meteorological variables, which are temperature and rainfall by using GCMs （global climate models）. The GCM used is SRES A2. The downscaled meteorological variables corresponding to SDSM were then used as input to the ANNs model calibrated with observed station data to simulate the corresponding future streamflow changes in the sub-catchment of Kurau River. This study has discovered the hydrological trend over the catchment. The projected monthly streamflow has shown a decreasing trend due to the increase in the, mean of temperature for overall months, except the month of August and November.展开更多
There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reac...There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.展开更多
In this study,artificial neural networks(ANNs)were implemented to determine design parameters for an impressed current cathodic protection(ICCP)prototype.An ASTM A36 steel plate was tested in 3.5%NaCl solution,seawate...In this study,artificial neural networks(ANNs)were implemented to determine design parameters for an impressed current cathodic protection(ICCP)prototype.An ASTM A36 steel plate was tested in 3.5%NaCl solution,seawater,and NS4 using electrochemical impedance spectroscopy(EIS)to monitor the evolution of the substrate surface,which affects the current required to reach the protection potential(Eprot).Experimental data were collected as training datasets and analyzed using statistical methods,including box plots and correlation matrices.Subsequently,ANNs were applied to predict the current demand at different exposure times,enabling the estimation of electrochemical parameters(limiting voltage values)that can be used to optimize a self-regulating ICCP system.The obtained electrochemical parameters were then used,through Particle Swarm Optimization(PSO),to fine-tune an ANN-based proportional-integral-derivative(PID)controller for the ICCP system.展开更多
The main purpose of this study was to develop and apply an adaptive neuro-fuzzy inference system(ANFIS)and Artificial Neural Networks(ANNs)model for predicting the drying characteristics of potato,garlic and cantaloup...The main purpose of this study was to develop and apply an adaptive neuro-fuzzy inference system(ANFIS)and Artificial Neural Networks(ANNs)model for predicting the drying characteristics of potato,garlic and cantaloupe at convective hot air dryer.Drying experiments were conducted at the air temperatures of 40,50,60 and 70C and the air speeds of 0.5,1 and l.5 m/s.Drying properties were including kinetic drying,effective moisture diffusivity(Deff)and specific energy consumption(SEC).The highest value of Deff obtained 9.76×10^-9,0.13×10^-9 and 9.97×10^-10 m^2/s for potato,garlic,and cantaloupe,respectively.The lowest value of SEC for potato,garlic,and cantaloupe were calculated 1.94105,4.52105 and 2.12105 kJ/kg,respectively.Results revealed that the ANFIS model had the high ability to predict the Deff(R^2=0.9900),SEC(R^2=0.9917),moisture ratio(R^2=0.9974)and drying rate(R^2=0.9901)during drying.So ANFIS method had the high ability to evaluate all output as compared to ANNs method.展开更多
The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measu...The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.展开更多
AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospecti...AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospective cohort study enrolled 29 patients diagnosed with OA-DLBCL based on histopathological biopsy between 2006 and 2023.Patients were stratified into two subgroups:primary OA-DLBCL(no prior history of lymphoma)and secondary OA-DLBCL(history of DLBCL at non-ocular adnexal sites).OS was defined as the time interval from OA-DLBCL diagnosis to death from any cause.Survival analysis was performed using the Kaplan–Meier method,and prognostic factors affecting OS were identified using multivariate Cox proportional hazards regression with a stepwise selection approach.RESULTS:The cohort included 24 patients with primary OA-DLBCL(13 males,11 females;mean age:61.36±18.29y)and 5 patients with secondary OA-DLBCL(2 males,3 females;mean age:50.94±18.17y).Among the primary OA-DLBCL subgroup,12 patients(50%)presented with advanced disease(Ann Arbor stage IIIE–IV),and 16 patients(66%)were classified as T4 disease according to the tumor-node-metastasis(TNM)staging system.The mean final visual