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Characteristics of Heat Transfer in a Reactive Third-Grade Fluid Flow through Porous Plates with Uniform Suction/Injection
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作者 Rajiva Lochan Mohanty Sumanta Chaudhuri Anish Pandey 《Frontiers in Heat and Mass Transfer》 2025年第3期899-919,共21页
Characteristics of heat transfer and flow of Newtonian and non-Newtonian fluids through porous walls and in porous media are studied due to their wide range of applications including geothermal reservoirs,heat exchang... Characteristics of heat transfer and flow of Newtonian and non-Newtonian fluids through porous walls and in porous media are studied due to their wide range of applications including geothermal reservoirs,heat exchangers,marine propulsion,and aerodynamics.The current study investigates the characteristics of heat transport in a reactive third-grade fluid,moving through permeable parallel plates,with uniform suction/injection velocity.The two permeable,parallel plates are maintained at the same,constant temperature.After being transformed into its dimensionless equivalent,governing equations are solved by employing the Least Squares Method(LSM).The LSM results are further validated with numerical solutions for temperature and velocity.The impact of cross-flow Reynolds number,Peclet number,heat generation parameter,non-Newtonian parameter,and Brinkman number on entropy generation,velocity,temperature,and Bejan number are investigated.Theresults indicate that temperature distribution is significantly influenced by the third-grade fluid parameter.The maximum temperature drops from almost 0.12 to 0.10 as the third-grade fluid parameter increases from0.05 to 0.4.When the cross-flow Reynolds number is raised from 0.05 to 3,the maximum temperature drops from 0.12 to around 0.09.Temperature is strongly influenced by the heat generation parameter.A greater understanding of the thermal characteristics necessary for the design of a variety of systems,such as heat exchangers,marine propulsion,aerodynamic systems,etc.,may be gained from the findings of the current study. 展开更多
关键词 Heat generation third grade fluids perturbation method least square method uniform suction/injection porous plates
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Simulation of Non-isothermal Injection Molding for a Non-Newtonian Fluid by Level Set Method 被引量:8
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作者 杨斌鑫 欧阳洁 +1 位作者 刘春太 李强 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2010年第4期600-608,共9页
A non-isothermal injection molding process for a non-Newtonian viscous pseudoplastic fluid is simulated.A conservative interface capturing technique and the flow field solving method are coupled to perform a dynamic s... A non-isothermal injection molding process for a non-Newtonian viscous pseudoplastic fluid is simulated.A conservative interface capturing technique and the flow field solving method are coupled to perform a dynamic simulation.The validity of the numerical method is verified by a benchmark problem.The melt interface evolution versus time is captured and the physical quantities such as temperature,velocity and pressure at each time step are obtained with corresponding analysis.A"frozen skin"layer with the thickness increasing versus time during the injection process is found.The fact that the"frozen skin"layer can be reduced by increasing the injection velocity is numerically verified.The fountain flow phenomenon near the melt interface is also captured.Moreover,comparisons with the non-isothermal Newtonian case show that the curvatures of the interface arcs and the pressure contours near the horizontal mid-line of the cavity for the non-Newtonian pseudoplastic case is larger than that for the Newtonian case.The velocity profiles are different at different positions for the non-Newtonian pseudoplastic case,while in the case of Newtonian flow the velocity profiles are parabolic and almost the same at different positions. 展开更多
关键词 injection molding Level Set method two-phase flow NON-ISOTHERMAL non-Newtonian flow
