Diabetes mellitus(DM)is a global health challenge with increasing prevalence rates,particularly in low-and middle-income countries.Anthocyanins(ACs)are potential bioactive compounds found in various fruits and vegetab...Diabetes mellitus(DM)is a global health challenge with increasing prevalence rates,particularly in low-and middle-income countries.Anthocyanins(ACs)are potential bioactive compounds found in various fruits and vegetables,attracting the attention of researchers due to their possible role in managing diabetes and its complications.Studies have demonstrated the beneficial effects of ACs on blood sugar levels,insulin sensitivity,and glucose tolerance.These effects may be associated with multiple mechanisms,including increased glucose transporter type 4(GLUT4)expression,enhanced glucose uptake,AMP-activated protein kinase(AMPK)and protein kinase C(PKC)phosphorylation,improved insulin sensitivity,activation of phosphoinositide 3-kinase/protein kinase B(PI3K/AKT)signaling,increased glutathione(GSH)synthesis,production of short-chain fatty acids(SCFAs),glucagon-like peptide-1(GLP-1)secretion,induction of antioxidant enzymes,improved beta-cell functioning,and activation of insulin signaling pathways.The activity of enzymes(alpha amylase,glucosidase,and dipeptidyl peptidase-IV[DPP-IV])and the expression of inflammatory biomarkers(tumor necrosis factor[TNF],IL6,and MCP1)are reduced.These findings suggest the potential of ACs as adjunctive therapies.However,further studies,including well-structured clinical trials,are needed to explore the optimal dosage and long-term efficacy of ACs in diabetes management.展开更多
Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is sig...Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.展开更多
This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors inf...This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.展开更多
文摘Diabetes mellitus(DM)is a global health challenge with increasing prevalence rates,particularly in low-and middle-income countries.Anthocyanins(ACs)are potential bioactive compounds found in various fruits and vegetables,attracting the attention of researchers due to their possible role in managing diabetes and its complications.Studies have demonstrated the beneficial effects of ACs on blood sugar levels,insulin sensitivity,and glucose tolerance.These effects may be associated with multiple mechanisms,including increased glucose transporter type 4(GLUT4)expression,enhanced glucose uptake,AMP-activated protein kinase(AMPK)and protein kinase C(PKC)phosphorylation,improved insulin sensitivity,activation of phosphoinositide 3-kinase/protein kinase B(PI3K/AKT)signaling,increased glutathione(GSH)synthesis,production of short-chain fatty acids(SCFAs),glucagon-like peptide-1(GLP-1)secretion,induction of antioxidant enzymes,improved beta-cell functioning,and activation of insulin signaling pathways.The activity of enzymes(alpha amylase,glucosidase,and dipeptidyl peptidase-IV[DPP-IV])and the expression of inflammatory biomarkers(tumor necrosis factor[TNF],IL6,and MCP1)are reduced.These findings suggest the potential of ACs as adjunctive therapies.However,further studies,including well-structured clinical trials,are needed to explore the optimal dosage and long-term efficacy of ACs in diabetes management.
文摘Severe acute pancreatitis(SAP)can induce acute respiratory distress syndrome(ARDS)and abdominal compartment syndrome(ACS).Although prone position ventilation(PPV)can improve outcomes in patients with ARDS,there is significant controversy regarding its concurrent use with ACS owing to concerns of increased risk of intra-abdominal pressure(IAP).[1]We present a case of successful PPV application without adverse eff ects.
基金Supported by Humanities and Social Sciences Project of Hubei Provincial Department of Education(22Q149&19Y090).
文摘This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.