acuity was 1.72±1.10 in the primary group and 0.90±1.18 in the secondary group.The 5-year OS rate for the entire cohort was 27.7%.Multivariate analysis identified five factors significantly associated with poor survival outcomes:epiphora[adjusted hazard ratio(aHR),36.95],atherosclerotic cardiovascular disease(aHR,10.08),human immunodeficiency virus(HIV)infection(aHR,12.47),M1 stage(aHR,6.99),and secondary OA-DLBCL(aHR,6.03;all P<0.05).The median OS was 1.68y for primary OA-DLBCL and 1.12y for secondary OA-DLBCL.CONCLUSION:A substantial proportion of patients with primary OA-DLBCL present with advanced-stage disease at diagnosis.Epiphora,atherosclerotic cardiovascular disease,HIV infection,M1 stage,and secondary OA-DLBCL are independent prognostic factors for poor survival outcomes.These findings emphasize the urgent need for optimized therapeutic strategies and early screening protocols to improve the management of OA-DLBCL,particularly in developing countries.展开更多
The present study was aimed to model the hydration characteristics of green chickpea(GC)using mathematical modelling and examine predictive ability of artificial neural network(ANN)modelling.Hydration of GC was perfor...The present study was aimed to model the hydration characteristics of green chickpea(GC)using mathematical modelling and examine predictive ability of artificial neural network(ANN)modelling.Hydration of GC was performed at different temperatures 25,35,45,55 and 65℃.Different mathematical models were tested for the hydration at different temperatures.In ANN modelling,the hydration time and hydration temperature were used as input variables and moisture ratio,moisture content and hydration ratio were taken as output variables.Peleg model best described the hydration behavior at 25℃;while hydration at high-temperature was better described by Page model and Ibarz et al.model.The optimum temperature obtained for hydration was 35℃.Effective mass diffusion coefficient(D_(e))increased from 1.5510^(-11)-1.7910^(-9) m^(2)/s with the increase in the hydration temperature.The low activation energy(39.66 kJ/moL)shows the low-temperature sensitiveness of GC.Low temperature hydration(25℃)required higher time(>200 min)to achieve the equilibrium moisture content(EMC),however high temperature hydration(35–65℃)reduced the EMC time(150 min).ANN was used to predict the hydration behavior and K fold cross validation was performed to check the over fitting of ANN model.Results show that the LOGSIGMOID transfer function showed better performance when used at the hidden layer input node in conjunction to both PURELIN and TANSIGMOID.TANSIGMOID was found suitable for moisture ratio(MR)and hydration ratio(HR)prediction,as opposed to PURELIN for moisture content(MC)data.Satisfactory model prediction was obtained when the number of neurons in the hidden layer for MC,MR and HR was 12,8 and 15,respectively.Mathematical and ANN modelling results are useful to improve/predict the MC,MR and HR during hydration process of GC at different temperature and other similar process.展开更多
目的探讨外周血miR-141、miR-451a与弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者化疗应答的预测价值。方法选取2021年6月至2023年4月我院92例DLBCL患者作为DLBCL组,根据化疗效果分为化疗无效亚组(n=29)与化疗有效亚组(...目的探讨外周血miR-141、miR-451a与弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者化疗应答的预测价值。方法选取2021年6月至2023年4月我院92例DLBCL患者作为DLBCL组,根据化疗效果分为化疗无效亚组(n=29)与化疗有效亚组(n=63)。随机选取同期92例入院体检健康者为对照组,采用实时荧光定量聚合酶链反应测定miR-141、miR-451a相对表达量。比较DLBCL组与健康对照组外周血miR-141、miR-451a表达,以logistic回归模型分析筛选DLBCL患者化疗应答影响因素,相关性分析DLBCL患者外周血miR-141、miR-451a与国际预后指数(international prognositic index,IPI)评分、Ann Arbor分期间相关性,受试者工作特征(receiver operating characteristic,ROC)曲线评价DLBCL患者miR-141、miR-451a单项检测及联合检测预测化疗应答的价值。结果DLBCL患者外周血miR-141、miR-451a表达均低于健康对照组(P<0.05);logistic回归分析结果显示Ann Arbor分期、IPI评分均为DLBCL患者化疗应答独立危险因素,外周血miR-141、miR-451a均为DLBCL患者化疗应答性独立保护因素(P<0.05);DLBCL患者外周血miR-141、miR-451a与IPI评分、Ann Arbor分期均具有显著负相关关系(P<0.05);外周血miR-141、miR-451a单独预测DLBCL患者化疗应答的曲线下面积(area under the curve,AUC)值分别为0.770、0.794,二者联合预测AUC值高达0.929,明显高于miR-141、miR-451a单独预测,此时灵敏度、特异度分别为86.21%、85.71%。结论DCBCL患者血清miR-141、miR-451a表达下调,且与应答有关,检测二者水平,可预测DCBCL患者化疗应答,为临床工作提供参考。展开更多
基金This research was partly supported by the UK Engineering and Physical Sciences Research Council(EPSRC)Studentship and Asset International,who provided the HDPE materials used to build bespoke constructed wetlands.