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A fast explicit finite difference method for determination of wellhead injection pressure 被引量:2
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作者 白冰 李小春 +2 位作者 刘明泽 石露 李琦 《Journal of Central South University》 SCIE EI CAS 2012年第11期3266-3272,共7页
A fast explicit finite difference method (FEFDM),derived from the differential equations of one-dimensional steady pipe flow,was presented for calculation of wellhead injection pressure.Recalculation with a traditiona... A fast explicit finite difference method (FEFDM),derived from the differential equations of one-dimensional steady pipe flow,was presented for calculation of wellhead injection pressure.Recalculation with a traditional numerical method of the same equations corroborates well the reliability and rate of FEFDM.Moreover,a flow rate estimate method was developed for the project whose injection rate has not been clearly determined.A wellhead pressure regime determined by this method was successfully applied to the trial injection operations in Shihezi formation of Shenhua CCS Project,which is a good practice verification of FEFDM.At last,this method was used to evaluate the effect of friction and acceleration terms on the flow equation on the wellhead pressure.The result shows that for deep wellbore,the friction term can be omitted when flow rate is low and in a wide range of velocity the acceleration term can always be deleted.It is also shown that with flow rate increasing,the friction term can no longer be neglected. 展开更多
关键词 wellhead pressure injection pressure bottom-hole pressure fast explicit finite difference method
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New approach to develop a 3D non-isothermal computational framework for injection molding process based on level set method 被引量:2
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作者 Xin Zhuang Jie Ouyang +1 位作者 Chuntao Jiang Qingsheng Liu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2016年第7期832-842,共11页
The simulation of three-dimensional (3D) non-isothermal, non-Newtonian fluid filling process is an extremely difficult task and remains a challenging problem, which includes polymer melt flow with free surface coupl... The simulation of three-dimensional (3D) non-isothermal, non-Newtonian fluid filling process is an extremely difficult task and remains a challenging problem, which includes polymer melt flow with free surface coupled with transient heat transfer. This paper presents a full 3D non-isothermal two-phase flow model to predict the complex flow in melt filling process, where the Cross-WLF model is applied to characterize the rheological behav- ior of polymer melt. The governing equations are solved using finite volume method with SIMPLEC algorithm on collocated grids and the melt front is accurately captured by a high resolution level set method. A domain exten- sion technique is adopted to deal with the complex cavities, which greatly reduces the computational burden. To verify the validity of the developed 3D approach, the melts filling processes in two thin rectangular cavities (one of them with a cylindrical insert) are simulated. The predicted melt front interfaces are in good agreement with the experiment and commercial software prediction. For a case with a rather complex cavity, the dynamic filling process in a hemispherical shell is successfully simulated. All of the numerical results show that the developed numerical procedure can provide a reasonable orediction for injection molding process. 展开更多
关键词 injection moldingNon-isothermalFinite voIume/SIMPLEC methodDomain extension techniqueHigh resolution level set method
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Oil oxidation in the whole temperature regions during oil reservoir air injection and development methods 被引量:1
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作者 LIAO Guangzhi WANG Hongzhuang +7 位作者 WANG Zhengmao TANG Junshi WANG Bojun PAN Jingjun YANG Huaijun LIU Weidong SONG Qiang PU Wanfen 《Petroleum Exploration and Development》 2020年第2期357-364,共8页
The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into fo... The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into four different parts: dissolving and inflation region, low temperature oxidation region, medium temperature oxidation region and high temperature oxidation region. The reaction mechanisms of different regions were explained. Based on the oil oxidation characteristics and filed tests results, light oil reservoirs air injection development methods were divided into two types: oxygen-reducing air flooding and air flooding;heavy oil reservoirs air injection in-situ combustion development methods were divided into two types: medium temperature in-situ combustion and high temperature in-situ combustion. When the reservoir temperature is lower than 120 ℃, oxygen-reducing air flooding should be used for light oil reservoir development. When the reservoir temperature is higher than 120 ℃, air flooding method should be used for light oil reservoir development. For a normal heavy oil reservoir, when the combustion front temperature is lower than 400 ℃, the development method is medium temperature in-situ combustion. For a heavy oil reservoir with high oil resin and asphalting contents, when the combustion front temperature is higher than 450 ℃, the development method at this condition is high temperature in-situ combustion. Ten years field tests of air injection carried out by PetroChina proved that air has advantages in technical, economical and gas source aspects compared with other gas agents for oilfield gas injection development. Air injection development can be used in low/super-low permeability light oil reservoirs, medium and high permeability light oil reservoirs and heavy oil reservoirs. Air is a very promising gas flooding agent. 展开更多
关键词 air injection full temperature regions oil oxidation reaction characteristics coke formation reservoir types development methods
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Power System State Estimation Solution With Zero Injection Constraints Using Modified Newton Method and Fast Decoupled Method in Polar Coordinate 被引量:13
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作者 GUO Ye ZHANG Boming WU Wenchuag SUN Hongbin 《中国电机工程学报》 EI CSCD 北大核心 2012年第22期I0015-I0015,11,共1页
如何保证零注入节点的注入功率在状态估计结果中严格为0是电力系统状态估计研究中的重要问题。在直角坐标下,由于零注入约束为线性约束,可使用修正牛顿法来有效地解决这一问题。因此,借鉴直角坐标下修正牛顿法的思路,提出了极坐标下的... 如何保证零注入节点的注入功率在状态估计结果中严格为0是电力系统状态估计研究中的重要问题。在直角坐标下,由于零注入约束为线性约束,可使用修正牛顿法来有效地解决这一问题。因此,借鉴直角坐标下修正牛顿法的思路,提出了极坐标下的修正牛顿法和修正快速解耦估计。这些方法的计算流程与传统的极坐标下的牛顿法和快速解耦估计非常相似,计算速度与大权重法相当,同时能够保证零注入约束严格满足。仿真结果验证了所得结论。 展开更多
关键词 状态估计模型 电力系统 解耦方法 注射 极坐标 牛顿法 基尔霍夫电流定律 电压变压器
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Experimental study on secondary air mixing along the bed height in a circulating fluidized bed with a multitracer-gas method 被引量:1
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作者 Qingyu Zhang Leming Cheng +3 位作者 Kun Li Qixun Kang Qiang Guo Chaogang Wu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第6期54-62,共9页
A multitracer-gas method was proposed to study the secondary air(SA)mixing along the bed height in a circulating fluidized bed(CFB)using carbon monoxide(CO),oxygen(O_(2)),and carbon dioxide(CO_(2))as tracer gases.Expe... A multitracer-gas method was proposed to study the secondary air(SA)mixing along the bed height in a circulating fluidized bed(CFB)using carbon monoxide(CO),oxygen(O_(2)),and carbon dioxide(CO_(2))as tracer gases.Experiments were carried out on a cold CFB test rig with a cross-section of 0.42 m×0.73 m and a height of 5.50 m.The effects of superficial velocity,SA ratio,bed inventory,and particle diameter on the SA mixing were investigated.The results indicate that there are some differences in the measurement results obtained using different tracer gases,wherein the deviation between CO and CO_(2) ranges from 42%to 66%and that between O_(2) and CO_(2) ranges from 45%to 71%in the lower part of the fluidized bed.However,these differences became less pronounced as the bed height increased.Besides,the high solid concentration and fine particle diameter in the CFB may weaken the difference.The measurement results of different tracer gases show the same trends under the variation of operating parameters.Increasing superficial velocity and SA ratio and decreasing particle diameter result in better mixing of the SA.The effect of bed inventory on SA mixing is not monotonic. 展开更多