文摘Growth in urban population,urbanisation,and economic development has increased the demand for water,especially in water-scarce regions.Therefore,sustainable approaches to water management are needed to cope with the effects of the urbanisation on the water environment.This study aimed to design novel configurations of tidal-flow vertical subsurface flow constructed wetlands(VFCWs)for treating urban stormwater.A series of laboratory experiments were conducted with semi-synthetic influent stormwater to examine the effects of the design and operation variables on the performance of the VFCWs and to identify optimal design and operational strategies,as well as maintenance requirements.The results show that the VFCWs can significantly reduce pollutants in urban stormwater,and that pollutant removal was related to specific VFCW designs.Models based on the artificial neural network(ANN)method were built using inputs derived from data exploratory techniques,such as analysis of variance(ANOVA)and principal component analysis(PCA).It was found that PCA reduced the dimensionality of input variables obtained from different experimental design conditions.The results show a satisfactory generalisation for predicting nitrogen and phosphorus removal with fewer variable inputs,indicating that monitoring costs and time can be reduced.
文摘In the present paper,the hydrodynamic performance of stepped planing craft is investigated by computational fluid dynamics(CFD)analysis.For this purpose,the hydrodynamic resistances of without step,one-step,and two-step hulls of Cougar planing craft are evaluated under different distances of the second step and LCG from aft,weight loadings,and Froude numbers(Fr).Our CFD results are appropriately validated against our conducted experimental test in National Iranians Marine Laboratory(NIMALA),Tehran,Iran.Then,the hydrodynamic resistance of intended planing crafts under various geometrical and physical conditions is predicted using artificial neural networks(ANNs).CFD analysis shows two different trends in the growth rate of resistance to weight ratio.So that,using steps for planing craft increases the resistance to weight ratio at lower Fr and decreases it at higher Fr.Additionally,by the increase of the distance between two steps,the resistance to weight ratio is decreased and the porpoising phenomenon is delayed.Furthermore,we obtained the maximum mean square error of ANNs output in the prediction of resistance to weight ratio equal to 0.0027.Finally,the predictive equation is suggested for the resistance to weight ratio of stepped planing craft according to weights and bias of designed ANNs.
基金National Natural Science Foundation of China (No. 70631003)
文摘In agent-based automated negotiation research area,a key problem is how to make software agent more adaptable to represent user preferences or suggestions,so that agent can take further proposals that reflect user requirements to implement ecommerce activities like automated transactions.The difficulty lies in the uncertainty of user preferences that include uncertain description and contents,non-linear and dynamic variability.In this paper,fuzzy language was used to describe the uncertainty and combine with multiple classified artificial neural networks(ANNs) for self-adaptive learning of user preferences.The refinement learning results of various negotiation contracts' satisfaction degrees in the extent of fuzzy classification can be achieved.Compared to unclassified computation,the experimental results illustrate that the learning ability and effectiveness of agents have been improved.
文摘The paper describes the application of SDSM （statistical downscaling model） and ANNs （artificial neural networks） models for prediction of the hydrological trend due to the climate-change. The SDSM has been calibrated and generated for the possible future scenarios of meteorological variables, which are temperature and rainfall by using GCMs （global climate models）. The GCM used is SRES A2. The downscaled meteorological variables corresponding to SDSM were then used as input to the ANNs model calibrated with observed station data to simulate the corresponding future streamflow changes in the sub-catchment of Kurau River. This study has discovered the hydrological trend over the catchment. The projected monthly streamflow has shown a decreasing trend due to the increase in the, mean of temperature for overall months, except the month of August and November.