关键词 Circulating fluidized bed Secondary air injection Gas mixing Multitracer-gas method
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Single Phase-to-Ground Fault Line Identification and Section Location Method for Non-Effectively Grounded Distribution Systems Based on Signal Injection
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作者 潘贞存 王成山 +1 位作者 丛伟 张帆 《Transactions of Tianjin University》 EI CAS 2008年第2期92-96,共5页
A diagnostic signal current trace detecting based single phase-to-ground fault line identifica- tion and section location method for non-effectively grounded distribution systems is presented in this paper.A special d... A diagnostic signal current trace detecting based single phase-to-ground fault line identifica- tion and section location method for non-effectively grounded distribution systems is presented in this paper.A special diagnostic signal current is injected into the fault distribution system,and then it is detected at the outlet terminals to identify the fault line and at the sectionalizing or branching point along the fault line to locate the fault section.The method has been put into application in actual distribution network and field experience shows that it can identify the fault line and locate the fault section correctly and effectively. 展开更多
关键词 single phase-to-ground fault (SPGF) signal injection method fault line identification fault location
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A New Method for the Dynamic Reserves of Gas Condensate Reservoir Using Cyclic Gas Injection Based on the Effects of Reinjection Ratio and Water Influx
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作者 Yu Xiong Ling Wang +1 位作者 Zhongqian Zhu Wei Xie 《Engineering(科研)》 2015年第7期455-461,共7页
As we all know, cyclic gas injection is one of the most effective development methods to improve condensate oil recovery. When dealing with the calculation of the reserves, the injection-production differences and wat... As we all know, cyclic gas injection is one of the most effective development methods to improve condensate oil recovery. When dealing with the calculation of the reserves, the injection-production differences and water influx create great influence on the accuracy. Based on the existing research, we proposed a new material balance equation which considered the differences of composition between produced and injected fluids and the effect of water influx, and a solution was provided in this paper. The results of the method are closer to the actual situation because they are built on the law of conservation of mass, and the using of curve fitting method can not only avoid the use of water influx coefficient but also obtain the water influx rate and reserves at the same time. The YH-23 gas condensate reservoir is taking as a typical subject to do the research, which has been exploited by cycle gas injection for 14 years. Three different methods are used to calculate the reserves, and the results show that the method proposed in this paper has minimum error of 2.96%. 展开更多
关键词 CONDENSATE GAS Reservoir Cyclic GAS injection Dynamic RESERVES Material Balance method REinjectION Ratio Water INFLUX
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Research on subsidence method aided by water injection and its engineering application for the north anchor of Taizhou Bridge
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作者 Ruan Jing Zhou Zhifang Zhao Yanrong 《Engineering Sciences》 EI 2011年第2期33-38,共6页
The north anchorage caisson of Taizhou Bridge encountered some difficulties during the sinking process for the large sidewall frictional resistances. To solve this problem, a new concept and method called subsidence m... The north anchorage caisson of Taizhou Bridge encountered some difficulties during the sinking process for the large sidewall frictional resistances. To solve this problem, a new concept and method called subsidence method aided by water injection is proposed. Numeral analysis is adopted to simulate the effects of this method for the north anchor of Taizhou Bridge, which confirmed the feasibility and validity. Finally, the method is applied to the north anchor caisson during the caisson sinking procedure and helps the caisson sink and embed to the designed position smoothly. 展开更多
关键词 ANCHORAGE SINK Taizhou Bridge subsidence method aided by water injection
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Research on the Equivalence Between Double Differential- mode Current Injection and Radiation Test Method 被引量:1
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作者 PAN Xiaodong WEI Guanghui +2 位作者 FAN Lisi LU Xinfu YANG Zhe 《高电压技术》 EI CAS CSCD 北大核心 2013年第8期2031-2037,共7页
There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cab... There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cable simultaneously, a double differential-mode current in- jection test method (DDMCI) is proposed. The method adopted the equivalence source wave theorem and Baum-Liu-Tesche(BLT) equation as its theory foundation. The equivalent corresponding relation between injection voltage and radiation electric field intensity is derived, and the phase relation between the two injection voltage sources is confirmed. The results indicate that the amplitude and phase of the equivalent injection voltage source is closely related to the S parameter of directional coupling device, the transmission line length, and the source vector in BLT equation, but has nothing to do with the reflection coefficient between the two equipment pieces. Therefore, by choosing the right amplitude and phase of the double injection voltage sources, the DDMCI test is equivalent to the radiation test for two interconnected equipment of a system. 展开更多
关键词 测试方法 差模电流 辐射测试 电流注入 等价 BLT方程 相位关系 敏感性试验
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Clinical Observation on Brachial Plexus Block with “One Injection Two Points” Method Guiding by Ultrasound
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作者 Huang Qiang Cai Lingling +10 位作者 Shi Wenjing Fang Zhiyuan Wu Meichao Sun Zhaohui Sun Yulan Li Yong Lu Shangting Xu Hui HWANG DONGWOOK Wang Hongliang Zhang Tao 《World Journal of Integrated Traditional and Western Medicine》 2017年第1期14-17,共4页
OBJECTIVE: To compare the clinical effect of brachial plexus block with "One Injection Two Points" guided under ultrasound and the conventional method guiding by ultrasound. METHODS: 70 patients were randomi... OBJECTIVE: To compare the clinical effect of brachial plexus block with "One Injection Two Points" guided under ultrasound and the conventional method guiding by ultrasound. METHODS: 70 patients were randomized evenly into 2 groups, with 35 patients in each group, while the Experiment Group(Group B) received One Injection Two Points" method, the Control Group(Group A) received the conventional method.The nerve block every 5 s, the success rate of anesthesia, the dosage of local anesthetics, second remedial anesthesia, adverse reactions, etc.were recorded. RESULTS: Group B was superior to group A in the success rate of anesthesia; There were 6 patients in group A who required constant pump injection of Remifentanil to remedy, while no patients in Group B needed remedy treatment. There were no serious adverse reactions in both groups.CONCLUSIONS: The clinical effect of brachial plexus block with "One Injection Two Points" method guided under ultrasoundguiding by ultrasound was superior to that of the conventional method. 展开更多
关键词 Clinical observation Ultrasound-guided Brachial plexus block "One injection Two Points" method
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Laboratory analysis of liquid injection method on hydraulic fracturing initiation and propagation in deep shale formation