基金supported by the Korea Institute of Energy Technology Evaluation and Planning(KETEP)and the Ministry of Trade,Industry&Energy(MOTIE)of the Republic of Korea(No.RS-2025-02315209).
文摘There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.
文摘In this study,artificial neural networks(ANNs)were implemented to determine design parameters for an impressed current cathodic protection(ICCP)prototype.An ASTM A36 steel plate was tested in 3.5%NaCl solution,seawater,and NS4 using electrochemical impedance spectroscopy(EIS)to monitor the evolution of the substrate surface,which affects the current required to reach the protection potential(Eprot).Experimental data were collected as training datasets and analyzed using statistical methods,including box plots and correlation matrices.Subsequently,ANNs were applied to predict the current demand at different exposure times,enabling the estimation of electrochemical parameters(limiting voltage values)that can be used to optimize a self-regulating ICCP system.The obtained electrochemical parameters were then used,through Particle Swarm Optimization(PSO),to fine-tune an ANN-based proportional-integral-derivative(PID)controller for the ICCP system.
文摘The main purpose of this study was to develop and apply an adaptive neuro-fuzzy inference system(ANFIS)and Artificial Neural Networks(ANNs)model for predicting the drying characteristics of potato,garlic and cantaloupe at convective hot air dryer.Drying experiments were conducted at the air temperatures of 40,50,60 and 70C and the air speeds of 0.5,1 and l.5 m/s.Drying properties were including kinetic drying,effective moisture diffusivity(Deff)and specific energy consumption(SEC).The highest value of Deff obtained 9.76×10^-9,0.13×10^-9 and 9.97×10^-10 m^2/s for potato,garlic,and cantaloupe,respectively.The lowest value of SEC for potato,garlic,and cantaloupe were calculated 1.94105,4.52105 and 2.12105 kJ/kg,respectively.Results revealed that the ANFIS model had the high ability to predict the Deff(R^2=0.9900),SEC(R^2=0.9917),moisture ratio(R^2=0.9974)and drying rate(R^2=0.9901)during drying.So ANFIS method had the high ability to evaluate all output as compared to ANNs method.
文摘The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.
基金Supported by the Faculty of Medicine,Prince of Songkla University.Wainipitapong S has received grants from the Faculty of Medicine,Prince of Songkla University。
文摘AIM:To investigate the clinical characteristics and treatment outcomes,including visual function and overall survival(OS)of patients with ocular adnexal diffuse large B-cell lymphoma(OA-DLBCL).METHODS:This retrospective cohort study enrolled 29 patients diagnosed with OA-DLBCL based on histopathological biopsy between 2006 and 2023.Patients were stratified into two subgroups:primary OA-DLBCL(no prior history of lymphoma)and secondary OA-DLBCL(history of DLBCL at non-ocular adnexal sites).OS was defined as the time interval from OA-DLBCL diagnosis to death from any cause.Survival analysis was performed using the Kaplan–Meier method,and prognostic factors affecting OS were identified using multivariate Cox proportional hazards regression with a stepwise selection approach.RESULTS:The cohort included 24 patients with primary OA-DLBCL(13 males,11 females;mean age:61.36±18.29y)and 5 patients with secondary OA-DLBCL(2 males,3 females;mean age:50.94±18.17y).Among the primary OA-DLBCL subgroup,12 patients(50%)presented with advanced disease(Ann Arbor stage IIIE–IV),and 16 patients(66%)were classified as T4 disease according to the tumor-node-metastasis(TNM)staging system.The mean final visual acuity was 1.72±1.10 in the primary group and 0.90±1.18 in the secondary group.The 5-year OS rate for the entire cohort was 27.7%.Multivariate analysis identified five factors significantly associated with poor survival outcomes:epiphora[adjusted hazard ratio(aHR),36.95],atherosclerotic cardiovascular disease(aHR,10.08),human immunodeficiency virus(HIV)infection(aHR,12.47),M1 stage(aHR,6.99),and secondary OA-DLBCL(aHR,6.03;all P<0.05).The median OS was 1.68y for primary OA-DLBCL and 1.12y for secondary OA-DLBCL.CONCLUSION:A substantial proportion of patients with primary OA-DLBCL present with advanced-stage disease at diagnosis.Epiphora,atherosclerotic cardiovascular disease,HIV infection,M1 stage,and secondary OA-DLBCL are independent prognostic factors for poor survival outcomes.These findings emphasize the urgent need for optimized therapeutic strategies and early screening protocols to improve the management of OA-DLBCL,particularly in developing countries.