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作者 Chang Xin 《Natural Gas Industry B》 2019年第6期652-658,共7页
Compared with the middle-shallow shale gas reservoirs,deep shale formation often reveals lower fracture complexity,smaller effective stimulated volumes,lower conductivity,and faster declined when the same injection mo... Compared with the middle-shallow shale gas reservoirs,deep shale formation often reveals lower fracture complexity,smaller effective stimulated volumes,lower conductivity,and faster declined when the same injection model and technical parameters were used.Therefore,it is necessary to research a special injection model for the deep shale formation.In this paper,a series of laboratory stimulated experiments were carried to analyze the injection method on hydraulic fracturing initiation and propagation in the deep shale formation.The outcrop shale of Longmaxi formation in Sichuan Basin was selected and three different injection methods(constant,stepped-rise and cyclic progressive uplift pump rate)were used in these experiments.The test results showed that the stepped-rise pump rate is conductive to opening the pre-existing natural fracture and bedding planes,the fracture complexity of this injection method is the highest.Meanwhile,the fracturing pressure and total injection volume are the lowest.In contrast,the cyclic-uplift injection method can only form a transverse fracture,and the fracturing pressure is the highest.The research results have an important theoretical guiding value for deep shale hydraulic fracturing operation. 展开更多
关键词 Deep shale gas injection method Hydraulic fracturing Crack initiation and propagation Laboratory experiments
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A calculation method for the allowable fracturing injection pressure of preventing casing deformation
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作者 Shen Xinpu Zhang Ping 《Natural Gas Industry B》 2019年第4期384-393,共10页
Injection pressure is one of the key parameters used in the design of shale gas reservoir stimulation.Higher injection pressure helps to initiate fractures,inject fracturing fluid and proppant smoothly and maximize th... Injection pressure is one of the key parameters used in the design of shale gas reservoir stimulation.Higher injection pressure helps to initiate fractures,inject fracturing fluid and proppant smoothly and maximize the stimulated reservoir volume as soon as possible.If the injection pressure is too high,however,the risk of casing deformation is increased significantly.In this paper,the numerical calculation format of the injection pressure safety window while ensuring casing integrity(i.e.,the maximum safety injection pressure)was proposed based on an example of an actual engineering project.Then,it was verified based on the actual situation of one shale gas well in Weiyuan.The numerical calculation format is as follows.First,a 3D finite element model of initial fine geostress field is established in the scale of block.Second,a primary submodel for introducing the asymmetric characteristics of reservoir stiffness to simulate the asymmetry of fracture distribution.Third,a secondary submodel containing the attributes of casing,cement sheath and reservoir material properties.Fourth,submodels are used to calculate the casing deformation generated by different injection loads and estimate the maximum allowable fracturing injection pressure(pj)while the safety requirement of casing deformation is satisfied.The calculation result of the case well shows that when the cementing quality is poor and fractures are distributed asymmetrically,the lateral and vertical displacements at the maximum displacement point of the casing under the injection pressure of 80 MPa are obviously lower than those under 90 MPa.According to the yield limit criterion of P-110 casing steel,the casing deformation in this case is elastic strain,so the injection pressure of 80 MPa is safe.In conclusion,this method has rational precision and accuracy,for its numerical result is consistent with the actual engineering phenomenon. 展开更多