文摘The present study was aimed to model the hydration characteristics of green chickpea(GC)using mathematical modelling and examine predictive ability of artificial neural network(ANN)modelling.Hydration of GC was performed at different temperatures 25,35,45,55 and 65℃.Different mathematical models were tested for the hydration at different temperatures.In ANN modelling,the hydration time and hydration temperature were used as input variables and moisture ratio,moisture content and hydration ratio were taken as output variables.Peleg model best described the hydration behavior at 25℃;while hydration at high-temperature was better described by Page model and Ibarz et al.model.The optimum temperature obtained for hydration was 35℃.Effective mass diffusion coefficient(D_(e))increased from 1.5510^(-11)-1.7910^(-9) m^(2)/s with the increase in the hydration temperature.The low activation energy(39.66 kJ/moL)shows the low-temperature sensitiveness of GC.Low temperature hydration(25℃)required higher time(>200 min)to achieve the equilibrium moisture content(EMC),however high temperature hydration(35–65℃)reduced the EMC time(150 min).ANN was used to predict the hydration behavior and K fold cross validation was performed to check the over fitting of ANN model.Results show that the LOGSIGMOID transfer function showed better performance when used at the hidden layer input node in conjunction to both PURELIN and TANSIGMOID.TANSIGMOID was found suitable for moisture ratio(MR)and hydration ratio(HR)prediction,as opposed to PURELIN for moisture content(MC)data.Satisfactory model prediction was obtained when the number of neurons in the hidden layer for MC,MR and HR was 12,8 and 15,respectively.Mathematical and ANN modelling results are useful to improve/predict the MC,MR and HR during hydration process of GC at different temperature and other similar process.
文摘目的探讨外周血miR-141、miR-451a与弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者化疗应答的预测价值。方法选取2021年6月至2023年4月我院92例DLBCL患者作为DLBCL组,根据化疗效果分为化疗无效亚组(n=29)与化疗有效亚组(n=63)。随机选取同期92例入院体检健康者为对照组,采用实时荧光定量聚合酶链反应测定miR-141、miR-451a相对表达量。比较DLBCL组与健康对照组外周血miR-141、miR-451a表达,以logistic回归模型分析筛选DLBCL患者化疗应答影响因素,相关性分析DLBCL患者外周血miR-141、miR-451a与国际预后指数(international prognositic index,IPI)评分、Ann Arbor分期间相关性,受试者工作特征(receiver operating characteristic,ROC)曲线评价DLBCL患者miR-141、miR-451a单项检测及联合检测预测化疗应答的价值。结果DLBCL患者外周血miR-141、miR-451a表达均低于健康对照组(P<0.05);logistic回归分析结果显示Ann Arbor分期、IPI评分均为DLBCL患者化疗应答独立危险因素,外周血miR-141、miR-451a均为DLBCL患者化疗应答性独立保护因素(P<0.05);DLBCL患者外周血miR-141、miR-451a与IPI评分、Ann Arbor分期均具有显著负相关关系(P<0.05);外周血miR-141、miR-451a单独预测DLBCL患者化疗应答的曲线下面积(area under the curve,AUC)值分别为0.770、0.794,二者联合预测AUC值高达0.929,明显高于miR-141、miR-451a单独预测,此时灵敏度、特异度分别为86.21%、85.71%。结论DCBCL患者血清miR-141、miR-451a表达下调,且与应答有关,检测二者水平,可预测DCBCL患者化疗应答,为临床工作提供参考。