关键词 Hydraulic fracturing injection pressure Casing integrity Shale gas reservoir Cement sheath Geostress Submodel Calculation method Weiyuan block
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Application of Taguchi Method in Parametric Study of Injection Molding of Display Front Panel
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作者 Hyoungjun Moon Sang-kyo Lee Sang-youn Lee Chongdu Cho 《材料科学与工程(中英文A版)》 2011年第1X期123-131,共9页
关键词 田口方法 注塑成型 前面板 显示器 计算机模拟 MOLDFLOW 应用 设计因素
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插排面板注塑成型多目标优化 被引量:1
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作者 刘巨保 廉成林 +3 位作者 杨明 李峰 张亮 侯健超 《塑料》 北大核心 2025年第3期112-119,共8页
以插排面板为研究对象,在Design-Expert软件中进行Box-Behnken方案设计,利用Moldflow软件对各方案进行模流分析,并且,采用响应面法建立工艺参数与响应目标之间的数学关系,采用实际值与预测值分布图以及决定系数R2检验其精度。利用非支... 以插排面板为研究对象,在Design-Expert软件中进行Box-Behnken方案设计,利用Moldflow软件对各方案进行模流分析,并且,采用响应面法建立工艺参数与响应目标之间的数学关系,采用实际值与预测值分布图以及决定系数R2检验其精度。利用非支配排序遗传算法(NSGA-Ⅱ)对响应面模型迭代寻优得到最优工艺参数组合,采用Moldflow软件对得到的最优工艺参数组合进行模拟,与优化算法预测值相比,翘曲变形和体积收缩率的误差分别为4.20%、0.78%,与原始方案相比,翘曲变形量降低了18.27%,体积收缩率降低了18.34%。试模验证结果表明,塑件的翘曲变形值与优化算法结果误差为2.83%,证明了采用的优化算法的准确性。 展开更多
关键词 注塑成型 响应面法 非支配排序遗传算法 模流分析 参数优化
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低频运行时MMC电容电压纹波抑制策略研究 被引量:1
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作者 刘伟 赵诗坛 《电气工程学报》 北大核心 2025年第1期140-149,共10页
低频运行时,模块化多电平变换器(Modular multilevel converter,MMC)存在较大的低频电容电压纹波,使输出电压波形畸变。针对这一问题,提出一种改进的高频注入策略。首先针对调制过程中模块电压计算值与实际值之间存在一定偏差的问题,选... 低频运行时,模块化多电平变换器(Modular multilevel converter,MMC)存在较大的低频电容电压纹波,使输出电压波形畸变。针对这一问题,提出一种改进的高频注入策略。首先针对调制过程中模块电压计算值与实际值之间存在一定偏差的问题,选择采用基于实际值的调制方法。接着分析电容电压波动机理,并对高频注入基本原理进行分析,为了在现有高频注入法的基础上进一步优化高频环流幅值,提出方波和梯形波相结合的高频注入方法。最后,利用Matlab/Simulink对所提方法进行仿真验证,结果表明,该方法可在实现低频电压纹波抑制的基础上进一步优化高频环流和桥臂电流幅值,减小系统损耗。 展开更多
关键词 模块化多电平变换器 低频运行 调制方法 高频注入
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高效液相色谱法分析检测注射用还原型谷胱甘肽中杂质成分 被引量:1
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作者 马海平 王曼 +1 位作者 赵吉平 朱军 《湖北医药学院学报》 2025年第4期452-456,共5页
目的:研究注射用还原性谷胱甘肽中杂质成分的类型和来源,通过稳定性试验,分析杂质变化规律,并针对杂质成分的性质,建立高效液相色谱测定方法,用于药品的质量控制和安全性评价。方法:采用C18色谱柱,磷酸二氢钾及庚烷磺酸钠溶液(50 mmol/... 目的:研究注射用还原性谷胱甘肽中杂质成分的类型和来源,通过稳定性试验,分析杂质变化规律,并针对杂质成分的性质,建立高效液相色谱测定方法,用于药品的质量控制和安全性评价。方法:采用C18色谱柱,磷酸二氢钾及庚烷磺酸钠溶液(50 mmol/L的磷酸二氢钾和0.22%的庚烷磺酸钠,磷酸调节pH值至3.0)-甲醇(970∶30),检测波长210 nm。结果:经湿热、强酸、强碱、氧化等方法破坏后,可测得杂质A、杂质B、杂质C、杂质D及半胱氨酸,且这5个杂质峰与主峰分离良好。五种杂质成分的检测限分别为0.50、0.30、0.21、0.31、0.22 ng。结论:该方法准确可靠,具有较好的专属性,能有效涵盖注射用还原型谷胱甘肽中的关键杂质成分,可用于该药品的质量控制。 展开更多
关键词 注射用还原型谷胱甘肽 杂质 高效液相色谱法
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激光衍射法测定中/长链脂肪乳注射液(C_(8~24)Ve)粒度
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作者 薛巧如 陈华 +3 位作者 欧爱萍 吴慧 谢兰桂 邓锋 《医药导报》 北大核心 2025年第11期1778-1783,共6页
目的以中/长链脂肪乳注射液(C_(8~24)Ve)为研究对象,建立基于激光衍射法的乳状注射液粒度分布测定方法。方法采用Mastersizer 3000激光粒度分析仪和Hydro EV型湿法进样器,以水为分散介质,考察样品颗粒的折射率、吸收率、遮光度、测量时... 目的以中/长链脂肪乳注射液(C_(8~24)Ve)为研究对象,建立基于激光衍射法的乳状注射液粒度分布测定方法。方法采用Mastersizer 3000激光粒度分析仪和Hydro EV型湿法进样器,以水为分散介质,考察样品颗粒的折射率、吸收率、遮光度、测量时间、搅拌速度、超声强度及时间,优化影响测定的关键因素,并对比分析不同计算模型、不同品牌仪器测定的结果。结果中/长链脂肪乳注射液(C_(8~24)Ve)的粒度分布光学参数选择吸收率0.001,折射率选择1.52,测量时间10 s,搅拌速度1200 r·min^(-1),不超声条件下,方法精密度、重复性和耐用性良好。结论该方法操作简单,准确度高,重复性好,适用于中/长链脂肪乳注射液(C_(8~24)Ve)的粒度分布测定,可为乳状液粒度测定方法开发提供参考。 展开更多
关键词 中/长链脂肪乳注射液(C_(8~24)Ve) 乳状注射液 粒度分布 激光衍射法
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基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价标准
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作者 郭媛媛 王超 +2 位作者 秦寅鹏 张弋 卜一珊 《中国药房》 北大核心 2025年第15期1841-1845,共5页
目的构建地佐辛注射液的药物利用评价标准,为医疗机构合理用药提供参考。方法以循证方法学为基础,查阅相关指南/专家共识、系统评价/Meta分析,筛选证据后,初步建立地佐辛注射液的评价标准框架。采用德尔菲法,选择28位来自天津、北京、... 目的构建地佐辛注射液的药物利用评价标准,为医疗机构合理用药提供参考。方法以循证方法学为基础,查阅相关指南/专家共识、系统评价/Meta分析,筛选证据后,初步建立地佐辛注射液的评价标准框架。采用德尔菲法,选择28位来自天津、北京、山东等8个省份的二级及以上级别医疗机构的临床医师和临床药师,进行2轮问卷调查,根据专家积极系数、权威系数及协调程度等确定最终指标。结果2轮问卷有效回收率分别为100%和92.86%;2轮专家权威系数分别为0.82、0.81,专家协调程度分别为0.29、0.31(P<0.001)。最终形成包含用药指征、用药过程和用药结果三大维度,涵盖11个一级指标(如适应证、用法用量等)和33个二级指标(如分娩镇痛、中大手术后重度疼痛镇痛应与其他镇痛药联合应用等)的地佐辛注射液药物利用评价标准体系,各指标的重要性评分均值为4.08~5.00分,总体评分均值为4.61分,变异系数为0~0.19。结论基于循证方法学和德尔菲法建立的地佐辛注射液药物利用评价标准具有较好的权威性和科学性,为后续临床用药合理性评价提供了参考依据。 展开更多
关键词 地佐辛注射液 药物利用 评价标准 循证方法学 德尔菲法
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